Fund Holdings — SPHERA FUNDS MANAGEMENT LTD.

Total Portfolio Value
$478.53M
Total Bought
$161.56M
Total Sold
$141.59M
Net Transaction
+$19.97M
Filing Period:
Securities
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SharesValue ($K)
Q3 2025
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Q4 2025
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Change
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Q3 2025
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Q4 2025
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Weight (%)
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Change
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COGENT BIOSCIENCES INC(COGT)98,526378,500+279,9741,41513,4442.81%+12,029
SYNDAX PHARMACEUTICALS INC(SNDX)387,716762,563+374,8475,96516,0213.35%+10,056
BIOMARIN PHARMACEUTICAL INC(BMRN)0147,000+147,00008,7361.83%+8,736
MINERALYS THERAPEUTICS INC(MLYS)219,910449,003+229,0938,33916,2943.41%+7,955
SCHOLAR ROCK HLDG CORP(SRRK)0158,265+158,26506,9721.46%+6,972
WAVE LIFE SCIENCES LTD(WVE)50,000408,166+358,1663666,9391.45%+6,573
BIOCRYST PHARMACEUTICALS INC(BCRX)0837,889+837,88906,5361.37%+6,536
BRIDGEBIO PHARMA INC(BBIO)40,746107,746+67,0002,1168,2411.72%+6,125
VOR BIOPHARMA INC(VOR)0410,417+410,41705,3681.12%+5,368
BIOGEN INC(BIIB)82,73894,738+12,00011,59016,6733.48%+5,083
ENPHASE ENERGY INC(ENPH)26,700186,500+159,8009455,9771.25%+5,032
KODIAK SCIENCES INC(KOD)0175,500+175,50004,9071.03%+4,907
APELLIS PHARMACEUTICALS INC
COM
63,660250,961+187,3011,4416,3041.32%+4,864
TANGO THERAPEUTICS INC(TNGX)0544,563+544,56304,8251.01%+4,825
TEVA PHARMACEUTICAL INDS LTD(TEVA)1,507,0251,123,525-383,50030,44235,0657.33%+4,623
CYBIN INC(HELP)370,376825,576+455,2002,1826,7531.41%+4,572
IMMATICS N.V(IMTX)583,105861,105+278,0004,9689,0421.89%+4,074
SOLENO THERAPEUTICS INC41,606136,314+94,7082,8136,3111.32%+3,499
PROTARA THERAPEUTICS INC(TARA)0650,000+650,00003,4650.72%+3,465
BIOAGE LABS INC(BIOA)0243,035+243,03503,2150.67%+3,215
ORIC PHARMACEUTICALS INC(ORIC)431,6931,004,378+572,6855,1808,2161.72%+3,035
ZIM INTEGRATED SHIPPING SERV
SHS
0136,005+136,00502,8870.60%+2,887
CLIMB BIO INC(CLYM)434,837932,247+497,4108743,7290.78%+2,855
EVOMMUNE INC(EVMN)0166,147+166,14702,8440.59%+2,844
ASTRIA THERAPEUTICS INC251,225355,725+104,5001,8294,6560.97%+2,828
ACADIA PHARMACEUTICALS INC148,900212,202+63,3023,1785,6681.18%+2,490
NURIX THERAPEUTICS INC(NRIX)0124,000+124,00002,3520.49%+2,352
ASCENDIS PHARMA A/S(ASND)011,000+11,00002,3460.49%+2,346
TENAX THERAPEUTICS INC(TENX)0190,111+190,11102,3170.48%+2,317
DYNE THERAPEUTICS INC(DYN)426,518392,894-33,6245,3957,6851.61%+2,290
SAVARA INC(SVRA)1,350,3331,178,164-172,1694,8217,1041.48%+2,284
ELI LILLY & CO(LLY)10,0409,040-1,0007,6619,7152.03%+2,055
ASTRAZENECA PLC(AZN)135,060135,060010,36212,4162.59%+2,054
CONTINEUM THERAPEUTICS INC(CTNM)0173,475+173,47501,9830.41%+1,983
VERASTEM INC(VSTM)78,307343,678+265,3716912,6530.55%+1,962
MADRIGAL PHARMACEUTICALS INC(MDGL)03,300+3,30001,9220.40%+1,922
NOVA LTD(NVMI)43,89647,846+3,95014,03215,7123.28%+1,680
PRECISION BIOSCIENCES INC(DTIL)0396,116+396,11601,6480.34%+1,648
TREVI THERAPEUTICS INC(TRVI)643,957598,534-45,4235,8927,4941.57%+1,601
AMICUS THERAPEUTICS INC
COM
991,142658,377-332,7657,8109,3751.96%+1,565
ALPHA COGNITION INC(ACOG)338,752567,616+228,8642,2053,6900.77%+1,484
REVOLUTION MEDICINES INC(RVMD)60,00052,500-7,5002,8024,1820.87%+1,380
ADVANCED MICRO DEVICES INC(AMD)15,47018,040+2,5702,5033,8630.81%+1,361
SANOFI SA(SNY)219,515239,515+20,00010,36111,6072.43%+1,246
BROADCOM INC(AVGO)6,5559,755+3,2002,1633,3760.71%+1,214
CAMTEK LTD(CAMT)29,04839,498+10,4503,0514,2000.88%+1,149
ENTRADA THERAPEUTICS INC(TRDA)0110,942+110,94201,1400.24%+1,140
CELLDEX THERAPEUTICS INC NEW(CLDX)207,764239,764+32,0005,3756,5121.36%+1,137
ANNEXON INC(ANNX)1,794,3871,316,212-478,1755,4736,6071.38%+1,135
TENAYA THERAPEUTICS INC(TNYA)01,500,000+1,500,00001,0670.22%+1,067
MERCK & CO INC(MRK)48,60048,60004,0795,1161.07%+1,037
MEDIWOUND LTD(MDWD)185,270230,347+45,0773,3394,2520.89%+914
KURA ONCOLOGY INC(KURA)245,522295,522+50,0002,1733,0700.64%+898
GSK PLC(GSK)122,000122,00005,2665,9831.25%+717
SHATTUCK LABS INC(STTK)0195,212+195,21207130.15%+713
TAYSHA GENE THERAPIES INC(TSHA)408,146368,146-40,0001,3352,0250.42%+690
SOLAREDGE TECHNOLOGIES INC(SEDG)140,966196,536+55,5705,2165,6701.18%+454
PALISADE BIO INC(PALI)0184,100+184,10004330.09%+433
VOYAGER THERAPEUTICS INC(VYGR)199,761339,761+140,0009331,3350.28%+402
NOVARTIS AG(NVS)37,00037,00004,7455,1011.07%+356
PRELUDE THERAPEUTICS INC(PRLD)0122,752+122,75203560.07%+356
VENTYX BIOSCIENCES INC440,114180,114-260,0001,3691,6260.34%+258
BRISTOL-MYERS SQUIBB CO(BMY)17,50017,50007899440.20%+155
CORVUS PHARMACEUTICALS INC(CRVS)407,709407,70903,0053,1390.66%+135
DAY ONE BIOPHARMACEUTICALS I
COM
175,371145,371-30,0001,2361,3550.28%+118
MEREO BIOPHARMA GROUP PLC(MREO)0255,400+255,40001060.02%+106
ISHARES BITCOIN TRUST ETF(IBIT)21,45530,055+8,6001,3951,4920.31%+98
PROMIS NEUROSCIENCES INC(PMN)011,807+11,8070810.02%+81
JANUX THERAPEUTICS INC(JANX)85,840157,840+72,0002,0982,1780.46%+80
ENLIVEN THERAPEUTICS INC166,765226,765+60,0003,4143,4920.73%+79
NOVO-NORDISK A S(NVO)105,677115,677+10,0005,8645,8861.23%+22
ONKURE THERAPEUTICS INC(OKUR)60,45460,45401661750.04%+9
PEPGEN INC(PEPG)171,467121,467-50,0007927910.17%-1
APPLIED THERAPEUTICS INC50,00050,00003050.00%-25
PFIZER INC(PFE)86,00086,00002,1912,1410.45%-50
ABBVIE INC(ABBV)25,25625,25605,8485,7711.21%-77
ELEDON PHARMACEUTICALS INC(ELDN)1,280,2332,132,131+851,8983,3163,2200.67%-96
PROMIS NEUROSCIENCES INC295,1870-295,1871250—-125
JOHNSON & JOHNSON(JNJ)40,83135,831-5,0007,5717,4151.55%-156
DESIGN THERAPEUTICS INC(DSGN)21,9180-21,9181650—-165
APREA THERAPEUTICS INC(APRE)270,000270,00003982300.05%-168
AMGEN INC(AMGN)9,5007,500-2,0002,6812,4550.51%-226
ELBIT SYS LTD(ESLT)6,7405,340-1,4003,4363,0850.64%-351
ARROWHEAD PHARMACEUTICALS IN(ARWR)12,4960-12,4964310—-431
CHEMOMAB THERAPEUTICS LTD(CMMB)179,4250-179,4254720—-472
MOONLAKE IMMUNOTHERAPEUTICS(MLTX)71,0100-71,0105090—-509
89BIO INC39,6750-39,6755830—-583
JASPER THERAPEUTICS INC(JSPR)629,470485,401-144,0691,4988880.19%-610
SOLAREDGE TECHNOLOGIES INC(SEDG)4,000,0004,000,00005,3334,6990.98%-633
ROIVANT SCIENCES LTD(ROIV)42,5710-42,5716440—-644
PERSPECTIVE THERAPEUTICS INC(CATX)510,343349,973-160,3701,7509620.20%-788
WEREWOLF THERAPEUTICS INC(HOWL)626,810626,81001,2353970.08%-838
LARIMAR THERAPEUTICS INC(LRMR)260,3850-260,3858410—-841
MAZE THERAPEUTICS INC(MAZE)154,34371,843-82,5004,0022,9760.62%-1,026
SAB BIOTHERAPEUTICS INC(SABS)566,3950-566,3951,1380—-1,138
PHARVARIS N V
COM
119,40663,953-55,4532,9791,7750.37%-1,204
BICARA THERAPEUTICS INC85,7470-85,7471,3540—-1,354
BIOHAVEN LTD(BHVN)91,1550-91,1551,3680—-1,368
UNIQURE NV(QURE)24,9000-24,9001,4530—-1,453
SKYE BIOSCIENCE INC(SKYE)478,928478,92801,8823590.08%-1,523
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SPHERA FUNDS MANAGEMENT LTD. — 13F Holdings — Q4 2025 | TickerTrail