Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,993,687 | 1,993,687 | 0 | $660.37M | $603.37M | 8.59% | -$57.00M |
| Natera, Inc.(NTRA) | 2,593,546 | 2,593,645 | +99 | $366.75M | $438.17M | 6.24% | +$71.42M |
| PTC Therapeutics, Inc.(PTCT) | 7,483,127 | 7,746,415 | +263,288 | $381.34M | $378.33M | 5.39% | -$3.01M |
| argenx SEADR(ARGX) | 673,497 | 673,497 | 0 | $398.62M | $371.25M | 5.29% | -$27.37M |
| Protagonist Therapeutics Inc | 5,719,415 | 5,756,277 | +36,862 | $276.59M | $318.15M | 4.53% | +$41.56M |
| Insmed Incorporated(INSM) | 3,014,558 | 3,084,558 | +70,000 | $229.98M | $310.43M | 4.42% | +$80.45M |
| Akero Therapeutics Inc | 7,419,340 | 5,477,561 | -1,941,779 | $300.33M | $292.28M | 4.16% | -$8.05M |
| Verona Pharma PlcADS | 2,848,800 | 3,051,878 | +203,078 | $180.87M | $288.65M | 4.11% | +$107.78M |
| Avidity Biosciences Inc | 8,746,926 | 9,618,845 | +871,919 | $258.21M | $273.18M | 3.89% | +$14.97M |
| Stryker Corporation(SYK) | 590,221 | 590,517 | +296 | $219.71M | $233.63M | 3.33% | +$13.92M |
| Penumbra, Inc.(PEN) | 862,770 | 863,553 | +783 | $230.71M | $221.61M | 3.16% | -$9.10M |
| Merus N V | 4,169,393 | 4,000,553 | -168,840 | $175.49M | $210.43M | 3.00% | +$34.94M |
| Acadia Pharmaceuticals Inc | 8,540,117 | 8,995,547 | +455,430 | $141.85M | $194.03M | 2.76% | +$52.18M |
| Zai Lab LimitedADR(ZLAB) | 3,136,680 | 5,536,876 | +2,400,196 | $113.36M | $193.62M | 2.76% | +$80.26M |
| Axsome Therapeutics, Inc.(AXSM) | 2,922,729 | 1,516,903 | -1,405,826 | $340.88M | $158.35M | 2.26% | -$182.53M |
| RadNet, Inc.(RDNT) | 2,317,582 | 2,690,344 | +372,762 | $115.23M | $153.11M | 2.18% | +$37.88M |
| Immunocore Holdings plcADS(IMCR) | 4,869,798 | 4,869,798 | 0 | $144.49M | $152.81M | 2.18% | +$8.33M |
| Alkermes plcSHS(ALKS) | 6,884,698 | 4,682,289 | -2,202,409 | $227.33M | $133.96M | 1.91% | -$93.37M |
| Neurocrine Biosciences, Inc.(NBIX) | 0 | 1,062,072 | +1,062,072 | $0 | $133.49M | 1.90% | +$133.49M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 3,316,032 | 3,111,680 | -204,352 | $170.34M | $126.05M | 1.80% | -$44.29M |
| Apogee Therapeutics Inc | 2,712,097 | 2,712,097 | 0 | $101.32M | $117.79M | 1.68% | +$16.46M |
| Masimo Corp | 683,294 | 683,294 | 0 | $113.84M | $114.94M | 1.64% | +$1.11M |
| Establishment Labs Holdings Inc.(ESTA) | 2,583,887 | 2,584,131 | +244 | $105.44M | $110.37M | 1.57% | +$4.93M |
| Intuitive Surgical, Inc.(ISRG) | 202,456 | 202,456 | 0 | $100.27M | $110.02M | 1.57% | +$9.75M |
| Cytokinetics, Incorporated(CYTK) | 2,721,158 | 2,721,158 | 0 | $109.36M | $89.91M | 1.28% | -$19.46M |
| Quest Diagnostics Incorporated(DGX) | 98,997 | 500,000 | +401,003 | $16.75M | $89.81M | 1.28% | +$73.06M |
| uniQure N.V.SHS(QURE) | 4,265,428 | 5,158,231 | +892,803 | $45.21M | $71.91M | 1.02% | +$26.69M |
| GH Research PLC(GHRS) | 5,499,769 | 5,540,457 | +40,688 | $60.66M | $67.54M | 0.96% | +$6.88M |
| UroGen Pharma Ltd.(URGN) | 3,834,794 | 4,543,895 | +709,101 | $42.41M | $62.25M | 0.89% | +$19.84M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,707,402 | 1,707,402 | 0 | $61.83M | $62.08M | 0.88% | +$256.1K |
| Abbott Labs | 0 | 444,000 | +444,000 | $0 | $60.39M | 0.86% | +$60.39M |
| Stoke Therapeutics, Inc.(STOK) | 5,123,525 | 5,123,525 | 0 | $34.07M | $58.15M | 0.83% | +$24.08M |
| Taysha Gene Therapies, Inc.(TSHA) | 18,787,866 | 25,021,584 | +6,233,718 | $26.12M | $57.80M | 0.82% | +$31.68M |
| Spyre Therapeutics, Inc.(SYRE) | 3,621,996 | 3,621,996 | 0 | $58.44M | $54.22M | 0.77% | -$4.22M |
| Beta Bionics, Inc.(BBNX) | 3,299,870 | 3,299,191 | -679 | $40.39M | $48.04M | 0.68% | +$7.65M |
| GE HealthCare Technologies Inc.(GEHC) | 520,000 | 626,000 | +106,000 | $41.97M | $46.37M | 0.66% | +$4.40M |
| Guardant Health, Inc.(GH) | 0 | 856,501 | +856,501 | $0 | $44.57M | 0.63% | +$44.57M |
| CG Oncology, Inc.(CGON) | 1,701,216 | 1,701,216 | 0 | $41.66M | $44.23M | 0.63% | +$2.57M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 17,687,772 | 17,687,772 | 0 | $117.98M | $43.34M | 0.62% | -$74.64M |
| Immatics N.V.SHS(IMTX) | 6,909,510 | 6,970,152 | +60,642 | $31.16M | $37.50M | 0.53% | +$6.34M |
| Soleno Therapeutics Inc | 0 | 424,408 | +424,408 | $0 | $35.56M | 0.51% | +$35.56M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 0 | 741,090 | +741,090 | $0 | $34.98M | 0.50% | +$34.98M |
| Tempus AI, Inc.CL A(TEM) | 400,000 | 400,000 | 0 | $19.30M | $25.42M | 0.36% | +$6.12M |
| LENZ Therapeutics, Inc.(LENZ) | 863,389 | 863,389 | 0 | $22.20M | $25.31M | 0.36% | +$3.11M |
| COMPASS Pathways plcADS(CMPS) | 5,538,168 | 8,221,929 | +2,683,761 | $15.84M | $23.02M | 0.33% | +$7.18M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 8,206,162 | 8,306,062 | +99,900 | $35.12M | $22.26M | 0.32% | -$12.86M |
| Oruka Therapeutics, Inc.(ORKA) | 1,945,649 | 1,945,649 | 0 | $19.96M | $21.81M | 0.31% | +$1.85M |
| Neurogene Inc.(NGNE) | 1,348,656 | 1,362,456 | +13,800 | $15.79M | $20.37M | 0.29% | +$4.58M |
| Centessa Pharmaceuticals PlcADS | 50,000 | 1,529,836 | +1,479,836 | $719.0K | $20.10M | 0.29% | +$19.38M |
| 89bio Inc | 1,967,527 | 1,967,527 | 0 | $14.30M | $19.32M | 0.28% | +$5.02M |
| Replimune Group, Inc.(REPL) | 2,065,010 | 2,065,010 | 0 | $20.13M | $19.18M | 0.27% | -$949.9K |
| Xencor, Inc.(XNCR) | 2,402,883 | 2,402,883 | 0 | $25.57M | $18.89M | 0.27% | -$6.68M |
| Verastem, Inc.(VSTM) | 4,245,476 | 4,251,616 | +6,140 | $25.60M | $17.64M | 0.25% | -$7.96M |
| Dyne Therapeutics, Inc.(DYN) | 1,690,567 | 1,690,567 | 0 | $17.68M | $16.09M | 0.23% | -$1.59M |
| Jade Biosciences Inc | 0 | 1,449,273 | +1,449,273 | $0 | $14.48M | 0.21% | +$14.48M |
| Crinetics Pharmaceuticals In | 0 | 467,000 | +467,000 | $0 | $13.43M | 0.19% | +$13.43M |
| Cullinan Therapeutics, Inc.(CGEM) | 1,705,960 | 1,705,960 | 0 | $12.91M | $12.85M | 0.18% | -$68.2K |
| Exagen Inc.(XGN) | 1,511,866 | 1,696,866 | +185,000 | $5.43M | $11.84M | 0.17% | +$6.42M |
| Rapt Therapeutics Inc | 0 | 1,470,499 | +1,470,499 | $0 | $11.76M | 0.17% | +$11.76M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 2,679,479 | 2,679,479 | 0 | $8.52M | $10.72M | 0.15% | +$2.20M |
| Perceptive Cap Solutions CorCL A CL A ORD SHS | 742,500 | 742,500 | 0 | $7.65M | $7.89M | 0.11% | +$237.6K |
| CytomX Therapeutics, Inc.(CTMX) | 0 | 3,461,500 | +3,461,500 | $0 | $7.86M | 0.11% | +$7.86M |
| Allurion Technologies Inc.(ALUR) | 1,050,063 | 2,542,603 | +1,492,540 | $3.37M | $6.18M | 0.09% | +$2.81M |
| Wave Life Sciences, Inc.SHS(WVE) | 900,000 | 900,000 | 0 | $7.27M | $5.85M | 0.08% | -$1.42M |
| Cargo Therapeutics Inc | 4,124,859 | 1,212,562 | -2,912,297 | $16.79M | $5.00M | 0.07% | -$11.79M |
| Milestone Pharmaceuticals Inc.(MIST) | 2,506,102 | 2,506,102 | 0 | $2.01M | $4.86M | 0.07% | +$2.86M |
| Omada Health, Inc.(OMDA) | 0 | 200,000 | +200,000 | $0 | $3.66M | 0.05% | +$3.66M |
| Kestra Med Technologies LtdSHS SHS | 200,000 | 200,000 | 0 | $4.98M | $3.32M | 0.05% | -$1.67M |
| CeriBell, Inc.(CBLL) | 150,000 | 150,000 | 0 | $2.88M | $2.81M | 0.04% | -$72.0K |
| Tenax Therapeutics, Inc.(TENX) | 378,346 | 378,346 | 0 | $2.48M | $2.18M | 0.03% | -$298.9K |
| Immunic, Inc.(IMUX) | 0 | 402,107 | +402,107 | $0 | $280.5K | 0.00% | +$280.5K |
| Adagio Medical Holdings, Inc.(ADGM) | 209,361 | 209,361 | 0 | $168.5K | $272.2K | 0.00% | +$103.7K |
| Rocket Pharmaceuticals, Inc.W EXP 09 02 202(RCKT) | 350,000 | 350,000 | 0 | $16.4K | $10.1K | 0.00% | -$6.4K |
| Arvinas, Inc.(ARVN) | 3,334,308 | 0 | -3,334,308 | $23.41M | $0 | — | -$23.41M |
| Beam Therapeutics Inc.(BEAM) | 438,659 | 0 | -438,659 | $8.57M | $0 | — | -$8.57M |
| BioAge Labs, Inc.(BIOA) | 786,353 | 0 | -786,353 | $2.96M | $0 | — | -$2.96M |
| Glaukos Corporation(GKOS) | 190,000 | 0 | -190,000 | $18.70M | $0 | — | -$18.70M |
| Globus Medical, Inc.CL A(GMED) | 1,125,000 | 0 | -1,125,000 | $82.35M | $0 | — | -$82.35M |
| Rapt Therapeutics Inc | 11,764,000 | 0 | -11,764,000 | $14.35M | $0 | — | -$14.35M |