Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| INSMED INC(INSM) | 3,084,558 | 4,842,879 | +1,758,321 | 444,207 | 842,855 | 8.44% | +398,647 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 1,993,687 | 1,993,687 | 0 | 914,424 | 1,161,004 | 11.63% | +246,579 |
| COGENT BIOSCIENCES INC(COGT) | 3,467,486 | 7,592,241 | +4,124,755 | 49,793 | 269,676 | 2.70% | +219,883 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 0 | 1,181,990 | +1,181,990 | 0 | 209,732 | 2.10% | +209,732 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 7,666,764 | +7,666,764 | 0 | 192,589 | 1.93% | +192,589 |
| REPLIGEN CORP(RGEN) | 0 | 1,064,000 | +1,064,000 | 0 | 174,347 | 1.75% | +174,347 |
| PTC THERAPEUTICS INC(PTCT) | 7,746,415 | 7,746,415 | 0 | 475,397 | 588,418 | 5.89% | +113,020 |
| APOGEE THERAPEUTICS INC(APGE) | 2,712,097 | 2,712,097 | 0 | 107,752 | 204,709 | 2.05% | +96,957 |
| INSULET CORP(PODD) | 0 | 324,600 | +324,600 | 0 | 92,264 | 0.92% | +92,264 |
| BELITE BIO INC(BLTE) | 312,500 | 715,332 | +402,832 | 23,125 | 114,425 | 1.15% | +91,300 |
| TARSUS PHARMACEUTICALS INC(TARS) | 3,177,436 | 3,335,320 | +157,884 | 188,835 | 273,096 | 2.74% | +84,261 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 2,588,831 | 2,588,831 | 0 | 106,116 | 188,674 | 1.89% | +82,558 |
| CASTLE BIOSCIENCES INC(CSTL) | 0 | 2,115,237 | +2,115,237 | 0 | 82,283 | 0.82% | +82,283 |
| IMMUNOVANT INC(IMVT) | 0 | 3,177,850 | +3,177,850 | 0 | 80,781 | 0.81% | +80,781 |
| SPYRE THERAPEUTICS INC(SYRE) | 3,621,996 | 4,171,996 | +550,000 | 60,705 | 136,675 | 1.37% | +75,970 |
| ARGENX SE(ARGX) | 673,497 | 673,497 | 0 | 496,744 | 566,377 | 5.67% | +69,633 |
| RADNET INC(RDNT) | 2,815,544 | 3,938,500 | +1,122,956 | 214,573 | 281,012 | 2.81% | +66,439 |
| PROTAGONIST THERAPEUTICS INC | 5,756,277 | 5,059,053 | -697,224 | 382,389 | 441,858 | 4.43% | +59,468 |
| GUARDANT HEALTH INC(GH) | 1,481,033 | 1,481,033 | 0 | 92,535 | 151,273 | 1.52% | +58,738 |
| STOKE THERAPEUTICS INC(STOK) | 5,123,525 | 5,546,856 | +423,331 | 120,403 | 176,057 | 1.76% | +55,654 |
| CELCUITY INC(CELC) | 0 | 550,160 | +550,160 | 0 | 54,873 | 0.55% | +54,873 |
| PENUMBRA INC(PEN) | 866,499 | 866,499 | 0 | 219,502 | 269,403 | 2.70% | +49,902 |
| ZAI LAB LTD(ZLAB) | 2,291,372 | 6,959,032 | +4,667,660 | 77,655 | 122,757 | 1.23% | +45,103 |
| IMMATICS N.V(IMTX) | 8,815,617 | 11,433,354 | +2,617,737 | 75,109 | 120,050 | 1.20% | +44,941 |
| REPLIMUNE GROUP INC(REPL) | 6,395,732 | 7,140,352 | +744,620 | 26,798 | 69,404 | 0.70% | +42,606 |
| KODIAK SCIENCES INC(KOD) | 0 | 1,487,933 | +1,487,933 | 0 | 41,603 | 0.42% | +41,603 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 0 | 584,716 | +584,716 | 0 | 38,819 | 0.39% | +38,819 |
| ACADIA PHARMACEUTICALS INC | 7,144,524 | 7,144,524 | 0 | 152,464 | 190,830 | 1.91% | +38,366 |
| SAVARA INC(SVRA) | 0 | 5,952,380 | +5,952,380 | 0 | 35,893 | 0.36% | +35,893 |
| XENCOR INC(XNCR) | 6,221,054 | 6,777,461 | +556,407 | 72,973 | 103,763 | 1.04% | +30,790 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 872,387 | 1,351,326 | +478,939 | 36,335 | 62,904 | 0.63% | +26,569 |
| AXSOME THERAPEUTICS INC(AXSM) | 1,118,883 | 888,001 | -230,882 | 135,888 | 162,185 | 1.62% | +26,296 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,945,649 | 2,058,148 | +112,499 | 37,415 | 62,382 | 0.62% | +24,968 |
| CYTOKINETICS INC(CYTK) | 2,721,158 | 2,721,158 | 0 | 149,555 | 172,902 | 1.73% | +23,348 |
| EVOMMUNE INC | 0 | 1,283,671 | +1,283,671 | 0 | 21,976 | 0.22% | +21,976 |
| NATERA INC(NTRA) | 2,000,000 | 1,500,000 | -500,000 | 321,940 | 343,635 | 3.44% | +21,695 |
| KYMERA THERAPEUTICS INC(KYMR) | 0 | 240,000 | +240,000 | 0 | 18,674 | 0.19% | +18,674 |
| FULGENT GENETICS INC | 0 | 705,027 | +705,027 | 0 | 18,521 | 0.19% | +18,521 |
| RAPT THERAPEUTICS INC | 1,470,499 | 1,637,165 | +166,666 | 37,924 | 55,451 | 0.56% | +17,527 |
| HINGE HEALTH INC(HNGE) | 0 | 353,500 | +353,500 | 0 | 16,420 | 0.16% | +16,420 |
| WAVE LIFE SCIENCES LTD(WVE) | 900,000 | 1,350,000 | +450,000 | 6,588 | 22,950 | 0.23% | +16,362 |
| BEAM THERAPEUTICS INC(BEAM) | 0 | 570,394 | +570,394 | 0 | 15,811 | 0.16% | +15,811 |
| UROGEN PHARMA LTD(URGN) | 4,543,895 | 4,543,895 | 0 | 90,651 | 106,418 | 1.07% | +15,767 |
| CG ONCOLOGY INC(CGON) | 1,701,216 | 2,012,127 | +310,911 | 68,525 | 83,544 | 0.84% | +15,019 |
| ORCHESTRA BIOMED HLDGS INC | 8,306,063 | 8,306,063 | 0 | 20,599 | 34,470 | 0.35% | +13,871 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 1,491,228 | +1,491,228 | 0 | 13,212 | 0.13% | +13,212 |
| LUMEXA IMAGING HOLDINGS INC(LMRI) | 0 | 650,000 | +650,000 | 0 | 12,025 | 0.12% | +12,025 |
| KALARIS THERAPEUTICS INC | 0 | 1,300,000 | +1,300,000 | 0 | 10,972 | 0.11% | +10,972 |
| BETA BIONICS INC | 3,299,191 | 2,500,000 | -799,191 | 65,555 | 76,175 | 0.76% | +10,620 |
| TAYSHA GENE THERAPIES INC(TSHA) | 24,354,291 | 16,398,297 | -7,955,994 | 79,639 | 90,191 | 0.90% | +10,552 |
| COMPASS PATHWAYS PLC(CMPS) | 8,707,390 | 8,757,390 | +50,000 | 49,893 | 60,426 | 0.61% | +10,533 |
| IQVIA HLDGS INC(IQV) | 0 | 46,000 | +46,000 | 0 | 10,369 | 0.10% | +10,369 |
| JADE BIOSCIENCES INC | 1,449,273 | 1,449,273 | 0 | 12,507 | 22,362 | 0.22% | +9,855 |
| ATAI BECKLEY NV | 0 | 2,000,000 | +2,000,000 | 0 | 8,180 | 0.08% | +8,180 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,705,960 | 1,705,960 | 0 | 10,116 | 17,657 | 0.18% | +7,540 |
| CAPRICOR THERAPEUTICS INC | 0 | 250,000 | +250,000 | 0 | 7,215 | 0.07% | +7,215 |
| STRUCTURE THERAPEUTICS INC | 0 | 100,000 | +100,000 | 0 | 6,955 | 0.07% | +6,955 |
| INVENTIVA SA(IVA) | 0 | 1,298,701 | +1,298,701 | 0 | 6,039 | 0.06% | +6,039 |
| AQUESTIVE THERAPEUTICS INC | 6,250,000 | 6,250,000 | 0 | 34,938 | 40,375 | 0.40% | +5,438 |
| COMPASS THERAPEUTICS INC | 2,500,000 | 2,500,000 | 0 | 8,750 | 13,425 | 0.13% | +4,675 |
| NEUROGENE INC | 1,362,456 | 1,362,456 | 0 | 23,611 | 28,067 | 0.28% | +4,455 |
| CRESCENT BIOPHARMA INC. | 0 | 372,856 | +372,856 | 0 | 4,422 | 0.04% | +4,422 |
| ROCKET PHARMACEUTICALS INC | 17,687,772 | 17,687,772 | 0 | 57,662 | 62,084 | 0.62% | +4,422 |
| MIND MEDICINE MINDMED INC | 0 | 300,000 | +300,000 | 0 | 4,017 | 0.04% | +4,017 |
| 4D MOLECULAR THERAPEUTICS IN | 0 | 475,737 | +475,737 | 0 | 3,568 | 0.04% | +3,568 |
| MEDLINE INC(MDLN) | 0 | 70,000 | +70,000 | 0 | 2,940 | 0.03% | +2,940 |
| VERASTEM INC | 5,426,306 | 6,576,306 | +1,150,000 | 47,914 | 50,769 | 0.51% | +2,855 |
| DISC MEDICINE INC(IRON) | 0 | 30,000 | +30,000 | 0 | 2,382 | 0.02% | +2,382 |
| ALLURION TECHNOLOGIES INC | 2,542,603 | 5,891,430 | +3,348,827 | 5,212 | 7,246 | 0.07% | +2,034 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 742,500 | 742,500 | 0 | 7,841 | 9,675 | 0.10% | +1,834 |
| LARIMAR THERAPEUTICS INC | 3,125,000 | 3,125,000 | 0 | 10,094 | 11,906 | 0.12% | +1,813 |
| TENAX THERAPEUTICS INC | 378,346 | 378,346 | 0 | 2,879 | 4,612 | 0.05% | +1,733 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 1,062,072 | 1,062,072 | 0 | 149,094 | 150,634 | 1.51% | +1,540 |
| ERASCA INC(ERAS) | 0 | 146,651 | +146,651 | 0 | 546 | 0.01% | +546 |
| MILESTONE PHARMACEUTICALS IN | 2,506,102 | 2,506,102 | 0 | 5,012 | 5,062 | 0.05% | +50 |
| ROCKET PHARMACEUTICALS INC | 350,000 | 350,000 | 0 | 14 | 9 | 0.00% | -5 |
| ADAGIO MED HLDGS INC | 209,361 | 0 | -209,361 | 406 | 0 | — | -406 |
| IMAGENEBIO INC | 334,445 | 334,445 | 0 | 2,726 | 2,308 | 0.02% | -418 |
| OMADA HEALTH INC(OMDA) | 200,000 | 200,000 | 0 | 4,422 | 3,156 | 0.03% | -1,266 |
| HEARTFLOW INC(HTFL) | 495,000 | 495,000 | 0 | 16,662 | 14,429 | 0.14% | -2,232 |
| ALKERMES PLC(ALKS) | 1,672,356 | 1,672,356 | 0 | 50,171 | 46,793 | 0.47% | -3,378 |
| GH RESEARCH PLC(GHRS) | 5,569,564 | 5,933,815 | +364,251 | 79,645 | 75,359 | 0.75% | -4,285 |
| TEMPUS AI INC(TEM) | 200,000 | 200,000 | 0 | 16,142 | 11,810 | 0.12% | -4,332 |
| PEPGEN INC | 1,500,000 | 0 | -1,500,000 | 6,930 | 0 | — | -6,930 |
| IMMUNOCORE HLDGS PLC(IMCR) | 4,869,798 | 4,869,798 | 0 | 176,920 | 169,031 | 1.69% | -7,889 |
| CENTESSA PHARMACEUTICALS PLC | 2,291,747 | 1,790,837 | -500,910 | 55,575 | 44,789 | 0.45% | -10,786 |
| CYTOMX THERAPEUTICS INC | 3,461,500 | 0 | -3,461,500 | 11,042 | 0 | — | -11,042 |
| MASIMO CORP | 683,294 | 683,294 | 0 | 100,820 | 88,869 | 0.89% | -11,951 |
| EXAGEN INC | 1,696,866 | 790,462 | -906,404 | 18,649 | 4,806 | 0.05% | -13,843 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 2,679,479 | 447,607 | -2,231,872 | 19,748 | 3,447 | 0.03% | -16,301 |
| ALECTOR INC | 6,990,806 | 0 | -6,990,806 | 20,693 | 0 | — | -20,693 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 3,258,266 | 3,000,139 | -258,127 | 98,009 | 69,003 | 0.69% | -29,005 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 393,500 | 0 | -393,500 | 29,552 | 0 | — | -29,552 |
| ABIVAX SA(ABVX) | 350,000 | 0 | -350,000 | 29,715 | 0 | — | -29,715 |
| INTUITIVE SURGICAL INC | 202,456 | 101,228 | -101,228 | 90,544 | 57,331 | 0.57% | -33,213 |
| DYNE THERAPEUTICS INC(DYN) | 2,890,567 | 0 | -2,890,567 | 36,566 | 0 | — | -36,566 |
| LENZ THERAPEUTICS INC | 863,389 | 0 | -863,389 | 40,217 | 0 | — | -40,217 |
| QUEST DIAGNOSTICS INC(DGX) | 250,000 | 0 | -250,000 | 47,645 | 0 | — | -47,645 |
| STRYKER CORPORATION(SYK) | 490,000 | 245,000 | -245,000 | 181,138 | 86,110 | 0.86% | -95,028 |
| UNIQURE NV(QURE) | 4,424,968 | 3,711,462 | -713,506 | 258,285 | 88,815 | 0.89% | -169,470 |