Fund Holdings — SPHERA FUNDS MANAGEMENT LTD.

Total Portfolio Value:
$581.48M
Total Bought:
$190.56M
Total Sold:
$96.79M
Net Transaction:
+$93.77M
Notable People:
Oshrat Levi
Securities
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SharesValue
Q4 2025
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Q1 2026
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Change
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Q4 2025
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Q1 2026
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Weight (%)
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Change
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Mineralys Therapeutics, Inc.(MLYS)449,0031,339,971+890,968$16.29M$36.30M6.24%+$20.01M
Teva Pharmaceutical Industries LimitedADS(TEVA)1,123,5251,136,975+13,450$35.07M$34.25M5.89%-$819.5K
Tower Semiconductor Ltd.SHS NEW(TSEM)122,513145,735+23,222$14.39M$25.57M4.40%+$11.19M
Nova Ltd.(NVMI)47,84653,366+5,520$15.71M$23.18M3.99%+$7.46M
BridgeBio Pharma, Inc.(BBIO)107,746245,246+137,500$8.24M$18.21M3.13%+$9.97M
Biogen Inc.(BIIB)94,73892,526-2,212$16.67M$16.96M2.92%+$289.9K
Ultragenyx Pharmaceutical Inc.(RARE)300,623809,333+508,710$6.91M$16.96M2.92%+$10.04M
Syndax Pharmaceuticals, Inc.(SNDX)762,563724,563-38,000$16.02M$16.93M2.91%+$904.3K
Cogent Biosciences, Inc.(COGT)378,500416,340+37,840$13.44M$16.02M2.76%+$2.58M
SanofiADR(SNY)239,515269,515+30,000$11.61M$12.99M2.23%+$1.38M
AstraZeneca PLC(AZN)062,530+62,530$0$12.33M2.12%+$12.33M
Amicus Therapeutic
COM
658,377603,377-55,000$9.38M$8.72M1.50%-$650.5K
Cellebrite DI Ltd.(CLBT)0631,521+631,521$0$8.70M1.50%+$8.70M
Apellis Pharmaceuticals Inc
COM
250,961214,914-36,047$6.30M$8.65M1.49%+$2.34M
Palo Alto Networks, Inc.(PANW)052,800+52,800$0$8.46M1.46%+$8.46M
Eli Lilly and Company(LLY)9,0409,0400$9.72M$8.31M1.43%-$1.40M
BioCryst Pharmaceuticals, Inc.(BCRX)837,889866,464+28,575$6.54M$8.25M1.42%+$1.71M
Camtek Ltd.(CAMT)39,49853,020+13,522$4.20M$8.04M1.38%+$3.84M
BioMarin Pharmaceutical Inc.(BMRN)147,000139,900-7,100$8.74M$7.90M1.36%-$833.3K
Celldex Therapeutics, Inc.(CLDX)239,764243,575+3,811$6.51M$7.73M1.33%+$1.21M
Ormat Technologies, Inc.(ORA)068,250+68,250$0$7.64M1.31%+$7.64M
Xenon Pharmaceuticals Inc.(XENE)0127,000+127,000$0$7.39M1.27%+$7.39M
Soleno Therapeutics Inc136,314216,281+79,967$6.31M$7.24M1.25%+$929.8K
Tango Therapeutics, Inc.(TNGX)544,563343,563-201,000$4.82M$7.19M1.24%+$2.36M
Johnson & Johnson(JNJ)35,83128,831-7,000$7.42M$7.05M1.21%-$367.8K
SolarEdge Technologies, Inc.NOTE 2 250 7 0(SEDG)4,000,0004,000,0000$4.70M$6.91M1.19%+$2.21M
Immatics N.V.SHS(IMTX)861,105696,105-165,000$9.04M$6.85M1.18%-$2.19M
Trevi Therapeutics, Inc.(TRVI)598,534574,029-24,505$7.49M$6.85M1.18%-$645.5K
ORIC Pharmaceuticals, Inc.(ORIC)1,004,378537,628-466,750$8.22M$6.81M1.17%-$1.40M
Maze Therapeutics, Inc.(MAZE)71,843227,343+155,500$2.98M$6.79M1.17%+$3.81M
GSK plcADR(GSK)122,000122,0000$5.98M$6.73M1.16%+$750.3K
Amazon.com, Inc.(AMZN)031,940+31,940$0$6.65M1.14%+$6.65M
AbbVie Inc.(ABBV)25,25630,256+5,000$5.77M$6.58M1.13%+$809.6K
Applied Optoelectronics, Inc.(AAOI)073,400+73,400$0$6.21M1.07%+$6.21M
Enliven Therapeutics Inc226,765153,265-73,500$3.49M$6.01M1.03%+$2.52M
Merck & Co., Inc.(MRK)48,60048,6000$5.12M$5.85M1.01%+$730.5K
Vor Biopharma Inc.(VOR)410,417321,917-88,500$5.37M$5.74M0.99%+$374.7K
Acadia Pharmaceuticals Inc212,202256,202+44,000$5.67M$5.70M0.98%+$35.1K
Novartis AGADR(NVS)37,00037,0000$5.10M$5.65M0.97%+$550.6K
Eledon Pharmaceuticals, Inc.(ELDN)2,132,1311,772,131-360,000$3.22M$5.46M0.94%+$2.24M
Enphase Energy, Inc.(ENPH)186,500142,419-44,081$5.98M$5.38M0.93%-$592.5K
Revolution Medicines, Inc.(RVMD)52,50055,110+2,610$4.18M$5.36M0.92%+$1.18M
Pfizer Inc.(PFE)86,000186,000+100,000$2.14M$5.22M0.90%+$3.08M
Biohaven Ltd.(BHVN)0594,000+594,000$0$5.03M0.86%+$5.03M
Forte Biosciences Inc185,869184,984-885$5.07M$4.79M0.82%-$277.6K
Cybin D/B/A Helus Pharma(HELP)825,576987,090+161,514$6.75M$4.74M0.81%-$2.02M
Madrigal Pharmaceuticals, Inc.(MDGL)3,3009,040+5,740$1.92M$4.73M0.81%+$2.81M
Scholar Rock Holding Corporation(SRRK)158,26594,265-64,000$6.97M$4.63M0.80%-$2.34M
Novo Nordisk A/SADR(NVO)115,677120,677+5,000$5.89M$4.43M0.76%-$1.45M
MediWound Ltd.SHS NEW(MDWD)230,347273,192+42,845$4.25M$4.40M0.76%+$148.9K
Kodiak Sciences Inc.(KOD)175,500114,796-60,704$4.91M$4.38M0.75%-$531.0K
Zenas BioPharma, Inc.(ZBIO)0214,334+214,334$0$4.19M0.72%+$4.19M
ProMIS Neurosciences, Inc.(PMN)11,807325,591+313,784$80.6K$4.14M0.71%+$4.05M
Relay Therapeutics, Inc.(RLAY)0408,436+408,436$0$4.06M0.70%+$4.06M
Savara Inc.(SVRA)1,178,164739,164-439,000$7.10M$4.04M0.69%-$3.07M
Wave Life Sciences, Inc.SHS(WVE)408,166548,272+140,106$6.94M$3.97M0.68%-$2.96M
Corvus Pharmaceuticals, Inc.(CRVS)407,709247,961-159,748$3.14M$3.63M0.62%+$488.3K
Ovid Therapeutics Inc.(OVID)01,622,828+1,622,828$0$3.60M0.62%+$3.60M
Disc Medicine, Inc.(IRON)053,538+53,538$0$3.42M0.59%+$3.42M
Upstream Bio, Inc.(UPB)0358,000+358,000$0$3.22M0.55%+$3.22M
Alpha Cognition Inc. Common Stock(ACOG)567,616567,6160$3.69M$3.12M0.54%-$573.3K
Palisade Bio, Inc.(PALI)184,1001,733,471+1,549,371$432.6K$3.03M0.52%+$2.60M
Dyne Therapeutics, Inc.(DYN)392,894160,594-232,300$7.69M$2.91M0.50%-$4.77M
Climb Bio, Inc.(CLYM)932,247419,247-513,000$3.73M$2.87M0.49%-$857.1K
Zim Integrated Shipping ServSHS
SHS
136,005105,950-30,055$2.89M$2.79M0.48%-$95.6K
Satellos Bioscience Inc.(MSLE)0489,207+489,207$0$2.75M0.47%+$2.75M
SolarEdge Technologies, Inc.(SEDG)196,53652,836-143,700$5.67M$2.70M0.46%-$2.97M
Amgen Inc.(AMGN)7,5007,5000$2.45M$2.64M0.45%+$184.1K
Cytokinetics, Incorporated(CYTK)91,71739,817-51,900$5.83M$2.62M0.45%-$3.20M
Structure Therapeutics IncADS41,00050,800+9,800$2.85M$2.45M0.42%-$403.0K
Kura Oncology, Inc.(KURA)295,522295,5220$3.07M$2.40M0.41%-$667.9K
Generate Biomedicines, Inc.(GENB)0185,000+185,000$0$2.31M0.40%+$2.31M
iShares Bitcoin Trust ETFSHS BEN INT(IBIT)30,05559,505+29,450$1.49M$2.29M0.39%+$794.0K
Contineum Therapeutics, Inc.CL A(CTNM)173,475173,4750$1.98M$2.27M0.39%+$282.8K
Tenax Therapeutics, Inc.(TENX)190,111136,015-54,096$2.32M$2.17M0.37%-$142.6K
Prelude Therapeutics Incorporated(PRLD)122,752558,339+435,587$356.0K$1.91M0.33%+$1.55M
Ascendis Pharma A/SADR(ASND)11,0008,000-3,000$2.35M$1.83M0.31%-$515.8K
Verastem, Inc.(VSTM)343,678343,6780$2.65M$1.82M0.31%-$831.7K
Voyager Therapeutics, Inc.(VYGR)339,761469,761+130,000$1.34M$1.81M0.31%+$478.0K
Shattuck Labs, Inc.(STTK)195,212280,786+85,574$712.5K$1.81M0.31%+$1.09M
Evommune, Inc.(EVMN)166,14778,234-87,913$2.84M$1.80M0.31%-$1.05M
BioAge Labs, Inc.(BIOA)243,03586,518-156,517$3.22M$1.51M0.26%-$1.70M
Organogenesis Holdings Inc.(ORGO)0550,000+550,000$0$1.30M0.22%+$1.30M
Curis, Inc.(CRIS)01,994,937+1,994,937$0$1.09M0.19%+$1.09M
Bristol-Myers Squibb Company(BMY)17,50017,5000$944.0K$1.06M0.18%+$117.4K
CytomX Therapeutics, Inc.(CTMX)0220,000+220,000$0$1.03M0.18%+$1.03M
NICE Ltd.ADR(NICE)05,611+5,611$0$618.7K0.11%+$618.7K
Werewolf Therapeutics, Inc.(HOWL)626,810626,8100$397.1K$521.9K0.09%+$124.8K
Skye Bioscience, Inc.(SKYE)478,928678,928+200,000$359.1K$417.3K0.07%+$58.2K
Precision BioSciences, Inc.(DTIL)396,11640,000-356,116$1.65M$220.0K0.04%-$1.43M
Aprea Therapeutics, Inc.(APRE)270,000270,0000$230.3K$206.0K0.04%-$24.3K
Foghorn Therapeutics Inc.(FHTX)012,224+12,224$0$58.4K0.01%+$58.4K
Advanced Micro Devices, Inc.(AMD)18,0400-18,040$3.86M$0—-$3.86M
Annexon, Inc.(ANNX)1,316,2120-1,316,212$6.61M$0—-$6.61M
Applied Therapeutics Inc50,0000-50,000$5.0K$0—-$5.0K
AstraZeneca PLCADR(AZN)135,0600-135,060$12.42M$0—-$12.42M
Astria Therapeutics Inc355,7250-355,725$4.66M$0—-$4.66M
Broadcom Inc.(AVGO)9,7550-9,755$3.38M$0—-$3.38M
Day One Biopharmaceuticals I
COM
145,3710-145,371$1.35M$0—-$1.35M
Elbit Systems Ltd.(ESLT)5,3400-5,340$3.08M$0—-$3.08M
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SPHERA FUNDS MANAGEMENT LTD. — 13F Holdings — Q1 2026 | TickerTrail