Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 10,478,000 | 11,964,000 | +1,486,000 | 197,510 | 347,435 | 8.66% | +149,924 |
| SYSCO CORP(SYY) | 0 | 1,083,790 | +1,083,790 | 0 | 79,864 | 1.99% | +79,864 |
| ARCUS BIOSCIENCES INC(RCUS) | 3,688,858 | 5,188,858 | +1,500,000 | 50,168 | 123,650 | 3.08% | +73,482 |
| EYEPOINT INC(EYPT) | 6,192,715 | 7,827,685 | +1,634,970 | 88,184 | 143,012 | 3.57% | +54,828 |
| CAPRICOR THERAPEUTICS INC(CAPR) | 0 | 1,785,610 | +1,785,610 | 0 | 51,533 | 1.28% | +51,533 |
| AMAZON COM INC(AMZN) | 218,547 | 406,146 | +187,599 | 47,986 | 93,747 | 2.34% | +45,760 |
| MGM RESORTS INTERNATIONAL(MGM) | 0 | 1,202,070 | +1,202,070 | 0 | 43,864 | 1.09% | +43,864 |
| PALVELLA THERAPEUTICS INC NE(PVLA) | 822,400 | 892,400 | +70,000 | 51,556 | 93,408 | 2.33% | +41,851 |
| SERVICENOW INC(NOW) | 22,000 | 389,445 | +367,445 | 20,246 | 59,659 | 1.49% | +39,413 |
| APELLIS PHARMACEUTICALS INC COM | 2,878,000 | 4,139,426 | +1,261,426 | 65,129 | 103,982 | 2.59% | +38,853 |
| BIOHAVEN LTD(BHVN) | 5,620,271 | 10,286,937 | +4,666,666 | 84,360 | 116,140 | 2.90% | +31,779 |
| UNIQURE NV(QURE) | 0 | 1,216,734 | +1,216,734 | 0 | 29,116 | 0.73% | +29,116 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 3,360,000 | 3,360,000 | 0 | 24,898 | 52,685 | 1.31% | +27,787 |
| COMPASS THERAPEUTICS INC(CMPX) | 14,101,159 | 14,182,379 | +81,220 | 49,354 | 76,159 | 1.90% | +26,805 |
| COHERENT CORP(COHR) | 0 | 137,930 | +137,930 | 0 | 25,458 | 0.63% | +25,458 |
| CHIPOTLE MEXICAN GRILL INC(CMG) | 0 | 686,300 | +686,300 | 0 | 25,393 | 0.63% | +25,393 |
| FULCRUM THERAPEUTICS INC(FULC) | 5,381,000 | 6,561,111 | +1,180,111 | 49,505 | 74,206 | 1.85% | +24,701 |
| BANK AMERICA CORP | 1,160,330 | 1,517,630 | +357,300 | 59,861 | 83,470 | 2.08% | +23,608 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 2,662,227 | +2,662,227 | 0 | 23,587 | 0.59% | +23,587 |
| SALESFORCE INC(CRM) | 125,250 | 199,900 | +74,650 | 29,684 | 52,956 | 1.32% | +23,271 |
| ERASCA INC(ERAS) | 14,502,004 | 14,502,004 | 0 | 31,614 | 53,947 | 1.34% | +22,333 |
| APOLLO GLOBAL MGMT INC(APO) | 431,260 | 542,890 | +111,630 | 57,474 | 78,589 | 1.96% | +21,115 |
| MICROSOFT CORP(MSFT) | 109,455 | 159,695 | +50,240 | 56,692 | 77,232 | 1.93% | +20,539 |
| LEGEND BIOTECH CORP(LEGN) | 3,818,009 | 6,608,629 | +2,790,620 | 124,505 | 143,672 | 3.58% | +19,166 |
| KALVISTA PHARMACEUTICALS INC | 4,768,712 | 4,768,712 | 0 | 58,083 | 77,015 | 1.92% | +18,932 |
| ADVANCED MICRO DEVICES INC(AMD) | 398,799 | 389,576 | -9,223 | 64,522 | 83,432 | 2.08% | +18,910 |
| KURA ONCOLOGY INC(KURA) | 8,116,000 | 8,575,422 | +459,422 | 71,827 | 89,099 | 2.22% | +17,272 |
| BENITEC BIOPHARMA INC(BNTC) | 9,876,506 | 11,548,351 | +1,671,845 | 138,567 | 155,556 | 3.88% | +16,989 |
| IMMATICS N.V(IMTX) | 12,030,129 | 11,190,129 | -840,000 | 102,497 | 117,496 | 2.93% | +15,000 |
| ARRIVENT BIOPHARMA INC(AVBP) | 3,703,452 | 4,106,035 | +402,583 | 68,329 | 82,613 | 2.06% | +14,285 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 1,250,000 | +1,250,000 | 0 | 12,413 | 0.31% | +12,413 |
| CONTINEUM THERAPEUTICS INC(CTNM) | 1,720,000 | 2,841,334 | +1,121,334 | 20,210 | 32,476 | 0.81% | +12,266 |
| NVIDIA CORPORATION(NVDA) | 483,535 | 530,900 | +47,365 | 90,218 | 99,013 | 2.47% | +8,795 |
| ADVISORSHARES TR PURE US CANN ETF | 7,167,000 | 8,669,600 | +1,502,600 | 34,330 | 40,921 | 1.02% | +6,591 |
| MODERNA INC(MRNA) | 0 | 205,593 | +205,593 | 0 | 6,063 | 0.15% | +6,063 |
| ZURA BIO LTD(ZURA) | 5,472,891 | 5,567,001 | +94,110 | 23,698 | 29,171 | 0.73% | +5,473 |
| DANAHER CORPORATION(DHR) | 255,800 | 244,300 | -11,500 | 50,715 | 55,925 | 1.39% | +5,210 |
| TAIWAN SEMICONDUCTOR MFG LTD(TSM) | 277,201 | 271,401 | -5,800 | 77,419 | 82,476 | 2.06% | +5,057 |
| EXACT SCIENCES CORP(EXK) | 94,100 | 94,100 | 0 | 5,148 | 9,557 | 0.24% | +4,409 |
| UNITEDHEALTH GROUP INC(UNH) | 96,220 | 111,320 | +15,100 | 33,225 | 36,748 | 0.92% | +3,523 |
| HOME DEPOT INC(HD) | 197,311 | 240,861 | +43,550 | 79,948 | 82,880 | 2.07% | +2,932 |
| GE AEROSPACE(GE) | 310,262 | 310,262 | 0 | 93,333 | 95,570 | 2.38% | +2,237 |
| GOLDMAN SACHS GROUP INC(GS) | 24,108 | 24,108 | 0 | 19,198 | 21,191 | 0.53% | +1,993 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 3,700,000 | 3,700,000 | 0 | 7,030 | 8,954 | 0.22% | +1,924 |
| MEDLINE INC(MDLN) | 0 | 42,500 | +42,500 | 0 | 1,785 | 0.04% | +1,785 |
| KEZAR LIFE SCIENCES INC COM NEW | 716,759 | 716,759 | 0 | 2,795 | 4,508 | 0.11% | +1,713 |
| MOLECULAR PARTNERS AG(MOLN) | 2,221,494 | 2,221,494 | 0 | 8,242 | 9,683 | 0.24% | +1,441 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 13,400 | 13,400 | 0 | 6,499 | 7,765 | 0.19% | +1,265 |
| NATERA INC(NTRA) | 10,100 | 10,100 | 0 | 1,626 | 2,314 | 0.06% | +688 |
| INTUITIVE SURGICAL INC | 5,200 | 5,200 | 0 | 2,326 | 2,945 | 0.07% | +619 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 16,700 | +16,700 | 0 | 520 | 0.01% | +520 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 7,500 | 7,500 | 0 | 3,144 | 3,654 | 0.09% | +510 |
| TESLA INC(TSLA) | 91,252 | 91,252 | 0 | 40,582 | 41,038 | 1.02% | +456 |
| REPLIMUNE GROUP INC(REPL) | 0 | 36,038 | +36,038 | 0 | 350 | 0.01% | +350 |
| METTLER TOLEDO INTERNATIONAL(MTD) | 1,964 | 1,964 | 0 | 2,411 | 2,738 | 0.07% | +327 |
| CENCORA INC | 12,488 | 12,488 | 0 | 3,903 | 4,218 | 0.11% | +315 |
| IQVIA HLDGS INC(IQV) | 7,175 | 7,175 | 0 | 1,363 | 1,617 | 0.04% | +254 |
| WATERS CORP(WAT) | 3,150 | 3,150 | 0 | 944 | 1,196 | 0.03% | +252 |
| CHARLES RIV LABS INTL INC(CRL) | 0 | 1,010 | +1,010 | 0 | 201 | 0.01% | +201 |
| COCA COLA CO(KO) | 1,455,080 | 1,382,750 | -72,330 | 96,501 | 96,668 | 2.41% | +167 |
| IONIS PHARMACEUTICALS INC(IONS) | 10,800 | 10,800 | 0 | 707 | 854 | 0.02% | +148 |
| HCA HEALTHCARE INC(HCA) | 3,190 | 3,190 | 0 | 1,360 | 1,489 | 0.04% | +130 |
| MCKESSON CORP(MCK) | 1,830 | 1,830 | 0 | 1,414 | 1,501 | 0.04% | +87 |
| EDWARDS LIFESCIENCES CORP | 11,100 | 11,100 | 0 | 863 | 946 | 0.02% | +83 |
| SAREPTA THERAPEUTICS INC(SRPT) | 17,888 | 17,888 | 0 | 345 | 385 | 0.01% | +40 |
| AGILENT TECHNOLOGIES INC(A) | 4,990 | 4,990 | 0 | 640 | 679 | 0.02% | +39 |
| MEDTRONIC PLC(MDT) | 25,060 | 25,060 | 0 | 2,387 | 2,407 | 0.06% | +21 |
| STERIS PLC(STE) | 1,530 | 1,530 | 0 | 379 | 388 | 0.01% | +9 |
| ABEONA THERAPEUTICS INC(ABEO) | 2,676,000 | 2,676,000 | 0 | 14,129 | 14,103 | 0.35% | -27 |
| ZIMMER BIOMET HOLDINGS INC(ZBH) | 3,260 | 3,260 | 0 | 321 | 293 | 0.01% | -28 |
| DEXCOM INC(DXCM) | 31,680 | 31,680 | 0 | 2,132 | 2,103 | 0.05% | -29 |
| VERALTO CORP(VLTO) | 5,475 | 5,475 | 0 | 584 | 546 | 0.01% | -37 |
| RESMED INC(RMD) | 2,390 | 2,390 | 0 | 654 | 576 | 0.01% | -79 |
| STRYKER CORPORATION(SYK) | 5,860 | 5,860 | 0 | 2,166 | 2,060 | 0.05% | -107 |
| PACS GROUP INC(PACS) | 20,000 | 0 | -20,000 | 275 | 0 | — | -275 |
| BIOGEN INC(BIIB) | 168,190 | 132,290 | -35,900 | 23,560 | 23,282 | 0.58% | -278 |
| ABBOTT LABS | 51,020 | 51,020 | 0 | 6,834 | 6,392 | 0.16% | -441 |
| INFLARX NV(IFRX) | 6,483,910 | 7,933,910 | +1,450,000 | 8,688 | 8,013 | 0.20% | -675 |
| BOSTON SCIENTIFIC CORP(BSX) | 353,561 | 353,561 | 0 | 34,518 | 33,712 | 0.84% | -806 |
| AVANTOR INC(AVTR) | 71,850 | 0 | -71,850 | 897 | 0 | — | -897 |
| GALAPAGOS NV(LKFT) | 37,111 | 0 | -37,111 | 1,286 | 0 | — | -1,286 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 3,843,333 | 2,992,735 | -850,598 | 12,529 | 10,505 | 0.26% | -2,025 |
| PROKIDNEY CORP(PROK) | 12,341,266 | 12,341,266 | 0 | 29,866 | 27,644 | 0.69% | -2,221 |
| AURA BIOSCIENCES INC(AURA) | 4,372,884 | 4,372,884 | 0 | 27,024 | 23,832 | 0.59% | -3,192 |
| JOHNSON & JOHNSON(JNJ) | 132,786 | 98,786 | -34,000 | 24,621 | 20,444 | 0.51% | -4,177 |
| ELANCO ANIMAL HEALTH INC(ELAN) | 253,600 | 0 | -253,600 | 5,108 | 0 | — | -5,108 |
| SUTRO BIOPHARMA INC(STRO) | 6,488,324 | 0 | -6,488,324 | 5,634 | 0 | — | -5,634 |
| DICKS SPORTING GOODS INC(DKS) | 128,290 | 114,300 | -13,990 | 28,509 | 22,628 | 0.56% | -5,881 |
| CAPITAL ONE FINL CORP(COF) | 238,770 | 171,970 | -66,800 | 50,758 | 41,679 | 1.04% | -9,079 |
| REGENERON PHARMACEUTICALS(REGN) | 17,730 | 0 | -17,730 | 9,969 | 0 | — | -9,969 |
| INSMED INC(INSM) | 217,783 | 109,313 | -108,470 | 31,363 | 19,025 | 0.47% | -12,338 |
| META PLATFORMS INC(META) | 170,973 | 169,069 | -1,904 | 125,559 | 111,601 | 2.78% | -13,958 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 2,019,000 | 2,019,000 | 0 | 60,732 | 46,437 | 1.16% | -14,295 |
| PINTEREST INC(PINS) | 497,185 | 0 | -497,185 | 15,994 | 0 | — | -15,994 |
| MERCK & CO INC(MRK) | 219,178 | 0 | -219,178 | 18,396 | 0 | — | -18,396 |
| ORACLE CORP(ORCL) | 226,318 | 226,318 | 0 | 63,650 | 44,112 | 1.10% | -19,538 |
| SNOWFLAKE INC(SNOW) | 89,200 | 0 | -89,200 | 20,119 | 0 | — | -20,119 |
| MARVELL TECHNOLOGY INC(MRVL) | 272,300 | 0 | -272,300 | 22,892 | 0 | — | -22,892 |
| MINERALYS THERAPEUTICS INC(MLYS) | 2,132,133 | 1,538,662 | -593,471 | 80,850 | 55,838 | 1.39% | -25,012 |
| AVIDITY BIOSCIENCES INC | 750,000 | 0 | -750,000 | 32,678 | 0 | — | -32,677 |