SPHERA FUNDS MANAGEMENT LTD.
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| NICE LTD(NICE) | 0 | 157,400 | +157,400 | 0 | 22,788,372 | 5.41% | +22,788,372 |
| MERUS N V(Call) | 0 | 150,000 | +150,000 | 0 | 14,122,500 | — | +14,122,500 |
| INVESCO QQQ TR | 0 | 22,960 | +22,960 | 0 | 13,784,495 | 3.27% | +13,784,495 |
| TOWER SEMICONDUCTOR LTD(TSEM) | 264,722 | 311,802 | +47,080 | 11,475,699 | 22,543,285 | 5.35% | +11,067,586 |
| CIDARA THERAPEUTICS INC(Call) | 0 | 100,000 | +100,000 | 0 | 9,576,000 | — | +9,576,000 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 100,085 | 352,558 | +252,473 | 3,639,091 | 10,604,945 | 2.52% | +6,965,854 |
| BRIDGEBIO PHARMA INC(BBIO)(Call) | 0 | 130,000 | +130,000 | 0 | 6,752,200 | — | +6,752,200 |
| CELLEBRITE DI LTD(CLBT) | 0 | 298,948 | +298,948 | 0 | 5,539,506 | 1.31% | +5,539,506 |
| SOLAREDGE TECHNOLOGIES INC(SEDG) | 0 | 4,000,000 | +4,000,000 | 0 | 5,332,890 | 1.26% | +5,332,890 |
| RAPPORT THERAPEUTICS INC(RAPP) | 0 | 157,533 | +157,533 | 0 | 4,678,730 | 1.11% | +4,678,730 |
| UNIQURE NV(QURE)(Put) | 0 | 75,000 | +75,000 | 0 | 4,377,750 | — | +4,377,750 |
| VARONIS SYS INC(VRNS) | 0 | 73,900 | +73,900 | 0 | 4,247,033 | 1.01% | +4,247,033 |
| MEDIWOUND LTD | 0 | 185,270 | +185,270 | 0 | 3,338,565 | 0.79% | +3,338,565 |
| DYNE THERAPEUTICS INC(DYN) | 221,416 | 426,518 | +205,102 | 2,107,880 | 5,395,453 | 1.28% | +3,287,573 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,620,990 | 1,507,025 | -113,965 | 27,167,792 | 30,441,905 | 7.22% | +3,274,113 |
| STRUCTURE THERAPEUTICS INC | 95,931 | 173,931 | +78,000 | 1,989,609 | 4,870,068 | 1.16% | +2,880,459 |
| SOLENO THERAPEUTICS INC | 0 | 41,606 | +41,606 | 0 | 2,812,566 | 0.67% | +2,812,566 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 60,000 | +60,000 | 0 | 2,802,000 | 0.66% | +2,802,000 |
| IDEAYA BIOSCIENCES INC(IDYA) | 0 | 100,000 | +100,000 | 0 | 2,721,000 | 0.65% | +2,721,000 |
| SOLAREDGE TECHNOLOGIES INC(SEDG) | 127,966 | 140,966 | +13,000 | 2,610,506 | 5,215,742 | 1.24% | +2,605,236 |
| TRAVERE THERAPEUTICS INC(TVTX)(Call) | 0 | 101,800 | +101,800 | 0 | 2,433,020 | — | +2,433,020 |
| ROIVANT SCIENCES LTD(ROIV)(Call) | 0 | 151,600 | +151,600 | 0 | 2,293,708 | — | +2,293,708 |
| CORVUS PHARMACEUTICALS INC(CRVS) | 183,094 | 407,709 | +224,615 | 732,376 | 3,004,815 | 0.71% | +2,272,439 |
| BROADCOM INC(AVGO) | 0 | 6,555 | +6,555 | 0 | 2,162,560 | 0.51% | +2,162,560 |
| AMICUS THERAPEUTICS INC | 990,718 | 991,142 | +424 | 5,676,814 | 7,810,199 | 1.85% | +2,133,385 |
| SAVARA INC(SVRA) | 1,310,233 | 1,350,333 | +40,100 | 2,987,331 | 4,820,689 | 1.14% | +1,833,358 |
| MINERALYS THERAPEUTICS INC(MLYS) | 480,974 | 219,910 | -261,064 | 6,507,578 | 8,338,987 | 1.98% | +1,831,409 |
| IMMATICS N.V(IMTX) | 583,105 | 583,105 | 0 | 3,137,105 | 4,968,055 | 1.18% | +1,830,950 |
| TECTONIC THERAPEUTIC INC | 0 | 115,908 | +115,908 | 0 | 1,818,597 | 0.43% | +1,818,597 |
| VAXCYTE INC(PCVX) | 0 | 50,000 | +50,000 | 0 | 1,801,000 | 0.43% | +1,801,000 |
| IMMUNOME INC(IMNM) | 0 | 147,200 | +147,200 | 0 | 1,723,712 | 0.41% | +1,723,712 |
| MILESTONE PHARMACEUTICALS IN | 0 | 820,000 | +820,000 | 0 | 1,640,000 | 0.39% | +1,640,000 |
| ENGENE HOLDINGS INC | 504,409 | 504,409 | 0 | 1,836,049 | 3,445,113 | 0.82% | +1,609,064 |
| TREVI THERAPEUTICS INC(TRVI) | 799,957 | 643,957 | -156,000 | 4,375,765 | 5,892,207 | 1.40% | +1,516,442 |
| UNIQURE NV(QURE) | 0 | 24,900 | +24,900 | 0 | 1,453,413 | 0.34% | +1,453,413 |
| JASPER THERAPEUTICS INC | 14,671 | 629,470 | +614,799 | 81,424 | 1,498,139 | 0.36% | +1,416,715 |
| STRUCTURE THERAPEUTICS INC(Call) | 0 | 50,000 | +50,000 | 0 | 1,400,000 | — | +1,400,000 |
| JOHNSON & JOHNSON(JNJ) | 40,831 | 40,831 | 0 | 6,236,935 | 7,570,884 | 1.80% | +1,333,949 |
| ADVANCED MICRO DEVICES INC(AMD) | 8,250 | 15,470 | +7,220 | 1,170,675 | 2,502,891 | 0.59% | +1,332,216 |
| ANNEXON INC(ANNX) | 1,764,387 | 1,794,387 | +30,000 | 4,234,529 | 5,472,880 | 1.30% | +1,238,351 |
| BIOGEN INC(BIIB) | 82,738 | 82,738 | 0 | 10,391,065 | 11,589,939 | 2.75% | +1,198,874 |
| TREVI THERAPEUTICS INC(TRVI)(Call) | 0 | 129,200 | +129,200 | 0 | 1,182,180 | — | +1,182,180 |
| ORIC PHARMACEUTICALS INC(ORIC) | 394,693 | 431,693 | +37,000 | 4,006,134 | 5,180,316 | 1.23% | +1,174,182 |
| ABBVIE INC(ABBV) | 25,256 | 25,256 | 0 | 4,688,019 | 5,847,774 | 1.39% | +1,159,755 |
| SAB BIOTHERAPEUTICS INC | 0 | 566,395 | +566,395 | 0 | 1,138,454 | 0.27% | +1,138,454 |
| CEVA INC(CEVA) | 48,920 | 81,085 | +32,165 | 1,075,262 | 2,141,455 | 0.51% | +1,066,193 |
| ENPHASE ENERGY INC(ENPH) | 0 | 26,700 | +26,700 | 0 | 944,913 | 0.22% | +944,913 |
| VOYAGER THERAPEUTICS INC | 0 | 199,761 | +199,761 | 0 | 932,884 | 0.22% | +932,884 |
| ASTRAZENECA PLC(AZN) | 135,060 | 135,060 | 0 | 9,437,993 | 10,361,803 | 2.46% | +923,810 |
| ENLIVEN THERAPEUTICS INC | 128,515 | 166,765 | +38,250 | 2,578,011 | 3,413,680 | 0.81% | +835,669 |
| KURA ONCOLOGY INC(KURA) | 235,522 | 245,522 | +10,000 | 1,358,962 | 2,172,870 | 0.52% | +813,908 |
| BICARA THERAPEUTICS INC | 65,679 | 85,747 | +20,068 | 610,158 | 1,353,945 | 0.32% | +743,787 |
| ELBIT SYS LTD(ESLT) | 6,000 | 6,740 | +740 | 2,697,000 | 3,436,052 | 0.82% | +739,052 |
| FORTE BIOSCIENCES INC(FBRX) | 495,109 | 474,309 | -20,800 | 6,401,759 | 7,114,635 | 1.69% | +712,876 |
| PERSPECTIVE THERAPEUTICS INC | 310,343 | 510,343 | +200,000 | 1,067,580 | 1,750,476 | 0.42% | +682,896 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 42,571 | +42,571 | 0 | 644,099 | 0.15% | +644,099 |
| PEPGEN INC | 156,467 | 171,467 | +15,000 | 173,678 | 792,178 | 0.19% | +618,500 |
| CLIMB BIO INC | 209,837 | 434,837 | +225,000 | 260,198 | 874,022 | 0.21% | +613,824 |
| GSK PLC(GSK) | 122,000 | 122,000 | 0 | 4,684,800 | 5,265,520 | 1.25% | +580,720 |
| WEREWOLF THERAPEUTICS INC | 626,810 | 626,810 | 0 | 683,223 | 1,234,816 | 0.29% | +551,593 |
| CIDARA THERAPEUTICS INC | 138,001 | 75,743 | -62,258 | 6,722,029 | 7,253,150 | 1.72% | +531,121 |
| ELEDON PHARMACEUTICALS INC(Put) | 0 | 200,000 | +200,000 | 0 | 518,000 | — | +518,000 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 71,010 | +71,010 | 0 | 509,142 | 0.12% | +509,142 |
| CHEMOMAB THERAPEUTICS LTD | 0 | 179,425 | +179,425 | 0 | 471,888 | 0.11% | +471,888 |
| ASTRIA THERAPEUTICS INC | 257,402 | 251,225 | -6,177 | 1,379,675 | 1,828,918 | 0.43% | +449,243 |
| COGENT BIOSCIENCES INC(COGT) | 143,693 | 98,526 | -45,167 | 1,031,716 | 1,414,833 | 0.34% | +383,117 |
| WAVE LIFE SCIENCES LTD(WVE) | 0 | 50,000 | +50,000 | 0 | 366,000 | 0.09% | +366,000 |
| TAYSHA GENE THERAPIES INC(TSHA) | 420,000 | 408,146 | -11,854 | 970,200 | 1,334,637 | 0.32% | +364,437 |
| CAMTEK LTD(CAMT) | 31,976 | 29,048 | -2,928 | 2,703,891 | 3,051,492 | 0.72% | +347,601 |
| SAREPTA THERAPEUTICS INC(SRPT)(Call) | 150,000 | 150,000 | 0 | 2,565,000 | 2,890,500 | — | +325,500 |
| LARIMAR THERAPEUTICS INC | 196,635 | 260,385 | +63,750 | 568,275 | 841,044 | 0.20% | +272,769 |
| NOVARTIS AG(NVS) | 37,000 | 37,000 | 0 | 4,477,370 | 4,744,880 | 1.13% | +267,510 |
| MERCK & CO INC(MRK) | 48,600 | 48,600 | 0 | 3,847,176 | 4,078,998 | 0.97% | +231,822 |
| VENTYX BIOSCIENCES INC | 555,814 | 440,114 | -115,700 | 1,189,442 | 1,368,755 | 0.32% | +179,313 |
| DESIGN THERAPEUTICS INC | 0 | 21,918 | +21,918 | 0 | 165,043 | 0.04% | +165,043 |
| JANUX THERAPEUTICS INC(JANX) | 85,840 | 85,840 | 0 | 1,982,904 | 2,097,930 | 0.50% | +115,026 |
| PFIZER INC(PFE) | 86,000 | 86,000 | 0 | 2,084,640 | 2,191,280 | 0.52% | +106,640 |
| DAY ONE BIOPHARMACEUTICALS I | 175,371 | 175,371 | 0 | 1,139,912 | 1,236,366 | 0.29% | +96,454 |
| ISHARES BITCOIN TRUST ETF(IBIT) | 21,455 | 21,455 | 0 | 1,313,261 | 1,394,575 | 0.33% | +81,314 |
| REZOLUTE INC | 751,447 | 363,947 | -387,500 | 3,351,454 | 3,421,102 | 0.81% | +69,648 |
| ISHARES TR(Call) | 47,000 | 47,000 | 0 | 4,147,750 | 4,200,390 | — | +52,640 |
| IMMUNOVANT INC(IMVT) | 256,743 | 256,743 | 0 | 4,107,888 | 4,138,697 | 0.98% | +30,809 |
| AMGEN INC(AMGN) | 9,500 | 9,500 | 0 | 2,652,495 | 2,680,900 | 0.64% | +28,405 |
| ONKURE THERAPEUTICS INC | 60,454 | 60,454 | 0 | 144,485 | 166,249 | 0.04% | +21,764 |
| APPLIED THERAPEUTICS INC | 50,000 | 50,000 | 0 | 15,555 | 30,245 | 0.01% | +14,690 |
| VERASTEM INC | 163,307 | 78,307 | -85,000 | 677,724 | 691,451 | 0.16% | +13,727 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 17,500 | 17,500 | 0 | 810,075 | 789,250 | 0.19% | -20,825 |
| APREA THERAPEUTICS INC | 270,000 | 270,000 | 0 | 456,300 | 398,250 | 0.09% | -58,050 |
| ELEDON PHARMACEUTICALS INC(Call) | 31,200 | 0 | -31,200 | 84,552 | 0 | — | -84,552 |
| ELEVATION ONCOLOGY INC | 328,562 | 0 | -328,562 | 120,615 | 0 | — | -120,615 |
| SANOFI SA(SNY) | 219,515 | 219,515 | 0 | 10,604,770 | 10,361,108 | 2.46% | -243,662 |
| SOLID BIOSCIENCES INC | 50,190 | 0 | -50,190 | 244,425 | 0 | — | -244,425 |
| KEZAR LIFE SCIENCES INC | 58,539 | 0 | -58,539 | 268,109 | 0 | — | -268,109 |
| SKYE BIOSCIENCE INC | 538,434 | 478,928 | -59,506 | 2,250,654 | 1,882,187 | 0.45% | -368,467 |
| MAZE THERAPEUTICS INC(MAZE) | 356,453 | 154,343 | -202,110 | 4,373,678 | 4,002,114 | 0.95% | -371,564 |
| COGNYTE SOFTWARE LTD | 45,181 | 0 | -45,181 | 417,472 | 0 | — | -417,472 |
| SENTINELONE INC(S) | 27,000 | 0 | -27,000 | 493,560 | 0 | — | -493,560 |
| APELLIS PHARMACEUTICALS INC | 114,346 | 63,660 | -50,686 | 1,979,329 | 1,440,626 | 0.34% | -538,703 |
| ACADIA PHARMACEUTICALS INC | 174,900 | 148,900 | -26,000 | 3,772,593 | 3,177,526 | 0.75% | -595,067 |
| BIOHAVEN LTD(BHVN) | 145,372 | 91,155 | -54,217 | 2,051,199 | 1,368,237 | 0.32% | -682,962 |