Fund Holdings — SPHERA FUNDS MANAGEMENT LTD.

Total Portfolio Value:
$382.49M
Total Bought:
$93.68M
Total Sold:
$113.43M
Net Transaction:
-$19.75M
Notable People:
Oshrat Levi
Securities
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SharesValue
Q1 2025
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Q2 2025
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Change
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Q1 2025
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Q2 2025
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Weight (%)
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Change
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Teva Pharmaceutical Industries LimitedADS(TEVA)1,572,1811,620,990+48,809$24.16M$27.17M7.10%+$3.00M
Nova Ltd.(NVMI)90,69775,836-14,861$16.72M$20.87M5.46%+$4.15M
Syndax Pharmaceuticals, Inc.(SNDX)1,663,9741,571,564-92,410$20.44M$14.72M3.85%-$5.72M
Tower Semiconductor Ltd.SHS NEW(TSEM)61,549264,722+203,173$2.19M$11.48M3.00%+$9.28M
Cytokinetics, Incorporated(CYTK)144,961326,718+181,757$5.83M$10.79M2.82%+$4.97M
SanofiADR(SNY)304,515219,515-85,000$16.89M$10.60M2.77%-$6.28M
Biogen Inc.(BIIB)22,73882,738+60,000$3.11M$10.39M2.72%+$7.28M
AstraZeneca PLCADR(AZN)175,060135,060-40,000$12.87M$9.44M2.47%-$3.43M
Eli Lilly and Company(LLY)11,69011,540-150$9.65M$9.00M2.35%-$659.1K
NVIDIA Corporation(NVDA)29,60554,515+24,910$3.21M$8.61M2.25%+$5.40M
Celldex Therapeutics, Inc.(CLDX)507,829419,540-88,289$9.22M$8.54M2.23%-$679.5K
Novo Nordisk A/SADR(NVO)118,080105,677-12,403$8.20M$7.29M1.91%-$905.6K
Amazon.com, Inc.(AMZN)36,60732,441-4,166$6.96M$7.12M1.86%+$152.4K
Cidara Therapeutics Inc17,128138,001+120,873$368.9K$6.72M1.76%+$6.35M
Ormat Technologies, Inc.(ORA)84,00078,000-6,000$5.94M$6.53M1.71%+$588.6K
Mineralys Therapeutics, Inc.(MLYS)465,526480,974+15,448$7.39M$6.51M1.70%-$885.0K
Forte Biosciences Inc0495,109+495,109$0$6.40M1.67%+$6.40M
Meta Platforms, Inc.CL A(META)9,9628,526-1,436$5.74M$6.29M1.65%+$551.3K
Johnson & Johnson(JNJ)52,83140,831-12,000$8.76M$6.24M1.63%-$2.52M
Microsoft Corporation(MSFT)4,59211,792+7,200$1.72M$5.87M1.53%+$4.14M
Amicus Therapeutics Inc
COM
0990,718+990,718$0$5.68M1.48%+$5.68M
Ormat Technologies IncDEBT 2 500 7 15,037,0005,037,0000$5.23M$5.61M1.47%+$379.6K
Pharvaris N V
COM
383,856309,931-73,925$6.03M$5.45M1.43%-$571.8K
Eledon Pharmaceuticals, Inc.(ELDN)2,307,1191,959,610-347,509$7.82M$5.31M1.39%-$2.51M
Travere Therapeutics, Inc.(TVTX)200,000335,333+135,333$3.58M$4.96M1.30%+$1.38M
AbbVie Inc.(ABBV)30,25625,256-5,000$6.34M$4.69M1.23%-$1.65M
GSK plcADR(GSK)130,000122,000-8,000$5.04M$4.68M1.22%-$351.4K
Praxis Precision Medicines, Inc.(PRAX)140,660109,757-30,903$5.33M$4.62M1.21%-$711.5K
Novartis AGADR(NVS)50,00037,000-13,000$5.57M$4.48M1.17%-$1.10M
Trevi Therapeutics, Inc.(TRVI)0799,957+799,957$0$4.38M1.14%+$4.38M
Maze Therapeutics, Inc.(MAZE)355,554356,453+899$3.91M$4.37M1.14%+$459.0K
Annexon, Inc.(ANNX)1,764,3871,764,3870$3.41M$4.23M1.11%+$829.3K
Immunovant, Inc.(IMVT)194,638256,743+62,105$3.33M$4.11M1.07%+$781.5K
ORIC Pharmaceuticals, Inc.(ORIC)234,834394,693+159,859$1.31M$4.01M1.05%+$2.70M
Merck & Co., Inc.(MRK)59,60048,600-11,000$5.35M$3.85M1.01%-$1.50M
Acadia Pharmaceuticals Inc0174,900+174,900$0$3.77M0.99%+$3.77M
BridgeBio Pharma, Inc.(BBIO)366,60887,108-279,500$12.67M$3.76M0.98%-$8.91M
Ultragenyx Pharmaceutical Inc.(RARE)267,385100,085-167,300$9.68M$3.64M0.95%-$6.04M
Avidity Biosciences Inc106,000126,000+20,000$3.13M$3.58M0.94%+$449.3K
Alpha Cognition Inc. Common Stock(ACOG)596,992376,649-220,343$3.02M$3.51M0.92%+$493.4K
Rezolute, Inc.(RZLT)1,081,447751,447-330,000$3.14M$3.35M0.88%+$215.3K
Cybin D/B/A Helus Pharma(HELP)527,222398,309-128,913$3.34M$3.34M0.87%-$776
Applied Matls Inc18,00018,0000$2.61M$3.30M0.86%+$683.1K
Arrowhead Pharmaceuticals, Inc.(ARWR)277,550202,996-74,554$3.54M$3.21M0.84%-$328.6K
Immatics N.V.SHS(IMTX)921,111583,105-338,006$4.15M$3.14M0.82%-$1.02M
Savara Inc.(SVRA)1,284,1511,310,233+26,082$3.56M$2.99M0.78%-$569.8K
Uber Technologies, Inc.(UBER)30,00030,0000$2.19M$2.80M0.73%+$613.2K
Sarepta Therapeutics, Inc.(SRPT)157,931159,323+1,392$10.08M$2.72M0.71%-$7.35M
Camtek Ltd.(CAMT)23,08631,976+8,890$1.35M$2.70M0.71%+$1.35M
Elbit Systems Ltd.(ESLT)06,000+6,000$0$2.70M0.71%+$2.70M
Palo Alto Networks, Inc.(PANW)013,114+13,114$0$2.68M0.70%+$2.68M
Wix Com LtdSHS
SHS
8,80016,931+8,131$1.44M$2.68M0.70%+$1.25M
Amgen Inc.(AMGN)10,0009,500-500$3.12M$2.65M0.69%-$463.0K
SolarEdge Technologies, Inc.(SEDG)309,216127,966-181,250$5.00M$2.61M0.68%-$2.39M
Enliven Therapeutics Inc111,743128,515+16,772$2.20M$2.58M0.67%+$378.9K
Skye Bioscience, Inc.(SKYE)1,476,353538,434-937,919$2.35M$2.25M0.59%-$96.7K
Dyne Therapeutics, Inc.(DYN)329,262221,416-107,846$3.44M$2.11M0.55%-$1.34M
Pfizer Inc.(PFE)90,00086,000-4,000$2.28M$2.08M0.55%-$196.0K
Biohaven Ltd.(BHVN)99,784145,372+45,588$2.40M$2.05M0.54%-$347.6K
Scholar Rock Holding Corporation(SRRK)78,19357,497-20,696$2.51M$2.04M0.53%-$477.4K
89bio Inc618,343205,675-412,668$4.50M$2.02M0.53%-$2.48M
Structure Therapeutics IncADS84,00095,931+11,931$1.45M$1.99M0.52%+$535.6K
Janux Therapeutics, Inc.(JANX)125,84085,840-40,000$3.40M$1.98M0.52%-$1.41M
Apellis Pharmaceuticals Inc
COM
181,346114,346-67,000$3.97M$1.98M0.52%-$1.99M
Salesforce, Inc.(CRM)9,1006,800-2,300$2.44M$1.85M0.48%-$587.8K
Engene Holdings Inc
COM
528,365504,409-23,956$2.37M$1.84M0.48%-$531.0K
Cyberark Software LtdSHS04,000+4,000$0$1.63M0.43%+$1.63M
Marvell Technology, Inc.(MRVL)15,07018,730+3,660$927.9K$1.45M0.38%+$521.8K
Astria Therapeutics Inc189,800257,402+67,602$1.01M$1.38M0.36%+$366.1K
Kura Oncology, Inc.(KURA)343,522235,522-108,000$2.27M$1.36M0.36%-$908.3K
iShares Bitcoin Trust ETFSHS BEN INT(IBIT)8,15021,455+13,305$381.5K$1.31M0.34%+$931.8K
Intellia Therapeutics, Inc.(NTLA)381,080128,780-252,300$2.71M$1.21M0.32%-$1.50M
Ventyx Biosciences Inc1,012,749555,814-456,935$1.16M$1.19M0.31%+$24.8K
Advanced Micro Devices, Inc.(AMD)08,250+8,250$0$1.17M0.31%+$1.17M
Nano Dimension Ltd.ADS(NNDM)717,518717,5180$1.14M$1.16M0.30%+$21.5K
Day One Biopharmaceuticals I
COM
334,987175,371-159,616$2.66M$1.14M0.30%-$1.52M
CEVA, Inc.(CEVA)48,92048,9200$1.25M$1.08M0.28%-$177.6K
Perspective Therapeutics, Inc.(CATX)460,247310,343-149,904$980.3K$1.07M0.28%+$87.3K
Cogent Biosciences, Inc.(COGT)335,024143,693-191,331$2.01M$1.03M0.27%-$975.1K
Krystal Biotech, Inc.(KRYS)07,335+7,335$0$1.01M0.26%+$1.01M
Taysha Gene Therapies, Inc.(TSHA)0420,000+420,000$0$970.2K0.25%+$970.2K
Promis Neurosciences Inc1,929,2971,899,297-30,000$1.34M$918.9K0.24%-$422.9K
Vistagen Therapeutics, Inc.(VTGN)790,550447,939-342,611$1.98M$895.9K0.23%-$1.08M
Chemomab Therapeutics LtdADS900,428738,048-162,380$981.5K$856.1K0.22%-$125.3K
Bristol-Myers Squibb Company(BMY)20,00017,500-2,500$1.22M$810.1K0.21%-$409.7K
Corvus Pharmaceuticals, Inc.(CRVS)205,859183,094-22,765$654.6K$732.4K0.19%+$77.7K
Werewolf Therapeutics, Inc.(HOWL)626,810626,8100$609.4K$683.2K0.18%+$73.8K
Verastem, Inc.(VSTM)0163,307+163,307$0$677.7K0.18%+$677.7K
Bicara Therapeutics Inc065,679+65,679$0$610.2K0.16%+$610.2K
Larimar Therapeutics, Inc.(LRMR)366,304196,635-169,669$787.6K$568.3K0.15%-$219.3K
SentinelOne, Inc.CL A(S)027,000+27,000$0$493.6K0.13%+$493.6K
Aprea Therapeutics, Inc.(APRE)270,000270,0000$550.8K$456.3K0.12%-$94.5K
Cognyte Software Ltd.(CGNT)045,181+45,181$0$417.5K0.11%+$417.5K
Kezar Life Sciences Inc
COM NEW
108,47358,539-49,934$529.3K$268.1K0.07%-$261.2K
Climb Bio, Inc.(CLYM)241,935209,837-32,098$295.2K$260.2K0.07%-$35.0K
Solid Biosciences Inc050,190+50,190$0$244.4K0.06%+$244.4K
PepGen Inc.(PEPG)0156,467+156,467$0$173.7K0.05%+$173.7K
OnKure Therapeutics, Inc.CL A(OKUR)80,45460,454-20,000$346.0K$144.5K0.04%-$201.5K
Elevation Oncology Inc358,562328,562-30,000$92.9K$120.6K0.03%+$27.7K
Jasper Therapeutics, Inc.(JSPR)122,01714,671-107,346$524.7K$81.4K0.02%-$443.2K
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SPHERA FUNDS MANAGEMENT LTD. — 13F Holdings — Q2 2025 | TickerTrail