Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,993,687 | 1,993,687 | 0 | $603.37M | $914.42M | 11.27% | +$311.06M |
| argenx SEADR(ARGX) | 673,497 | 673,497 | 0 | $371.25M | $496.74M | 6.12% | +$125.50M |
| Avidity Biosciences Inc | 9,618,845 | 11,372,829 | +1,753,984 | $273.18M | $495.51M | 6.11% | +$222.34M |
| PTC Therapeutics, Inc.(PTCT) | 7,746,415 | 7,746,415 | 0 | $378.33M | $475.40M | 5.86% | +$97.06M |
| Insmed Incorporated(INSM) | 3,084,558 | 3,084,558 | 0 | $310.43M | $444.21M | 5.47% | +$133.78M |
| Protagonist Therapeutics Inc | 5,756,277 | 5,756,277 | 0 | $318.15M | $382.39M | 4.71% | +$64.24M |
| Natera, Inc.(NTRA) | 2,593,645 | 2,000,000 | -593,645 | $438.17M | $321.94M | 3.97% | -$116.23M |
| Akero Therapeutics Inc | 5,477,561 | 5,477,561 | 0 | $292.28M | $260.07M | 3.20% | -$32.21M |
| uniQure N.V.SHS(QURE) | 5,158,231 | 4,424,968 | -733,263 | $71.91M | $258.29M | 3.18% | +$186.38M |
| Penumbra, Inc.(PEN) | 863,553 | 866,499 | +2,946 | $221.61M | $219.50M | 2.70% | -$2.11M |
| RadNet, Inc.(RDNT) | 2,690,344 | 2,815,544 | +125,200 | $153.11M | $214.57M | 2.64% | +$61.47M |
| Merus N V | 4,000,553 | 2,025,277 | -1,975,276 | $210.43M | $190.68M | 2.35% | -$19.75M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 3,111,680 | 3,177,436 | +65,756 | $126.05M | $188.84M | 2.33% | +$62.78M |
| Stryker Corporation(SYK) | 590,517 | 490,000 | -100,517 | $233.63M | $181.14M | 2.23% | -$52.49M |
| Immunocore Holdings plcADS(IMCR) | 4,869,798 | 4,869,798 | 0 | $152.81M | $176.92M | 2.18% | +$24.11M |
| Acadia Pharmaceuticals Inc | 8,995,547 | 7,144,524 | -1,851,023 | $194.03M | $152.46M | 1.88% | -$41.57M |
| Cytokinetics, Incorporated(CYTK) | 2,721,158 | 2,721,158 | 0 | $89.91M | $149.55M | 1.84% | +$59.65M |
| Neurocrine Biosciences, Inc.(NBIX) | 1,062,072 | 1,062,072 | 0 | $133.49M | $149.09M | 1.84% | +$15.60M |
| Axsome Therapeutics, Inc.(AXSM) | 1,516,903 | 1,118,883 | -398,020 | $158.35M | $135.89M | 1.67% | -$22.46M |
| Stoke Therapeutics, Inc.(STOK) | 5,123,525 | 5,123,525 | 0 | $58.15M | $120.40M | 1.48% | +$62.25M |
| Apogee Therapeutics Inc | 2,712,097 | 2,712,097 | 0 | $117.79M | $107.75M | 1.33% | -$10.03M |
| Establishment Labs Holdings Inc.(ESTA) | 2,584,131 | 2,588,831 | +4,700 | $110.37M | $106.12M | 1.31% | -$4.25M |
| Masimo Corp | 683,294 | 683,294 | 0 | $114.94M | $100.82M | 1.24% | -$14.12M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,707,402 | 3,258,266 | +1,550,864 | $62.08M | $98.01M | 1.21% | +$35.93M |
| Guardant Health, Inc.(GH) | 856,501 | 1,481,033 | +624,532 | $44.57M | $92.53M | 1.14% | +$47.96M |
| UroGen Pharma Ltd.(URGN) | 4,543,895 | 4,543,895 | 0 | $62.25M | $90.65M | 1.12% | +$28.40M |
| Intuitive Surgical, Inc.(ISRG) | 202,456 | 202,456 | 0 | $110.02M | $90.54M | 1.12% | -$19.47M |
| GH Research PLC(GHRS) | 5,540,457 | 5,569,564 | +29,107 | $67.54M | $79.64M | 0.98% | +$12.11M |
| Taysha Gene Therapies, Inc.(TSHA) | 25,021,584 | 24,354,291 | -667,293 | $57.80M | $79.64M | 0.98% | +$21.84M |
| Zai Lab LimitedADR(ZLAB) | 5,536,876 | 2,291,372 | -3,245,504 | $193.62M | $77.65M | 0.96% | -$115.97M |
| Immatics N.V.SHS(IMTX) | 6,970,152 | 8,815,617 | +1,845,465 | $37.50M | $75.11M | 0.93% | +$37.61M |
| Xencor, Inc.(XNCR) | 2,402,883 | 6,221,054 | +3,818,171 | $18.89M | $72.97M | 0.90% | +$54.09M |
| CG Oncology, Inc.(CGON) | 1,701,216 | 1,701,216 | 0 | $44.23M | $68.52M | 0.84% | +$24.29M |
| Beta Bionics, Inc.(BBNX) | 3,299,191 | 3,299,191 | 0 | $48.04M | $65.55M | 0.81% | +$17.52M |
| Spyre Therapeutics, Inc.(SYRE) | 3,621,996 | 3,621,996 | 0 | $54.22M | $60.70M | 0.75% | +$6.48M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 17,687,772 | 17,687,772 | 0 | $43.34M | $57.66M | 0.71% | +$14.33M |
| Centessa Pharmaceuticals PlcADS | 1,529,836 | 2,291,747 | +761,911 | $20.10M | $55.57M | 0.68% | +$35.47M |
| Alkermes plcSHS(ALKS) | 4,682,289 | 1,672,356 | -3,009,933 | $133.96M | $50.17M | 0.62% | -$83.79M |
| COMPASS Pathways plcADS(CMPS) | 8,221,929 | 8,707,390 | +485,461 | $23.02M | $49.89M | 0.61% | +$26.87M |
| Cogent Biosciences, Inc.(COGT) | 0 | 3,467,486 | +3,467,486 | $0 | $49.79M | 0.61% | +$49.79M |
| Verastem, Inc.(VSTM) | 4,251,616 | 5,426,306 | +1,174,690 | $17.64M | $47.91M | 0.59% | +$30.27M |
| Quest Diagnostics Incorporated(DGX) | 500,000 | 250,000 | -250,000 | $89.81M | $47.65M | 0.59% | -$42.17M |
| LENZ Therapeutics, Inc.(LENZ) | 863,389 | 863,389 | 0 | $25.31M | $40.22M | 0.50% | +$14.91M |
| Rapt Therapeutics Inc | 1,470,499 | 1,470,499 | 0 | $11.76M | $37.92M | 0.47% | +$26.16M |
| Oruka Therapeutics, Inc.(ORKA) | 1,945,649 | 1,945,649 | 0 | $21.81M | $37.41M | 0.46% | +$15.60M |
| Dyne Therapeutics, Inc.(DYN) | 1,690,567 | 2,890,567 | +1,200,000 | $16.09M | $36.57M | 0.45% | +$20.47M |
| Crinetics Pharmaceuticals In | 467,000 | 872,387 | +405,387 | $13.43M | $36.33M | 0.45% | +$22.90M |
| Aquestive Therapeutics Inc | 0 | 6,250,000 | +6,250,000 | $0 | $34.94M | 0.43% | +$34.94M |
| ABIVAX Société AnonymeADS(ABVX) | 0 | 350,000 | +350,000 | $0 | $29.71M | 0.37% | +$29.71M |
| GE HealthCare Technologies Inc.(GEHC) | 626,000 | 393,500 | -232,500 | $46.37M | $29.55M | 0.36% | -$16.82M |
| Replimune Group, Inc.(REPL) | 2,065,010 | 6,395,732 | +4,330,722 | $19.18M | $26.80M | 0.33% | +$7.61M |
| Neurogene Inc.(NGNE) | 1,362,456 | 1,362,456 | 0 | $20.37M | $23.61M | 0.29% | +$3.24M |
| Belite Bio, IncADS(BLTE) | 0 | 312,500 | +312,500 | $0 | $23.13M | 0.28% | +$23.13M |
| Alector Inc | 0 | 6,990,806 | +6,990,806 | $0 | $20.69M | 0.25% | +$20.69M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 8,306,062 | 8,306,063 | +1 | $22.26M | $20.60M | 0.25% | -$1.66M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 2,679,479 | 2,679,479 | 0 | $10.72M | $19.75M | 0.24% | +$9.03M |
| Exagen Inc.(XGN) | 1,696,866 | 1,696,866 | 0 | $11.84M | $18.65M | 0.23% | +$6.80M |
| Heartflow, Inc.(HTFL) | 0 | 495,000 | +495,000 | $0 | $16.66M | 0.21% | +$16.66M |
| Tempus AI, Inc.CL A(TEM) | 400,000 | 200,000 | -200,000 | $25.42M | $16.14M | 0.20% | -$9.27M |
| Jade Biosciences Inc | 1,449,273 | 1,449,273 | 0 | $14.48M | $12.51M | 0.15% | -$1.97M |
| CytomX Therapeutics, Inc.(CTMX) | 3,461,500 | 3,461,500 | 0 | $7.86M | $11.04M | 0.14% | +$3.18M |
| Cullinan Therapeutics, Inc.(CGEM) | 1,705,960 | 1,705,960 | 0 | $12.85M | $10.12M | 0.12% | -$2.73M |
| Larimar Therapeutics, Inc.(LRMR) | 0 | 3,125,000 | +3,125,000 | $0 | $10.09M | 0.12% | +$10.09M |
| Compass Therapeutics, Inc.(CMPX) | 0 | 2,500,000 | +2,500,000 | $0 | $8.75M | 0.11% | +$8.75M |
| Perceptive Cap Solutions CorCL A CL A ORD SHS | 742,500 | 742,500 | 0 | $7.89M | $7.84M | 0.10% | -$44.5K |
| PepGen Inc.(PEPG) | 0 | 1,500,000 | +1,500,000 | $0 | $6.93M | 0.09% | +$6.93M |
| Wave Life Sciences, Inc.SHS(WVE) | 900,000 | 900,000 | 0 | $5.85M | $6.59M | 0.08% | +$738.0K |
| Allurion Technologies Inc.(ALUR) | 2,542,603 | 2,542,603 | 0 | $6.18M | $5.21M | 0.06% | -$966.2K |
| Milestone Pharmaceuticals Inc.(MIST) | 2,506,102 | 2,506,102 | 0 | $4.86M | $5.01M | 0.06% | +$150.4K |
| Omada Health, Inc.(OMDA) | 200,000 | 200,000 | 0 | $3.66M | $4.42M | 0.05% | +$762.0K |
| Tenax Therapeutics, Inc.(TENX) | 378,346 | 378,346 | 0 | $2.18M | $2.88M | 0.04% | +$699.9K |
| ImageneBio, Inc.(IMA) | 0 | 334,445 | +334,445 | $0 | $2.73M | 0.03% | +$2.73M |
| Adagio Medical Holdings, Inc.(ADGM) | 209,361 | 209,361 | 0 | $272.2K | $406.2K | 0.01% | +$134.0K |
| Rocket Pharmaceuticals, Inc.W EXP 09 02 202(RCKT) | 350,000 | 350,000 | 0 | $10.1K | $13.7K | 0.00% | +$3.6K |
| 89bio Inc | 1,967,527 | 0 | -1,967,527 | $19.32M | $0 | — | -$19.32M |
| Abbott Labs | 444,000 | 0 | -444,000 | $60.39M | $0 | — | -$60.39M |
| Cargo Therapeutics Inc | 1,212,562 | 0 | -1,212,562 | $5.00M | $0 | — | -$5.00M |
| CeriBell, Inc.(CBLL) | 150,000 | 0 | -150,000 | $2.81M | $0 | — | -$2.81M |
| Immunic, Inc.(IMUX) | 402,107 | 0 | -402,107 | $280.5K | $0 | — | -$280.5K |
| Kestra Med Technologies LtdSHS SHS | 200,000 | 0 | -200,000 | $3.32M | $0 | — | -$3.32M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 741,090 | 0 | -741,090 | $34.98M | $0 | — | -$34.98M |
| Soleno Therapeutics Inc | 424,408 | 0 | -424,408 | $35.56M | $0 | — | -$35.56M |
| Verona Pharma PlcADS | 3,051,878 | 0 | -3,051,878 | $288.65M | $0 | — | -$288.65M |