Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| REVOLUTION MEDICINES INC(RVMD) | 1,335,270 | 1,335,270 | 0 | 62,357 | 106,354 | 5.45% | +43,997 |
| ELI LILLY & CO(LLY) | 105,400 | 105,400 | 0 | 80,420 | 113,271 | 5.81% | +32,851 |
| TRAVERE THERAPEUTICS INC(TVTX) | 2,164,773 | 2,210,322 | +45,549 | 51,738 | 84,456 | 4.33% | +32,718 |
| EXACT SCIENCES CORP(EXK) | 593,500 | 601,800 | +8,300 | 32,470 | 61,119 | 3.13% | +28,648 |
| SPDR SERIES TRUST ST STR SP BIOT | 0 | 222,000 | +222,000 | 0 | 27,068 | 1.39% | +27,068 |
| STRUCTURE THERAPEUTICS INC | 951,154 | 748,236 | -202,918 | 26,632 | 52,040 | 2.67% | +25,408 |
| CIDARA THERAPEUTICS INC | 249,402 | 204,878 | -44,524 | 23,883 | 45,256 | 2.32% | +21,373 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 137,746 | 139,618 | +1,872 | 63,179 | 81,305 | 4.17% | +18,127 |
| COGENT BIOSCIENCES INC(COGT) | 1,008,308 | 849,030 | -159,278 | 14,479 | 30,158 | 1.55% | +15,678 |
| UNITEDHEALTH GROUP INC(UNH) | 0 | 40,800 | +40,800 | 0 | 13,468 | 0.69% | +13,468 |
| KYMERA THERAPEUTICS INC(KYMR) | 450,374 | 496,871 | +46,497 | 25,491 | 38,662 | 1.98% | +13,170 |
| AMICUS THERAPEUTICS INC COM | 1,947,374 | 1,929,931 | -17,443 | 15,345 | 27,482 | 1.41% | +12,137 |
| VERA THERAPEUTICS INC(VERA) | 617,396 | 568,579 | -48,817 | 17,942 | 28,793 | 1.48% | +10,851 |
| INTUITIVE SURGICAL INC | 82,000 | 82,000 | 0 | 36,673 | 46,442 | 2.38% | +9,769 |
| IMMUNOME INC(IMNM) | 0 | 347,666 | +347,666 | 0 | 7,468 | 0.38% | +7,468 |
| DYNE THERAPEUTICS INC(DYN) | 824,061 | 912,955 | +88,894 | 10,424 | 17,857 | 0.92% | +7,433 |
| RAPT THERAPEUTICS INC | 0 | 213,731 | +213,731 | 0 | 7,239 | 0.37% | +7,239 |
| PENUMBRA INC(PEN) | 120,500 | 120,500 | 0 | 30,525 | 37,465 | 1.92% | +6,940 |
| CENTESSA PHARMACEUTICALS PLC | 69,240 | 324,015 | +254,775 | 1,679 | 8,104 | 0.42% | +6,425 |
| COMPASS THERAPEUTICS INC | 4,474,702 | 3,927,202 | -547,500 | 15,661 | 21,089 | 1.08% | +5,428 |
| ZENAS BIOPHARMA INC(ZBIO) | 580,677 | 502,077 | -78,600 | 12,891 | 18,230 | 0.93% | +5,339 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 89,750 | 125,500 | +35,750 | 12,599 | 17,800 | 0.91% | +5,201 |
| SURGERY PARTNERS INC(SGRY) | 0 | 310,000 | +310,000 | 0 | 4,790 | 0.25% | +4,790 |
| PTC THERAPEUTICS INC(PTCT) | 0 | 61,879 | +61,879 | 0 | 4,700 | 0.24% | +4,700 |
| ACLARIS THERAPEUTICS INC(ACRS) | 4,609,309 | 4,453,741 | -155,568 | 8,758 | 13,406 | 0.69% | +4,648 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 761,126 | 762,294 | +1,168 | 55,798 | 60,214 | 3.09% | +4,415 |
| TERNS PHARMACEUTICALS INC | 0 | 108,481 | +108,481 | 0 | 4,383 | 0.22% | +4,383 |
| ARCUS BIOSCIENCES INC(RCUS) | 0 | 180,000 | +180,000 | 0 | 4,289 | 0.22% | +4,289 |
| EYEPOINT INC(EYPT) | 31,655 | 258,739 | +227,084 | 451 | 4,727 | 0.24% | +4,276 |
| TARSUS PHARMACEUTICALS INC(TARS) | 288,344 | 260,344 | -28,000 | 17,136 | 21,317 | 1.09% | +4,181 |
| MBX BIOSCIENCES INC(MBX) | 282,624 | 282,624 | 0 | 4,946 | 8,914 | 0.46% | +3,968 |
| THERAVANCE BIOPHARMA INC(TBPH) | 0 | 208,771 | +208,771 | 0 | 3,906 | 0.20% | +3,906 |
| INSPIRE MED SYS INC(INSP) | 110,500 | 131,000 | +20,500 | 8,199 | 12,082 | 0.62% | +3,883 |
| INDIVIOR PLC | 0 | 105,100 | +105,100 | 0 | 3,771 | 0.19% | +3,771 |
| ERASCA INC(ERAS) | 0 | 951,710 | +951,710 | 0 | 3,540 | 0.18% | +3,540 |
| BRIDGEBIO PHARMA INC(BBIO) | 85,000 | 103,500 | +18,500 | 4,415 | 7,917 | 0.41% | +3,502 |
| TANGO THERAPEUTICS INC(TNGX) | 0 | 386,915 | +386,915 | 0 | 3,428 | 0.18% | +3,428 |
| AZENTA INC(AZTA) | 540,400 | 569,100 | +28,700 | 15,520 | 18,928 | 0.97% | +3,408 |
| MERSANA THERAPEUTICS INC | 152,586 | 152,586 | 0 | 1,184 | 4,414 | 0.23% | +3,230 |
| BOSTON SCIENTIFIC CORP(BSX) | 360,250 | 399,050 | +38,800 | 35,171 | 38,049 | 1.95% | +2,878 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 794,133 | 733,477 | -60,656 | 29,574 | 32,310 | 1.66% | +2,736 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 595,929 | 557,194 | -38,735 | 16,948 | 19,546 | 1.00% | +2,598 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 98,240 | +98,240 | 0 | 2,456 | 0.13% | +2,456 |
| CYTOKINETICS INC(CYTK) | 0 | 35,853 | +35,853 | 0 | 2,278 | 0.12% | +2,278 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 717,102 | 695,010 | -22,092 | 72,420 | 74,394 | 3.81% | +1,974 |
| ALPHATEC HLDGS INC(ATEC) | 302,500 | 302,500 | 0 | 4,398 | 6,365 | 0.33% | +1,966 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 88,750 | +88,750 | 0 | 1,926 | 0.10% | +1,926 |
| DANAHER CORPORATION(DHR) | 61,500 | 61,500 | 0 | 12,193 | 14,079 | 0.72% | +1,886 |
| VAXCYTE INC(PCVX) | 11,100 | 47,000 | +35,900 | 400 | 2,169 | 0.11% | +1,769 |
| CORCEPT THERAPEUTICS INC(CORT) | 0 | 50,250 | +50,250 | 0 | 1,749 | 0.09% | +1,749 |
| PHARVARIS N V COM | 623,402 | 623,402 | 0 | 15,554 | 17,299 | 0.89% | +1,746 |
| DEXCOM INC(DXCM) | 316,900 | 347,300 | +30,400 | 21,324 | 23,050 | 1.18% | +1,726 |
| APELLIS PHARMACEUTICALS INC COM | 92,000 | 150,500 | +58,500 | 2,082 | 3,781 | 0.19% | +1,699 |
| GOSSAMER BIO INC | 3,266,960 | 3,266,960 | 0 | 8,592 | 10,128 | 0.52% | +1,535 |
| REGENERON PHARMACEUTICALS(REGN) | 11,300 | 10,100 | -1,200 | 6,354 | 7,796 | 0.40% | +1,442 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 0 | 45,500 | +45,500 | 0 | 1,420 | 0.07% | +1,420 |
| BICARA THERAPEUTICS INC | 370,666 | 429,095 | +58,429 | 5,853 | 7,222 | 0.37% | +1,369 |
| EDAP TMS S A | 1,270,000 | 1,286,500 | +16,500 | 2,908 | 4,233 | 0.22% | +1,324 |
| IRHYTHM TECHNOLOGIES INC(IRTC) | 235,000 | 235,000 | 0 | 40,418 | 41,698 | 2.14% | +1,281 |
| SIONNA THERAPEUTICS INC | 99,429 | 99,429 | 0 | 2,924 | 4,091 | 0.21% | +1,166 |
| XENON PHARMACEUTICALS INC(XENE) | 851,744 | 787,788 | -63,956 | 34,198 | 35,309 | 1.81% | +1,111 |
| SOLENO THERAPEUTICS INC | 154,528 | 247,053 | +92,525 | 10,446 | 11,439 | 0.59% | +992 |
| THERMO FISHER SCIENTIFIC INC(TMO) | 10,000 | 10,000 | 0 | 4,850 | 5,795 | 0.30% | +944 |
| TALPHERA INC | 3,589,186 | 3,589,186 | 0 | 3,206 | 4,092 | 0.21% | +886 |
| ARDELYX INC | 2,286,273 | 2,299,473 | +13,200 | 12,597 | 13,406 | 0.69% | +809 |
| ASCENDIS PHARMA A/S(ASND) | 214,500 | 203,500 | -11,000 | 42,645 | 43,394 | 2.23% | +750 |
| LEGEND BIOTECH CORP(LEGN) | 0 | 33,800 | +33,800 | 0 | 735 | 0.04% | +735 |
| ALKERMES PLC(ALKS) | 106,537 | 139,228 | +32,691 | 3,196 | 3,896 | 0.20% | +699 |
| OCULAR THERAPEUTIX INC(OCUL) | 300,000 | 345,820 | +45,820 | 3,507 | 4,198 | 0.22% | +691 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 28,200 | 61,700 | +33,500 | 202 | 813 | 0.04% | +611 |
| NEUROGENE INC | 104,339 | 104,339 | 0 | 1,808 | 2,149 | 0.11% | +341 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 0 | 1,750 | +1,750 | 0 | 298 | 0.02% | +298 |
| NEWAMSTERDAM PHARMA COMPANY(Call) ORDINARY SHARES | 31,600 | 31,600 | 0 | 899 | 1,109 | — | +210 |
| EDWARDS LIFESCIENCES CORP | 88,000 | 82,500 | -5,500 | 6,844 | 7,033 | 0.36% | +189 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 721,538 | 692,538 | -29,000 | 18,666 | 18,809 | 0.96% | +143 |
| INSMED INC(INSM) | 385,000 | 319,250 | -65,750 | 55,444 | 55,562 | 2.85% | +118 |
| MINERALYS THERAPEUTICS INC(MLYS) | 408,313 | 427,596 | +19,283 | 15,483 | 15,517 | 0.80% | +34 |
| NUVATION BIO INC(NUVB) | 134,028 | 134,028 | 0 | 27 | 44 | 0.00% | +17 |
| COMPUGEN LTD | 13,430 | 0 | -13,430 | 20 | 0 | — | -20 |
| GOSSAMER BIO INC | 0 | 0 | 0 | 6,719 | 6,559 | 0.34% | -159 |
| JANUX THERAPEUTICS INC(JANX) | 210,366 | 358,798 | +148,432 | 5,141 | 4,951 | 0.25% | -190 |
| PROTHENA CORP PLC SHS | 25,398 | 0 | -25,398 | 248 | 0 | — | -248 |
| HEARTFLOW INC(HTFL) | 250,000 | 277,700 | +27,700 | 8,415 | 8,095 | 0.42% | -320 |
| NOVAVAX INC(NVAX) | 45,000 | 0 | -45,000 | 390 | 0 | — | -390 |
| CHARLES RIV LABS INTL INC(CRL) | 2,700 | 0 | -2,700 | 422 | 0 | — | -422 |
| TENET HEALTHCARE CORP(THC) | 125,000 | 125,000 | 0 | 25,380 | 24,840 | 1.27% | -540 |
| JASPER THERAPEUTICS INC | 1,100,726 | 1,100,726 | 0 | 2,620 | 2,014 | 0.10% | -605 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 499,764 | 499,764 | 0 | 6,792 | 6,037 | 0.31% | -755 |
| IMMUNOVANT INC(IMVT) | 72,965 | 0 | -72,965 | 1,176 | 0 | — | -1,176 |
| APPLIED THERAPEUTICS INC | 2,075,991 | 0 | -2,075,991 | 1,256 | 0 | — | -1,256 |
| PERSPECTIVE THERAPEUTICS INC | 444,383 | 0 | -444,383 | 1,524 | 0 | — | -1,524 |
| KORRO BIO INC | 35,719 | 0 | -35,719 | 1,711 | 0 | — | -1,711 |
| ENLIVEN THERAPEUTICS INC | 686,107 | 798,405 | +112,298 | 14,045 | 12,295 | 0.63% | -1,749 |
| SUMMIT THERAPEUTICS INC(SMMT) | 710,000 | 710,000 | 0 | 14,669 | 12,418 | 0.64% | -2,251 |
| ACADIA HEALTHCARE COMPANY IN(ACHC) | 170,000 | 120,000 | -50,000 | 4,209 | 1,703 | 0.09% | -2,506 |
| WEST PHARMACEUTICAL SVSC INC(WST) | 9,750 | 0 | -9,750 | 2,558 | 0 | — | -2,558 |
| AGILON HEALTH INC(AGL) | 6,966,300 | 6,500,000 | -466,300 | 7,175 | 4,477 | 0.23% | -2,699 |
| PHREESIA INC | 749,116 | 876,600 | +127,484 | 17,619 | 14,832 | 0.76% | -2,787 |
| ARCELLX INC COMMON STOCK | 178,982 | 169,859 | -9,123 | 14,694 | 11,075 | 0.57% | -3,620 |
| CARIS LIFE SCIENCES INC(CAI) | 793,651 | 687,500 | -106,151 | 24,008 | 18,549 | 0.95% | -5,459 |