Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 1,993,687 | 1,993,687 | 0 | 603,369 | 914,424 | 11.27% | +311,055 |
| AVIDITY BIOSCIENCES INC | 9,618,845 | 11,372,829 | +1,753,984 | 273,175 | 495,514 | 6.11% | +222,339 |
| UNIQURE NV(QURE) | 5,158,231 | 4,424,968 | -733,263 | 71,906 | 258,285 | 3.18% | +186,380 |
| INSMED INC(INSM) | 3,084,558 | 3,084,558 | 0 | 310,430 | 444,207 | 5.47% | +133,777 |
| ARGENX SE(ARGX) | 673,497 | 673,497 | 0 | 371,245 | 496,744 | 6.12% | +125,499 |
| PTC THERAPEUTICS INC(PTCT) | 7,746,415 | 7,746,415 | 0 | 378,335 | 475,397 | 5.86% | +97,063 |
| PROTAGONIST THERAPEUTICS INC | 5,756,277 | 5,756,277 | 0 | 318,149 | 382,389 | 4.71% | +64,240 |
| TARSUS PHARMACEUTICALS INC(TARS) | 3,111,680 | 3,177,436 | +65,756 | 126,054 | 188,835 | 2.33% | +62,781 |
| STOKE THERAPEUTICS INC(STOK) | 5,123,525 | 5,123,525 | 0 | 58,152 | 120,403 | 1.48% | +62,251 |
| RADNET INC(RDNT) | 2,690,344 | 2,815,544 | +125,200 | 153,107 | 214,573 | 2.64% | +61,465 |
| CYTOKINETICS INC(CYTK) | 2,721,158 | 2,721,158 | 0 | 89,907 | 149,555 | 1.84% | +59,648 |
| XENCOR INC(XNCR) | 2,402,883 | 6,221,054 | +3,818,171 | 18,887 | 72,973 | 0.90% | +54,086 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 3,467,486 | +3,467,486 | 0 | 49,793 | 0.61% | +49,793 |
| GUARDANT HEALTH INC(GH) | 856,501 | 1,481,033 | +624,532 | 44,572 | 92,535 | 1.14% | +47,963 |
| IMMATICS N.V(IMTX) | 6,970,152 | 8,815,617 | +1,845,465 | 37,499 | 75,109 | 0.93% | +37,610 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 1,707,402 | 3,258,266 | +1,550,864 | 62,081 | 98,009 | 1.21% | +35,928 |
| CENTESSA PHARMACEUTICALS PLC | 1,529,836 | 2,291,747 | +761,911 | 20,102 | 55,575 | 0.68% | +35,473 |
| AQUESTIVE THERAPEUTICS INC | 0 | 6,250,000 | +6,250,000 | 0 | 34,938 | 0.43% | +34,938 |
| VERASTEM INC(VSTM) | 4,251,616 | 5,426,306 | +1,174,690 | 17,644 | 47,914 | 0.59% | +30,270 |
| ABIVAX SA(ABVX) | 0 | 350,000 | +350,000 | 0 | 29,715 | 0.37% | +29,715 |
| UROGEN PHARMA LTD(URGN) | 4,543,895 | 4,543,895 | 0 | 62,251 | 90,651 | 1.12% | +28,399 |
| COMPASS PATHWAYS PLC(CMPS) | 8,221,929 | 8,707,390 | +485,461 | 23,021 | 49,893 | 0.61% | +26,872 |
| RAPT THERAPEUTICS INC | 1,470,499 | 1,470,499 | 0 | 11,764 | 37,924 | 0.47% | +26,160 |
| CG ONCOLOGY INC(CGON) | 1,701,216 | 1,701,216 | 0 | 44,232 | 68,525 | 0.84% | +24,293 |
| IMMUNOCORE HLDGS PLC(IMCR) | 4,869,798 | 4,869,798 | 0 | 152,814 | 176,920 | 2.18% | +24,106 |
| BELITE BIO INC(BLTE) | 0 | 312,500 | +312,500 | 0 | 23,125 | 0.28% | +23,125 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 467,000 | 872,387 | +405,387 | 13,431 | 36,335 | 0.45% | +22,904 |
| TAYSHA GENE THERAPIES INC(TSHA) | 25,021,584 | 24,354,291 | -667,293 | 57,800 | 79,639 | 0.98% | +21,839 |
| ALECTOR INC | 0 | 6,990,806 | +6,990,806 | 0 | 20,693 | 0.25% | +20,693 |
| DYNE THERAPEUTICS INC(DYN) | 1,690,567 | 2,890,567 | +1,200,000 | 16,094 | 36,566 | 0.45% | +20,471 |
| BETA BIONICS INC(BBNX) | 3,299,191 | 3,299,191 | 0 | 48,036 | 65,555 | 0.81% | +17,519 |
| HEARTFLOW INC(HTFL) | 0 | 495,000 | +495,000 | 0 | 16,662 | 0.21% | +16,662 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,945,649 | 1,945,649 | 0 | 21,811 | 37,415 | 0.46% | +15,604 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 1,062,072 | 1,062,072 | 0 | 133,492 | 149,094 | 1.84% | +15,602 |
| LENZ THERAPEUTICS INC(LENZ) | 863,389 | 863,389 | 0 | 25,306 | 40,217 | 0.50% | +14,911 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 17,687,772 | 17,687,772 | 0 | 43,335 | 57,662 | 0.71% | +14,327 |
| GH RESEARCH PLC(GHRS) | 5,540,457 | 5,569,564 | +29,107 | 67,538 | 79,645 | 0.98% | +12,107 |
| LARIMAR THERAPEUTICS INC(LRMR) | 0 | 3,125,000 | +3,125,000 | 0 | 10,094 | 0.12% | +10,094 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 2,679,479 | 2,679,479 | 0 | 10,718 | 19,748 | 0.24% | +9,030 |
| COMPASS THERAPEUTICS INC(CMPX) | 0 | 2,500,000 | +2,500,000 | 0 | 8,750 | 0.11% | +8,750 |
| REPLIMUNE GROUP INC(REPL) | 2,065,010 | 6,395,732 | +4,330,722 | 19,184 | 26,798 | 0.33% | +7,614 |
| PEPGEN INC(PEPG) | 0 | 1,500,000 | +1,500,000 | 0 | 6,930 | 0.09% | +6,930 |
| EXAGEN INC(XGN) | 1,696,866 | 1,696,866 | 0 | 11,844 | 18,649 | 0.23% | +6,804 |
| SPYRE THERAPEUTICS INC(SYRE) | 3,621,996 | 3,621,996 | 0 | 54,221 | 60,705 | 0.75% | +6,483 |
| NEUROGENE INC(NGNE) | 1,362,456 | 1,362,456 | 0 | 20,369 | 23,611 | 0.29% | +3,243 |
| CYTOMX THERAPEUTICS INC(CTMX) | 3,461,500 | 3,461,500 | 0 | 7,858 | 11,042 | 0.14% | +3,185 |
| IMAGENEBIO INC(IMA) | 0 | 334,445 | +334,445 | 0 | 2,726 | 0.03% | +2,726 |
| OMADA HEALTH INC(OMDA) | 200,000 | 200,000 | 0 | 3,660 | 4,422 | 0.05% | +762 |
| WAVE LIFE SCIENCES LTD(WVE) | 900,000 | 900,000 | 0 | 5,850 | 6,588 | 0.08% | +738 |
| TENAX THERAPEUTICS INC(TENX) | 378,346 | 378,346 | 0 | 2,179 | 2,879 | 0.04% | +700 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 2,506,102 | 2,506,102 | 0 | 4,862 | 5,012 | 0.06% | +150 |
| ADAGIO MED HLDGS INC(ADGM) | 209,361 | 209,361 | 0 | 272 | 406 | 0.01% | +134 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 350,000 | 350,000 | 0 | 10 | 14 | 0.00% | +4 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 742,500 | 742,500 | 0 | 7,885 | 7,841 | 0.10% | -45 |
| IMMUNIC INC(IMUX) | 402,107 | 0 | -402,107 | 280 | 0 | — | -280 |
| ALLURION TECHNOLOGIES INC(ALUR) | 2,542,603 | 2,542,603 | 0 | 6,179 | 5,212 | 0.06% | -966 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 8,306,062 | 8,306,063 | +1 | 22,260 | 20,599 | 0.25% | -1,661 |
| JADE BIOSCIENCES INC | 1,449,273 | 1,449,273 | 0 | 14,478 | 12,507 | 0.15% | -1,971 |
| PENUMBRA INC(PEN) | 863,553 | 866,499 | +2,946 | 221,614 | 219,502 | 2.70% | -2,112 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,705,960 | 1,705,960 | 0 | 12,846 | 10,116 | 0.12% | -2,730 |
| CERIBELL INC(CBLL) | 150,000 | 0 | -150,000 | 2,810 | 0 | — | -2,809 |
| KESTRA MED TECHNOLOGIES LTD SHS | 200,000 | 0 | -200,000 | 3,316 | 0 | — | -3,316 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 2,584,131 | 2,588,831 | +4,700 | 110,368 | 106,116 | 1.31% | -4,252 |
| CARGO THERAPEUTICS INC | 1,212,562 | 0 | -1,212,562 | 4,996 | 0 | — | -4,996 |
| TEMPUS AI INC(TEM) | 400,000 | 200,000 | -200,000 | 25,416 | 16,142 | 0.20% | -9,274 |
| APOGEE THERAPEUTICS INC(APGE) | 2,712,097 | 2,712,097 | 0 | 117,786 | 107,752 | 1.33% | -10,035 |
| MASIMO CORP | 683,294 | 683,294 | 0 | 114,944 | 100,820 | 1.24% | -14,124 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 626,000 | 393,500 | -232,500 | 46,368 | 29,552 | 0.36% | -16,816 |
| 89BIO INC | 1,967,527 | 0 | -1,967,527 | 19,321 | 0 | — | -19,321 |
| INTUITIVE SURGICAL INC | 202,456 | 202,456 | 0 | 110,017 | 90,544 | 1.12% | -19,472 |
| MERUS N V | 4,000,553 | 2,025,277 | -1,975,276 | 210,429 | 190,680 | 2.35% | -19,749 |
| AXSOME THERAPEUTICS INC(AXSM) | 1,516,903 | 1,118,883 | -398,020 | 158,350 | 135,888 | 1.67% | -22,461 |
| AKERO THERAPEUTICS INC | 5,477,561 | 5,477,561 | 0 | 292,283 | 260,075 | 3.20% | -32,208 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 741,090 | 0 | -741,090 | 34,979 | 0 | — | -34,979 |
| SOLENO THERAPEUTICS INC | 424,408 | 0 | -424,408 | 35,557 | 0 | — | -35,557 |
| ACADIA PHARMACEUTICALS INC | 8,995,547 | 7,144,524 | -1,851,023 | 194,034 | 152,464 | 1.88% | -41,570 |
| QUEST DIAGNOSTICS INC(DGX) | 500,000 | 250,000 | -250,000 | 89,815 | 47,645 | 0.59% | -42,170 |
| STRYKER CORPORATION(SYK) | 590,517 | 490,000 | -100,517 | 233,626 | 181,138 | 2.23% | -52,488 |
| ABBOTT LABS | 444,000 | 0 | -444,000 | 60,388 | 0 | — | -60,388 |
| ALKERMES PLC(ALKS) | 4,682,289 | 1,672,356 | -3,009,933 | 133,960 | 50,171 | 0.62% | -83,790 |
| ZAI LAB LTD(ZLAB) | 5,536,876 | 2,291,372 | -3,245,504 | 193,625 | 77,655 | 0.96% | -115,970 |
| NATERA INC(NTRA) | 2,593,645 | 2,000,000 | -593,645 | 438,170 | 321,940 | 3.97% | -116,230 |
| VERONA PHARMA PLC | 3,051,878 | 0 | -3,051,878 | 288,647 | 0 | — | -288,647 |