Fund Holdings — SPHERA FUNDS MANAGEMENT LTD.

Total Portfolio Value:
$421.60M
Total Bought:
$128.41M
Total Sold:
$117.08M
Net Transaction:
+$11.33M
Notable People:
Oshrat Levi
Securities
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SharesValue
Q2 2025
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Q3 2025
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Change
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Q2 2025
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Q3 2025
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Weight (%)
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Change
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Teva Pharmaceutical Industries LimitedADS(TEVA)1,620,9901,507,025-113,965$27.17M$30.44M7.22%+$3.27M
NICE Ltd.ADR(NICE)0157,400+157,400$0$22.79M5.41%+$22.79M
Tower Semiconductor Ltd.SHS NEW(TSEM)264,722311,802+47,080$11.48M$22.54M5.35%+$11.07M
Nova Ltd.(NVMI)75,83643,896-31,940$20.87M$14.03M3.33%-$6.84M
Invesco Qqq TrUNIT SER 1022,960+22,960$0$13.78M3.27%+$13.78M
Biogen Inc.(BIIB)82,73882,7380$10.39M$11.59M2.75%+$1.20M
Ultragenyx Pharmaceutical Inc.(RARE)100,085352,558+252,473$3.64M$10.60M2.52%+$6.97M
AstraZeneca PLCADR(AZN)135,060135,0600$9.44M$10.36M2.46%+$923.8K
SanofiADR(SNY)219,515219,5150$10.60M$10.36M2.46%-$243.7K
Cytokinetics, Incorporated(CYTK)326,718161,517-165,201$10.79M$8.88M2.11%-$1.92M
Mineralys Therapeutics, Inc.(MLYS)480,974219,910-261,064$6.51M$8.34M1.98%+$1.83M
Amicus Therapeutics Inc
COM
990,718991,142+424$5.68M$7.81M1.85%+$2.13M
Eli Lilly and Company(LLY)11,54010,040-1,500$9.00M$7.66M1.82%-$1.34M
Johnson & Johnson(JNJ)40,83140,8310$6.24M$7.57M1.80%+$1.33M
Cidara Therapeutics Inc138,00175,743-62,258$6.72M$7.25M1.72%+$531.1K
Forte Biosciences Inc495,109474,309-20,800$6.40M$7.11M1.69%+$712.9K
Syndax Pharmaceuticals, Inc.(SNDX)1,571,564387,716-1,183,848$14.72M$5.97M1.41%-$8.75M
Trevi Therapeutics, Inc.(TRVI)799,957643,957-156,000$4.38M$5.89M1.40%+$1.52M
Novo Nordisk A/SADR(NVO)105,677105,6770$7.29M$5.86M1.39%-$1.43M
AbbVie Inc.(ABBV)25,25625,2560$4.69M$5.85M1.39%+$1.16M
Cellebrite DI Ltd.(CLBT)0298,948+298,948$0$5.54M1.31%+$5.54M
Annexon, Inc.(ANNX)1,764,3871,794,387+30,000$4.23M$5.47M1.30%+$1.24M
Dyne Therapeutics, Inc.(DYN)221,416426,518+205,102$2.11M$5.40M1.28%+$3.29M
Celldex Therapeutics, Inc.(CLDX)419,540207,764-211,776$8.54M$5.37M1.27%-$3.16M
SolarEdge Technologies, Inc.NOTE 2 250 7 0(SEDG)04,000,000+4,000,000$0$5.33M1.26%+$5.33M
GSK plcADR(GSK)122,000122,0000$4.68M$5.27M1.25%+$580.7K
SolarEdge Technologies, Inc.(SEDG)127,966140,966+13,000$2.61M$5.22M1.24%+$2.61M
ORIC Pharmaceuticals, Inc.(ORIC)394,693431,693+37,000$4.01M$5.18M1.23%+$1.17M
Immatics N.V.SHS(IMTX)583,105583,1050$3.14M$4.97M1.18%+$1.83M
Structure Therapeutics IncADS95,931173,931+78,000$1.99M$4.87M1.16%+$2.88M
Savara Inc.(SVRA)1,310,2331,350,333+40,100$2.99M$4.82M1.14%+$1.83M
Novartis AGADR(NVS)37,00037,0000$4.48M$4.74M1.13%+$267.5K
Rapport Therapeutics, Inc.(RAPP)0157,533+157,533$0$4.68M1.11%+$4.68M
Varonis Systems, Inc.(VRNS)073,900+73,900$0$4.25M1.01%+$4.25M
Immunovant, Inc.(IMVT)256,743256,7430$4.11M$4.14M0.98%+$30.8K
Merck & Co., Inc.(MRK)48,60048,6000$3.85M$4.08M0.97%+$231.8K
Maze Therapeutics, Inc.(MAZE)356,453154,343-202,110$4.37M$4.00M0.95%-$371.6K
Engene Holdings Inc
COM
504,409504,4090$1.84M$3.45M0.82%+$1.61M
Elbit Systems Ltd.(ESLT)6,0006,740+740$2.70M$3.44M0.82%+$739.1K
Rezolute, Inc.(RZLT)751,447363,947-387,500$3.35M$3.42M0.81%+$69.6K
Enliven Therapeutics Inc128,515166,765+38,250$2.58M$3.41M0.81%+$835.7K
MediWound Ltd.SHS NEW(MDWD)0185,270+185,270$0$3.34M0.79%+$3.34M
Eledon Pharmaceuticals, Inc.(ELDN)1,959,6101,280,233-679,377$5.31M$3.32M0.79%-$1.99M
Acadia Pharmaceuticals Inc174,900148,900-26,000$3.77M$3.18M0.75%-$595.1K
Praxis Precision Medicines, Inc.(PRAX)109,75757,901-51,856$4.62M$3.07M0.73%-$1.55M
Camtek Ltd.(CAMT)31,97629,048-2,928$2.70M$3.05M0.72%+$347.6K
Amazon.com, Inc.(AMZN)32,44113,760-18,681$7.12M$3.02M0.72%-$4.10M
Corvus Pharmaceuticals, Inc.(CRVS)183,094407,709+224,615$732.4K$3.00M0.71%+$2.27M
Pharvaris N V
COM
309,931119,406-190,525$5.45M$2.98M0.71%-$2.48M
Meta Platforms, Inc.CL A(META)8,5263,924-4,602$6.29M$2.88M0.68%-$3.41M
Soleno Therapeutics Inc041,606+41,606$0$2.81M0.67%+$2.81M
Revolution Medicines, Inc.(RVMD)060,000+60,000$0$2.80M0.66%+$2.80M
Ormat Technologies, Inc.(ORA)78,00029,000-49,000$6.53M$2.79M0.66%-$3.74M
IDEAYA Biosciences, Inc.(IDYA)0100,000+100,000$0$2.72M0.65%+$2.72M
Amgen Inc.(AMGN)9,5009,5000$2.65M$2.68M0.64%+$28.4K
Advanced Micro Devices, Inc.(AMD)8,25015,470+7,220$1.17M$2.50M0.59%+$1.33M
Alpha Cognition Inc. Common Stock(ACOG)376,649338,752-37,897$3.51M$2.21M0.52%-$1.31M
Pfizer Inc.(PFE)86,00086,0000$2.08M$2.19M0.52%+$106.6K
Cybin D/B/A Helus Pharma(HELP)398,309370,376-27,933$3.34M$2.18M0.52%-$1.16M
Kura Oncology, Inc.(KURA)235,522245,522+10,000$1.36M$2.17M0.52%+$813.9K
Broadcom Inc.(AVGO)06,555+6,555$0$2.16M0.51%+$2.16M
CEVA, Inc.(CEVA)48,92081,085+32,165$1.08M$2.14M0.51%+$1.07M
BridgeBio Pharma, Inc.(BBIO)87,10840,746-46,362$3.76M$2.12M0.50%-$1.64M
Janux Therapeutics, Inc.(JANX)85,84085,8400$1.98M$2.10M0.50%+$115.0K
Skye Bioscience, Inc.(SKYE)538,434478,928-59,506$2.25M$1.88M0.45%-$368.5K
Astria Therapeutics Inc257,402251,225-6,177$1.38M$1.83M0.43%+$449.2K
Tectonic Therapeutic, Inc.(TECX)0115,908+115,908$0$1.82M0.43%+$1.82M
Vaxcyte, Inc.(PCVX)050,000+50,000$0$1.80M0.43%+$1.80M
Perspective Therapeutics, Inc.(CATX)310,343510,343+200,000$1.07M$1.75M0.42%+$682.9K
Immunome, Inc.(IMNM)0147,200+147,200$0$1.72M0.41%+$1.72M
Milestone Pharmaceuticals Inc.(MIST)0820,000+820,000$0$1.64M0.39%+$1.64M
Jasper Therapeutics, Inc.(JSPR)14,671629,470+614,799$81.4K$1.50M0.36%+$1.42M
uniQure N.V.SHS(QURE)024,900+24,900$0$1.45M0.34%+$1.45M
Apellis Pharmaceuticals Inc
COM
114,34663,660-50,686$1.98M$1.44M0.34%-$538.7K
Cogent Biosciences, Inc.(COGT)143,69398,526-45,167$1.03M$1.41M0.34%+$383.1K
iShares Bitcoin Trust ETFSHS BEN INT(IBIT)21,45521,4550$1.31M$1.39M0.33%+$81.3K
Ventyx Biosciences Inc555,814440,114-115,700$1.19M$1.37M0.32%+$179.3K
Biohaven Ltd.(BHVN)145,37291,155-54,217$2.05M$1.37M0.32%-$683.0K
Bicara Therapeutics Inc65,67985,747+20,068$610.2K$1.35M0.32%+$743.8K
Taysha Gene Therapies, Inc.(TSHA)420,000408,146-11,854$970.2K$1.33M0.32%+$364.4K
Day One Biopharmaceuticals I
COM
175,371175,3710$1.14M$1.24M0.29%+$96.5K
Werewolf Therapeutics, Inc.(HOWL)626,810626,8100$683.2K$1.23M0.29%+$551.6K
SAB Biotherapeutics, Inc.(SABS)0566,395+566,395$0$1.14M0.27%+$1.14M
Enphase Energy, Inc.(ENPH)026,700+26,700$0$944.9K0.22%+$944.9K
Voyager Therapeutics, Inc.(VYGR)0199,761+199,761$0$932.9K0.22%+$932.9K
Climb Bio, Inc.(CLYM)209,837434,837+225,000$260.2K$874.0K0.21%+$613.8K
Larimar Therapeutics, Inc.(LRMR)196,635260,385+63,750$568.3K$841.0K0.20%+$272.8K
PepGen Inc.(PEPG)156,467171,467+15,000$173.7K$792.2K0.19%+$618.5K
Bristol-Myers Squibb Company(BMY)17,50017,5000$810.1K$789.3K0.19%-$20.8K
Verastem, Inc.(VSTM)163,30778,307-85,000$677.7K$691.5K0.16%+$13.7K
Roivant Sciences Ltd.SHS(ROIV)042,571+42,571$0$644.1K0.15%+$644.1K
89bio Inc205,67539,675-166,000$2.02M$583.2K0.14%-$1.44M
MoonLake ImmunotherapeuticsCL A(MLTX)071,010+71,010$0$509.1K0.12%+$509.1K
Chemomab Therapeutics Ltd.ADS(CMMB)0179,425+179,425$0$471.9K0.11%+$471.9K
Arrowhead Pharmaceuticals, Inc.(ARWR)202,99612,496-190,500$3.21M$431.0K0.10%-$2.78M
Aprea Therapeutics, Inc.(APRE)270,000270,0000$456.3K$398.3K0.09%-$58.0K
Wave Life Sciences, Inc.SHS(WVE)050,000+50,000$0$366.0K0.09%+$366.0K
OnKure Therapeutics, Inc.CL A(OKUR)60,45460,4540$144.5K$166.2K0.04%+$21.8K
Design Therapeutics, Inc.(DSGN)021,918+21,918$0$165.0K0.04%+$165.0K
Promis Neurosciences Inc1,899,297295,187-1,604,110$918.9K$125.5K0.03%-$793.4K
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SPHERA FUNDS MANAGEMENT LTD. — 13F Holdings — Q3 2025 | TickerTrail