Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BLUEPRINT MEDICINES CORP | 2,685,294 | 2,881,567 | +196,273 | 134,855 | 265,796 | 6.56% | +130,940 |
| KARUNA THERAPEUTICS INC | 505,433 | 515,024 | +9,591 | 85,464 | 163,010 | 4.02% | +77,547 |
| CEREVEL THERAPEUTICS HLDNG I | 2,529,116 | 2,674,245 | +145,129 | 55,211 | 113,388 | 2.80% | +58,177 |
| ELI LILLY & CO(LLY) | 0 | 69,500 | +69,500 | 0 | 40,513 | 1.00% | +40,513 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 1,597,123 | 1,522,893 | -74,230 | 36,614 | 70,007 | 1.73% | +33,393 |
| INSULET CORP(PODD) | 380,000 | 431,750 | +51,750 | 60,606 | 93,681 | 2.31% | +33,075 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 1,476,441 | 1,754,038 | +277,597 | 52,635 | 83,878 | 2.07% | +31,243 |
| IMMUNOCORE HLDGS PLC(IMCR) | 2,943,710 | 2,661,507 | -282,203 | 152,779 | 181,834 | 4.49% | +29,056 |
| EVOLENT HEALTH INC(EVH) | 3,865,000 | 3,960,000 | +95,000 | 105,244 | 130,799 | 3.23% | +25,555 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 500,101 | 969,646 | +469,545 | 13,763 | 38,456 | 0.95% | +24,693 |
| ACADIA HEALTHCARE COMPANY IN(ACHC) | 908,000 | 1,073,500 | +165,500 | 63,841 | 83,475 | 2.06% | +19,634 |
| DEXCOM INC(DXCM) | 584,000 | 596,000 | +12,000 | 54,487 | 73,958 | 1.83% | +19,470 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 1,236,000 | 1,196,000 | -40,000 | 139,050 | 157,585 | 3.89% | +18,535 |
| PHREESIA INC(PHR) | 1,776,391 | 2,206,700 | +430,309 | 33,183 | 51,085 | 1.26% | +17,902 |
| KYMERA THERAPEUTICS INC(KYMR) | 1,504,351 | 1,522,238 | +17,887 | 20,910 | 38,756 | 0.96% | +17,846 |
| XENON PHARMACEUTICALS INC(XENE) | 1,178,002 | 1,255,577 | +77,575 | 40,241 | 57,832 | 1.43% | +17,591 |
| OLINK HLDG AB | 1,676,500 | 1,676,500 | 0 | 24,728 | 42,164 | 1.04% | +17,436 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 196,369 | 198,169 | +1,800 | 28,678 | 45,852 | 1.13% | +17,175 |
| IMMUNOVANT INC(IMVT) | 644,344 | 983,301 | +338,957 | 24,736 | 41,426 | 1.02% | +16,690 |
| IDEXX LABS INC(IDXX) | 194,500 | 179,250 | -15,250 | 85,049 | 99,493 | 2.46% | +14,444 |
| FRESHPET INC(FRPT) | 662,500 | 662,500 | 0 | 43,646 | 57,479 | 1.42% | +13,833 |
| INTUITIVE SURGICAL INC | 298,500 | 298,500 | 0 | 87,249 | 100,702 | 2.49% | +13,453 |
| PENUMBRA INC(PEN) | 503,750 | 537,500 | +33,750 | 121,862 | 135,203 | 3.34% | +13,341 |
| STRUCTURE THERAPEUTICS INC | 0 | 286,676 | +286,676 | 0 | 11,685 | 0.29% | +11,685 |
| INSPIRE MED SYS INC(INSP) | 44,500 | 99,000 | +54,500 | 8,831 | 20,140 | 0.50% | +11,309 |
| ACCOLADE INC | 2,913,000 | 3,485,000 | +572,000 | 30,820 | 41,855 | 1.03% | +11,035 |
| IMMUNOGEN INC | 759,365 | 759,365 | 0 | 12,051 | 22,515 | 0.56% | +10,464 |
| LIFESTANCE HEALTH GROUP INC(LFST) | 3,670,000 | 4,535,000 | +865,000 | 25,213 | 35,509 | 0.88% | +10,296 |
| BOSTON SCIENTIFIC CORP(BSX) | 1,160,000 | 1,232,500 | +72,500 | 61,248 | 71,251 | 1.76% | +10,003 |
| AZENTA INC(AZTA) | 477,500 | 507,500 | +30,000 | 23,966 | 33,059 | 0.82% | +9,093 |
| TRAVERE THERAPEUTICS INC(TVTX) | 1,807,742 | 2,771,446 | +963,704 | 16,161 | 24,915 | 0.62% | +8,754 |
| MEREO BIOPHARMA GROUP PLC(MREO) | 7,676,481 | 7,983,851 | +307,370 | 9,903 | 18,443 | 0.46% | +8,540 |
| WARBY PARKER INC(WRBY) | 1,575,000 | 2,028,300 | +453,300 | 20,727 | 28,599 | 0.71% | +7,872 |
| ICOSAVAX INC | 868,409 | 868,409 | 0 | 6,730 | 13,686 | 0.34% | +6,956 |
| OSCAR HEALTH INC(OSCR) | 0 | 735,000 | +735,000 | 0 | 6,725 | 0.17% | +6,725 |
| EXACT SCIENCES CORP(EXK) | 1,018,250 | 1,019,500 | +1,250 | 69,465 | 75,423 | 1.86% | +5,958 |
| MACROGENICS INC(MGNX) | 1,178,796 | 1,178,796 | 0 | 5,493 | 11,340 | 0.28% | +5,847 |
| UNITEDHEALTH GROUP INC(UNH) | 230,000 | 230,000 | 0 | 115,964 | 121,088 | 2.99% | +5,124 |
| COLLEGIUM PHARMACEUTICAL INC(COLL) | 562,000 | 562,000 | 0 | 12,561 | 17,298 | 0.43% | +4,738 |
| EDWARDS LIFESCIENCES CORP | 647,300 | 647,300 | 0 | 44,845 | 49,357 | 1.22% | +4,512 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 350,750 | 350,750 | 0 | 33,062 | 37,544 | 0.93% | +4,483 |
| MERUS N V | 838,428 | 872,069 | +33,641 | 19,770 | 23,982 | 0.59% | +4,212 |
| DISC MEDICINE INC(IRON) | 363,468 | 363,468 | 0 | 17,076 | 20,994 | 0.52% | +3,918 |
| PACIRA BIOSCIENCES INC(PCRX) | 1,055,500 | 1,055,500 | 0 | 32,383 | 35,613 | 0.88% | +3,230 |
| AMGEN INC(AMGN) | 68,000 | 74,500 | +6,500 | 18,276 | 21,457 | 0.53% | +3,182 |
| MERSANA THERAPEUTICS INC | 3,403,133 | 3,046,782 | -356,351 | 4,322 | 7,069 | 0.17% | +2,747 |
| KRYSTAL BIOTECH INC(KRYS) | 90,560 | 103,969 | +13,409 | 10,505 | 12,898 | 0.32% | +2,393 |
| ESSA PHARMA INC | 677,005 | 677,005 | 0 | 2,092 | 4,468 | 0.11% | +2,376 |
| AMICUS THERAPEUTICS INC COM | 1,063,806 | 1,063,806 | 0 | 12,936 | 15,095 | 0.37% | +2,160 |
| LEAP THERAPEUTICS INC(CYPH) | 1,074,517 | 832,937 | -241,580 | 1,483 | 3,453 | 0.09% | +1,970 |
| RELAY THERAPEUTICS INC(RLAY) | 673,966 | 673,966 | 0 | 5,668 | 7,420 | 0.18% | +1,752 |
| FULCRUM THERAPEUTICS INC(FULC) | 727,673 | 727,673 | 0 | 3,231 | 4,912 | 0.12% | +1,681 |
| PULMONX CORP(LUNG) | 652,400 | 652,400 | 0 | 6,739 | 8,318 | 0.21% | +1,579 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 2,551,226 | 3,270,381 | +719,155 | 18,063 | 19,590 | 0.48% | +1,527 |
| SPRUCE BIOSCIENCES INC | 2,728,125 | 2,609,125 | -119,000 | 6,166 | 7,645 | 0.19% | +1,479 |
| COMPUGEN LTD(CGEN) | 1,289,990 | 1,289,990 | 0 | 1,200 | 2,554 | 0.06% | +1,354 |
| ZAI LAB LTD(ZLAB) | 1,237,023 | 1,137,023 | -100,000 | 30,072 | 31,075 | 0.77% | +1,003 |
| APPLIED THERAPEUTICS INC | 808,809 | 895,195 | +86,386 | 2,014 | 2,999 | 0.07% | +985 |
| REVOLUTION MEDICINES INC(RVMD) | 725,152 | 725,152 | 0 | 20,072 | 20,797 | 0.51% | +725 |
| BEAM THERAPEUTICS INC(BEAM) | 111,430 | 111,430 | 0 | 2,680 | 3,033 | 0.07% | +353 |
| GOSSAMER BIO INC(GOSS) | 3,266,960 | 3,266,960 | 0 | 2,721 | 2,981 | 0.07% | +260 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 0 | 0 | 1,498 | 1,753 | 0.04% | +256 |
| INOZYME PHARMA INC | 3,681,174 | 3,681,174 | 0 | 15,461 | 15,682 | 0.39% | +221 |
| VINCERX PHARMA INC | 891,719 | 891,719 | 0 | 901 | 1,052 | 0.03% | +152 |
| BIOMEA FUSION INC(BMEA) | 181,147 | 181,147 | 0 | 2,493 | 2,630 | 0.06% | +138 |
| TRAVERE THERAPEUTICS INC | 0 | 0 | 0 | 2,677 | 2,768 | 0.07% | +90 |
| ACELRX PHARMACEUTICALS INC(TLPH) | 316,460 | 316,460 | 0 | 184 | 233 | 0.01% | +49 |
| NEVRO CORP | 0 | 0 | 0 | 472 | 482 | 0.01% | +10 |
| NUVATION BIO INC(NUVB) | 134,028 | 134,028 | 0 | 13 | 8 | 0.00% | -5 |
| AURINIA PHARMACEUTICALS INC(AUPH) | 479,540 | 412,570 | -66,970 | 3,726 | 3,709 | 0.09% | -17 |
| GAMIDA CELL LTD | 52,015 | 0 | -52,015 | 54 | 0 | — | -54 |
| SPERO THERAPEUTICS INC(SPRO) | 57,373 | 0 | -57,373 | 69 | 0 | — | -69 |
| ATRECA INC | 362,530 | 0 | -362,530 | 95 | 0 | — | -95 |
| TEMPEST THERAPEUTICS INC(TPST) | 536,214 | 0 | -536,214 | 163 | 0 | — | -163 |
| MIRATI THERAPEUTICS INC | 1,131,207 | 835,776 | -295,431 | 49,275 | 49,102 | 1.21% | -174 |
| GOSSAMER BIO INC(GOSS) | 0 | 0 | 0 | 3,708 | 3,488 | 0.09% | -220 |
| ADAPTIMMUNE THERAPEUTICS PLC(ADAPY) | 2,787,845 | 2,425,468 | -362,377 | 2,175 | 1,923 | 0.05% | -251 |
| INVITAE CORP | 585,659 | 0 | -585,659 | 354 | 0 | — | -354 |
| CERVOMED INC(CRVO) | 80,033 | 0 | -80,033 | 370 | 0 | — | -370 |
| NKARTA INC(NKTX) | 331,571 | 0 | -331,571 | 461 | 0 | — | -461 |
| KINNATE BIOPHARMA INC | 405,811 | 0 | -405,811 | 568 | 0 | — | -568 |
| VIGIL NEUROSCIENCE INC | 471,958 | 471,958 | 0 | 2,544 | 1,595 | 0.04% | -949 |
| MINERALYS THERAPEUTICS INC(MLYS) | 1,167,492 | 1,167,492 | 0 | 11,103 | 10,040 | 0.25% | -1,062 |
| DESIGN THERAPEUTICS INC(DSGN) | 460,391 | 0 | -460,391 | 1,087 | 0 | — | -1,087 |
| LEGEND BIOTECH CORP(LEGN) | 458,265 | 492,444 | +34,179 | 30,782 | 29,630 | 0.73% | -1,151 |
| THESEUS PHARMACEUTICALS INC | 437,329 | 0 | -437,329 | 1,176 | 0 | — | -1,176 |
| NEVRO CORP | 1,211,600 | 1,025,000 | -186,600 | 23,287 | 22,058 | 0.54% | -1,229 |
| FATE THERAPEUTICS INC(FATE) | 612,215 | 0 | -612,215 | 1,298 | 0 | — | -1,298 |
| ACELYRIN INC | 141,876 | 0 | -141,876 | 1,443 | 0 | — | -1,443 |
| PLIANT THERAPEUTICS INC(PLRX) | 491,221 | 384,996 | -106,225 | 8,518 | 6,972 | 0.17% | -1,545 |
| AEGLEA BIOTHERAPEUTICS INC(SYRE) | 136,556 | 0 | -136,556 | 1,673 | 0 | — | -1,673 |
| IMMATICS N.V(IMTX) | 1,875,466 | 1,875,466 | 0 | 21,718 | 19,749 | 0.49% | -1,969 |
| NOVAVAX INC(NVAX) | 647,700 | 537,625 | -110,075 | 4,689 | 2,581 | 0.06% | -2,109 |
| EDAP TMS S A(FOCL) | 1,360,000 | 1,386,425 | +26,425 | 9,547 | 7,320 | 0.18% | -2,227 |
| XILIO THERAPEUTICS INC(XLO) | 1,440,759 | 1,440,759 | 0 | 3,040 | 792 | 0.02% | -2,248 |
| COMPASS THERAPEUTICS INC(CMPX) | 5,513,788 | 5,513,788 | 0 | 10,862 | 8,602 | 0.21% | -2,261 |
| SAGIMET BIOSCIENCES INC(SGMT) | 738,355 | 738,355 | 0 | 6,498 | 4,002 | 0.10% | -2,496 |
| ACUMEN PHARMACEUTICALS INC(ABOS) | 2,812,579 | 2,300,059 | -512,520 | 11,672 | 8,832 | 0.22% | -2,840 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 1,820,733 | 1,851,464 | +30,731 | 57,535 | 54,655 | 1.35% | -2,880 |
| HEALTH CATALYST INC(HCAT) | 307,500 | 0 | -307,500 | 3,112 | 0 | — | -3,112 |