Fund Holdings — SPHERA FUNDS MANAGEMENT LTD.

Total Portfolio Value
$581.48M
Total Bought
$190.56M
Total Sold
$96.79M
Net Transaction
+$93.77M
Filing Period:
Securities
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SharesValue ($K)
Q4 2025
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Q1 2026
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Change
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Q4 2025
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Q1 2026
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Weight (%)
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Change
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MINERALYS THERAPEUTICS INC(MLYS)449,0031,339,971+890,96816,29436,3006.24%+20,005
ASTRAZENECA PLC(AZN)062,530+62,530012,3322.12%+12,332
TOWER SEMICONDUCTOR LTD(TSEM)122,513145,735+23,22214,38525,5744.40%+11,188
ULTRAGENYX PHARMACEUTICAL IN(RARE)300,623809,333+508,7106,91416,9562.92%+10,041
BRIDGEBIO PHARMA INC(BBIO)107,746245,246+137,5008,24118,2123.13%+9,970
CELLEBRITE DI LTD(CLBT)0631,521+631,52108,7021.50%+8,702
PALO ALTO NETWORKS INC(PANW)052,800+52,80008,4651.46%+8,465
ORMAT TECHNOLOGIES INC(ORA)068,250+68,25007,6391.31%+7,639
NOVA LTD(NVMI)47,84653,366+5,52015,71223,1763.99%+7,464
XENON PHARMACEUTICALS INC(XENE)0127,000+127,00007,3851.27%+7,385
AMAZON COM INC(AMZN)031,940+31,94006,6521.14%+6,652
APPLIED OPTOELECTRONICS INC(AAOI)073,400+73,40006,2091.07%+6,209
BIOHAVEN LTD(BHVN)0594,000+594,00005,0250.86%+5,025
ZENAS BIOPHARMA INC(ZBIO)0214,334+214,33404,1900.72%+4,190
RELAY THERAPEUTICS INC(RLAY)0408,436+408,43604,0640.70%+4,064
PROMIS NEUROSCIENCES INC(PMN)11,807325,591+313,784814,1350.71%+4,054
CAMTEK LTD(CAMT)39,49853,020+13,5224,2008,0381.38%+3,838
MAZE THERAPEUTICS INC(MAZE)71,843227,343+155,5002,9766,7861.17%+3,810
OVID THERAPEUTICS INC(OVID)01,622,828+1,622,82803,6030.62%+3,603
DISC MEDICINE INC(IRON)053,538+53,53803,4230.59%+3,423
UPSTREAM BIO INC(UPB)0358,000+358,00003,2220.55%+3,222
PFIZER INC(PFE)86,000186,000+100,0002,1415,2230.90%+3,081
MADRIGAL PHARMACEUTICALS INC(MDGL)3,3009,040+5,7401,9224,7320.81%+2,810
SATELLOS BIOSCIENCE INC(MSLE)0489,207+489,20702,7540.47%+2,754
PALISADE BIO INC(PALI)184,1001,733,471+1,549,3714333,0340.52%+2,601
COGENT BIOSCIENCES INC(COGT)378,500416,340+37,84013,44416,0252.76%+2,581
ENLIVEN THERAPEUTICS INC226,765153,265-73,5003,4926,0081.03%+2,516
TANGO THERAPEUTICS INC(TNGX)544,563343,563-201,0004,8257,1871.24%+2,363
APELLIS PHARMACEUTICALS INC
COM
250,961214,914-36,0476,3048,6461.49%+2,342
GENERATE BIOMEDICINES INC(GENB)0185,000+185,00002,3130.40%+2,313
ELEDON PHARMACEUTICALS INC(ELDN)2,132,1311,772,131-360,0003,2205,4580.94%+2,239
SOLAREDGE TECHNOLOGIES INC(SEDG)4,000,0004,000,00004,6996,9101.19%+2,210
BIOCRYST PHARMACEUTICALS INC(BCRX)837,889866,464+28,5756,5368,2491.42%+1,713
PRELUDE THERAPEUTICS INC(PRLD)122,752558,339+435,5873561,9100.33%+1,554
SANOFI SA(SNY)239,515269,515+30,00011,60712,9852.23%+1,378
ORGANOGENESIS HLDGS INC(ORGO)0550,000+550,00001,3040.22%+1,304
CELLDEX THERAPEUTICS INC NEW(CLDX)239,764243,575+3,8116,5127,7261.33%+1,214
REVOLUTION MEDICINES INC(RVMD)52,50055,110+2,6104,1825,3590.92%+1,178
SHATTUCK LABS INC(STTK)195,212280,786+85,5747131,8050.31%+1,093
CURIS INC(CRIS)01,994,937+1,994,93701,0920.19%+1,092
CYTOMX THERAPEUTICS INC.(CTMX)0220,000+220,00001,0340.18%+1,034
SOLENO THERAPEUTICS INC136,314216,281+79,9676,3117,2411.25%+930
SYNDAX PHARMACEUTICALS INC(SNDX)762,563724,563-38,00016,02116,9262.91%+904
ABBVIE INC(ABBV)25,25630,256+5,0005,7716,5801.13%+810
ISHARES BITCOIN TRUST ETF(IBIT)30,05559,505+29,4501,4922,2860.39%+794
GSK PLC(GSK)122,000122,00005,9836,7331.16%+750
MERCK & CO INC(MRK)48,60048,60005,1165,8461.01%+730
NICE LTD(NICE)05,611+5,61106190.11%+619
NOVARTIS AG(NVS)37,00037,00005,1015,6520.97%+551
CORVUS PHARMACEUTICALS INC(CRVS)407,709247,961-159,7483,1393,6280.62%+488
VOYAGER THERAPEUTICS INC(VYGR)339,761469,761+130,0001,3351,8130.31%+478
VOR BIOPHARMA INC(VOR)410,417321,917-88,5005,3685,7430.99%+375
BIOGEN INC(BIIB)94,73892,526-2,21216,67316,9632.92%+290
CONTINEUM THERAPEUTICS INC(CTNM)173,475173,47501,9832,2660.39%+283
AMGEN INC(AMGN)7,5007,50002,4552,6390.45%+184
MEDIWOUND LTD(MDWD)230,347273,192+42,8454,2524,4010.76%+149
WEREWOLF THERAPEUTICS INC(HOWL)626,810626,81003975220.09%+125
BRISTOL-MYERS SQUIBB CO(BMY)17,50017,50009441,0610.18%+117
FOGHORN THERAPEUTICS INC(FHTX)012,224+12,2240580.01%+58
SKYE BIOSCIENCE INC(SKYE)478,928678,928+200,0003594170.07%+58
ACADIA PHARMACEUTICALS INC212,202256,202+44,0005,6685,7030.98%+35
APPLIED THERAPEUTICS INC50,0000-50,00050—-5
APREA THERAPEUTICS INC(APRE)270,000270,00002302060.04%-24
ZIM INTEGRATED SHIPPING SERV
SHS
136,005105,950-30,0552,8872,7920.48%-96
MEREO BIOPHARMA GROUP PLC(MREO)255,4000-255,4001060—-106
TENAX THERAPEUTICS INC(TENX)190,111136,015-54,0962,3172,1750.37%-143
ONKURE THERAPEUTICS INC(OKUR)60,4540-60,4541750—-175
FORTE BIOSCIENCES INC(FBRX)185,869184,984-8855,0694,7910.82%-278
JOHNSON & JOHNSON(JNJ)35,83128,831-7,0007,4157,0471.21%-368
STRUCTURE THERAPEUTICS INC41,00050,800+9,8002,8522,4490.42%-403
ASCENDIS PHARMA A/S(ASND)11,0008,000-3,0002,3461,8300.31%-516
KODIAK SCIENCES INC(KOD)175,500114,796-60,7044,9074,3760.75%-531
ALPHA COGNITION INC(ACOG)567,616567,61603,6903,1160.54%-573
ENPHASE ENERGY INC(ENPH)186,500142,419-44,0815,9775,3850.93%-592
TREVI THERAPEUTICS INC(TRVI)598,534574,029-24,5057,4946,8481.18%-645
AMICUS THERAPEUTIC
COM
658,377603,377-55,0009,3758,7251.50%-650
KURA ONCOLOGY INC(KURA)295,522295,52203,0702,4030.41%-668
PEPGEN INC(PEPG)121,4670-121,4677910—-791
TEVA PHARMACEUTICAL INDS LTD(TEVA)1,123,5251,136,975+13,45035,06534,2465.89%-820
VERASTEM INC(VSTM)343,678343,67802,6531,8210.31%-832
BIOMARIN PHARMACEUTICAL INC(BMRN)147,000139,900-7,1008,7367,9031.36%-833
CLIMB BIO INC(CLYM)932,247419,247-513,0003,7292,8720.49%-857
JASPER THERAPEUTICS INC(JSPR)485,4010-485,4018880—-888
PERSPECTIVE THERAPEUTICS INC(CATX)349,9730-349,9739620—-962
EVOMMUNE INC(EVMN)166,14778,234-87,9132,8441,7990.31%-1,046
TENAYA THERAPEUTICS INC(TNYA)1,500,0000-1,500,0001,0670—-1,067
ENTRADA THERAPEUTICS INC(TRDA)110,9420-110,9421,1400—-1,140
DAY ONE BIOPHARMACEUTICALS I
COM
145,3710-145,3711,3550—-1,355
ELI LILLY & CO(LLY)9,0409,04009,7158,3151.43%-1,400
ORIC PHARMACEUTICALS INC(ORIC)1,004,378537,628-466,7508,2166,8121.17%-1,404
PRECISION BIOSCIENCES INC(DTIL)396,11640,000-356,1161,6482200.04%-1,428
NOVO-NORDISK A S(NVO)115,677120,677+5,0005,8864,4350.76%-1,451
VENTYX BIOSCIENCES INC180,1140-180,1141,6260—-1,626
BIOAGE LABS INC(BIOA)243,03586,518-156,5173,2151,5130.26%-1,702
VARONIS SYS INC(VRNS)52,5000-52,5001,7220—-1,722
PHARVARIS N V
COM
63,9530-63,9531,7750—-1,775
CYBIN INC(HELP)825,576987,090+161,5146,7534,7380.81%-2,015
TAYSHA GENE THERAPIES INC(TSHA)368,1460-368,1462,0250—-2,025
JANUX THERAPEUTICS INC(JANX)157,8400-157,8402,1780—-2,178
IMMATICS N.V(IMTX)861,105696,105-165,0009,0426,8501.18%-2,192
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SPHERA FUNDS MANAGEMENT LTD. — 13F Holdings — Q1 2026 | TickerTrail