Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| AGIOS PHARMACEUTICALS INC(AGIO) | 342,180 | 989,745 | +647,565 | 10,026 | 32,919 | 2.05% | +22,893 |
| CARIS LIFE SCIENCES INC(CAI) | 0 | 793,651 | +793,651 | 0 | 21,206 | 1.32% | +21,206 |
| OMADA HEALTH INC(OMDA) | 0 | 919,951 | +919,951 | 0 | 16,835 | 1.05% | +16,835 |
| MERUS N V | 980,751 | 1,063,608 | +82,857 | 41,280 | 55,946 | 3.49% | +14,666 |
| INSMED INC(INSM) | 515,900 | 525,000 | +9,100 | 39,358 | 52,836 | 3.29% | +13,478 |
| SPDR SERIES TRUST ST STR SP BIOT | 0 | 151,750 | +151,750 | 0 | 12,585 | 0.78% | +12,585 |
| ARCELLX INC COMMON STOCK | 0 | 186,314 | +186,314 | 0 | 12,269 | 0.76% | +12,269 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 254,300 | 242,500 | -11,800 | 26,620 | 37,335 | 2.33% | +10,715 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 834,188 | 861,153 | +26,965 | 44,187 | 54,416 | 3.39% | +10,229 |
| BOSTON SCIENTIFIC CORP(BSX) | 277,000 | 355,000 | +78,000 | 27,944 | 38,131 | 2.38% | +10,187 |
| EXACT SCIENCES CORP(EXK) | 480,000 | 572,000 | +92,000 | 20,779 | 30,396 | 1.89% | +9,617 |
| AKERO THERAPEUTICS INC | 672,759 | 640,526 | -32,233 | 27,233 | 34,178 | 2.13% | +6,945 |
| CIDARA THERAPEUTICS INC | 0 | 134,133 | +134,133 | 0 | 6,534 | 0.41% | +6,534 |
| EVOLENT HEALTH INC(EVH) | 2,695,700 | 2,820,700 | +125,000 | 25,528 | 31,761 | 1.98% | +6,233 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 800,199 | +800,199 | 0 | 5,745 | 0.36% | +5,745 |
| TENET HEALTHCARE CORP(THC) | 130,000 | 130,000 | 0 | 17,485 | 22,880 | 1.43% | +5,395 |
| ENLIVEN THERAPEUTICS INC | 465,871 | 701,408 | +235,537 | 9,168 | 14,070 | 0.88% | +4,902 |
| REGENERON PHARMACEUTICALS(REGN) | 2,800 | 11,300 | +8,500 | 1,776 | 5,933 | 0.37% | +4,157 |
| SOLENO THERAPEUTICS INC | 124,095 | 154,528 | +30,433 | 8,867 | 12,946 | 0.81% | +4,080 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 0 | 10,000 | +10,000 | 0 | 4,055 | 0.25% | +4,055 |
| STRUCTURE THERAPEUTICS INC | 1,132,979 | 1,135,879 | +2,900 | 19,612 | 23,558 | 1.47% | +3,946 |
| ASCENDIS PHARMA A/S(ASND) | 216,000 | 217,000 | +1,000 | 33,666 | 37,454 | 2.33% | +3,788 |
| REVOLUTION MEDICINES INC(RVMD) | 1,281,640 | 1,330,960 | +49,320 | 45,319 | 48,966 | 3.05% | +3,647 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 761,541 | 794,133 | +32,592 | 24,484 | 28,128 | 1.75% | +3,645 |
| COMPASS THERAPEUTICS INC(CMPX) | 4,962,955 | 4,962,955 | 0 | 9,430 | 12,904 | 0.80% | +3,474 |
| VERA THERAPEUTICS INC(VERA) | 520,796 | 617,396 | +96,600 | 12,510 | 14,546 | 0.91% | +2,036 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 343,228 | 499,764 | +156,536 | 1,215 | 3,203 | 0.20% | +1,988 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 812,653 | 812,653 | 0 | 14,750 | 16,537 | 1.03% | +1,788 |
| OSCAR HEALTH INC(OSCR) | 1,050,000 | 700,000 | -350,000 | 13,766 | 15,008 | 0.94% | +1,243 |
| PHARVARIS N V COM | 623,402 | 623,402 | 0 | 9,787 | 10,972 | 0.68% | +1,184 |
| ARDELYX INC | 1,604,975 | 2,286,273 | +681,298 | 7,880 | 8,962 | 0.56% | +1,082 |
| SIONNA THERAPEUTICS INC(SION) | 99,429 | 99,429 | 0 | 1,040 | 1,725 | 0.11% | +685 |
| JASPER THERAPEUTICS INC(JSPR) | 545,171 | 545,171 | 0 | 2,344 | 3,026 | 0.19% | +681 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 444,383 | 444,383 | 0 | 947 | 1,529 | 0.10% | +582 |
| GOSSAMER BIO INC(GOSS) | 3,266,960 | 3,266,960 | 0 | 3,594 | 4,018 | 0.25% | +425 |
| CHARLES RIV LABS INTL INC(CRL) | 0 | 2,700 | +2,700 | 0 | 410 | 0.03% | +410 |
| VAXCYTE INC(PCVX) | 0 | 11,100 | +11,100 | 0 | 361 | 0.02% | +361 |
| NEUROGENE INC(NGNE) | 104,339 | 104,339 | 0 | 1,222 | 1,560 | 0.10% | +338 |
| LENZ THERAPEUTICS INC(LENZ) | 83,082 | 83,982 | +900 | 2,136 | 2,462 | 0.15% | +325 |
| COMPUGEN LTD(CGEN) | 989,990 | 989,990 | 0 | 1,445 | 1,762 | 0.11% | +317 |
| ALPHATEC HLDGS INC(ATEC) | 267,500 | 267,500 | 0 | 2,712 | 2,969 | 0.19% | +257 |
| CULLINAN THERAPEUTICS INC(CGEM) | 644,633 | 668,233 | +23,600 | 4,880 | 5,032 | 0.31% | +152 |
| ADAPTIMMUNE THERAPEUTICS PLC(ADAPY) | 2,483,468 | 2,483,468 | 0 | 489 | 595 | 0.04% | +106 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 1,394,434 | 1,391,072 | -3,362 | 50,492 | 50,579 | 3.15% | +87 |
| DYNE THERAPEUTICS INC(DYN) | 524,499 | 580,998 | +56,499 | 5,486 | 5,531 | 0.34% | +45 |
| NUVATION BIO INC(NUVB) | 134,028 | 134,028 | 0 | 32 | 36 | 0.00% | +4 |
| TALPHERA INC(TLPH) | 316,460 | 316,460 | 0 | 157 | 146 | 0.01% | -11 |
| AZENTA INC(AZTA) | 475,000 | 530,400 | +55,400 | 16,454 | 16,326 | 1.02% | -128 |
| KORRO BIO INC(KRRO) | 35,719 | 35,719 | 0 | 622 | 446 | 0.03% | -176 |
| MERSANA THERAPEUTICS INC | 3,814,684 | 3,814,684 | 0 | 1,313 | 1,129 | 0.07% | -184 |
| APELLIS PHARMACEUTICALS INC COM | 80,000 | 84,300 | +4,300 | 1,750 | 1,459 | 0.09% | -290 |
| GOSSAMER BIO INC(GOSS) | 0 | 0 | 0 | 5,260 | 4,952 | 0.31% | -308 |
| APPLIED THERAPEUTICS INC | 2,074,891 | 2,075,991 | +1,100 | 1,014 | 646 | 0.04% | -369 |
| EDAP TMS S A(FOCL) | 1,270,000 | 1,270,000 | 0 | 2,489 | 2,096 | 0.13% | -394 |
| DANAHER CORPORATION(DHR) | 58,800 | 59,000 | +200 | 12,054 | 11,655 | 0.73% | -399 |
| JANUX THERAPEUTICS INC(JANX) | 204,466 | 210,266 | +5,800 | 5,521 | 4,857 | 0.30% | -663 |
| MINERALYS THERAPEUTICS INC(MLYS) | 320,813 | 324,513 | +3,700 | 5,095 | 4,391 | 0.27% | -704 |
| ZENAS BIOPHARMA INC(ZBIO) | 878,667 | 640,467 | -238,200 | 6,941 | 6,206 | 0.39% | -735 |
| SPRUCE BIOSCIENCES INC | 2,609,125 | 0 | -2,609,125 | 757 | 0 | — | -757 |
| PLIANT THERAPEUTICS INC(PLRX) | 589,996 | 0 | -589,996 | 796 | 0 | — | -796 |
| VIGIL NEUROSCIENCE INC | 471,958 | 0 | -471,958 | 840 | 0 | — | -840 |
| ACLARIS THERAPEUTICS INC(ACRS) | 5,046,309 | 4,769,309 | -277,000 | 7,721 | 6,772 | 0.42% | -948 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 951,765 | 818,206 | -133,559 | 42,877 | 41,639 | 2.59% | -1,239 |
| BICARA THERAPEUTICS INC | 336,070 | 336,070 | 0 | 4,379 | 3,122 | 0.19% | -1,257 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 536,111 | 536,111 | 0 | 10,974 | 9,709 | 0.60% | -1,265 |
| MACROGENICS INC(MGNX) | 1,145,214 | 0 | -1,145,214 | 1,454 | 0 | — | -1,454 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 222,011 | 0 | -222,011 | 1,665 | 0 | — | -1,665 |
| PULMONX CORP(LUNG) | 503,700 | 651,100 | +147,400 | 3,390 | 1,686 | 0.11% | -1,704 |
| INSPIRE MED SYS INC(INSP) | 99,250 | 107,500 | +8,250 | 15,809 | 13,950 | 0.87% | -1,858 |
| KYMERA THERAPEUTICS INC(KYMR) | 794,437 | 450,374 | -344,063 | 21,744 | 19,654 | 1.22% | -2,089 |
| XENON PHARMACEUTICALS INC(XENE) | 931,681 | 931,681 | 0 | 31,258 | 29,162 | 1.82% | -2,096 |
| DEXCOM INC(DXCM) | 397,650 | 286,750 | -110,900 | 27,156 | 25,030 | 1.56% | -2,125 |
| ZAI LAB LTD(ZLAB) | 904,592 | 871,392 | -33,200 | 32,692 | 30,473 | 1.90% | -2,219 |
| WEST PHARMACEUTICAL SVSC INC(WST) | 60,250 | 51,030 | -9,220 | 13,489 | 11,165 | 0.70% | -2,323 |
| SAGIMET BIOSCIENCES INC(SGMT) | 787,808 | 0 | -787,808 | 2,568 | 0 | — | -2,568 |
| ELI LILLY & CO(LLY) | 113,500 | 116,500 | +3,000 | 93,741 | 90,815 | 5.66% | -2,926 |
| BEAM THERAPEUTICS INC(BEAM) | 150,020 | 0 | -150,020 | 2,930 | 0 | — | -2,930 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 6,684,247 | 4,465,292 | -2,218,955 | 15,040 | 12,101 | 0.75% | -2,939 |
| TARSUS PHARMACEUTICALS INC(TARS) | 354,376 | 373,750 | +19,374 | 18,204 | 15,141 | 0.94% | -3,064 |
| PROTHENA CORP PLC SHS | 492,601 | 492,601 | 0 | 6,096 | 2,990 | 0.19% | -3,106 |
| INOZYME PHARMA INC | 3,445,299 | 0 | -3,445,299 | 3,135 | 0 | — | -3,135 |
| KESTRA MED TECHNOLOGIES LTD SHS | 145,000 | 0 | -145,000 | 3,613 | 0 | — | -3,613 |
| NOVAVAX INC(NVAX) | 650,000 | 53,900 | -596,100 | 4,167 | 340 | 0.02% | -3,827 |
| SUMMIT THERAPEUTICS INC(SMMT) | 995,000 | 710,000 | -285,000 | 19,194 | 15,109 | 0.94% | -4,085 |
| AMICUS THERAPEUTICS INC COM | 1,909,362 | 1,960,334 | +50,972 | 15,580 | 11,233 | 0.70% | -4,348 |
| NEVRO CORP | 800,494 | 0 | -800,494 | 4,675 | 0 | — | -4,675 |
| ACADIA HEALTHCARE COMPANY IN(ACHC) | 681,100 | 696,000 | +14,900 | 20,651 | 15,792 | 0.98% | -4,859 |
| PHREESIA INC(PHR) | 1,148,336 | 837,300 | -311,036 | 29,351 | 23,830 | 1.48% | -5,522 |
| 89BIO INC | 844,441 | 40,000 | -804,441 | 6,139 | 393 | 0.02% | -5,746 |
| INTUITIVE SURGICAL INC | 102,000 | 82,000 | -20,000 | 50,518 | 44,560 | 2.78% | -5,958 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 143,250 | 100,000 | -43,250 | 38,680 | 32,609 | 2.03% | -6,071 |
| ARGENX SE(ARGX) | 175,750 | 175,750 | 0 | 104,020 | 96,877 | 6.04% | -7,143 |
| EDWARDS LIFESCIENCES CORP | 255,000 | 131,000 | -124,000 | 18,482 | 10,246 | 0.64% | -8,237 |
| SAREPTA THERAPEUTICS INC(SRPT) | 159,300 | 68,600 | -90,700 | 10,167 | 1,173 | 0.07% | -8,993 |
| PENUMBRA INC(PEN) | 171,000 | 128,500 | -42,500 | 45,727 | 32,977 | 2.05% | -12,750 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 166,698 | 140,296 | -26,402 | 55,215 | 42,459 | 2.65% | -12,756 |
| IMMUNOVANT INC(IMVT) | 975,803 | 221,500 | -754,303 | 16,676 | 3,544 | 0.22% | -13,132 |
| AGILON HEALTH INC(AGL) | 6,950,000 | 6,550,400 | -399,600 | 30,094 | 15,066 | 0.94% | -15,028 |
| WARBY PARKER INC(WRBY) | 835,000 | 0 | -835,000 | 15,222 | 0 | — | -15,222 |
| LEGEND BIOTECH CORP(LEGN) | 512,932 | 0 | -512,932 | 17,404 | 0 | — | -17,404 |