Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| AGILON HEALTH INC(AGL) | 7,463,300 | 6,950,000 | -513,300 | 14,180 | 30,094 | 1.72% | +15,913 |
| TARSUS PHARMACEUTICALS INC(TARS) | 110,889 | 354,376 | +243,487 | 6,140 | 18,204 | 1.04% | +12,064 |
| DANAHER CORPORATION(DHR) | 0 | 58,800 | +58,800 | 0 | 12,054 | 0.69% | +12,054 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 320,813 | +320,813 | 0 | 5,095 | 0.29% | +5,095 |
| MERUS N V | 892,549 | 980,751 | +88,202 | 37,532 | 41,280 | 2.36% | +3,748 |
| KESTRA MED TECHNOLOGIES LTD SHS | 0 | 145,000 | +145,000 | 0 | 3,613 | 0.21% | +3,613 |
| SOLENO THERAPEUTICS INC | 124,095 | 124,095 | 0 | 5,578 | 8,867 | 0.51% | +3,289 |
| EVOLENT HEALTH INC(EVH) | 2,060,000 | 2,695,700 | +635,700 | 23,175 | 25,528 | 1.46% | +2,353 |
| 89BIO INC | 552,741 | 844,441 | +291,700 | 4,322 | 6,139 | 0.35% | +1,817 |
| REGENERON PHARMACEUTICALS(REGN) | 0 | 2,800 | +2,800 | 0 | 1,776 | 0.10% | +1,776 |
| INSMED INC(INSM) | 550,000 | 515,900 | -34,100 | 37,972 | 39,358 | 2.25% | +1,386 |
| LENZ THERAPEUTICS INC(LENZ) | 29,305 | 83,082 | +53,777 | 846 | 2,136 | 0.12% | +1,290 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 343,228 | +343,228 | 0 | 1,215 | 0.07% | +1,215 |
| TENET HEALTHCARE CORP(THC) | 129,200 | 130,000 | +800 | 16,309 | 17,485 | 1.00% | +1,176 |
| COMPASS THERAPEUTICS INC(CMPX) | 5,779,575 | 4,962,955 | -816,620 | 8,380 | 9,430 | 0.54% | +1,049 |
| SIONNA THERAPEUTICS INC(SION) | 0 | 99,429 | +99,429 | 0 | 1,040 | 0.06% | +1,040 |
| AKERO THERAPEUTICS INC | 946,499 | 672,759 | -273,740 | 26,332 | 27,233 | 1.56% | +902 |
| ALPHATEC HLDGS INC(ATEC) | 200,000 | 267,500 | +67,500 | 1,836 | 2,712 | 0.16% | +876 |
| LEGEND BIOTECH CORP(LEGN) | 512,132 | 512,932 | +800 | 16,665 | 17,404 | 1.00% | +739 |
| GOSSAMER BIO INC(GOSS) | 3,266,960 | 3,266,960 | 0 | 2,955 | 3,594 | 0.21% | +638 |
| ARDELYX INC | 1,463,629 | 1,604,975 | +141,346 | 7,421 | 7,880 | 0.45% | +460 |
| SUMMIT THERAPEUTICS INC(SMMT) | 1,054,000 | 995,000 | -59,000 | 18,809 | 19,194 | 1.10% | +385 |
| GOSSAMER BIO INC(GOSS) | 0 | 0 | 0 | 5,070 | 5,260 | 0.30% | +191 |
| VIGIL NEUROSCIENCE INC | 471,958 | 471,958 | 0 | 802 | 840 | 0.05% | +38 |
| NUVATION BIO INC(NUVB) | 134,028 | 134,028 | 0 | 31 | 32 | 0.00% | +1 |
| TALPHERA INC(TLPH) | 316,460 | 316,460 | 0 | 166 | 157 | 0.01% | -9 |
| COMPUGEN LTD(CGEN) | 989,990 | 989,990 | 0 | 1,515 | 1,445 | 0.08% | -69 |
| VINCERX PHARMA INC | 891,719 | 0 | -891,719 | 234 | 0 | — | -234 |
| ZENAS BIOPHARMA INC(ZBIO) | 878,667 | 878,667 | 0 | 7,196 | 6,941 | 0.40% | -255 |
| DEXCOM INC(DXCM) | 353,000 | 397,650 | +44,650 | 27,453 | 27,156 | 1.55% | -297 |
| SPRUCE BIOSCIENCES INC | 2,609,125 | 2,609,125 | 0 | 1,096 | 757 | 0.04% | -339 |
| OSCAR HEALTH INC(OSCR) | 1,050,000 | 1,050,000 | 0 | 14,112 | 13,766 | 0.79% | -346 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 444,383 | 444,383 | 0 | 1,418 | 947 | 0.05% | -471 |
| ENLIVEN THERAPEUTICS INC | 428,571 | 465,871 | +37,300 | 9,643 | 9,168 | 0.52% | -475 |
| NEVRO CORP | 0 | 0 | 0 | 489 | 0 | — | -489 |
| APPLIED THERAPEUTICS INC | 1,917,191 | 2,074,891 | +157,700 | 1,641 | 1,014 | 0.06% | -627 |
| KYVERNA THERAPEUTICS INC(KYTX) | 178,963 | 0 | -178,963 | 669 | 0 | — | -669 |
| BIOMEA FUSION INC(BMEA) | 181,147 | 0 | -181,147 | 703 | 0 | — | -703 |
| KORRO BIO INC(KRRO) | 35,719 | 35,719 | 0 | 1,360 | 622 | 0.04% | -738 |
| APELLIS PHARMACEUTICALS INC COM | 80,000 | 80,000 | 0 | 2,553 | 1,750 | 0.10% | -803 |
| ADAPTIMMUNE THERAPEUTICS PLC(ADAPY) | 2,483,468 | 2,483,468 | 0 | 1,338 | 489 | 0.03% | -849 |
| NEUROGENE INC(NGNE) | 95,407 | 104,339 | +8,932 | 2,181 | 1,222 | 0.07% | -959 |
| SAGIMET BIOSCIENCES INC(SGMT) | 787,808 | 787,808 | 0 | 3,545 | 2,568 | 0.15% | -977 |
| EDAP TMS S A(FOCL) | 1,591,800 | 1,270,000 | -321,800 | 3,518 | 2,489 | 0.14% | -1,029 |
| NOVAVAX INC(NVAX) | 650,000 | 650,000 | 0 | 5,226 | 4,167 | 0.24% | -1,059 |
| ALLAKOS INC | 1,100,409 | 0 | -1,100,409 | 1,331 | 0 | — | -1,331 |
| NEVRO CORP | 1,648,100 | 800,494 | -847,606 | 6,131 | 4,675 | 0.27% | -1,456 |
| ZAI LAB LTD(ZLAB) | 1,305,337 | 904,592 | -400,745 | 34,187 | 32,692 | 1.87% | -1,495 |
| PULMONX CORP(LUNG) | 772,151 | 503,700 | -268,451 | 5,243 | 3,390 | 0.19% | -1,853 |
| MACROGENICS INC(MGNX) | 1,053,647 | 1,145,214 | +91,567 | 3,424 | 1,454 | 0.08% | -1,970 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 1,032,988 | 0 | -1,032,988 | 2,428 | 0 | — | -2,428 |
| ACADIA HEALTHCARE COMPANY IN(ACHC) | 583,500 | 681,100 | +97,600 | 23,136 | 20,651 | 1.18% | -2,485 |
| PROTHENA CORP PLC SHS | 644,601 | 492,601 | -152,000 | 8,928 | 6,096 | 0.35% | -2,832 |
| XILIO THERAPEUTICS INC(XLO) | 3,003,259 | 0 | -3,003,259 | 2,868 | 0 | — | -2,868 |
| ACUMEN PHARMACEUTICALS INC(ABOS) | 1,838,916 | 0 | -1,838,916 | 3,163 | 0 | — | -3,163 |
| BEAM THERAPEUTICS INC(BEAM) | 252,223 | 150,020 | -102,203 | 6,255 | 2,930 | 0.17% | -3,325 |
| NUVALENT INC | 429,994 | 427,532 | -2,462 | 33,660 | 30,321 | 1.73% | -3,339 |
| BICARA THERAPEUTICS INC | 445,975 | 336,070 | -109,905 | 7,769 | 4,379 | 0.25% | -3,390 |
| MERSANA THERAPEUTICS INC | 3,431,684 | 3,814,684 | +383,000 | 4,907 | 1,313 | 0.08% | -3,594 |
| LEAP THERAPEUTICS INC(CYPH) | 1,266,546 | 0 | -1,266,546 | 3,641 | 0 | — | -3,641 |
| CULLINAN THERAPEUTICS INC(CGEM) | 742,114 | 644,633 | -97,481 | 9,039 | 4,880 | 0.28% | -4,159 |
| EXACT SCIENCES CORP(EXK) | 450,000 | 480,000 | +30,000 | 25,286 | 20,779 | 1.19% | -4,506 |
| PLIANT THERAPEUTICS INC(PLRX) | 404,796 | 589,996 | +185,200 | 5,331 | 796 | 0.05% | -4,535 |
| BIOHAVEN LTD(BHVN) | 129,858 | 0 | -129,858 | 4,850 | 0 | — | -4,850 |
| PHARVARIS N V COM | 775,131 | 623,402 | -151,729 | 14,859 | 9,787 | 0.56% | -5,072 |
| JANUX THERAPEUTICS INC(JANX) | 204,466 | 204,466 | 0 | 10,947 | 5,521 | 0.32% | -5,427 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 471,086 | 342,180 | -128,906 | 15,480 | 10,026 | 0.57% | -5,454 |
| DYNE THERAPEUTICS INC(DYN) | 474,528 | 524,499 | +49,971 | 11,180 | 5,486 | 0.31% | -5,694 |
| IMMUNOVANT INC(IMVT) | 909,103 | 975,803 | +66,700 | 22,518 | 16,676 | 0.95% | -5,842 |
| BLUEPRINT MEDICINES CORP | 1,096,899 | 1,007,569 | -89,330 | 95,672 | 89,180 | 5.10% | -6,492 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 716,782 | 761,541 | +44,759 | 30,979 | 24,484 | 1.40% | -6,496 |
| WARBY PARKER INC(WRBY) | 920,000 | 835,000 | -85,000 | 22,273 | 15,222 | 0.87% | -7,051 |
| AZENTA INC(AZTA) | 475,000 | 475,000 | 0 | 23,750 | 16,454 | 0.94% | -7,296 |
| JASPER THERAPEUTICS INC(JSPR) | 463,088 | 545,171 | +82,083 | 9,901 | 2,344 | 0.13% | -7,557 |
| INOZYME PHARMA INC | 3,861,983 | 3,445,299 | -416,684 | 10,698 | 3,135 | 0.18% | -7,562 |
| ACLARIS THERAPEUTICS INC(ACRS) | 6,204,309 | 5,046,309 | -1,158,000 | 15,387 | 7,721 | 0.44% | -7,666 |
| REVOLUTION MEDICINES INC(RVMD) | 1,213,257 | 1,281,640 | +68,383 | 53,068 | 45,319 | 2.59% | -7,749 |
| VERA THERAPEUTICS INC(VERA) | 487,863 | 520,796 | +32,933 | 20,632 | 12,510 | 0.72% | -8,122 |
| INSPIRE MED SYS INC(INSP) | 130,000 | 99,250 | -30,750 | 24,099 | 15,809 | 0.90% | -8,291 |
| ASCENDIS PHARMA A/S(ASND) | 305,000 | 216,000 | -89,000 | 41,989 | 33,666 | 1.93% | -8,324 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 767,522 | 536,111 | -231,411 | 19,725 | 10,974 | 0.63% | -8,751 |
| AMICUS THERAPEUTICS INC COM | 2,599,425 | 1,909,362 | -690,063 | 24,487 | 15,580 | 0.89% | -8,906 |
| XENCOR INC(XNCR) | 401,013 | 0 | -401,013 | 9,215 | 0 | — | -9,215 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 397,500 | 254,300 | -143,200 | 35,843 | 26,620 | 1.52% | -9,222 |
| STRUCTURE THERAPEUTICS INC | 1,080,963 | 1,132,979 | +52,016 | 29,316 | 19,612 | 1.12% | -9,704 |
| NEUMORA THERAPEUTICS INC.(NMRA) | 955,106 | 0 | -955,106 | 10,124 | 0 | — | -10,124 |
| PENUMBRA INC(PEN) | 240,000 | 171,000 | -69,000 | 56,995 | 45,727 | 2.62% | -11,268 |
| SPRINGWORKS THERAPEUTICS INC | 328,911 | 0 | -328,911 | 11,884 | 0 | — | -11,884 |
| BOSTON SCIENTIFIC CORP(BSX) | 460,000 | 277,000 | -183,000 | 41,087 | 27,944 | 1.60% | -13,143 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 294,100 | 0 | -294,100 | 15,037 | 0 | — | -15,037 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 1,222,182 | 812,653 | -409,529 | 30,885 | 14,750 | 0.84% | -16,135 |
| ELI LILLY & CO(LLY) | 144,500 | 113,500 | -31,000 | 111,554 | 93,741 | 5.36% | -17,813 |
| XENON PHARMACEUTICALS INC(XENE) | 1,251,859 | 931,681 | -320,178 | 49,073 | 31,258 | 1.79% | -17,815 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 1,471,564 | 951,765 | -519,799 | 60,849 | 42,877 | 2.45% | -17,972 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 2,677,996 | 222,011 | -2,455,985 | 20,139 | 1,665 | 0.10% | -18,473 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 9,599,170 | 6,684,247 | -2,914,923 | 33,597 | 15,040 | 0.86% | -18,558 |
| LIFESTANCE HEALTH GROUP INC(LFST) | 2,550,000 | 0 | -2,550,000 | 18,794 | 0 | — | -18,793 |
| KYMERA THERAPEUTICS INC(KYMR) | 1,034,137 | 794,437 | -239,700 | 41,603 | 21,744 | 1.24% | -19,860 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 1,162,718 | 834,188 | -328,530 | 65,089 | 44,187 | 2.53% | -20,902 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 256,200 | 143,250 | -112,950 | 60,286 | 38,680 | 2.21% | -21,606 |