Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| LEGEND BIOTECH CORP(LEGN) | 0 | 3,496,234 | +3,496,234 | 0 | 113,767 | 4.21% | +113,767 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 10,721,511 | 11,399,138 | +677,627 | 99,710 | 158,790 | 5.88% | +59,080 |
| IMMATICS N.V(IMTX) | 0 | 5,065,277 | +5,065,277 | 0 | 36,014 | 1.33% | +36,014 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 0 | 2,566,951 | +2,566,951 | 0 | 32,267 | 1.20% | +32,267 |
| BENITEC BIOPHARMA INC(BNTC) | 8,829,053 | 8,960,009 | +130,956 | 81,139 | 113,165 | 4.19% | +32,026 |
| COCA COLA CO(KO) | 588,912 | 1,137,853 | +548,941 | 42,319 | 70,843 | 2.62% | +28,524 |
| BOEING CO(BA) | 0 | 155,197 | +155,197 | 0 | 27,470 | 1.02% | +27,470 |
| CAESARS ENTERTAINMENT INC NE(CZR) | 0 | 772,412 | +772,412 | 0 | 25,814 | 0.96% | +25,814 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 793,187 | +793,187 | 0 | 25,311 | 0.94% | +25,311 |
| DATADOG INC(DDOG) | 0 | 176,450 | +176,450 | 0 | 25,213 | 0.93% | +25,213 |
| NVIDIA CORPORATION(NVDA) | 0 | 180,756 | +180,756 | 0 | 24,274 | 0.90% | +24,274 |
| 89BIO INC | 7,991,644 | 10,202,696 | +2,211,052 | 59,138 | 79,785 | 2.96% | +20,647 |
| UNITED AIRLS HLDGS INC(UAL) | 0 | 200,650 | +200,650 | 0 | 19,483 | 0.72% | +19,483 |
| APOLLO GLOBAL MGMT INC(APO) | 465,050 | 464,140 | -910 | 58,089 | 76,657 | 2.84% | +18,568 |
| ARRIVENT BIOPHARMA INC(AVBP) | 1,845,162 | 2,246,000 | +400,838 | 43,361 | 59,833 | 2.22% | +16,472 |
| DOMINOS PIZZA INC(DPZ) | 0 | 38,340 | +38,340 | 0 | 16,094 | 0.60% | +16,094 |
| TESLA INC(TSLA) | 193,842 | 163,630 | -30,212 | 50,715 | 66,080 | 2.45% | +15,365 |
| INTRA-CELLULAR THERAPIES INC | 1,439,026 | 1,439,026 | 0 | 105,294 | 120,187 | 4.45% | +14,894 |
| BOSTON SCIENTIFIC CORP(BSX) | 251,689 | 397,679 | +145,990 | 21,092 | 35,521 | 1.32% | +14,429 |
| BIOGEN INC(BIIB) | 29,946 | 115,436 | +85,490 | 5,805 | 17,652 | 0.65% | +11,848 |
| FULCRUM THERAPEUTICS INC(FULC) | 1,182,791 | 3,338,466 | +2,155,675 | 4,223 | 15,691 | 0.58% | +11,468 |
| AMAZON COM INC(AMZN) | 352,069 | 351,281 | -788 | 65,601 | 77,068 | 2.85% | +11,467 |
| DISNEY WALT CO(DIS) | 0 | 94,580 | +94,580 | 0 | 10,531 | 0.39% | +10,531 |
| CAPITAL ONE FINL CORP(COF) | 235,600 | 251,642 | +16,042 | 35,276 | 44,873 | 1.66% | +9,596 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 5,175,823 | 6,783,091 | +1,607,268 | 41,355 | 50,534 | 1.87% | +9,179 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 0 | 714,463 | +714,463 | 0 | 8,574 | 0.32% | +8,574 |
| MOLECULAR PARTNERS AG(MOLN) | 400,000 | 2,221,494 | +1,821,494 | 2,035 | 10,548 | 0.39% | +8,513 |
| MICROSOFT CORP(MSFT) | 96,526 | 118,397 | +21,871 | 41,535 | 49,904 | 1.85% | +8,369 |
| TAIWAN SEMICONDUCTOR MFG LTD(TSM) | 348,742 | 345,912 | -2,830 | 60,566 | 68,314 | 2.53% | +7,748 |
| INFLARX NV(IFRX) | 5,733,910 | 5,733,910 | 0 | 8,773 | 14,163 | 0.52% | +5,390 |
| MERCK & CO INC(MRK) | 0 | 53,000 | +53,000 | 0 | 5,272 | 0.20% | +5,272 |
| KEZAR LIFE SCIENCES INC COM NEW | 0 | 716,759 | +716,759 | 0 | 4,817 | 0.18% | +4,817 |
| META PLATFORMS INC(META) | 168,488 | 170,338 | +1,850 | 96,449 | 99,735 | 3.69% | +3,285 |
| SAREPTA THERAPEUTICS INC(SRPT) | 0 | 17,888 | +17,888 | 0 | 2,175 | 0.08% | +2,175 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 0 | 33,800 | +33,800 | 0 | 1,912 | 0.07% | +1,912 |
| ELEVANCE HEALTH INC(ELV) | 0 | 2,740 | +2,740 | 0 | 1,011 | 0.04% | +1,011 |
| DEXCOM INC(DXCM) | 31,680 | 31,680 | 0 | 2,124 | 2,464 | 0.09% | +340 |
| NATERA INC(NTRA) | 10,100 | 10,100 | 0 | 1,282 | 1,599 | 0.06% | +317 |
| INTUITIVE SURGICAL INC | 5,200 | 5,200 | 0 | 2,555 | 2,714 | 0.10% | +160 |
| MCKESSON CORP(MCK) | 1,830 | 1,830 | 0 | 905 | 1,043 | 0.04% | +138 |
| EDWARDS LIFESCIENCES CORP | 11,100 | 11,100 | 0 | 732 | 822 | 0.03% | +89 |
| WATERS CORP(WAT) | 3,150 | 3,150 | 0 | 1,134 | 1,169 | 0.04% | +35 |
| CENCORA INC | 12,488 | 12,488 | 0 | 2,811 | 2,806 | 0.10% | -5 |
| STRYKER CORPORATION(SYK) | 4,360 | 4,360 | 0 | 1,575 | 1,570 | 0.06% | -5 |
| ZIMMER BIOMET HOLDINGS INC(ZBH) | 3,260 | 3,260 | 0 | 352 | 344 | 0.01% | -8 |
| ABBOTT LABS | 33,520 | 33,520 | 0 | 3,822 | 3,791 | 0.14% | -30 |
| RESMED INC(RMD) | 2,390 | 2,390 | 0 | 583 | 547 | 0.02% | -37 |
| ALIGN TECHNOLOGY INC | 1,100 | 1,100 | 0 | 280 | 229 | 0.01% | -50 |
| VERALTO CORP(VLTO) | 5,475 | 5,475 | 0 | 612 | 558 | 0.02% | -55 |
| IONIS PHARMACEUTICALS INC(IONS) | 10,800 | 10,800 | 0 | 433 | 378 | 0.01% | -55 |
| STERIS PLC(STE) | 1,530 | 1,530 | 0 | 371 | 315 | 0.01% | -57 |
| BAXTER INTL INC | 7,970 | 7,970 | 0 | 303 | 232 | 0.01% | -70 |
| AGILENT TECHNOLOGIES INC(A) | 4,990 | 4,990 | 0 | 741 | 670 | 0.02% | -71 |
| MEDTRONIC PLC(MDT) | 17,460 | 17,460 | 0 | 1,572 | 1,395 | 0.05% | -177 |
| BIO-TECHNE CORP(TECH) | 2,600 | 0 | -2,600 | 208 | 0 | — | -208 |
| IQVIA HLDGS INC(IQV) | 7,175 | 7,175 | 0 | 1,700 | 1,410 | 0.05% | -290 |
| GALAPAGOS NV(LKFT) | 47,200 | 37,111 | -10,089 | 1,359 | 1,021 | 0.04% | -338 |
| HCA HEALTHCARE INC(HCA) | 3,190 | 3,190 | 0 | 1,297 | 957 | 0.04% | -339 |
| AVANTOR INC(AVTR) | 71,850 | 71,850 | 0 | 1,859 | 1,514 | 0.06% | -345 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 7,260 | 7,900 | +640 | 4,491 | 4,110 | 0.15% | -381 |
| PACS GROUP INC(PACS) | 20,000 | 20,000 | 0 | 799 | 262 | 0.01% | -537 |
| METTLER TOLEDO INTERNATIONAL(MTD) | 1,964 | 1,964 | 0 | 2,945 | 2,403 | 0.09% | -542 |
| ELANCO ANIMAL HEALTH INC(ELAN) | 253,600 | 253,600 | 0 | 3,725 | 3,071 | 0.11% | -654 |
| CVS HEALTH CORP(CVS) | 17,170 | 0 | -17,170 | 1,080 | 0 | — | -1,080 |
| CENTESSA PHARMACEUTICALS PLC | 70,000 | 0 | -70,000 | 1,119 | 0 | — | -1,119 |
| EXACT SCIENCES CORP(EXK) | 94,100 | 94,100 | 0 | 6,410 | 5,287 | 0.20% | -1,123 |
| ILLUMINA INC(ILMN) | 8,730 | 0 | -8,730 | 1,138 | 0 | — | -1,138 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 75,000 | 75,000 | 0 | 7,039 | 5,864 | 0.22% | -1,175 |
| DANAHER CORPORATION(DHR) | 16,427 | 13,600 | -2,827 | 4,567 | 3,122 | 0.12% | -1,445 |
| MCDONALDS CORP(MCD) | 103,638 | 103,638 | 0 | 31,559 | 30,044 | 1.11% | -1,515 |
| ARCUS BIOSCIENCES INC(RCUS) | 663,603 | 576,156 | -87,447 | 10,146 | 8,579 | 0.32% | -1,568 |
| FERGUSON ENTERPRISES INC(FERG) | 225,210 | 245,530 | +20,320 | 44,720 | 42,617 | 1.58% | -2,103 |
| JOHNSON & JOHNSON(JNJ) | 138,447 | 139,986 | +1,539 | 22,437 | 20,245 | 0.75% | -2,192 |
| ORACLE CORP(ORCL) | 237,094 | 226,318 | -10,776 | 40,401 | 37,714 | 1.40% | -2,687 |
| ABEONA THERAPEUTICS INC(ABEO) | 3,685,503 | 3,685,503 | 0 | 23,292 | 20,528 | 0.76% | -2,764 |
| SCPHARMACEUTICALS INC | 2,049,009 | 1,840,891 | -208,118 | 9,343 | 6,517 | 0.24% | -2,827 |
| PROKIDNEY CORP(PROK) | 12,341,266 | 12,341,266 | 0 | 23,695 | 20,857 | 0.77% | -2,838 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 2,659,000 | 1,563,798 | -1,095,202 | 14,093 | 10,853 | 0.40% | -3,240 |
| SANOFI(SNY) | 174,901 | 131,501 | -43,400 | 10,080 | 6,342 | 0.23% | -3,737 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 13,824 | 0 | -13,824 | 3,802 | 0 | — | -3,802 |
| KENVUE INC(KVUE) | 171,596 | 0 | -171,596 | 3,969 | 0 | — | -3,969 |
| GE AEROSPACE(GE) | 200,662 | 200,662 | 0 | 37,841 | 33,468 | 1.24% | -4,372 |
| VERIZON COMMUNICATIONS INC(VZ) | 758,674 | 738,414 | -20,260 | 34,072 | 29,529 | 1.09% | -4,543 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 268,100 | 0 | -268,100 | 4,831 | 0 | — | -4,831 |
| KEZAR LIFE SCIENCES INC | 7,167,591 | 0 | -7,167,591 | 5,542 | 0 | — | -5,542 |
| STARBUCKS CORP(SBUX) | 550,309 | 514,922 | -35,387 | 53,650 | 46,987 | 1.74% | -6,663 |
| ERASCA INC(ERAS) | 13,768,039 | 12,315,004 | -1,453,035 | 37,587 | 30,911 | 1.15% | -6,676 |
| KALVISTA PHARMACEUTICALS INC | 4,212,005 | 4,913,012 | +701,007 | 48,775 | 41,613 | 1.54% | -7,162 |
| ZURA BIO LTD(ZURA) | 4,860,939 | 4,860,939 | 0 | 19,735 | 12,152 | 0.45% | -7,583 |
| ISHARES TR | 242,500 | 0 | -242,500 | 7,707 | 0 | — | -7,707 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 1,720,000 | 1,720,000 | 0 | 32,921 | 25,198 | 0.93% | -7,723 |
| KRANESHARES TRUST | 230,000 | 0 | -230,000 | 7,825 | 0 | — | -7,825 |
| INSMED INC(INSM) | 1,635,709 | 1,611,561 | -24,148 | 119,407 | 111,262 | 4.12% | -8,145 |
| MARINUS PHARMACEUTICALS INC | 5,073,913 | 0 | -5,073,913 | 8,930 | 0 | — | -8,930 |
| CRH PLC ORD | 538,894 | 436,394 | -102,500 | 49,977 | 40,375 | 1.50% | -9,602 |
| PEPGEN INC(PEPG) | 1,660,932 | 1,174,321 | -486,611 | 14,201 | 4,451 | 0.16% | -9,750 |
| GOLDMAN SACHS GROUP INC(GS) | 108,308 | 74,198 | -34,110 | 53,624 | 42,487 | 1.57% | -11,137 |
| SUTRO BIOPHARMA INC(STRO) | 7,187,495 | 7,462,495 | +275,000 | 24,869 | 13,731 | 0.51% | -11,138 |
| WYNN RESORTS LTD(WYNN) | 133,000 | 0 | -133,000 | 12,752 | 0 | — | -12,752 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 1,151,314 | 1,151,314 | 0 | 63,955 | 48,436 | 1.79% | -15,520 |