Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| argenx SEADR(ARGX) | 233,500 | 229,600 | -3,900 | $126.58M | $141.20M | 5.38% | +$14.63M |
| Intuitive Surgical, Inc.(ISRG) | 270,000 | 216,000 | -54,000 | $132.64M | $112.74M | 4.29% | -$19.90M |
| Eli Lilly and Company(LLY) | 142,000 | 144,500 | +2,500 | $125.80M | $111.55M | 4.25% | -$14.25M |
| Neurocrine Biosciences, Inc.(NBIX) | 939,000 | 720,500 | -218,500 | $108.19M | $98.35M | 3.74% | -$9.84M |
| Blueprint Medicines Corp | 768,776 | 1,096,899 | +328,123 | $71.11M | $95.67M | 3.64% | +$24.56M |
| UnitedHealth Group Incorporated(UNH) | 294,250 | 176,000 | -118,250 | $172.04M | $89.03M | 3.39% | -$83.01M |
| Travere Therapeutics, Inc.(TVTX) | 4,684,476 | 4,973,649 | +289,173 | $65.54M | $86.64M | 3.30% | +$21.11M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 263,062 | 265,212 | +2,150 | $55.83M | $81.84M | 3.12% | +$26.01M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 1,978,272 | 1,739,813 | -238,459 | $109.89M | $73.19M | 2.79% | -$36.70M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 1,228,093 | 1,162,718 | -65,375 | $64.34M | $65.09M | 2.48% | +$749.2K |
| Mirum Pharmaceuticals, Inc.(MIRM) | 1,580,488 | 1,471,564 | -108,924 | $61.64M | $60.85M | 2.32% | -$789.9K |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 250,000 | 256,200 | +6,200 | $68.76M | $60.29M | 2.30% | -$8.47M |
| Penumbra, Inc.(PEN) | 265,000 | 240,000 | -25,000 | $51.49M | $57.00M | 2.17% | +$5.50M |
| West Pharmaceutical Services, Inc.(WST) | 167,750 | 168,750 | +1,000 | $50.35M | $55.28M | 2.10% | +$4.92M |
| Revolution Medicines, Inc.(RVMD) | 1,009,945 | 1,213,257 | +203,312 | $45.80M | $53.07M | 2.02% | +$7.27M |
| Phreesia, Inc.(PHR) | 2,282,500 | 2,040,000 | -242,500 | $52.02M | $51.33M | 1.95% | -$691.8K |
| Xenon Pharmaceuticals Inc.(XENE) | 1,316,477 | 1,251,859 | -64,618 | $51.83M | $49.07M | 1.87% | -$2.76M |
| Freshpet, Inc.(FRPT) | 446,500 | 327,500 | -119,000 | $61.07M | $48.51M | 1.85% | -$12.56M |
| Ascendis Pharma A/SADR(ASND) | 325,000 | 305,000 | -20,000 | $48.53M | $41.99M | 1.60% | -$6.54M |
| Kymera Therapeutics, Inc.(KYMR) | 1,049,386 | 1,034,137 | -15,249 | $49.67M | $41.60M | 1.58% | -$8.06M |
| Boston Scientific Corporation(BSX) | 460,000 | 460,000 | 0 | $38.55M | $41.09M | 1.56% | +$2.54M |
| Edwards Lifesciences Corp | 576,900 | 545,000 | -31,900 | $38.07M | $40.35M | 1.54% | +$2.28M |
| Insmed Incorporated(INSM) | 683,344 | 550,000 | -133,344 | $49.88M | $37.97M | 1.45% | -$11.91M |
| Merus N V | 892,549 | 892,549 | 0 | $44.59M | $37.53M | 1.43% | -$7.06M |
| Sarepta Therapeutics, Inc.(SRPT) | 307,500 | 307,500 | 0 | $38.40M | $37.39M | 1.42% | -$1.01M |
| iRhythm Holdings, Inc.(IRTC) | 397,500 | 397,500 | 0 | $29.51M | $35.84M | 1.36% | +$6.33M |
| Zai Lab LimitedADR(ZLAB) | 1,315,673 | 1,305,337 | -10,336 | $31.76M | $34.19M | 1.30% | +$2.43M |
| Nuvalent Inc | 429,994 | 429,994 | 0 | $43.99M | $33.66M | 1.28% | -$10.33M |
| Mereo BioPharma Group plcADS(MREO) | 9,534,170 | 9,599,170 | +65,000 | $39.19M | $33.60M | 1.28% | -$5.59M |
| Scholar Rock Holding Corporation(SRRK) | 0 | 716,782 | +716,782 | $0 | $30.98M | 1.18% | +$30.98M |
| Celldex Therapeutics, Inc.(CLDX) | 1,103,778 | 1,222,182 | +118,404 | $37.52M | $30.88M | 1.18% | -$6.63M |
| Insulet Corporation(PODD) | 134,000 | 114,250 | -19,750 | $31.19M | $29.83M | 1.14% | -$1.36M |
| Structure Therapeutics IncADS | 1,063,910 | 1,080,963 | +17,053 | $46.70M | $29.32M | 1.12% | -$17.38M |
| DexCom, Inc.(DXCM) | 524,000 | 353,000 | -171,000 | $35.13M | $27.45M | 1.05% | -$7.68M |
| Akero Therapeutics Inc | 933,399 | 946,499 | +13,100 | $26.78M | $26.33M | 1.00% | -$447.6K |
| Endeavour Silver Corp.(EXK) | 1,147,500 | 450,000 | -697,500 | $78.17M | $25.29M | 0.96% | -$52.88M |
| Amicus Therapeutics Inc COM | 1,250,280 | 2,599,425 | +1,349,145 | $13.35M | $24.49M | 0.93% | +$11.13M |
| Inspire Medical Systems, Inc.(INSP) | 130,000 | 130,000 | 0 | $27.44M | $24.10M | 0.92% | -$3.34M |
| Azenta, Inc.(AZTA) | 532,500 | 475,000 | -57,500 | $25.79M | $23.75M | 0.90% | -$2.04M |
| Evolent Health, Inc.CL A(EVH) | 2,070,000 | 2,060,000 | -10,000 | $58.54M | $23.18M | 0.88% | -$35.36M |
| Acadia Healthcare Company, Inc.(ACHC) | 815,000 | 583,500 | -231,500 | $51.68M | $23.14M | 0.88% | -$28.54M |
| Immunovant, Inc.(IMVT) | 1,221,309 | 909,103 | -312,206 | $34.82M | $22.52M | 0.86% | -$12.30M |
| Warby Parker Inc.CL A(WRBY) | 1,439,050 | 920,000 | -519,050 | $23.50M | $22.27M | 0.85% | -$1.23M |
| Vera Therapeutics, Inc.CL A(VERA) | 383,492 | 487,863 | +104,371 | $16.95M | $20.63M | 0.79% | +$3.68M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 3,622,358 | 2,677,996 | -944,362 | $27.53M | $20.14M | 0.77% | -$7.39M |
| Newamsterdam Pharma Company ORDINARY SHARES | 353,319 | 767,522 | +414,203 | $5.87M | $19.73M | 0.75% | +$13.86M |
| Summit Therapeutics Inc.(SMMT) | 1,040,000 | 1,054,000 | +14,000 | $22.78M | $18.81M | 0.72% | -$3.97M |
| LifeStance Health Group, Inc.(LFST) | 3,101,000 | 2,550,000 | -551,000 | $21.71M | $18.79M | 0.72% | -$2.91M |
| Legend Biotech CorporationADS(LEGN) | 508,932 | 512,132 | +3,200 | $24.80M | $16.66M | 0.63% | -$8.14M |
| Tenet Healthcare Corporation(THC) | 0 | 129,200 | +129,200 | $0 | $16.31M | 0.62% | +$16.31M |
| Agios Pharmaceuticals, Inc.(AGIO) | 699,389 | 471,086 | -228,303 | $31.07M | $15.48M | 0.59% | -$15.59M |
| Aclaris Therapeutics, Inc.(ACRS) | 2,753,495 | 6,204,309 | +3,450,814 | $3.17M | $15.39M | 0.59% | +$12.22M |
| Crinetics Pharmaceuticals In | 289,400 | 294,100 | +4,700 | $14.79M | $15.04M | 0.57% | +$249.0K |
| Pharvaris N V COM | 756,931 | 775,131 | +18,200 | $14.02M | $14.86M | 0.57% | +$840.9K |
| agilon health, inc.(AGL) | 9,096,800 | 7,463,300 | -1,633,500 | $35.75M | $14.18M | 0.54% | -$21.57M |
| Oscar Health, Inc.CL A(OSCR) | 1,011,400 | 1,050,000 | +38,600 | $21.45M | $14.11M | 0.54% | -$7.34M |
| Springworks Therapeutics Inc | 199,855 | 328,911 | +129,056 | $6.40M | $11.88M | 0.45% | +$5.48M |
| Dyne Therapeutics, Inc.(DYN) | 461,028 | 474,528 | +13,500 | $16.56M | $11.18M | 0.43% | -$5.38M |
| Janux Therapeutics, Inc.(JANX) | 0 | 204,466 | +204,466 | $0 | $10.95M | 0.42% | +$10.95M |
| Inozyme Pharma Inc | 3,802,883 | 3,861,983 | +59,100 | $19.89M | $10.70M | 0.41% | -$9.19M |
| Neumora Therapeutics, Inc.(NMRA) | 828,101 | 955,106 | +127,005 | $10.94M | $10.12M | 0.39% | -$815.1K |
| Jasper Therapeutics, Inc.(JSPR) | 459,088 | 463,088 | +4,000 | $8.64M | $9.90M | 0.38% | +$1.27M |
| Enliven Therapeutics Inc | 428,571 | 428,571 | 0 | $10.95M | $9.64M | 0.37% | -$1.30M |
| Xencor, Inc.(XNCR) | 401,013 | 401,013 | 0 | $8.06M | $9.22M | 0.35% | +$1.15M |
| Cullinan Therapeutics, Inc.(CGEM) | 736,914 | 742,114 | +5,200 | $12.34M | $9.04M | 0.34% | -$3.30M |
| Prothena Corp PlcSHS SHS | 625,048 | 644,601 | +19,553 | $10.46M | $8.93M | 0.34% | -$1.53M |
| Compass Therapeutics, Inc.(CMPX) | 5,629,239 | 5,779,575 | +150,336 | $10.36M | $8.38M | 0.32% | -$1.98M |
| Bicara Therapeutics Inc | 445,975 | 445,975 | 0 | $11.36M | $7.77M | 0.30% | -$3.59M |
| Ardelyx Inc | 0 | 1,463,629 | +1,463,629 | $0 | $7.42M | 0.28% | +$7.42M |
| Zenas BioPharma, Inc.(ZBIO) | 878,667 | 878,667 | 0 | $14.87M | $7.20M | 0.27% | -$7.67M |
| Beam Therapeutics Inc.(BEAM) | 249,923 | 252,223 | +2,300 | $6.12M | $6.26M | 0.24% | +$132.0K |
| Tarsus Pharmaceuticals, Inc.(TARS) | 0 | 110,889 | +110,889 | $0 | $6.14M | 0.23% | +$6.14M |
| Nevro Corp | 1,381,500 | 1,648,100 | +266,600 | $7.72M | $6.13M | 0.23% | -$1.59M |
| Soleno Therapeutics Inc | 0 | 124,095 | +124,095 | $0 | $5.58M | 0.21% | +$5.58M |
| Pliant Therapeutics, Inc.(PLRX) | 384,996 | 404,796 | +19,800 | $4.32M | $5.33M | 0.20% | +$1.02M |
| Pulmonx Corporation(LUNG) | 691,300 | 772,151 | +80,851 | $5.73M | $5.24M | 0.20% | -$488.0K |
| Novavax, Inc.(NVAX) | 650,000 | 650,000 | 0 | $8.21M | $5.23M | 0.20% | -$2.98M |
| Gossamer Bio, Inc.NOTE 5 000 6 0(GOSS) | 0 | 0 | 0 | $5.01M | $5.07M | 0.19% | +$57.3K |
| Mersana Therapeutics Inc | 3,046,782 | 3,431,684 | +384,902 | $5.76M | $4.91M | 0.19% | -$851.1K |
| Biohaven Ltd.(BHVN) | 127,558 | 129,858 | +2,300 | $6.37M | $4.85M | 0.18% | -$1.52M |
| 89bio Inc | 0 | 552,741 | +552,741 | $0 | $4.32M | 0.16% | +$4.32M |
| Cypherpunk Technologies Inc.(CYPH) | 1,266,546 | 1,266,546 | 0 | $3.26M | $3.64M | 0.14% | +$386.3K |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 787,808 | 787,808 | 0 | $2.18M | $3.55M | 0.13% | +$1.36M |
| EDAP TMS S.A.ADR(FOCL) | 1,568,000 | 1,591,800 | +23,800 | $4.00M | $3.52M | 0.13% | -$480.5K |
| MacroGenics, Inc.(MGNX) | 1,053,647 | 1,053,647 | 0 | $3.47M | $3.42M | 0.13% | -$42.1K |
| Acumen Pharmaceuticals, Inc.(ABOS) | 2,300,059 | 1,838,916 | -461,143 | $5.70M | $3.16M | 0.12% | -$2.54M |
| Gossamer Bio, Inc.(GOSS) | 3,266,960 | 3,266,960 | 0 | $3.22M | $2.96M | 0.11% | -$267.2K |
| Xilio Therapeutics, Inc.(XLO) | 3,003,259 | 3,003,259 | 0 | $2.37M | $2.87M | 0.11% | +$502.4K |
| Apellis Pharmaceuticals Inc COM | 80,000 | 80,000 | 0 | $2.31M | $2.55M | 0.10% | +$245.6K |
| Autolus Therapeutics plcADS(AUTL) | 1,032,988 | 1,032,988 | 0 | $3.75M | $2.43M | 0.09% | -$1.32M |
| Neurogene Inc.(NGNE) | 0 | 95,407 | +95,407 | $0 | $2.18M | 0.08% | +$2.18M |
| Alphatec Holdings, Inc.(ATEC) | 0 | 200,000 | +200,000 | $0 | $1.84M | 0.07% | +$1.84M |
| Applied Therapeutics Inc | 1,746,449 | 1,917,191 | +170,742 | $14.84M | $1.64M | 0.06% | -$13.20M |
| Compugen Ltd.(CGEN) | 989,990 | 989,990 | 0 | $1.79M | $1.51M | 0.06% | -$277.2K |
| Perspective Therapeutics, Inc.(CATX) | 414,396 | 444,383 | +29,987 | $5.53M | $1.42M | 0.05% | -$4.11M |
| Korro Bio, Inc.(KRRO) | 35,719 | 35,719 | 0 | $1.19M | $1.36M | 0.05% | +$166.1K |
| Adaptimmune Therapeutics plcADR(ADAPY) | 2,425,468 | 2,483,468 | +58,000 | $2.31M | $1.34M | 0.05% | -$967.3K |
| Allakos Inc | 1,200,409 | 1,100,409 | -100,000 | $784.1K | $1.33M | 0.05% | +$547.4K |
| Spruce Biosciences Inc | 2,609,125 | 2,609,125 | 0 | $1.24M | $1.10M | 0.04% | -$143.2K |
| LENZ Therapeutics, Inc.(LENZ) | 0 | 29,305 | +29,305 | $0 | $846.0K | 0.03% | +$846.0K |