Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,993,687 | 1,993,687 | 0 | $914.42M | $1.16B | 11.63% | +$246.58M |
| Insmed Incorporated(INSM) | 3,084,558 | 4,842,879 | +1,758,321 | $444.21M | $842.85M | 8.44% | +$398.65M |
| PTC Therapeutics, Inc.(PTCT) | 7,746,415 | 7,746,415 | 0 | $475.40M | $588.42M | 5.89% | +$113.02M |
| argenx SEADR(ARGX) | 673,497 | 673,497 | 0 | $496.74M | $566.38M | 5.67% | +$69.63M |
| Protagonist Therapeutics Inc | 5,756,277 | 5,059,053 | -697,224 | $382.39M | $441.86M | 4.43% | +$59.47M |
| Natera, Inc.(NTRA) | 2,000,000 | 1,500,000 | -500,000 | $321.94M | $343.63M | 3.44% | +$21.70M |
| RadNet, Inc.(RDNT) | 2,815,544 | 3,938,500 | +1,122,956 | $214.57M | $281.01M | 2.81% | +$66.44M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 3,177,436 | 3,335,320 | +157,884 | $188.84M | $273.10M | 2.74% | +$84.26M |
| Cogent Biosciences, Inc.(COGT) | 3,467,486 | 7,592,241 | +4,124,755 | $49.79M | $269.68M | 2.70% | +$219.88M |
| Penumbra, Inc.(PEN) | 866,499 | 866,499 | 0 | $219.50M | $269.40M | 2.70% | +$49.90M |
| iRhythm Holdings, Inc.(IRTC) | 0 | 1,181,990 | +1,181,990 | $0 | $209.73M | 2.10% | +$209.73M |
| Apogee Therapeutics Inc | 2,712,097 | 2,712,097 | 0 | $107.75M | $204.71M | 2.05% | +$96.96M |
| Apellis Pharmaceuticals Inc COM | 0 | 7,666,764 | +7,666,764 | $0 | $192.59M | 1.93% | +$192.59M |
| Acadia Pharmaceuticals Inc | 7,144,524 | 7,144,524 | 0 | $152.46M | $190.83M | 1.91% | +$38.37M |
| Establishment Labs Holdings Inc.(ESTA) | 2,588,831 | 2,588,831 | 0 | $106.12M | $188.67M | 1.89% | +$82.56M |
| Stoke Therapeutics, Inc.(STOK) | 5,123,525 | 5,546,856 | +423,331 | $120.40M | $176.06M | 1.76% | +$55.65M |
| Repligen Corporation(RGEN) | 0 | 1,064,000 | +1,064,000 | $0 | $174.35M | 1.75% | +$174.35M |
| Cytokinetics, Incorporated(CYTK) | 2,721,158 | 2,721,158 | 0 | $149.55M | $172.90M | 1.73% | +$23.35M |
| Immunocore Holdings plcADS(IMCR) | 4,869,798 | 4,869,798 | 0 | $176.92M | $169.03M | 1.69% | -$7.89M |
| Axsome Therapeutics, Inc.(AXSM) | 1,118,883 | 888,001 | -230,882 | $135.89M | $162.18M | 1.62% | +$26.30M |
| Guardant Health, Inc.(GH) | 1,481,033 | 1,481,033 | 0 | $92.53M | $151.27M | 1.52% | +$58.74M |
| Neurocrine Biosciences, Inc.(NBIX) | 1,062,072 | 1,062,072 | 0 | $149.09M | $150.63M | 1.51% | +$1.54M |
| Spyre Therapeutics, Inc.(SYRE) | 3,621,996 | 4,171,996 | +550,000 | $60.70M | $136.67M | 1.37% | +$75.97M |
| Zai Lab LimitedADR(ZLAB) | 2,291,372 | 6,959,032 | +4,667,660 | $77.65M | $122.76M | 1.23% | +$45.10M |
| Immatics N.V.SHS(IMTX) | 8,815,617 | 11,433,354 | +2,617,737 | $75.11M | $120.05M | 1.20% | +$44.94M |
| Belite Bio, IncADS(BLTE) | 312,500 | 715,332 | +402,832 | $23.13M | $114.42M | 1.15% | +$91.30M |
| UroGen Pharma Ltd.(URGN) | 4,543,895 | 4,543,895 | 0 | $90.65M | $106.42M | 1.07% | +$15.77M |
| Xencor, Inc.(XNCR) | 6,221,054 | 6,777,461 | +556,407 | $72.97M | $103.76M | 1.04% | +$30.79M |
| Insulet Corporation(PODD) | 0 | 324,600 | +324,600 | $0 | $92.26M | 0.92% | +$92.26M |
| Taysha Gene Therapies, Inc.(TSHA) | 24,354,291 | 16,398,297 | -7,955,994 | $79.64M | $90.19M | 0.90% | +$10.55M |
| Masimo Corp | 683,294 | 683,294 | 0 | $100.82M | $88.87M | 0.89% | -$11.95M |
| uniQure N.V.SHS(QURE) | 4,424,968 | 3,711,462 | -713,506 | $258.29M | $88.82M | 0.89% | -$169.47M |
| Stryker Corporation(SYK) | 490,000 | 245,000 | -245,000 | $181.14M | $86.11M | 0.86% | -$95.03M |
| CG Oncology, Inc.(CGON) | 1,701,216 | 2,012,127 | +310,911 | $68.52M | $83.54M | 0.84% | +$15.02M |
| Castle Biosciences, Inc.(CSTL) | 0 | 2,115,237 | +2,115,237 | $0 | $82.28M | 0.82% | +$82.28M |
| Immunovant, Inc.(IMVT) | 0 | 3,177,850 | +3,177,850 | $0 | $80.78M | 0.81% | +$80.78M |
| Beta Bionics, Inc.(BBNX) | 3,299,191 | 2,500,000 | -799,191 | $65.55M | $76.17M | 0.76% | +$10.62M |
| GH Research PLC(GHRS) | 5,569,564 | 5,933,815 | +364,251 | $79.64M | $75.36M | 0.75% | -$4.29M |
| Replimune Group, Inc.(REPL) | 6,395,732 | 7,140,352 | +744,620 | $26.80M | $69.40M | 0.70% | +$42.61M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 3,258,266 | 3,000,139 | -258,127 | $98.01M | $69.00M | 0.69% | -$29.01M |
| Crinetics Pharmaceuticals In | 872,387 | 1,351,326 | +478,939 | $36.33M | $62.90M | 0.63% | +$26.57M |
| Oruka Therapeutics, Inc.(ORKA) | 1,945,649 | 2,058,148 | +112,499 | $37.41M | $62.38M | 0.62% | +$24.97M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 17,687,772 | 17,687,772 | 0 | $57.66M | $62.08M | 0.62% | +$4.42M |
| COMPASS Pathways plcADS(CMPS) | 8,707,390 | 8,757,390 | +50,000 | $49.89M | $60.43M | 0.61% | +$10.53M |
| Intuitive Surgical, Inc.(ISRG) | 202,456 | 101,228 | -101,228 | $90.54M | $57.33M | 0.57% | -$33.21M |
| Rapt Therapeutics Inc | 1,470,499 | 1,637,165 | +166,666 | $37.92M | $55.45M | 0.56% | +$17.53M |
| Celcuity Inc.(CELC) | 0 | 550,160 | +550,160 | $0 | $54.87M | 0.55% | +$54.87M |
| Verastem, Inc.(VSTM) | 5,426,306 | 6,576,306 | +1,150,000 | $47.91M | $50.77M | 0.51% | +$2.85M |
| Alkermes plcSHS(ALKS) | 1,672,356 | 1,672,356 | 0 | $50.17M | $46.79M | 0.47% | -$3.38M |
| Centessa Pharmaceuticals PlcADS | 2,291,747 | 1,790,837 | -500,910 | $55.57M | $44.79M | 0.45% | -$10.79M |
| Kodiak Sciences Inc.(KOD) | 0 | 1,487,933 | +1,487,933 | $0 | $41.60M | 0.42% | +$41.60M |
| Aquestive Therapeutics Inc | 6,250,000 | 6,250,000 | 0 | $34.94M | $40.38M | 0.40% | +$5.44M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 0 | 584,716 | +584,716 | $0 | $38.82M | 0.39% | +$38.82M |
| Savara Inc.(SVRA) | 0 | 5,952,380 | +5,952,380 | $0 | $35.89M | 0.36% | +$35.89M |
| Orchestra BioMed Holdings, Inc.(OBIO) | 8,306,063 | 8,306,063 | 0 | $20.60M | $34.47M | 0.35% | +$13.87M |
| Neurogene Inc.(NGNE) | 1,362,456 | 1,362,456 | 0 | $23.61M | $28.07M | 0.28% | +$4.46M |
| Wave Life Sciences, Inc.SHS(WVE) | 900,000 | 1,350,000 | +450,000 | $6.59M | $22.95M | 0.23% | +$16.36M |
| Jade Biosciences Inc | 1,449,273 | 1,449,273 | 0 | $12.51M | $22.36M | 0.22% | +$9.86M |
| Evommune, Inc.(EVMN) | 0 | 1,283,671 | +1,283,671 | $0 | $21.98M | 0.22% | +$21.98M |
| Kymera Therapeutics, Inc.(KYMR) | 0 | 240,000 | +240,000 | $0 | $18.67M | 0.19% | +$18.67M |
| Fulgent Genetics, Inc.(FLGT) | 0 | 705,027 | +705,027 | $0 | $18.52M | 0.19% | +$18.52M |
| Cullinan Therapeutics, Inc.(CGEM) | 1,705,960 | 1,705,960 | 0 | $10.12M | $17.66M | 0.18% | +$7.54M |
| Hinge Health, Inc.CL A(HNGE) | 0 | 353,500 | +353,500 | $0 | $16.42M | 0.16% | +$16.42M |
| Beam Therapeutics Inc.(BEAM) | 0 | 570,394 | +570,394 | $0 | $15.81M | 0.16% | +$15.81M |
| Heartflow, Inc.(HTFL) | 495,000 | 495,000 | 0 | $16.66M | $14.43M | 0.14% | -$2.23M |
| Compass Therapeutics, Inc.(CMPX) | 2,500,000 | 2,500,000 | 0 | $8.75M | $13.43M | 0.13% | +$4.67M |
| Tango Therapeutics, Inc.(TNGX) | 0 | 1,491,228 | +1,491,228 | $0 | $13.21M | 0.13% | +$13.21M |
| Lumexa Imaging Holdings, Inc.(LMRI) | 0 | 650,000 | +650,000 | $0 | $12.03M | 0.12% | +$12.03M |
| Larimar Therapeutics, Inc.(LRMR) | 3,125,000 | 3,125,000 | 0 | $10.09M | $11.91M | 0.12% | +$1.81M |
| Tempus AI, Inc.CL A(TEM) | 200,000 | 200,000 | 0 | $16.14M | $11.81M | 0.12% | -$4.33M |
| Kalaris Therapeutics, Inc.(KLRS) | 0 | 1,300,000 | +1,300,000 | $0 | $10.97M | 0.11% | +$10.97M |
| IQVIA Holdings Inc.(IQV) | 0 | 46,000 | +46,000 | $0 | $10.37M | 0.10% | +$10.37M |
| Perceptive Cap Solutions CorCL A CL A ORD SHS | 742,500 | 742,500 | 0 | $7.84M | $9.67M | 0.10% | +$1.83M |
| Atai Beckley NvSHS | 0 | 2,000,000 | +2,000,000 | $0 | $8.18M | 0.08% | +$8.18M |
| Allurion Technologies Inc.(ALUR) | 2,542,603 | 5,891,430 | +3,348,827 | $5.21M | $7.25M | 0.07% | +$2.03M |
| Capricor Therapeutics, Inc.(CAPR) | 0 | 250,000 | +250,000 | $0 | $7.21M | 0.07% | +$7.21M |
| Structure Therapeutics IncADS | 0 | 100,000 | +100,000 | $0 | $6.96M | 0.07% | +$6.96M |
| Inventiva S.A.ADS(IVA) | 0 | 1,298,701 | +1,298,701 | $0 | $6.04M | 0.06% | +$6.04M |
| Milestone Pharmaceuticals Inc.(MIST) | 2,506,102 | 2,506,102 | 0 | $5.01M | $5.06M | 0.05% | +$50.1K |
| Exagen Inc.(XGN) | 1,696,866 | 790,462 | -906,404 | $18.65M | $4.81M | 0.05% | -$13.84M |
| Tenax Therapeutics, Inc.(TENX) | 378,346 | 378,346 | 0 | $2.88M | $4.61M | 0.05% | +$1.73M |
| Crescent Biopharma, Inc.(CBIO) | 0 | 372,856 | +372,856 | $0 | $4.42M | 0.04% | +$4.42M |
| Mind Medicine Mindmed Inc | 0 | 300,000 | +300,000 | $0 | $4.02M | 0.04% | +$4.02M |
| 4d Molecular Therapeutics In | 0 | 475,737 | +475,737 | $0 | $3.57M | 0.04% | +$3.57M |
| Corvus Pharmaceuticals, Inc.(CRVS) | 2,679,479 | 447,607 | -2,231,872 | $19.75M | $3.45M | 0.03% | -$16.30M |
| Omada Health, Inc.(OMDA) | 200,000 | 200,000 | 0 | $4.42M | $3.16M | 0.03% | -$1.27M |
| Medline Inc.CL A(MDLN) | 0 | 70,000 | +70,000 | $0 | $2.94M | 0.03% | +$2.94M |
| Disc Medicine, Inc.(IRON) | 0 | 30,000 | +30,000 | $0 | $2.38M | 0.02% | +$2.38M |
| ImageneBio, Inc.(IMA) | 334,445 | 334,445 | 0 | $2.73M | $2.31M | 0.02% | -$418.1K |
| Erasca, Inc.(ERAS) | 0 | 146,651 | +146,651 | $0 | $545.5K | 0.01% | +$545.5K |
| Rocket Pharmaceuticals, Inc.W EXP 09 02 202(RCKT) | 350,000 | 350,000 | 0 | $13.7K | $8.5K | 0.00% | -$5.2K |
| ABIVAX Société AnonymeADS(ABVX) | 350,000 | 0 | -350,000 | $29.71M | $0 | — | -$29.71M |
| Adagio Medical Holdings, Inc.(ADGM) | 209,361 | 0 | -209,361 | $406.2K | $0 | — | -$406.2K |
| Akero Therapeutics Inc | 5,477,561 | 0 | -5,477,561 | $260.07M | $0 | — | -$260.07M |
| Alector Inc | 6,990,806 | 0 | -6,990,806 | $20.69M | $0 | — | -$20.69M |
| Avidity Biosciences Inc | 11,372,829 | 0 | -11,372,829 | $495.51M | $0 | — | -$495.51M |
| CytomX Therapeutics, Inc.(CTMX) | 3,461,500 | 0 | -3,461,500 | $11.04M | $0 | — | -$11.04M |
| Dyne Therapeutics, Inc.(DYN) | 2,890,567 | 0 | -2,890,567 | $36.57M | $0 | — | -$36.57M |
| GE HealthCare Technologies Inc.(GEHC) | 393,500 | 0 | -393,500 | $29.55M | $0 | — | -$29.55M |
| LENZ Therapeutics, Inc.(LENZ) | 863,389 | 0 | -863,389 | $40.22M | $0 | — | -$40.22M |