Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Revolution Medicines, Inc.(RVMD) | 1,335,270 | 1,209,465 | -125,805 | $106.35M | $117.62M | 6.93% | +$11.27M |
| Eli Lilly and Company(LLY) | 105,400 | 98,700 | -6,700 | $113.27M | $90.78M | 5.35% | -$22.49M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 139,618 | 170,999 | +31,381 | $81.31M | $89.51M | 5.28% | +$8.21M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 762,294 | 811,294 | +49,000 | $60.21M | $74.95M | 4.42% | +$14.73M |
| argenx SEADR(ARGX) | 103,250 | 98,500 | -4,750 | $86.83M | $71.93M | 4.24% | -$14.90M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 695,010 | 689,748 | -5,262 | $74.39M | $59.99M | 3.54% | -$14.41M |
| Insmed Incorporated(INSM) | 319,250 | 314,300 | -4,950 | $55.56M | $51.39M | 3.03% | -$4.17M |
| Ascendis Pharma A/SADR(ASND) | 203,500 | 194,000 | -9,500 | $43.39M | $44.37M | 2.62% | +$979.3K |
| Xenon Pharmaceuticals Inc.(XENE) | 787,788 | 763,020 | -24,768 | $35.31M | $44.37M | 2.62% | +$9.06M |
| Travere Therapeutics, Inc.(TVTX) | 2,210,322 | 1,477,954 | -732,368 | $84.46M | $43.91M | 2.59% | -$40.55M |
| Kymera Therapeutics, Inc.(KYMR) | 496,871 | 496,871 | 0 | $38.66M | $41.38M | 2.44% | +$2.72M |
| Penumbra, Inc.(PEN) | 120,500 | 120,500 | 0 | $37.46M | $39.57M | 2.33% | +$2.10M |
| Intuitive Surgical, Inc.(ISRG) | 82,000 | 82,000 | 0 | $46.44M | $37.80M | 2.23% | -$8.64M |
| Scholar Rock Holding Corporation(SRRK) | 733,477 | 739,816 | +6,339 | $32.31M | $36.37M | 2.14% | +$4.06M |
| Enliven Therapeutics Inc | 798,405 | 826,500 | +28,095 | $12.30M | $32.40M | 1.91% | +$20.10M |
| Boston Scientific Corporation(BSX) | 399,050 | 515,300 | +116,250 | $38.05M | $32.34M | 1.91% | -$5.71M |
| iRhythm Holdings, Inc.(IRTC) | 235,000 | 261,750 | +26,750 | $41.70M | $30.89M | 1.82% | -$10.81M |
| Structure Therapeutics IncADS | 748,236 | 640,217 | -108,019 | $52.04M | $30.86M | 1.82% | -$21.18M |
| Agios Pharmaceuticals, Inc.(AGIO) | 799,163 | 799,163 | 0 | $21.75M | $27.04M | 1.59% | +$5.28M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,267,241 | 1,218,773 | -48,468 | $29.15M | $25.53M | 1.50% | -$3.61M |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 71,250 | 74,000 | +2,750 | $28.33M | $24.48M | 1.44% | -$3.85M |
| Cogent Biosciences, Inc.(COGT) | 849,030 | 624,155 | -224,875 | $30.16M | $24.02M | 1.42% | -$6.13M |
| Tenet Healthcare Corporation(THC) | 125,000 | 125,000 | 0 | $24.84M | $23.59M | 1.39% | -$1.25M |
| DexCom, Inc.(DXCM) | 347,300 | 355,600 | +8,300 | $23.05M | $22.33M | 1.32% | -$718.6K |
| Celldex Therapeutics, Inc.(CLDX) | 692,538 | 650,270 | -42,268 | $18.81M | $20.63M | 1.22% | +$1.82M |
| Vera Therapeutics, Inc.CL A(VERA) | 568,579 | 503,585 | -64,994 | $28.79M | $20.26M | 1.19% | -$8.53M |
| Neurocrine Biosciences, Inc.(NBIX) | 125,500 | 150,450 | +24,950 | $17.80M | $19.82M | 1.17% | +$2.02M |
| Arcellx Inc COMMON STOCK | 169,859 | 169,859 | 0 | $11.07M | $19.50M | 1.15% | +$8.43M |
| Newamsterdam Pharma Company ORDINARY SHARES | 557,194 | 588,794 | +31,600 | $19.55M | $18.85M | 1.11% | -$699.1K |
| Pharvaris N V COM | 623,402 | 645,533 | +22,131 | $17.30M | $18.24M | 1.07% | +$936.9K |
| Erasca, Inc.(ERAS) | 951,710 | 1,103,469 | +151,759 | $3.54M | $17.85M | 1.05% | +$14.31M |
| Dyne Therapeutics, Inc.(DYN) | 912,955 | 972,198 | +59,243 | $17.86M | $17.63M | 1.04% | -$231.4K |
| Compass Therapeutics, Inc.(CMPX) | 3,927,202 | 3,305,308 | -621,894 | $21.09M | $17.49M | 1.03% | -$3.60M |
| Aclaris Therapeutics, Inc.(ACRS) | 4,453,741 | 4,472,650 | +18,909 | $13.41M | $16.77M | 0.99% | +$3.37M |
| Tarsus Pharmaceuticals, Inc.(TARS) | 260,344 | 225,179 | -35,165 | $21.32M | $15.80M | 0.93% | -$5.52M |
| MiniMed Group, Inc.(MMED) | 0 | 1,055,000 | +1,055,000 | $0 | $15.74M | 0.93% | +$15.74M |
| Zai Lab LimitedADR(ZLAB) | 811,546 | 814,707 | +3,161 | $14.32M | $15.32M | 0.90% | +$1.01M |
| UnitedHealth Group Incorporated(UNH) | 40,800 | 53,000 | +12,200 | $13.47M | $14.34M | 0.85% | +$872.8K |
| Centessa Pharmaceuticals PlcADS | 324,015 | 351,828 | +27,813 | $8.10M | $13.97M | 0.82% | +$5.87M |
| Heartflow, Inc.(HTFL) | 277,700 | 572,500 | +294,800 | $8.09M | $13.93M | 0.82% | +$5.83M |
| Ardelyx Inc | 2,299,473 | 2,299,473 | 0 | $13.41M | $13.77M | 0.81% | +$367.9K |
| Summit Therapeutics Inc.(SMMT) | 710,000 | 710,000 | 0 | $12.42M | $13.46M | 0.79% | +$1.04M |
| Azenta, Inc.(AZTA) | 569,100 | 569,100 | 0 | $18.93M | $12.03M | 0.71% | -$6.90M |
| Mineralys Therapeutics, Inc.(MLYS) | 427,596 | 439,751 | +12,155 | $15.52M | $11.91M | 0.70% | -$3.60M |
| Danaher Corporation(DHR) | 61,500 | 61,500 | 0 | $14.08M | $11.66M | 0.69% | -$2.42M |
| PTC Therapeutics, Inc.(PTCT) | 61,879 | 161,798 | +99,919 | $4.70M | $11.02M | 0.65% | +$6.32M |
| Caris Life Sciences, Inc.(CAI) | 687,500 | 563,000 | -124,500 | $18.55M | $10.07M | 0.59% | -$8.48M |
| Zenas BioPharma, Inc.(ZBIO) | 502,077 | 502,077 | 0 | $18.23M | $9.82M | 0.58% | -$8.41M |
| Bicara Therapeutics Inc | 429,095 | 489,095 | +60,000 | $7.22M | $9.73M | 0.57% | +$2.51M |
| BridgeBio Pharma, Inc.(BBIO) | 103,500 | 128,250 | +24,750 | $7.92M | $9.52M | 0.56% | +$1.61M |
| Soleno Therapeutics Inc | 247,053 | 257,253 | +10,200 | $11.44M | $8.61M | 0.51% | -$2.83M |
| MBX Biosciences, Inc.(MBX) | 282,624 | 287,967 | +5,343 | $8.91M | $8.60M | 0.51% | -$318.1K |
| Tango Therapeutics, Inc.(TNGX) | 386,915 | 386,915 | 0 | $3.43M | $8.09M | 0.48% | +$4.67M |
| Regeneron Pharmaceuticals, Inc.(REGN) | 10,100 | 10,100 | 0 | $7.80M | $7.80M | 0.46% | +$7.8K |
| Immunome, Inc.(IMNM) | 347,666 | 347,666 | 0 | $7.47M | $7.60M | 0.45% | +$135.6K |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 499,764 | 499,764 | 0 | $6.04M | $6.95M | 0.41% | +$909.6K |
| Omada Health, Inc.(OMDA) | 740,000 | 541,000 | -199,000 | $11.68M | $6.80M | 0.40% | -$4.88M |
| Inspire Medical Systems, Inc.(INSP) | 131,000 | 131,800 | +800 | $12.08M | $6.80M | 0.40% | -$5.28M |
| Apellis Pharmaceuticals Inc COM | 150,500 | 162,750 | +12,250 | $3.78M | $6.55M | 0.39% | +$2.77M |
| Alkermes plcSHS(ALKS) | 139,228 | 183,986 | +44,758 | $3.90M | $6.51M | 0.38% | +$2.61M |
| Evolent Health, Inc.CL A(EVH) | 2,675,000 | 2,675,000 | 0 | $10.70M | $6.10M | 0.36% | -$4.60M |
| Indivior Pharmaceuticals, Inc.(INDV) | 0 | 200,000 | +200,000 | $0 | $6.10M | 0.36% | +$6.10M |
| Terns Pharmaceuticals Inc | 108,481 | 113,748 | +5,267 | $4.38M | $6.00M | 0.35% | +$1.61M |
| EDAP TMS S.A.ADR(FOCL) | 1,286,500 | 1,378,000 | +91,500 | $4.23M | $5.13M | 0.30% | +$893.6K |
| Janux Therapeutics, Inc.(JANX) | 358,798 | 367,009 | +8,211 | $4.95M | $5.10M | 0.30% | +$150.0K |
| Phreesia, Inc.(PHR) | 876,600 | 600,400 | -276,200 | $14.83M | $5.03M | 0.30% | -$9.80M |
| Thermo Fisher Scientific Inc.(TMO) | 10,000 | 10,000 | 0 | $5.79M | $4.92M | 0.29% | -$879.2K |
| Stryker Corporation(SYK) | 0 | 14,800 | +14,800 | $0 | $4.86M | 0.29% | +$4.86M |
| Sionna Therapeutics, Inc.(SION) | 99,429 | 99,429 | 0 | $4.09M | $3.99M | 0.23% | -$104.4K |
| Arcus Biosciences, Inc.(RCUS) | 180,000 | 180,000 | 0 | $4.29M | $3.89M | 0.23% | -$401.4K |
| Spdr Series TrustSTATE STREET SPD ST STR SP BIOT | 222,000 | 30,000 | -192,000 | $27.07M | $3.83M | 0.23% | -$23.24M |
| Alphatec Holdings, Inc.(ATEC) | 302,500 | 350,000 | +47,500 | $6.36M | $3.81M | 0.22% | -$2.56M |
| Vaxcyte, Inc.(PCVX) | 47,000 | 60,250 | +13,250 | $2.17M | $3.50M | 0.21% | +$1.33M |
| EyePoint, Inc.(EYPT) | 258,739 | 258,739 | 0 | $4.73M | $3.34M | 0.20% | -$1.39M |
| Novo Nordisk A/SADR(NVO) | 0 | 90,000 | +90,000 | $0 | $3.31M | 0.19% | +$3.31M |
| Ocular Therapeutix, Inc.(OCUL) | 345,820 | 383,716 | +37,896 | $4.20M | $3.25M | 0.19% | -$948.2K |
| Viking Therapeutics, Inc.(VKTX) | 0 | 96,000 | +96,000 | $0 | $3.12M | 0.18% | +$3.12M |
| Cytokinetics, Incorporated(CYTK) | 35,853 | 45,364 | +9,511 | $2.28M | $2.99M | 0.18% | +$711.8K |
| Century Therapeutics, Inc.(IPSC) | 0 | 1,304,347 | +1,304,347 | $0 | $2.95M | 0.17% | +$2.95M |
| CVS Health Corporation(CVS) | 0 | 40,000 | +40,000 | $0 | $2.87M | 0.17% | +$2.87M |
| Roivant Sciences Ltd.SHS(ROIV) | 88,750 | 97,000 | +8,250 | $1.93M | $2.69M | 0.16% | +$761.0K |
| Talphera, Inc.(TLPH) | 3,589,186 | 3,589,186 | 0 | $4.09M | $2.68M | 0.16% | -$1.41M |
| Olema Pharmaceuticals, Inc.(OLMA) | 98,240 | 170,378 | +72,138 | $2.46M | $2.54M | 0.15% | +$84.3K |
| Surgery Partners, Inc.(SGRY) | 310,000 | 208,000 | -102,000 | $4.79M | $2.48M | 0.15% | -$2.31M |
| LENZ Therapeutics, Inc.(LENZ) | 257,460 | 257,460 | 0 | $4.12M | $2.36M | 0.14% | -$1.76M |
| Edwards Lifesciences Corp | 82,500 | 28,900 | -53,600 | $7.03M | $2.31M | 0.14% | -$4.72M |
| Dianthus Therapeutics, Inc.(DNTH) | 0 | 26,757 | +26,757 | $0 | $2.25M | 0.13% | +$2.25M |
| Neurogene Inc.(NGNE) | 104,339 | 104,339 | 0 | $2.15M | $2.10M | 0.12% | -$45.9K |
| agilon health, inc.(AGL) | 0 | 260,000 | +260,000 | $0 | $2.06M | 0.12% | +$2.06M |
| Corcept Therapeutics Incorporated(CORT) | 50,250 | 50,250 | 0 | $1.75M | $2.03M | 0.12% | +$276.9K |
| Acadia Healthcare Company, Inc.(ACHC) | 120,000 | 75,500 | -44,500 | $1.70M | $1.77M | 0.10% | +$63.1K |
| Teva Pharmaceutical Industries LimitedADS(TEVA) | 45,500 | 45,500 | 0 | $1.42M | $1.37M | 0.08% | -$49.6K |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 61,700 | 61,700 | 0 | $813.2K | $1.15M | 0.07% | +$336.9K |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 1,750 | 5,750 | +4,000 | $297.5K | $1.09M | 0.06% | +$789.5K |
| Jasper Therapeutics, Inc.(JSPR) | 1,100,726 | 1,100,726 | 0 | $2.01M | $964.5K | 0.06% | -$1.05M |
| Legend Biotech CorporationADS(LEGN) | 33,800 | 40,500 | +6,700 | $734.8K | $732.6K | 0.04% | -$2.2K |
| Gossamer Bio, Inc.(GOSS) | 3,266,960 | 1,609,492 | -1,657,468 | $10.13M | $528.7K | 0.03% | -$9.60M |
| Amicus Therapeutic COM | 1,929,931 | 21,062 | -1,908,869 | $27.48M | $304.6K | 0.02% | -$27.18M |
| Oruka Therapeutics, Inc.(ORKA) | 0 | 4,123 | +4,123 | $0 | $202.2K | 0.01% | +$202.2K |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 0 | 12,600 | +12,600 | $0 | $120.0K | 0.01% | +$120.0K |