Fund HoldingsSPHERA FUNDS MANAGEMENT LTD.

Total Portfolio Value
$426.14M
Total Bought
$127.17M
Total Sold
$132.50M
Net Transaction
-$5.34M
Filing Period:
Securities
SharesValue ($K)
Q1 2025
Q2 2025
Change
Q1 2025
Q2 2025
Weight (%)
Change
SPDR SERIES TRUST(Put)
ST STR SP BIOT
0200,000+200,000016,586+16,586
TOWER SEMICONDUCTOR LTD(TSEM)0264,722+264,722011,4762.69%+11,476
BIOGEN INC(BIIB)22,73882,738+60,0003,11110,3912.44%+7,280
FORTE BIOSCIENCES INC(FBRX)0495,109+495,10906,4021.50%+6,402
CIDARA THERAPEUTICS INC17,128138,001+120,8733696,7221.58%+6,353
MOONLAKE IMMUNOTHERAPEUTICS(MLTX)(Call)0125,000+125,00005,900+5,900
AMICUS THERAPEUTICS INC
COM
0990,718+990,71805,6771.33%+5,677
NVIDIA CORPORATION(NVDA)29,60554,515+24,9103,2098,6132.02%+5,404
CYTOKINETICS INC(CYTK)144,961326,718+181,7575,82610,7952.53%+4,969
ULTRAGENYX PHARMACEUTICAL IN(RARE)(Call)50,000180,600+130,6001,8116,567+4,756
TREVI THERAPEUTICS INC(TRVI)0799,957+799,95704,3761.03%+4,376
NOVA LTD(NVMI)90,69775,836-14,86116,71820,8704.90%+4,152
MICROSOFT CORP(MSFT)011,792+11,79205,8651.38%+5,865
ACADIA PHARMACEUTICALS INC0174,900+174,90003,7730.89%+3,773
TEVA PHARMACEUTICAL INDS LTD(TEVA)01,620,990+1,620,990027,1686.38%+27,168
ELBIT SYS LTD(ESLT)06,000+6,00002,6970.63%+2,697
ORIC PHARMACEUTICALS INC(ORIC)234,834394,693+159,8591,3104,0060.94%+2,696
PALO ALTO NETWORKS INC(PANW)013,114+13,11402,6840.63%+2,684
SAREPTA THERAPEUTICS INC(SRPT)(Call)0150,000+150,00002,565+2,565
BRIDGEBIO PHARMA INC(BBIO)(Put)049,900+49,90002,155+2,155
CYBERARK SOFTWARE LTD04,000+4,00001,6280.38%+1,628
COGENT BIOSCIENCES INC(COGT)(Call)0200,000+200,00001,436+1,436
TRAVERE THERAPEUTICS INC(TVTX)200,000335,333+135,3333,5844,9631.16%+1,379
CAMTEK LTD(CAMT)23,08631,976+8,8901,3542,7040.63%+1,350
WIX COM LTD
SHS
016,931+16,93102,6830.63%+2,683
ADVANCED MICRO DEVICES INC(AMD)08,250+8,25001,1710.27%+1,171
KRYSTAL BIOTECH INC(KRYS)07,335+7,33501,0080.24%+1,008
TAYSHA GENE THERAPIES INC(TSHA)0420,000+420,00009700.23%+970
ISHARES BITCOIN TRUST ETF(IBIT)8,15021,455+13,3053821,3130.31%+932
ANNEXON INC(ANNX)01,764,387+1,764,38704,2350.99%+4,235
IMMUNOVANT INC(IMVT)194,638256,743+62,1053,3264,1080.96%+782
APPLIED MATLS INC18,00018,00002,6123,2950.77%+683
VERASTEM INC0163,307+163,30706780.16%+678
UBER TECHNOLOGIES INC(UBER)30,00030,00002,1862,7990.66%+613
BICARA THERAPEUTICS INC065,679+65,67906100.14%+610
ORMAT TECHNOLOGIES INC(ORA)84,00078,000-6,0005,9456,5331.53%+589
META PLATFORMS INC(META)08,526+8,52606,2931.48%+6,293
STRUCTURE THERAPEUTICS INC84,00095,931+11,9311,4541,9900.47%+536
MARVELL TECHNOLOGY INC(MRVL)018,730+18,73001,4500.34%+1,450
SENTINELONE INC(S)027,000+27,00004940.12%+494
ALPHA COGNITION INC596,992376,649-220,3433,0213,5140.82%+493
MAZE THERAPEUTICS INC(MAZE)355,554356,453+8993,9154,3741.03%+459
AVIDITY BIOSCIENCES INC106,000126,000+20,0003,1293,5780.84%+449
PRAXIS PRECISION MEDICINES I(PRAX)(Call)0100,000+100,00004,205+4,205
COGNYTE SOFTWARE LTD045,181+45,18104170.10%+417
ORMAT TECHNOLOGIES INC5,037,0005,037,00005,2305,6101.32%+380
ENLIVEN THERAPEUTICS INC111,743128,515+16,7722,1992,5780.60%+379
ASTRIA THERAPEUTICS INC189,800257,402+67,6021,0141,3800.32%+366
SOLID BIOSCIENCES INC050,190+50,19002440.06%+244
REZOLUTE INC0751,447+751,44703,3510.79%+3,351
PEPGEN INC0156,467+156,46701740.04%+174
AMAZON COM INC(AMZN)032,441+32,44107,1171.67%+7,117
PERSPECTIVE THERAPEUTICS INC460,247310,343-149,9049801,0680.25%+87
ELEDON PHARMACEUTICALS INC(Call)031,200+31,200085+85
CORVUS PHARMACEUTICALS INC(CRVS)205,859183,094-22,7656557320.17%+78
WEREWOLF THERAPEUTICS INC626,810626,81006096830.16%+74
ELEVATION ONCOLOGY INC358,562328,562-30,000931210.03%+28
VENTYX BIOSCIENCES INC1,012,749555,814-456,9351,1651,1890.28%+25
NANO DIMENSION LTD717,518717,51801,1411,1620.27%+22
CYBIN INC527,222398,309-128,9133,3433,3420.78%-1
IMMATICS N.V100,0000-100,00020-2
APPLIED THERAPEUTICS INC50,00050,000024160.00%-9
CLIMB BIO INC241,935209,837-32,0982952600.06%-35
LAVA THERAPEUTICS NV48,4200-48,420610-61
APREA THERAPEUTICS INC270,000270,00005514560.11%-94
SKYE BIOSCIENCE INC1,476,353538,434-937,9192,3472,2510.53%-97
CHEMOMAB THERAPEUTICS LTD900,428738,048-162,3809818560.20%-125
ALECTOR INC109,2080-109,2081340-134
CEVA INC(CEVA)48,92048,92001,2531,0750.25%-178
PFIZER INC(PFE)90,00086,000-4,0002,2812,0850.49%-196
ONKURE THERAPEUTICS INC80,45460,454-20,0003461440.03%-201
LARIMAR THERAPEUTICS INC366,304196,635-169,6697885680.13%-219
KEZAR LIFE SCIENCES INC
COM NEW
108,47358,539-49,9345292680.06%-261
FATE THERAPEUTICS INC397,1770-397,1773140-314
ARROWHEAD PHARMACEUTICALS IN(ARWR)277,550202,996-74,5543,5363,2070.75%-329
BIOHAVEN LTD(BHVN)0145,372+145,37202,0510.48%+2,051
GSK PLC(GSK)130,000122,000-8,0005,0364,6851.10%-351
BRISTOL-MYERS SQUIBB CO(BMY)20,00017,500-2,5001,2208100.19%-410
PROMIS NEUROSCIENCES INC1,929,2971,899,297-30,0001,3429190.22%-423
JASPER THERAPEUTICS INC122,01714,671-107,346525810.02%-443
AMGEN INC(AMGN)10,0009,500-5003,1162,6520.62%-463
SCHOLAR ROCK HLDG CORP(SRRK)78,19357,497-20,6962,5142,0370.48%-477
ENGENE HOLDINGS INC
COM
528,365504,409-23,9562,3671,8360.43%-531
ZURA BIO LTD421,2290-421,2295430-543
SAVARA INC(SVRA)1,284,1511,310,233+26,0823,5572,9870.70%-570
PHARVARIS N V
COM
383,856309,931-73,9256,0275,4551.28%-572
SALESFORCE INC(CRM)9,1006,800-2,3002,4421,8540.44%-588
VIR BIOTECHNOLOGY INC(VIR)000000
ELI LILLY & CO(LLY)11,69011,540-1509,6558,9962.11%-659
CELLDEX THERAPEUTICS INC NEW(CLDX)0419,540+419,54008,5382.00%+8,538
PRAXIS PRECISION MEDICINES I(PRAX)140,660109,757-30,9035,3274,6151.08%-712
REGULUS THERAPEUTICS INC452,8450-452,8457920-792
PERION NETWORK LTD102,6120-102,6128350-835
XENON PHARMACEUTICALS INC(XENE)26,0970-26,0978760-876
ARVINAS INC125,0000-125,0008780-877
MINERALYS THERAPEUTICS INC(MLYS)465,526480,974+15,4487,3936,5081.53%-885
NOVO-NORDISK A S(NVO)118,080105,677-12,4038,1997,2941.71%-906
KURA ONCOLOGY INC(KURA)0235,522+235,52201,3590.32%+1,359
COGENT BIOSCIENCES INC(COGT)335,024143,693-191,3312,0071,0320.24%-975
IMMATICS N.V(IMTX)0583,105+583,10503,1370.74%+3,137
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