SPHERA FUNDS MANAGEMENT LTD.
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| MINERALYS THERAPEUTICS INC(MLYS) | 449,003 | 1,339,971 | +890,968 | 16,294,319 | 36,299,814 | 6.24% | +20,005,495 |
| CYTOKINETICS INC(CYTK)(Call) | 0 | 259,300 | +259,300 | 0 | 17,090,464 | — | +17,090,464 |
| SPDR SERIES TRUST(Put) ST STR SP BIOT | 70,000 | 200,000 | +130,000 | 8,535,100 | 25,546,001 | — | +17,010,901 |
| ASTRAZENECA PLC(AZN) | 0 | 62,530 | +62,530 | 0 | 12,332,167 | 2.12% | +12,332,167 |
| TOWER SEMICONDUCTOR LTD(TSEM) | 122,513 | 145,735 | +23,222 | 14,385,476 | 25,573,578 | 4.40% | +11,188,102 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 300,623 | 809,333 | +508,710 | 6,914,329 | 16,955,526 | 2.92% | +10,041,197 |
| BRIDGEBIO PHARMA INC(BBIO) | 107,746 | 245,246 | +137,500 | 8,241,492 | 18,211,968 | 3.13% | +9,970,476 |
| CELLEBRITE DI LTD(CLBT) | 0 | 631,521 | +631,521 | 0 | 8,702,359 | 1.50% | +8,702,359 |
| PALO ALTO NETWORKS INC(PANW) | 0 | 52,800 | +52,800 | 0 | 8,464,896 | 1.46% | +8,464,896 |
| ORMAT TECHNOLOGIES INC(ORA) | 0 | 68,250 | +68,250 | 0 | 7,638,540 | 1.31% | +7,638,540 |
| NOVA LTD(NVMI) | 47,846 | 53,366 | +5,520 | 15,712,148 | 23,175,786 | 3.99% | +7,463,638 |
| XENON PHARMACEUTICALS INC(XENE) | 0 | 127,000 | +127,000 | 0 | 7,385,050 | 1.27% | +7,385,050 |
| AMAZON COM INC(AMZN) | 0 | 31,940 | +31,940 | 0 | 6,652,144 | 1.14% | +6,652,144 |
| APPLIED OPTOELECTRONICS INC(AAOI) | 0 | 73,400 | +73,400 | 0 | 6,208,906 | 1.07% | +6,208,906 |
| BIOHAVEN LTD(BHVN) | 0 | 594,000 | +594,000 | 0 | 5,025,240 | 0.86% | +5,025,240 |
| ZENAS BIOPHARMA INC(ZBIO) | 0 | 214,334 | +214,334 | 0 | 4,190,230 | 0.72% | +4,190,230 |
| RELAY THERAPEUTICS INC(RLAY) | 0 | 408,436 | +408,436 | 0 | 4,063,938 | 0.70% | +4,063,938 |
| PROMIS NEUROSCIENCES INC | 11,807 | 325,591 | +313,784 | 80,586 | 4,135,012 | 0.71% | +4,054,426 |
| CAMTEK LTD(CAMT) | 39,498 | 53,020 | +13,522 | 4,200,415 | 8,038,362 | 1.38% | +3,837,947 |
| MAZE THERAPEUTICS INC(MAZE) | 71,843 | 227,343 | +155,500 | 2,976,455 | 6,786,189 | 1.17% | +3,809,734 |
| OVID THERAPEUTICS INC | 0 | 1,622,828 | +1,622,828 | 0 | 3,602,678 | 0.62% | +3,602,678 |
| DISC MEDICINE INC(IRON) | 0 | 53,538 | +53,538 | 0 | 3,423,220 | 0.59% | +3,423,220 |
| UPSTREAM BIO INC | 0 | 358,000 | +358,000 | 0 | 3,222,000 | 0.55% | +3,222,000 |
| PFIZER INC(PFE) | 86,000 | 186,000 | +100,000 | 2,141,400 | 5,222,880 | 0.90% | +3,081,480 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 3,300 | 9,040 | +5,740 | 1,921,722 | 4,732,169 | 0.81% | +2,810,447 |
| SATELLOS BIOSCIENCE INC | 0 | 489,207 | +489,207 | 0 | 2,754,235 | 0.47% | +2,754,235 |
| PALISADE BIO INC | 184,100 | 1,733,471 | +1,549,371 | 432,635 | 3,033,574 | 0.52% | +2,600,939 |
| COGENT BIOSCIENCES INC(COGT) | 378,500 | 416,340 | +37,840 | 13,444,320 | 16,024,927 | 2.76% | +2,580,607 |
| ENLIVEN THERAPEUTICS INC | 226,765 | 153,265 | -73,500 | 3,492,181 | 6,007,988 | 1.03% | +2,515,807 |
| TANGO THERAPEUTICS INC(TNGX) | 544,563 | 343,563 | -201,000 | 4,824,828 | 7,187,338 | 1.24% | +2,362,510 |
| APELLIS PHARMACEUTICALS INC COM | 250,961 | 214,914 | -36,047 | 6,304,140 | 8,645,990 | 1.49% | +2,341,850 |
| GENERATE BIOMEDICINES INC(GENB) | 0 | 185,000 | +185,000 | 0 | 2,312,500 | 0.40% | +2,312,500 |
| ELEDON PHARMACEUTICALS INC | 2,132,131 | 1,772,131 | -360,000 | 3,219,518 | 5,458,163 | 0.94% | +2,238,645 |
| SOLAREDGE TECHNOLOGIES INC(SEDG) | 4,000,000 | 4,000,000 | 0 | 4,699,440 | 6,909,620 | 1.19% | +2,210,180 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 837,889 | 866,464 | +28,575 | 6,535,534 | 8,248,737 | 1.42% | +1,713,203 |
| PRELUDE THERAPEUTICS INC | 122,752 | 558,339 | +435,587 | 355,981 | 1,909,519 | 0.33% | +1,553,538 |
| OLEMA PHARMACEUTICALS INC(OLMA)(Call) | 0 | 100,000 | +100,000 | 0 | 1,491,000 | — | +1,491,000 |
| SANOFI SA(SNY) | 239,515 | 269,515 | +30,000 | 11,606,897 | 12,985,233 | 2.23% | +1,378,336 |
| ORGANOGENESIS HLDGS INC | 0 | 550,000 | +550,000 | 0 | 1,303,500 | 0.22% | +1,303,500 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 239,764 | 243,575 | +3,811 | 6,511,990 | 7,726,199 | 1.33% | +1,214,209 |
| REVOLUTION MEDICINES INC(RVMD) | 52,500 | 55,110 | +2,610 | 4,181,625 | 5,359,448 | 0.92% | +1,177,823 |
| SHATTUCK LABS INC | 195,212 | 280,786 | +85,574 | 712,524 | 1,805,454 | 0.31% | +1,092,930 |
| CURIS INC | 0 | 1,994,937 | +1,994,937 | 0 | 1,091,829 | 0.19% | +1,091,829 |
| CYTOMX THERAPEUTICS INC. | 0 | 220,000 | +220,000 | 0 | 1,034,000 | 0.18% | +1,034,000 |
| SOLENO THERAPEUTICS INC | 136,314 | 216,281 | +79,967 | 6,311,338 | 7,241,088 | 1.25% | +929,750 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 762,563 | 724,563 | -38,000 | 16,021,449 | 16,925,792 | 2.91% | +904,343 |
| ABBVIE INC(ABBV) | 25,256 | 30,256 | +5,000 | 5,770,743 | 6,580,377 | 1.13% | +809,634 |
| ISHARES BITCOIN TRUST ETF(IBIT) | 30,055 | 59,505 | +29,450 | 1,492,231 | 2,286,182 | 0.39% | +793,951 |
| GSK PLC(GSK) | 122,000 | 122,000 | 0 | 5,982,880 | 6,733,180 | 1.16% | +750,300 |
| MERCK & CO INC(MRK) | 48,600 | 48,600 | 0 | 5,115,636 | 5,846,094 | 1.01% | +730,458 |
| NICE LTD(NICE) | 0 | 5,611 | +5,611 | 0 | 618,669 | 0.11% | +618,669 |
| NOVARTIS AG(NVS) | 37,000 | 37,000 | 0 | 5,101,190 | 5,651,750 | 0.97% | +550,560 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 407,709 | 247,961 | -159,748 | 3,139,359 | 3,627,669 | 0.62% | +488,310 |
| VOYAGER THERAPEUTICS INC | 339,761 | 469,761 | +130,000 | 1,335,261 | 1,813,277 | 0.31% | +478,016 |
| VOR BIOPHARMA INC(VOR) | 410,417 | 321,917 | -88,500 | 5,368,254 | 5,742,999 | 0.99% | +374,745 |
| BIOGEN INC(BIIB) | 94,738 | 92,526 | -2,212 | 16,672,941 | 16,962,792 | 2.92% | +289,851 |
| CONTINEUM THERAPEUTICS INC | 173,475 | 173,475 | 0 | 1,982,819 | 2,265,584 | 0.39% | +282,765 |
| AMGEN INC(AMGN) | 7,500 | 7,500 | 0 | 2,454,825 | 2,638,875 | 0.45% | +184,050 |
| MEDIWOUND LTD | 230,347 | 273,192 | +42,845 | 4,252,206 | 4,401,123 | 0.76% | +148,917 |
| WEREWOLF THERAPEUTICS INC | 626,810 | 626,810 | 0 | 397,084 | 521,882 | 0.09% | +124,798 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 17,500 | 17,500 | 0 | 943,950 | 1,061,375 | 0.18% | +117,425 |
| FOGHORN THERAPEUTICS INC | 0 | 12,224 | +12,224 | 0 | 58,431 | 0.01% | +58,431 |
| SKYE BIOSCIENCE INC | 478,928 | 678,928 | +200,000 | 359,052 | 417,269 | 0.07% | +58,217 |
| ACADIA PHARMACEUTICALS INC | 212,202 | 256,202 | +44,000 | 5,667,915 | 5,703,057 | 0.98% | +35,142 |
| APPLIED THERAPEUTICS INC | 50,000 | 0 | -50,000 | 5,000 | 0 | — | -5,000 |
| ISHARES TR(Call) | 47,000 | 47,000 | 0 | 4,096,520 | 4,074,430 | — | -22,090 |
| APREA THERAPEUTICS INC | 270,000 | 270,000 | 0 | 230,310 | 205,983 | 0.04% | -24,327 |
| ZIM INTEGRATED SHIPPING SERV SHS | 136,005 | 105,950 | -30,055 | 2,887,386 | 2,791,783 | 0.48% | -95,603 |
| MEREO BIOPHARMA GROUP PLC | 255,400 | 0 | -255,400 | 106,425 | 0 | — | -106,425 |
| TENAX THERAPEUTICS INC | 190,111 | 136,015 | -54,096 | 2,317,453 | 2,174,880 | 0.37% | -142,573 |
| ONKURE THERAPEUTICS INC | 60,454 | 0 | -60,454 | 175,317 | 0 | — | -175,317 |
| FORTE BIOSCIENCES INC(FBRX) | 185,869 | 184,984 | -885 | 5,068,648 | 4,791,086 | 0.82% | -277,562 |
| JOHNSON & JOHNSON(JNJ) | 35,831 | 28,831 | -7,000 | 7,415,225 | 7,047,450 | 1.21% | -367,775 |
| STRUCTURE THERAPEUTICS INC | 41,000 | 50,800 | +9,800 | 2,851,550 | 2,448,560 | 0.42% | -402,990 |
| ASCENDIS PHARMA A/S(ASND) | 11,000 | 8,000 | -3,000 | 2,345,640 | 1,829,840 | 0.31% | -515,800 |
| KODIAK SCIENCES INC(KOD) | 175,500 | 114,796 | -60,704 | 4,906,980 | 4,376,024 | 0.75% | -530,956 |
| ALPHA COGNITION INC | 567,616 | 567,616 | 0 | 3,689,504 | 3,116,212 | 0.54% | -573,292 |
| ENPHASE ENERGY INC(ENPH) | 186,500 | 142,419 | -44,081 | 5,977,325 | 5,384,862 | 0.93% | -592,463 |
| TREVI THERAPEUTICS INC(TRVI) | 598,534 | 574,029 | -24,505 | 7,493,646 | 6,848,166 | 1.18% | -645,480 |
| AMICUS THERAPEUTIC COM | 658,377 | 603,377 | -55,000 | 9,375,288 | 8,724,831 | 1.50% | -650,457 |
| KURA ONCOLOGY INC(KURA) | 295,522 | 295,522 | 0 | 3,070,474 | 2,402,594 | 0.41% | -667,880 |
| PEPGEN INC | 121,467 | 0 | -121,467 | 790,750 | 0 | — | -790,750 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,123,525 | 1,136,975 | +13,450 | 35,065,215 | 34,245,687 | 5.89% | -819,528 |
| VERASTEM INC | 343,678 | 343,678 | 0 | 2,653,194 | 1,821,493 | 0.31% | -831,701 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 147,000 | 139,900 | -7,100 | 8,736,210 | 7,902,951 | 1.36% | -833,259 |
| CLIMB BIO INC | 932,247 | 419,247 | -513,000 | 3,728,988 | 2,871,842 | 0.49% | -857,146 |
| JASPER THERAPEUTICS INC | 485,401 | 0 | -485,401 | 888,284 | 0 | — | -888,284 |
| PERSPECTIVE THERAPEUTICS INC | 349,973 | 0 | -349,973 | 962,426 | 0 | — | -962,426 |
| EVOMMUNE INC | 166,147 | 78,234 | -87,913 | 2,844,437 | 1,798,600 | 0.31% | -1,045,837 |
| TENAYA THERAPEUTICS INC | 1,500,000 | 0 | -1,500,000 | 1,067,250 | 0 | — | -1,067,250 |
| ENTRADA THERAPEUTICS INC | 110,942 | 0 | -110,942 | 1,140,484 | 0 | — | -1,140,484 |
| DAY ONE BIOPHARMACEUTICALS I COM | 145,371 | 0 | -145,371 | 1,354,858 | 0 | — | -1,354,858 |
| ELI LILLY & CO(LLY) | 9,040 | 9,040 | 0 | 9,715,107 | 8,314,721 | 1.43% | -1,400,386 |
| ORIC PHARMACEUTICALS INC(ORIC) | 1,004,378 | 537,628 | -466,750 | 8,215,812 | 6,811,747 | 1.17% | -1,404,065 |
| PRECISION BIOSCIENCES INC | 396,116 | 40,000 | -356,116 | 1,647,843 | 220,000 | 0.04% | -1,427,843 |
| NOVO-NORDISK A S(NVO) | 115,677 | 120,677 | +5,000 | 5,885,646 | 4,434,880 | 0.76% | -1,450,766 |
| VENTYX BIOSCIENCES INC | 180,114 | 0 | -180,114 | 1,626,429 | 0 | — | -1,626,429 |
| BIOAGE LABS INC(BIOA) | 243,035 | 86,518 | -156,517 | 3,215,353 | 1,513,200 | 0.26% | -1,702,153 |
| VARONIS SYS INC(VRNS) | 52,500 | 0 | -52,500 | 1,722,000 | 0 | — | -1,722,000 |
| PHARVARIS N V COM | 63,953 | 0 | -63,953 | 1,774,696 | 0 | — | -1,774,696 |