Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PRAXIS PRECISION MEDICINES I(PRAX) | 1,000,000 | 950,000 | -50,000 | 53,000 | 280,003 | 15.87% | +227,003 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 2,750,000 | +2,750,000 | 0 | 68,750 | 3.90% | +68,750 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 1,994,173 | 4,355,433 | +2,361,260 | 14,298 | 57,405 | 3.25% | +43,106 |
| EYEPOINT INC(EYPT) | 8,325,000 | 8,265,000 | -60,000 | 118,548 | 151,002 | 8.56% | +32,454 |
| ALUMIS INC | 2,147,396 | 3,635,596 | +1,488,200 | 8,568 | 35,483 | 2.01% | +26,915 |
| ASCENDIS PHARMA A/S(ASND) | 0 | 100,000 | +100,000 | 0 | 21,324 | 1.21% | +21,324 |
| ENGENE HOLDINGS INC COM | 2,323,595 | 4,000,000 | +1,676,405 | 15,870 | 36,120 | 2.05% | +20,250 |
| BRIDGEBIO PHARMA INC(BBIO) | 1,400,000 | 1,200,000 | -200,000 | 72,716 | 91,788 | 5.20% | +19,072 |
| BRIGHT MINDS BIOSCIENCES INC(DRUG) | 1,059,331 | 1,059,331 | 0 | 64,259 | 82,670 | 4.69% | +18,411 |
| BRIDGEBIO ONCOLOGY THERAPEUT(BBOT) | 17,878,594 | 17,878,594 | 0 | 207,034 | 223,840 | 12.69% | +16,806 |
| ABIVAX SA(ABVX) | 1,950,000 | 1,350,000 | -600,000 | 165,555 | 182,054 | 10.32% | +16,499 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 4,010,000 | 3,285,000 | -725,000 | 65,042 | 81,517 | 4.62% | +16,475 |
| BIOAGE LABS INC(BIOA) | 2,140,605 | 2,040,605 | -100,000 | 12,587 | 26,997 | 1.53% | +14,410 |
| MBX BIOSCIENCES INC(MBX) | 1,225,000 | 1,120,000 | -105,000 | 21,438 | 35,325 | 2.00% | +13,887 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 225,000 | +225,000 | 0 | 7,992 | 0.45% | +7,992 |
| ORUKA THERAPEUTICS INC(ORKA) | 533,340 | 533,340 | 0 | 10,256 | 16,166 | 0.92% | +5,909 |
| TARSUS PHARMACEUTICALS INC(TARS) | 300,000 | 250,000 | -50,000 | 17,829 | 20,470 | 1.16% | +2,641 |
| AXSOME THERAPEUTICS INC(AXSM) | 100,000 | 75,000 | -25,000 | 12,145 | 13,698 | 0.78% | +1,553 |
| BIOHAVEN LTD(BHVN) | 10,000 | 10,000 | 0 | 150 | 113 | 0.01% | -37 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 775,000 | 500,000 | -275,000 | 14,609 | 14,520 | 0.82% | -89 |
| VAXCYTE INC(PCVX) | 175,000 | 125,000 | -50,000 | 6,304 | 5,768 | 0.33% | -536 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 500,000 | 400,000 | -100,000 | 6,795 | 4,832 | 0.27% | -1,963 |
| CABALETTA BIO INC(CABA) | 5,000,000 | 4,400,000 | -600,000 | 11,700 | 9,636 | 0.55% | -2,064 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 400,000 | 300,000 | -100,000 | 16,660 | 13,965 | 0.79% | -2,695 |
| RAPPORT THERAPEUTICS INC(RAPP) | 3,192,521 | 3,027,521 | -165,000 | 94,818 | 91,855 | 5.21% | -2,963 |
| PHARVARIS N V COM | 1,363,200 | 1,083,000 | -280,200 | 34,012 | 30,053 | 1.70% | -3,959 |
| ENLIVEN THERAPEUTICS INC | 200,000 | 0 | -200,000 | 4,094 | 0 | — | -4,094 |
| BIOMEA FUSION INC(BMEA) | 3,570,872 | 0 | -3,570,872 | 7,213 | 0 | — | -7,213 |
| GH RESEARCH PLC(GHRS) | 1,916,439 | 1,300,000 | -616,439 | 27,405 | 16,510 | 0.94% | -10,895 |
| CORBUS PHARMACEUTICALS HLDGS(CRBP) | 2,375,000 | 2,344,971 | -30,029 | 30,044 | 19,088 | 1.08% | -10,956 |
| JANUX THERAPEUTICS INC(JANX) | 850,000 | 650,000 | -200,000 | 20,774 | 8,970 | 0.51% | -11,804 |
| AVIDITY BIOSCIENCES INC | 300,000 | 0 | -300,000 | 13,071 | 0 | — | -13,071 |
| CENTESSA PHARMACEUTICALS PLC | 1,925,000 | 1,325,000 | -600,000 | 46,681 | 33,138 | 1.88% | -13,543 |
| INSMED INC(INSM) | 430,000 | 275,000 | -155,000 | 61,924 | 47,861 | 2.71% | -14,063 |
| METSERA INC | 400,000 | 0 | -400,000 | 20,932 | 0 | — | -20,932 |
| KORRO BIO INC(KRRO) | 465,000 | 0 | -465,000 | 22,269 | 0 | — | -22,269 |
| CG ONCOLOGY INC(CGON) | 625,000 | 0 | -625,000 | 25,175 | 0 | — | -25,175 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 2,175,000 | 1,000,000 | -1,175,000 | 61,857 | 35,080 | 1.99% | -26,777 |
| ARCELLX INC COMMON STOCK | 775,000 | 0 | -775,000 | 63,628 | 0 | — | -63,627 |