Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| TRAVERE THERAPEUTICS INC(TVTX) | 1,908,208 | 2,164,773 | +256,565 | 28,241 | 51,738 | 3.02% | +23,497 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 140,296 | 137,746 | -2,550 | 42,459 | 63,179 | 3.69% | +20,719 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 861,153 | 717,102 | -144,051 | 54,416 | 72,420 | 4.23% | +18,004 |
| CIDARA THERAPEUTICS INC | 134,133 | 249,402 | +115,269 | 6,534 | 23,883 | 1.40% | +17,349 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 818,206 | 761,126 | -57,080 | 41,639 | 55,798 | 3.26% | +14,160 |
| REVOLUTION MEDICINES INC(RVMD) | 1,330,960 | 1,335,270 | +4,310 | 48,966 | 62,357 | 3.65% | +13,391 |
| MINERALYS THERAPEUTICS INC(MLYS) | 324,513 | 408,313 | +83,800 | 4,391 | 15,483 | 0.91% | +11,093 |
| COGENT BIOSCIENCES INC(COGT) | 800,199 | 1,008,308 | +208,109 | 5,745 | 14,479 | 0.85% | +8,734 |
| LENZ THERAPEUTICS INC(LENZ) | 83,982 | 236,227 | +152,245 | 2,462 | 11,003 | 0.64% | +8,542 |
| HEARTFLOW INC(HTFL) | 0 | 250,000 | +250,000 | 0 | 8,415 | 0.49% | +8,415 |
| ARGENX SE(ARGX) | 175,750 | 142,750 | -33,000 | 96,877 | 105,287 | 6.15% | +8,410 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 536,111 | 595,929 | +59,818 | 9,709 | 16,948 | 0.99% | +7,239 |
| ZENAS BIOPHARMA INC(ZBIO) | 640,467 | 580,677 | -59,790 | 6,206 | 12,891 | 0.75% | +6,685 |
| KYMERA THERAPEUTICS INC(KYMR) | 450,374 | 450,374 | 0 | 19,654 | 25,491 | 1.49% | +5,837 |
| AGIOS PHARMACEUTICALS INC(AGIO) | 989,745 | 958,542 | -31,203 | 32,919 | 38,476 | 2.25% | +5,557 |
| ASCENDIS PHARMA A/S(ASND) | 217,000 | 214,500 | -2,500 | 37,454 | 42,645 | 2.49% | +5,191 |
| XENON PHARMACEUTICALS INC(XENE) | 931,681 | 851,744 | -79,937 | 29,162 | 34,198 | 2.00% | +5,036 |
| MBX BIOSCIENCES INC(MBX) | 0 | 282,624 | +282,624 | 0 | 4,946 | 0.29% | +4,946 |
| DYNE THERAPEUTICS INC(DYN) | 580,998 | 824,061 | +243,063 | 5,531 | 10,424 | 0.61% | +4,893 |
| PHARVARIS N V COM | 623,402 | 623,402 | 0 | 10,972 | 15,554 | 0.91% | +4,582 |
| GOSSAMER BIO INC(GOSS) | 3,266,960 | 3,266,960 | 0 | 4,018 | 8,592 | 0.50% | +4,574 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 85,000 | +85,000 | 0 | 4,415 | 0.26% | +4,415 |
| AMICUS THERAPEUTICS INC COM | 1,960,334 | 1,947,374 | -12,960 | 11,233 | 15,345 | 0.90% | +4,113 |
| ARDELYX INC | 2,286,273 | 2,286,273 | 0 | 8,962 | 12,597 | 0.74% | +3,635 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 499,764 | 499,764 | 0 | 3,203 | 6,792 | 0.40% | +3,588 |
| OCULAR THERAPEUTIX INC(OCUL) | 0 | 300,000 | +300,000 | 0 | 3,507 | 0.21% | +3,507 |
| OMADA HEALTH INC(OMDA) | 919,951 | 919,950 | -1 | 16,835 | 20,340 | 1.19% | +3,505 |
| VERA THERAPEUTICS INC(VERA) | 617,396 | 617,396 | 0 | 14,546 | 17,942 | 1.05% | +3,396 |
| ALKERMES PLC(ALKS) | 0 | 106,537 | +106,537 | 0 | 3,196 | 0.19% | +3,196 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 242,500 | 235,000 | -7,500 | 37,335 | 40,418 | 2.36% | +3,082 |
| STRUCTURE THERAPEUTICS INC | 1,135,879 | 951,154 | -184,725 | 23,558 | 26,632 | 1.56% | +3,074 |
| TALPHERA INC(TLPH) | 316,460 | 3,589,186 | +3,272,726 | 146 | 3,206 | 0.19% | +3,060 |
| CARIS LIFE SCIENCES INC(CAI) | 793,651 | 793,651 | 0 | 21,206 | 24,008 | 1.40% | +2,802 |
| COMPASS THERAPEUTICS INC(CMPX) | 4,962,955 | 4,474,702 | -488,253 | 12,904 | 15,661 | 0.92% | +2,758 |
| BICARA THERAPEUTICS INC | 336,070 | 370,666 | +34,596 | 3,122 | 5,853 | 0.34% | +2,731 |
| SPDR SERIES TRUST ST STR SP BIOT | 151,750 | 151,750 | 0 | 12,585 | 15,205 | 0.89% | +2,621 |
| INSMED INC(INSM) | 525,000 | 385,000 | -140,000 | 52,836 | 55,444 | 3.24% | +2,608 |
| TENET HEALTHCARE CORP(THC) | 130,000 | 125,000 | -5,000 | 22,880 | 25,380 | 1.48% | +2,500 |
| ARCELLX INC COMMON STOCK | 186,314 | 178,982 | -7,332 | 12,269 | 14,694 | 0.86% | +2,426 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 812,653 | 721,538 | -91,115 | 16,537 | 18,666 | 1.09% | +2,129 |
| EXACT SCIENCES CORP(EXK) | 572,000 | 593,500 | +21,500 | 30,396 | 32,470 | 1.90% | +2,074 |
| TARSUS PHARMACEUTICALS INC(TARS) | 373,750 | 288,344 | -85,406 | 15,141 | 17,136 | 1.00% | +1,996 |
| ACLARIS THERAPEUTICS INC(ACRS) | 4,769,309 | 4,609,309 | -160,000 | 6,772 | 8,758 | 0.51% | +1,985 |
| GOSSAMER BIO INC(GOSS) | 0 | 0 | 0 | 4,952 | 6,719 | 0.39% | +1,766 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 69,240 | +69,240 | 0 | 1,679 | 0.10% | +1,679 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 794,133 | 794,133 | 0 | 28,128 | 29,574 | 1.73% | +1,445 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 88,800 | 89,750 | +950 | 11,161 | 12,599 | 0.74% | +1,438 |
| ALPHATEC HLDGS INC(ATEC) | 267,500 | 302,500 | +35,000 | 2,969 | 4,398 | 0.26% | +1,429 |
| KORRO BIO INC(KRRO) | 35,719 | 35,719 | 0 | 446 | 1,711 | 0.10% | +1,264 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 100,000 | 74,250 | -25,750 | 32,609 | 33,858 | 1.98% | +1,249 |
| SIONNA THERAPEUTICS INC(SION) | 99,429 | 99,429 | 0 | 1,725 | 2,924 | 0.17% | +1,199 |
| MERSANA THERAPEUTICS INC | 0 | 152,586 | +152,586 | 0 | 1,184 | 0.07% | +1,184 |
| EDAP TMS S A(FOCL) | 1,270,000 | 1,270,000 | 0 | 2,096 | 2,908 | 0.17% | +813 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 10,000 | 10,000 | 0 | 4,055 | 4,850 | 0.28% | +796 |
| APELLIS PHARMACEUTICALS INC COM | 84,300 | 92,000 | +7,700 | 1,459 | 2,082 | 0.12% | +623 |
| APPLIED THERAPEUTICS INC | 2,075,991 | 2,075,991 | 0 | 646 | 1,256 | 0.07% | +610 |
| DANAHER CORPORATION(DHR) | 59,000 | 61,500 | +2,500 | 11,655 | 12,193 | 0.71% | +538 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 31,655 | +31,655 | 0 | 451 | 0.03% | +451 |
| REGENERON PHARMACEUTICALS(REGN) | 11,300 | 11,300 | 0 | 5,933 | 6,354 | 0.37% | +421 |
| JANUX THERAPEUTICS INC(JANX) | 210,266 | 210,366 | +100 | 4,857 | 5,141 | 0.30% | +284 |
| MERUS N V | 1,063,608 | 597,051 | -466,557 | 55,946 | 56,212 | 3.29% | +267 |
| NEUROGENE INC(NGNE) | 104,339 | 104,339 | 0 | 1,560 | 1,808 | 0.11% | +248 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 0 | 28,200 | +28,200 | 0 | 202 | 0.01% | +202 |
| NOVAVAX INC(NVAX) | 53,900 | 45,000 | -8,900 | 340 | 390 | 0.02% | +51 |
| VAXCYTE INC(PCVX) | 11,100 | 11,100 | 0 | 361 | 400 | 0.02% | +39 |
| CHARLES RIV LABS INTL INC(CRL) | 2,700 | 2,700 | 0 | 410 | 422 | 0.02% | +13 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 444,383 | 444,383 | 0 | 1,529 | 1,524 | 0.09% | -4 |
| NUVATION BIO INC(NUVB) | 134,028 | 134,028 | 0 | 36 | 27 | 0.00% | -9 |
| ENLIVEN THERAPEUTICS INC | 701,408 | 686,107 | -15,301 | 14,070 | 14,045 | 0.82% | -26 |
| 89BIO INC | 40,000 | 0 | -40,000 | 393 | 0 | — | -393 |
| JASPER THERAPEUTICS INC(JSPR) | 545,171 | 1,100,726 | +555,555 | 3,026 | 2,620 | 0.15% | -406 |
| SUMMIT THERAPEUTICS INC(SMMT) | 710,000 | 710,000 | 0 | 15,109 | 14,669 | 0.86% | -440 |
| ADAPTIMMUNE THERAPEUTICS PLC(ADAPY) | 2,483,468 | 0 | -2,483,468 | 595 | 0 | — | -595 |
| AZENTA INC(AZTA) | 530,400 | 540,400 | +10,000 | 16,326 | 15,520 | 0.91% | -805 |
| MERSANA THERAPEUTICS INC | 3,814,684 | 0 | -3,814,684 | 1,129 | 0 | — | -1,129 |
| SAREPTA THERAPEUTICS INC(SRPT) | 68,600 | 0 | -68,600 | 1,173 | 0 | — | -1,173 |
| PULMONX CORP(LUNG) | 651,100 | 0 | -651,100 | 1,686 | 0 | — | -1,686 |
| COMPUGEN LTD(CGEN) | 989,990 | 13,430 | -976,560 | 1,762 | 20 | 0.00% | -1,742 |
| IMMUNOVANT INC(IMVT) | 221,500 | 72,965 | -148,535 | 3,544 | 1,176 | 0.07% | -2,368 |
| PENUMBRA INC(PEN) | 128,500 | 120,500 | -8,000 | 32,977 | 30,525 | 1.78% | -2,452 |
| SOLENO THERAPEUTICS INC | 154,528 | 154,528 | 0 | 12,946 | 10,446 | 0.61% | -2,500 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 4,465,292 | 4,570,649 | +105,357 | 12,101 | 9,416 | 0.55% | -2,685 |
| PROTHENA CORP PLC SHS | 492,601 | 25,398 | -467,203 | 2,990 | 248 | 0.01% | -2,742 |
| BOSTON SCIENTIFIC CORP(BSX) | 355,000 | 360,250 | +5,250 | 38,131 | 35,171 | 2.06% | -2,959 |
| EDWARDS LIFESCIENCES CORP | 131,000 | 88,000 | -43,000 | 10,246 | 6,844 | 0.40% | -3,402 |
| ZAI LAB LTD(ZLAB) | 871,392 | 791,193 | -80,199 | 30,473 | 26,814 | 1.57% | -3,659 |
| DEXCOM INC(DXCM) | 286,750 | 316,900 | +30,150 | 25,030 | 21,324 | 1.25% | -3,706 |
| AKERO THERAPEUTICS INC | 640,526 | 626,526 | -14,000 | 34,178 | 29,747 | 1.74% | -4,431 |
| CULLINAN THERAPEUTICS INC(CGEM) | 668,233 | 0 | -668,233 | 5,032 | 0 | — | -5,032 |
| INSPIRE MED SYS INC(INSP) | 107,500 | 110,500 | +3,000 | 13,950 | 8,199 | 0.48% | -5,751 |
| PHREESIA INC(PHR) | 837,300 | 749,116 | -88,184 | 23,830 | 17,619 | 1.03% | -6,210 |
| EVOLENT HEALTH INC(EVH) | 2,820,700 | 2,950,000 | +129,300 | 31,761 | 24,957 | 1.46% | -6,804 |
| NUVALENT INC | 93,328 | 0 | -93,328 | 7,121 | 0 | — | -7,121 |
| INTUITIVE SURGICAL INC | 82,000 | 82,000 | 0 | 44,560 | 36,673 | 2.14% | -7,887 |
| AGILON HEALTH INC(AGL) | 6,550,400 | 6,966,300 | +415,900 | 15,066 | 7,175 | 0.42% | -7,891 |
| WEST PHARMACEUTICAL SVSC INC(WST) | 51,030 | 9,750 | -41,280 | 11,165 | 2,558 | 0.15% | -8,608 |
| ELI LILLY & CO(LLY) | 116,500 | 105,400 | -11,100 | 90,815 | 80,420 | 4.70% | -10,395 |
| ACADIA HEALTHCARE COMPANY IN(ACHC) | 696,000 | 170,000 | -526,000 | 15,792 | 4,209 | 0.25% | -11,583 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 1,391,072 | 1,246,341 | -144,731 | 50,579 | 37,490 | 2.19% | -13,089 |
| OSCAR HEALTH INC(OSCR) | 700,000 | 0 | -700,000 | 15,008 | 0 | — | -15,008 |