Fund HoldingsSPHERA FUNDS MANAGEMENT LTD.

Total Portfolio Value
$434.31M
Total Bought
$97.45M
Total Sold
$154.50M
Net Transaction
-$57.05M
Filing Period:
Securities
SharesValue ($K)
Q4 2024
Q1 2025
Change
Q4 2024
Q1 2025
Weight (%)
Change
ISHARES TR(Call)0255,100+255,100023,222+23,222
MINERALYS THERAPEUTICS INC(MLYS)190,672465,526+274,8542,3477,3931.70%+5,045
MAZE THERAPEUTICS INC(MAZE)0355,554+355,55403,9150.90%+3,915
IMMUNOVANT INC(IMVT)0194,638+194,63803,3260.77%+3,326
NOVA LTD(NVMI)68,14690,697+22,55113,42116,7183.85%+3,297
NVIDIA CORPORATION(NVDA)029,605+29,60503,2090.74%+3,209
AVIDITY BIOSCIENCES INC0106,000+106,00003,1290.72%+3,129
AMGEN INC(AMGN)010,000+10,00003,1160.72%+3,116
APPLIED MATLS INC018,000+18,00002,6120.60%+2,612
SALESFORCE INC(CRM)09,100+9,10002,4420.56%+2,442
ENLIVEN THERAPEUTICS INC0111,743+111,74302,1990.51%+2,199
SYNDAX PHARMACEUTICALS INC(SNDX)1,381,2411,663,974+282,73318,26020,4424.71%+2,182
COGENT BIOSCIENCES INC(COGT)0335,024+335,02402,0070.46%+2,007
NIKE INC(NKE)030,050+30,05001,9080.44%+1,908
ULTRAGENYX PHARMACEUTICAL IN(RARE)(Call)050,000+50,00001,811+1,811
STRUCTURE THERAPEUTICS INC084,000+84,00001,4540.33%+1,454
CEVA INC(CEVA)048,920+48,92001,2530.29%+1,253
NANO DIMENSION LTD0717,518+717,51801,1410.26%+1,141
OUTLOOK THERAPEUTICS INC0857,142+857,14201,0460.24%+1,046
ARVINAS INC0125,000+125,00008780.20%+878
REGULUS THERAPEUTICS INC0452,845+452,84507920.18%+792
NOVARTIS AG(NVS)50,00050,00004,8665,5741.28%+709
GSK PLC(GSK)130,000130,00004,3975,0361.16%+640
ORMAT TECHNOLOGIES INC(ORA)79,00084,000+5,0005,3505,9451.37%+595
ISHARES BITCOIN TRUST ETF(IBIT)08,150+8,15003820.09%+382
UBER TECHNOLOGIES INC(UBER)30,00030,00001,8102,1860.50%+376
CIDARA THERAPEUTICS INC017,128+17,12803690.08%+369
VIGIL NEUROSCIENCE INC01,604,429+1,604,42902,8560.66%+2,856
ABBVIE INC(ABBV)34,25630,256-4,0006,0876,3391.46%+252
ORMAT TECHNOLOGIES INC5,037,0005,037,00005,0185,2301.20%+212
89BIO INC556,532618,343+61,8114,3524,4951.04%+143
BRISTOL-MYERS SQUIBB CO(BMY)20,00020,00001,1311,2200.28%+89
ULTRAGENYX PHARMACEUTICAL IN(RARE)228,776267,385+38,6099,6259,6822.23%+57
APPLIED THERAPEUTICS INC050,000+50,0000240.01%+24
IMMATICS N.V100,000100,00002520.00%-24
PERION NETWORK LTD102,612102,61208698350.19%-34
LAVA THERAPEUTICS NV126,32848,420-77,908120610.01%-59
SOLAREDGE TECHNOLOGIES INC(SEDG)375,000309,216-65,7845,1005,0031.15%-97
PFIZER INC(PFE)90,00090,00002,3882,2810.53%-107
CLIMB BIO INC251,935241,935-10,0004532950.07%-158
SAVARA INC(SVRA)1,211,5331,284,151+72,6183,7193,5570.82%-162
ARROWHEAD PHARMACEUTICALS IN(ARWR)197,550277,550+80,0003,7143,5360.81%-178
KEZAR LIFE SCIENCES INC
COM NEW
108,473108,47307295290.12%-200
ASTRIA THERAPEUTICS INC139,800189,800+50,0001,2501,0140.23%-236
NOVO-NORDISK A S(NVO)98,080118,080+20,0008,4378,1991.89%-237
WORKDAY INC(WDAY)10,00010,00002,5802,3350.54%-245
TRAVERE THERAPEUTICS INC(TVTX)220,700200,000-20,7003,8453,5840.83%-261
JANUX THERAPEUTICS INC(JANX)68,333125,840+57,5073,6593,3980.78%-261
COMPUGEN LTD177,0940-177,0942710-271
IONIS PHARMACEUTICALS INC(IONS)63,82163,82102,2311,9250.44%-306
WEREWOLF THERAPEUTICS INC626,810626,81009286090.14%-318
APREA THERAPEUTICS INC270,000270,00008885510.13%-337
FATE THERAPEUTICS INC397,177397,17706553140.07%-342
SHL TELEMEDICINE LTD632,456632,45601,6761,3110.30%-365
BIOGEN INC(BIIB)22,73822,73803,4773,1110.72%-366
ONKURE THERAPEUTICS INC87,35480,454-6,9007513460.08%-405
VISTAGEN THERAPEUTICS INC808,550790,550-18,0002,3851,9760.46%-409
KYVERNA THERAPEUTICS INC118,7580-118,7584440-444
ALECTOR INC0109,208+109,20801340.03%+134
ELEVATION ONCOLOGY INC1,018,562358,562-660,000573930.02%-480
PROMIS NEUROSCIENCES INC1,929,2971,929,29701,8291,3420.31%-487
PERSPECTIVE THERAPEUTICS INC0460,247+460,24709800.23%+980
ELI LILLY & CO(LLY)13,19011,690-1,50010,1839,6552.22%-528
MERCK & CO INC(MRK)59,60059,60005,9295,3501.23%-579
ALPHA COGNITION INC620,000596,992-23,0083,6523,0210.70%-631
ORIC PHARMACEUTICALS INC(ORIC)273,213234,834-38,3792,2051,3100.30%-894
NUTRIEN LTD(NTR)55,89430,894-25,0002,5011,5350.35%-967
LARIMAR THERAPEUTICS INC455,604366,304-89,3001,7637880.18%-976
ALUMIS INC125,0000-125,0009830-982
MERSANA THERAPEUTICS INC690,2720-690,2729870-987
MERUS N V0106,532+106,53204,4841.03%+4,484
VENTYX BIOSCIENCES INC1,012,7491,012,74902,2181,1650.27%-1,053
XENON PHARMACEUTICALS INC(XENE)52,09726,097-26,0002,0428760.20%-1,167
ZURA BIO LTD690,718421,229-269,4891,7275430.13%-1,183
CHEMOMAB THERAPEUTICS LTD1,214,575900,428-314,1472,1989810.23%-1,217
JASPER THERAPEUTICS INC(Call)61,1000-61,1001,3060-1,306
SPRINGWORKS THERAPEUTICS INC100,00052,009-47,9913,6132,2950.53%-1,318
JOHNSON & JOHNSON(JNJ)69,83152,831-17,00010,0998,7612.02%-1,337
ENGENE HOLDINGS INC
COM
560,000528,365-31,6353,7242,3670.55%-1,357
CYTOKINETICS INC(CYTK)0144,961+144,96105,8261.34%+5,826
SCHOLAR ROCK HLDG CORP(SRRK)90,19378,193-12,0003,8982,5140.58%-1,384
CYBIN INC0527,222+527,22203,3430.77%+3,343
PHARVARIS N V
COM
388,183383,856-4,3277,4416,0271.39%-1,415
CAMTEK LTD(CAMT)36,28723,086-13,2012,9311,3540.31%-1,577
DAY ONE BIOPHARMACEUTICALS I
COM
334,987334,98704,2442,6560.61%-1,588
ROCKET PHARMACEUTICALS INC271,792271,79203,4161,8130.42%-1,604
SANOFI(SNY)0304,515+304,515016,8883.89%+16,888
JASPER THERAPEUTICS INC(Put)77,5000-77,5001,6570-1,657
PRAXIS PRECISION MEDICINES I(PRAX)91,583140,660+49,0777,0485,3271.23%-1,721
ASTRAZENECA PLC(AZN)225,060175,060-50,00014,74612,8672.96%-1,879
SAREPTA THERAPEUTICS INC(SRPT)0157,931+157,931010,0792.32%+10,079
BROADCOM INC(AVGO)16,88011,695-5,1853,9131,9580.45%-1,955
CORVUS PHARMACEUTICALS INC(CRVS)500,491205,859-294,6322,6786550.15%-2,023
SKYE BIOSCIENCE INC1,564,6281,476,353-88,2754,4282,3470.54%-2,080
NICE LTD(NICE)033,303+33,30305,1341.18%+5,134
DYNE THERAPEUTICS INC(DYN)236,262329,262+93,0005,5663,4440.79%-2,122
VIKING THERAPEUTICS INC(VKTX)083,270+83,27002,0110.46%+2,011
INOZYME PHARMA INC01,191,140+1,191,14001,0840.25%+1,084
CYTOKINETICS INC(CYTK)(Call)50,0000-50,0002,3520-2,352
JASPER THERAPEUTICS INC135,720122,017-13,7032,9025250.12%-2,377
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