Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| PFIZER INC(PFE)(Call) | 0 | 5,000,000 | +5,000,000 | 0 | 132,650 | — | +132,650 |
| SAREPTA THERAPEUTICS INC(SRPT) | 0 | 770,000 | +770,000 | 0 | 93,624 | 3.54% | +93,624 |
| UNIQURE NV(QURE) | 0 | 3,400,000 | +3,400,000 | 0 | 60,044 | 2.27% | +60,044 |
| SPRINGWORKS THERAPEUTICS INC | 0 | 1,560,000 | +1,560,000 | 0 | 56,363 | 2.13% | +56,363 |
| ZYMEWORKS INC(ZYME) | 13,437,473 | 15,028,079 | +1,590,606 | 168,640 | 220,011 | 8.32% | +51,371 |
| APELLIS PHARMACEUTICALS INC COM | 11,890,843 | 11,890,843 | 0 | 342,932 | 379,437 | 14.35% | +36,505 |
| XENCOR INC(XNCR) | 5,330,416 | 6,144,767 | +814,351 | 107,195 | 141,207 | 5.34% | +34,012 |
| MBX BIOSCIENCES INC(MBX) | 0 | 1,259,273 | +1,259,273 | 0 | 23,208 | 0.88% | +23,208 |
| ETON PHARMACEUTICALS INC(ETON) | 566,075 | 1,829,603 | +1,263,528 | 3,396 | 24,370 | 0.92% | +20,974 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 1,706,469 | 1,706,469 | 0 | 190,118 | 210,152 | 7.95% | +20,034 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 332,522 | +332,522 | 0 | 18,006 | 0.68% | +18,006 |
| GINKGO BIOWORKS HOLDINGS INC | 0 | 1,743,344 | +1,743,344 | 0 | 17,120 | 0.65% | +17,120 |
| KYMERA THERAPEUTICS INC(KYMR) | 0 | 350,000 | +350,000 | 0 | 14,081 | 0.53% | +14,081 |
| TECTONIC THERAPEUTIC INC | 849,143 | 849,143 | 0 | 25,729 | 39,205 | 1.48% | +13,476 |
| JANUX THERAPEUTICS INC(JANX) | 1,469,818 | 1,469,818 | 0 | 66,774 | 78,694 | 2.98% | +11,920 |
| ALIGOS THERAPEUTICS INC | 0 | 255,573 | +255,573 | 0 | 10,182 | 0.38% | +10,182 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 75,000 | 75,000 | 0 | 15,917 | 23,143 | 0.87% | +7,226 |
| UNIQURE NV(QURE)(Call) | 0 | 385,000 | +385,000 | 0 | 6,799 | — | +6,799 |
| FATE THERAPEUTICS INC | 0 | 3,049,405 | +3,049,405 | 0 | 5,032 | 0.19% | +5,032 |
| ATARA BIOTHERAPEUTICS INC | 468,938 | 532,134 | +63,196 | 3,812 | 7,083 | 0.27% | +3,270 |
| NUVATION BIO INC(NUVB) | 0 | 963,333 | +963,333 | 0 | 2,562 | 0.10% | +2,562 |
| DESIGN THERAPEUTICS INC(DSGN) | 53,834 | 426,683 | +372,849 | 290 | 2,633 | 0.10% | +2,343 |
| VERVE THERAPEUTICS INC | 1,250,000 | 1,250,000 | 0 | 6,050 | 7,050 | 0.27% | +1,000 |
| UPSTREAM BIO INC | 0 | 60,000 | +60,000 | 0 | 986 | 0.04% | +986 |
| REPLIMUNE GROUP INC(REPL) | 850,341 | 850,341 | 0 | 9,320 | 10,298 | 0.39% | +978 |
| HOOKIPA PHARMA INC | 0 | 388,861 | +388,861 | 0 | 782 | 0.03% | +782 |
| ETON PHARMACEUTICALS INC(ETON)(Call) | 228,000 | 151,400 | -76,600 | 1,368 | 2,017 | — | +649 |
| ARTIVA BIOTHERAPEUTICS INC | 0 | 41,453 | +41,453 | 0 | 418 | 0.02% | +418 |
| SURROZEN INC | 66,665 | 66,665 | 0 | 799 | 957 | 0.04% | +158 |
| MONTE ROSA THERAPEUTICS INC(GLUE)(Call) | 0 | 21,700 | +21,700 | 0 | 151 | — | +151 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 4,288,120 | 4,288,120 | 0 | 219,123 | 219,252 | 8.29% | +129 |
| ALLAKOS INC | 192,346 | 0 | -192,346 | 126 | 0 | — | -126 |
| CAREMAX INC | 100,000 | 0 | -100,000 | 170 | 0 | — | -170 |
| MACROGENICS INC | 56,018 | 0 | -56,018 | 184 | 0 | — | -184 |
| GALAPAGOS NV(LKFT) | 155,006 | 155,006 | 0 | 4,463 | 4,263 | 0.16% | -200 |
| ARTIVA BIOTHERAPEUTICS INC | 41,453 | 0 | -41,453 | 640 | 0 | — | -640 |
| PRIME MEDICINE INC | 700,000 | 700,000 | 0 | 2,709 | 2,044 | 0.08% | -665 |
| VOYAGER THERAPEUTICS INC | 3,917,546 | 3,917,546 | 0 | 22,918 | 22,212 | 0.84% | -705 |
| DAY ONE BIOPHARMACEUTICALS I COM | 862,068 | 862,068 | 0 | 12,009 | 10,922 | 0.41% | -1,086 |
| KYVERNA THERAPEUTICS INC | 450,000 | 0 | -450,000 | 2,201 | 0 | — | -2,200 |
| NUVATION BIO INC(NUVB) | 963,333 | 0 | -963,333 | 2,206 | 0 | — | -2,206 |
| ALIGOS THERAPEUTICS INC | 255,573 | 0 | -255,573 | 2,213 | 0 | — | -2,213 |
| HOOKIPA PHARMA INC | 571,727 | 0 | -571,727 | 2,458 | 0 | — | -2,458 |
| AADI BIOSCIENCE INC | 1,845,253 | 345,253 | -1,500,000 | 3,801 | 1,089 | 0.04% | -2,712 |
| GENERATION BIO CO | 2,046,867 | 2,046,867 | 0 | 5,056 | 2,170 | 0.08% | -2,886 |
| PROQR THRAPEUTICS N V SHS EURO | 1,835,991 | 0 | -1,835,991 | 3,342 | 0 | — | -3,342 |
| BRIDGEBIO PHARMA INC(BBIO) | 170,172 | 0 | -170,172 | 4,333 | 0 | — | -4,333 |
| ALLOVIR INC | 11,294,585 | 408,688 | -10,885,897 | 9,132 | 3,948 | 0.15% | -5,184 |
| NEUMORA THERAPEUTICS INC. | 2,071,450 | 2,071,450 | 0 | 27,364 | 21,957 | 0.83% | -5,406 |
| CARGO THERAPEUTICS INC | 1,470,000 | 1,470,000 | 0 | 27,122 | 21,197 | 0.80% | -5,924 |
| DYNE THERAPEUTICS INC(DYN) | 555,644 | 555,644 | 0 | 19,959 | 13,091 | 0.49% | -6,868 |
| ATEA PHARMACEUTICALS INC | 5,441,896 | 3,341,653 | -2,100,243 | 18,230 | 11,195 | 0.42% | -7,036 |
| ORIC PHARMACEUTICALS INC(ORIC) | 3,418,068 | 3,418,068 | 0 | 35,035 | 27,584 | 1.04% | -7,451 |
| BICYCLE THERAPEUTICS PLC | 910,000 | 910,000 | 0 | 20,593 | 12,740 | 0.48% | -7,853 |
| KEROS THERAPEUTICS INC | 187,500 | 187,500 | 0 | 10,888 | 2,968 | 0.11% | -7,920 |
| LENZ THERAPEUTICS INC | 346,772 | 0 | -346,772 | 8,232 | 0 | — | -8,232 |
| TSCAN THERAPEUTICS INC | 5,000,000 | 5,000,000 | 0 | 24,900 | 15,200 | 0.57% | -9,700 |
| THIRD HARMONIC BIO INC | 3,182,444 | 3,182,444 | 0 | 43,122 | 32,747 | 1.24% | -10,375 |
| CRISPR THERAPEUTICS AG(CRSP) | 1,389,276 | 1,389,276 | 0 | 65,268 | 54,682 | 2.07% | -10,586 |
| ADAPTIMMUNE THERAPEUTICS PLC | 27,404,070 | 27,404,070 | 0 | 26,045 | 14,763 | 0.56% | -11,282 |
| RELAY THERAPEUTICS INC(RLAY) | 2,500,000 | 641,426 | -1,858,574 | 17,700 | 2,643 | 0.10% | -15,057 |
| IMMUNOME INC(IMNM) | 3,879,415 | 3,879,415 | 0 | 56,717 | 41,199 | 1.56% | -15,518 |
| ITEOS THERAPEUTICS INC | 1,608,616 | 0 | -1,608,616 | 16,424 | 0 | — | -16,424 |
| PHARVARIS N V COM | 900,000 | 0 | -900,000 | 16,668 | 0 | — | -16,668 |
| AVIDITY BIOSCIENCES INC | 757,576 | 557,576 | -200,000 | 34,795 | 16,214 | 0.61% | -18,581 |
| IONIS PHARMACEUTICALS INC(IONS) | 500,000 | 0 | -500,000 | 20,030 | 0 | — | -20,030 |
| MERSANA THERAPEUTICS INC | 19,364,688 | 11,328,000 | -8,036,688 | 36,599 | 16,199 | 0.61% | -20,400 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 650,000 | 0 | -650,000 | 22,094 | 0 | — | -22,093 |
| NEUROGENE INC | 1,271,342 | 1,271,342 | 0 | 53,346 | 29,063 | 1.10% | -24,283 |
| MBX BIOSCIENCES INC(MBX) | 1,175,809 | 0 | -1,175,809 | 30,548 | 0 | — | -30,548 |
| PROTHENA CORP PLC SHS | 11,584,280 | 11,584,280 | 0 | 193,805 | 160,442 | 6.07% | -33,363 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 1,250,385 | 0 | -1,250,385 | 33,373 | 0 | — | -33,373 |
| ARVINAS INC | 6,726,491 | 6,726,491 | 0 | 165,673 | 128,947 | 4.87% | -36,727 |
| VAXCYTE INC(PCVX) | 352,464 | 0 | -352,464 | 40,276 | 0 | — | -40,276 |
| NUVATION BIO INC(NUVB) | 19,209,643 | 0 | -19,209,643 | 43,990 | 0 | — | -43,990 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 1,958,847 | 0 | -1,958,847 | 44,564 | 0 | — | -44,564 |
| CENTESSA PHARMACEUTICALS PLC | 3,223,851 | 0 | -3,223,851 | 51,549 | 0 | — | -51,549 |
| TANGO THERAPEUTICS INC(TNGX) | 13,330,736 | 10,630,736 | -2,700,000 | 102,647 | 32,849 | 1.24% | -69,798 |
| KURA ONCOLOGY INC(KURA) | 5,806,871 | 3,557,269 | -2,249,602 | 113,466 | 30,984 | 1.17% | -82,482 |
| ANAPTYSBIO INC | 7,794,996 | 7,873,448 | +78,452 | 261,132 | 104,244 | 3.94% | -156,888 |