Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SAREPTA THERAPEUTICS INC(SRPT) | 832,907 | 1,919,835 | +1,086,928 | 80,317 | 248,542 | 6.31% | +168,225 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 2,012,517 | 4,155,375 | +2,142,858 | 71,605 | 194,513 | 4.94% | +122,908 |
| CRISPR THERAPEUTICS AG(CRSP) | 0 | 1,389,276 | +1,389,276 | 0 | 94,693 | 2.40% | +94,693 |
| MORPHIC HLDG INC | 211,262 | 2,384,384 | +2,173,122 | 6,101 | 83,930 | 2.13% | +77,829 |
| IMMUNOME INC(IMNM) | 3,879,415 | 3,879,415 | 0 | 41,510 | 95,744 | 2.43% | +54,234 |
| ADAPTIMMUNE THERAPEUTICS PLC(ADAPY) | 0 | 27,404,070 | +27,404,070 | 0 | 43,298 | 1.10% | +43,298 |
| MERSANA THERAPEUTICS INC | 19,364,688 | 19,364,688 | 0 | 44,926 | 86,754 | 2.20% | +41,828 |
| NUVATION BIO INC(NUVB) | 19,209,643 | 19,209,643 | 0 | 29,007 | 69,923 | 1.78% | +40,917 |
| KURA ONCOLOGY INC(KURA) | 5,806,871 | 5,806,871 | 0 | 83,503 | 123,861 | 3.14% | +40,358 |
| NEUROGENE INC(NGNE) | 1,271,342 | 1,271,342 | 0 | 24,639 | 64,711 | 1.64% | +40,073 |
| CELLDEX THERAPEUTICS INC(CLDX) | 0 | 650,000 | +650,000 | 0 | 27,281 | 0.69% | +27,281 |
| LENZ THERAPEUTICS INC(LENZ) | 0 | 1,219,774 | +1,219,774 | 0 | 27,238 | 0.69% | +27,238 |
| NKARTA INC(NKTX) | 0 | 2,000,000 | +2,000,000 | 0 | 21,620 | 0.55% | +21,620 |
| VAXCYTE INC(PCVX) | 0 | 300,000 | +300,000 | 0 | 20,493 | 0.52% | +20,493 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 0 | 75,000 | +75,000 | 0 | 20,028 | 0.51% | +20,028 |
| AVIDITY BIOSCIENCES INC | 0 | 757,576 | +757,576 | 0 | 19,333 | 0.49% | +19,333 |
| CENTESSA PHARMACEUTICALS PLC | 5,618,779 | 5,618,779 | 0 | 44,725 | 63,492 | 1.61% | +18,767 |
| ORIC PHARMACEUTICALS INC(ORIC) | 3,418,068 | 3,418,068 | 0 | 31,446 | 46,998 | 1.19% | +15,552 |
| ITEOS THERAPEUTICS INC | 1,115,022 | 1,999,249 | +884,227 | 12,209 | 27,270 | 0.69% | +15,060 |
| KEROS THERAPEUTICS INC(KROS) | 0 | 187,500 | +187,500 | 0 | 12,413 | 0.32% | +12,413 |
| DYNE THERAPEUTICS INC(DYN) | 0 | 427,039 | +427,039 | 0 | 12,124 | 0.31% | +12,124 |
| KYVERNA THERAPEUTICS INC(KYTX) | 0 | 450,000 | +450,000 | 0 | 11,178 | 0.28% | +11,178 |
| TSCAN THERAPEUTICS INC(TCRX) | 5,000,000 | 5,000,000 | 0 | 29,150 | 39,700 | 1.01% | +10,550 |
| ALLOVIR INC | 0 | 11,294,585 | +11,294,585 | 0 | 8,526 | 0.22% | +8,526 |
| KODIAK SCIENCES INC(KOD) | 0 | 1,613,600 | +1,613,600 | 0 | 8,488 | 0.22% | +8,488 |
| ANAPTYSBIO INC | 7,521,024 | 7,521,024 | 0 | 161,100 | 169,373 | 4.30% | +8,273 |
| XENCOR INC(XNCR) | 5,282,516 | 5,330,416 | +47,900 | 112,148 | 117,962 | 3.00% | +5,814 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 0 | 500,000 | +500,000 | 0 | 4,955 | 0.13% | +4,955 |
| GENERATION BIO CO | 2,046,867 | 2,046,867 | 0 | 3,377 | 8,331 | 0.21% | +4,953 |
| PRIME MEDICINE INC(PRME) | 0 | 700,000 | +700,000 | 0 | 4,900 | 0.12% | +4,900 |
| VOYAGER THERAPEUTICS INC(VYGR) | 3,851,507 | 3,917,546 | +66,039 | 32,507 | 36,472 | 0.93% | +3,966 |
| ATEA PHARMACEUTICALS INC(AVIR) | 6,995,861 | 6,145,861 | -850,000 | 21,337 | 24,829 | 0.63% | +3,492 |
| GOSSAMER BIO INC(GOSS) | 9,195,404 | 9,195,404 | 0 | 8,391 | 10,851 | 0.28% | +2,460 |
| NUVATION BIO INC(NUVB) | 963,333 | 963,333 | 0 | 1,455 | 3,507 | 0.09% | +2,052 |
| ALIGOS THERAPEUTICS INC | 6,389,468 | 6,389,468 | 0 | 4,243 | 6,262 | 0.16% | +2,019 |
| ATARA BIOTHERAPEUTICS INC | 10,067,043 | 10,167,043 | +100,000 | 5,162 | 7,056 | 0.18% | +1,894 |
| ZYMEWORKS INC(ZYME) | 13,437,473 | 13,437,473 | 0 | 139,615 | 141,362 | 3.59% | +1,747 |
| ARVINAS INC(ARVN) | 6,726,491 | 6,726,491 | 0 | 276,862 | 277,670 | 7.05% | +807 |
| PROQR THRAPEUTICS N V SHS EURO | 2,980,016 | 2,884,357 | -95,659 | 5,900 | 6,605 | 0.17% | +704 |
| CAREMAX INC | 100,000 | 100,000 | 0 | 50 | 482 | 0.01% | +432 |
| SURROZEN INC(SRZN) | 66,665 | 66,665 | 0 | 627 | 1,047 | 0.03% | +421 |
| ALPINE IMMUNE SCIENCES INC | 0 | 1,000 | +1,000 | 0 | 40 | 0.00% | +40 |
| HOOKIPA PHARMA INC | 4,595,024 | 4,595,024 | 0 | 3,722 | 3,272 | 0.08% | -450 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 66,665 | 0 | -66,665 | 745 | 0 | — | -745 |
| PMV PHARMACEUTICALS INC(PMVP) | 566,879 | 566,879 | 0 | 1,757 | 964 | 0.02% | -794 |
| VERVE THERAPEUTICS INC | 1,250,000 | 1,250,000 | 0 | 17,425 | 16,600 | 0.42% | -825 |
| OVID THERAPEUTICS INC(OVID) | 6,117,400 | 6,117,400 | 0 | 19,698 | 18,658 | 0.47% | -1,040 |
| APELLIS PHARMACEUTICALS INC COM | 11,173,068 | 11,357,425 | +184,357 | 668,820 | 667,589 | 16.95% | -1,230 |
| PHATHOM PHARMACEUTICALS INC(PHAT) | 198,480 | 0 | -198,480 | 1,812 | 0 | — | -1,812 |
| TYRA BIOSCIENCES INC(TYRA) | 137,014 | 0 | -137,014 | 1,898 | 0 | — | -1,898 |
| ALLAKOS INC | 748,900 | 0 | -748,900 | 2,044 | 0 | — | -2,044 |
| NGM BIOPHARMACEUTICALS INC | 2,385,873 | 0 | -2,385,873 | 2,049 | 0 | — | -2,049 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 1,013,952 | 1,013,952 | 0 | 124,716 | 122,100 | 3.10% | -2,616 |
| REVOLUTION MEDICINES INC(RVMD) | 132,579 | 0 | -132,579 | 3,802 | 0 | — | -3,802 |
| PHARVARIS N V COM | 900,000 | 900,000 | 0 | 25,245 | 20,799 | 0.53% | -4,446 |
| THIRD HARMONIC BIO INC | 3,182,444 | 3,182,444 | 0 | 34,911 | 30,042 | 0.76% | -4,869 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 2,071,450 | 2,071,450 | 0 | 35,318 | 28,482 | 0.72% | -6,836 |
| ALECTOR INC | 4,056,548 | 4,056,548 | 0 | 32,371 | 24,420 | 0.62% | -7,951 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 3,493,194 | 1,250,385 | -2,242,809 | 38,216 | 22,807 | 0.58% | -15,409 |
| SPYRE THERAPEUTICS INC(SYRE) | 887,076 | 0 | -887,076 | 19,090 | 0 | — | -19,090 |
| GRAPHITE BIO INC | 8,538,446 | 0 | -8,538,446 | 22,371 | 0 | — | -22,371 |
| TANGO THERAPEUTICS INC(TNGX) | 13,330,736 | 13,330,736 | 0 | 131,974 | 105,846 | 2.69% | -26,128 |
| GALAPAGOS NV(LKFT) | 5,756,268 | 5,756,268 | 0 | 233,992 | 185,352 | 4.71% | -48,640 |
| ACADIA PHARMACEUTICALS INC | 5,991,479 | 5,991,479 | 0 | 187,593 | 110,782 | 2.81% | -76,811 |
| ARGENX SE(ARGX) | 300,997 | 0 | -300,997 | 114,508 | 0 | — | -114,508 |
| PROTHENA CORP PLC SHS | 11,584,280 | 11,584,280 | 0 | 420,973 | 286,943 | 7.29% | -134,030 |
| MIRATI THERAPEUTICS INC | 7,396,979 | 0 | -7,396,979 | 434,573 | 0 | — | -434,573 |