Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ITEOS THERAPEUTICS INC | 0 | 10,688,978 | +10,688,978 | 0 | 106,569 | 6.32% | +106,569 |
| ZYMEWORKS INC(ZYME) | 17,259,548 | 22,970,388 | +5,710,840 | 205,561 | 288,278 | 17.08% | +82,717 |
| TANGO THERAPEUTICS INC(TNGX) | 10,630,736 | 10,630,736 | 0 | 14,564 | 54,429 | 3.23% | +39,865 |
| ANAPTYSBIO INC | 7,880,094 | 7,880,094 | 0 | 146,491 | 174,938 | 10.37% | +28,447 |
| GALAPAGOS NV(LKFT) | 155,006 | 1,036,945 | +881,939 | 3,894 | 29,024 | 1.72% | +25,130 |
| CRISPR THERAPEUTICS AG(CRSP) | 1,389,276 | 1,389,276 | 0 | 47,277 | 67,574 | 4.00% | +20,297 |
| VERONA PHARMA PLC | 0 | 200,000 | +200,000 | 0 | 18,916 | 1.12% | +18,916 |
| ALKERMES PLC(ALKS) | 0 | 500,000 | +500,000 | 0 | 14,305 | 0.85% | +14,305 |
| UNIQURE NV(QURE) | 3,988,971 | 3,988,971 | 0 | 42,283 | 55,606 | 3.30% | +13,323 |
| PACIRA BIOSCIENCES INC(PCRX) | 0 | 457,471 | +457,471 | 0 | 10,934 | 0.65% | +10,934 |
| IMMUNOME INC(IMNM) | 4,079,415 | 4,079,415 | 0 | 27,454 | 37,939 | 2.25% | +10,484 |
| KURA ONCOLOGY INC(KURA) | 2,640,298 | 4,200,000 | +1,559,702 | 17,426 | 24,234 | 1.44% | +6,808 |
| METSERA INC | 50,000 | 271,529 | +221,529 | 1,361 | 7,725 | 0.46% | +6,364 |
| AKERO THERAPEUTICS INC | 440,000 | 440,000 | 0 | 17,811 | 23,478 | 1.39% | +5,667 |
| HILLEVAX INC | 0 | 2,420,243 | +2,420,243 | 0 | 4,816 | 0.29% | +4,816 |
| NEUROGENE INC(NGNE) | 1,271,342 | 1,271,342 | 0 | 14,887 | 19,007 | 1.13% | +4,119 |
| MBX BIOSCIENCES INC(MBX) | 1,259,273 | 1,149,794 | -109,479 | 9,293 | 13,119 | 0.78% | +3,826 |
| ETON PHARMACEUTICALS INC(ETON) | 1,939,288 | 2,030,544 | +91,256 | 25,172 | 28,935 | 1.71% | +3,763 |
| TECTONIC THERAPEUTIC INC(TECX) | 935,121 | 935,121 | 0 | 16,561 | 18,581 | 1.10% | +2,020 |
| MACROGENICS INC(MGNX) | 0 | 1,602,717 | +1,602,717 | 0 | 1,939 | 0.11% | +1,939 |
| ADAPTIMMUNE THERAPEUTICS PLC(ADAPY) | 27,404,070 | 27,404,070 | 0 | 5,399 | 6,569 | 0.39% | +1,170 |
| ATARA BIOTHERAPEUTICS INC | 573,183 | 573,183 | 0 | 3,405 | 4,425 | 0.26% | +1,020 |
| NUVATION BIO INC(NUVB) | 963,333 | 963,333 | 0 | 1,695 | 1,878 | 0.11% | +183 |
| SURROZEN INC(SRZN) | 66,665 | 66,665 | 0 | 777 | 596 | 0.04% | -181 |
| UPSTREAM BIO INC(UPB) | 60,000 | 0 | -60,000 | 367 | 0 | — | -367 |
| REPLIMUNE GROUP INC(REPL) | 850,341 | 850,341 | 0 | 8,291 | 7,900 | 0.47% | -391 |
| ALIGOS THERAPEUTICS INC(ALGS) | 88,569 | 0 | -88,569 | 731 | 0 | — | -731 |
| TSCAN THERAPEUTICS INC(TCRX) | 662,833 | 0 | -662,833 | 915 | 0 | — | -915 |
| VOYAGER THERAPEUTICS INC(VYGR) | 3,917,546 | 3,917,546 | 0 | 13,241 | 12,184 | 0.72% | -1,058 |
| DAY ONE BIOPHARMACEUTICALS I COM | 862,068 | 862,068 | 0 | 6,836 | 5,603 | 0.33% | -1,233 |
| PRIME MEDICINE INC(PRME) | 700,000 | 0 | -700,000 | 1,393 | 0 | — | -1,393 |
| KALARIS THERAPEUTICS INC(KLRS) | 201,718 | 0 | -201,718 | 1,620 | 0 | — | -1,620 |
| WHITEHAWK THERAPEUTICS INC(WHWK) | 2,082,000 | 1,091,417 | -990,583 | 3,706 | 2,041 | 0.12% | -1,665 |
| RELAY THERAPEUTICS INC(RLAY) | 641,426 | 0 | -641,426 | 1,681 | 0 | — | -1,681 |
| KEROS THERAPEUTICS INC(KROS) | 187,500 | 0 | -187,500 | 1,911 | 0 | — | -1,911 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 75,000 | 75,000 | 0 | 24,842 | 22,698 | 1.35% | -2,144 |
| AVIDITY BIOSCIENCES INC | 557,576 | 500,000 | -57,576 | 16,460 | 14,200 | 0.84% | -2,260 |
| ORIC PHARMACEUTICALS INC(ORIC) | 3,418,068 | 1,618,068 | -1,800,000 | 19,073 | 16,423 | 0.97% | -2,649 |
| SOLID BIOSCIENCES INC | 744,450 | 0 | -744,450 | 2,754 | 0 | — | -2,754 |
| VERVE THERAPEUTICS INC | 1,250,000 | 0 | -1,250,000 | 5,713 | 0 | — | -5,712 |
| JANUX THERAPEUTICS INC(JANX) | 1,469,818 | 1,469,818 | 0 | 39,685 | 33,953 | 2.01% | -5,732 |
| BICYCLE THERAPEUTICS PLC | 910,000 | 0 | -910,000 | 7,726 | 0 | — | -7,726 |
| GINKGO BIOWORKS HOLDINGS INC(DNA) | 1,462,328 | 0 | -1,462,328 | 8,335 | 0 | — | -8,335 |
| BEAM THERAPEUTICS INC(BEAM) | 526,685 | 0 | -526,685 | 10,286 | 0 | — | -10,286 |
| XENCOR INC(XNCR) | 6,144,767 | 6,144,767 | 0 | 65,380 | 48,298 | 2.86% | -17,082 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 4,288,120 | 4,288,120 | 0 | 143,824 | 123,326 | 7.31% | -20,497 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 1,706,469 | 1,706,469 | 0 | 211,858 | 181,090 | 10.73% | -30,768 |
| APELLIS PHARMACEUTICALS INC COM | 11,895,808 | 11,895,808 | 0 | 260,161 | 205,916 | 12.20% | -54,245 |
| SAREPTA THERAPEUTICS INC(SRPT) | 1,292,386 | 0 | -1,292,386 | 82,480 | 0 | — | -82,480 |
| PROTHENA CORP PLC SHS | 11,584,280 | 0 | -11,584,280 | 143,355 | 0 | — | -143,355 |