Rock Springs Capital Management LP
Comparing Q4 2025 vs Q3 2025
Sorting applies to all holdings for this quarter on the server, then the page is sliced. Prior-quarter values come from the full prior-quarter filing.
Issuer ▲▼ | Shares | Value ($K) | ||||
|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | |
| REVOLUTION MEDICINES INC | 1,335,270 | 1,335,270 | 0 | 62,357,109 | 106,354,256 | +43,997,147 |
| ELI LILLY & CO | 105,400 | 105,400 | 0 | 80,420,200 | 113,271,272 | +32,851,072 |
| TRAVERE THERAPEUTICS INC | 2,164,773 | 2,210,322 | +45,549 | 51,738,075 | 84,456,404 | +32,718,329 |
| EXACT SCIENCES CORP | 593,500 | 601,800 | +8,300 | 32,470,385 | 61,118,808 | +28,648,423 |
| SPDR SERIES TRUST | 0 | 222,000 | +222,000 | 0 | 27,068,460 | +27,068,460 |
| STRUCTURE THERAPEUTICS INC | 951,154 | 748,236 | -202,918 | 26,632,312 | 52,039,814 | +25,407,502 |
| CIDARA THERAPEUTICS INC | 249,402 | 204,878 | -44,524 | 23,882,736 | 45,255,501 | +21,372,765 |
| MADRIGAL PHARMACEUTICALS INC | 137,746 | 139,618 | +1,872 | 63,178,580 | 81,305,146 | +18,126,566 |
| COGENT BIOSCIENCES INC | 1,008,308 | 849,030 | -159,278 | 14,479,303 | 30,157,546 | +15,678,243 |
| UNITEDHEALTH GROUP INC | 0 | 40,800 | +40,800 | 0 | 13,468,488 | +13,468,488 |
| KYMERA THERAPEUTICS INC | 450,374 | 496,871 | +46,497 | 25,491,168 | 38,661,533 | +13,170,365 |
| AMICUS THERAPEUTICS INC | 1,947,374 | 1,929,931 | -17,443 | 15,345,307 | 27,482,217 | +12,136,910 |
| VERA THERAPEUTICS INC | 617,396 | 568,579 | -48,817 | 17,941,528 | 28,792,841 | +10,851,313 |
| INTUITIVE SURGICAL INC | 82,000 | 82,000 | 0 | 36,672,860 | 46,441,520 | +9,768,660 |
| IMMUNOME INC | 0 | 347,666 | +347,666 | 0 | 7,467,866 | +7,467,866 |
| DYNE THERAPEUTICS INC | 824,061 | 912,955 | +88,894 | 10,424,372 | 17,857,400 | +7,433,028 |
| RAPT THERAPEUTICS INC | 0 | 213,731 | +213,731 | 0 | 7,239,069 | +7,239,069 |
| PENUMBRA INC | 120,500 | 120,500 | 0 | 30,525,060 | 37,464,655 | +6,939,595 |
| CENTESSA PHARMACEUTICALS PLC | 69,240 | 324,015 | +254,775 | 1,679,070 | 8,103,615 | +6,424,545 |
| COMPASS THERAPEUTICS INC | 4,474,702 | 3,927,202 | -547,500 | 15,661,457 | 21,089,075 | +5,427,618 |
| ZENAS BIOPHARMA INC | 580,677 | 502,077 | -78,600 | 12,891,029 | 18,230,416 | +5,339,387 |
| NEUROCRINE BIOSCIENCES INC | 89,750 | 125,500 | +35,750 | 12,599,105 | 17,799,665 | +5,200,560 |
| SURGERY PARTNERS INC | 0 | 310,000 | +310,000 | 0 | 4,789,500 | +4,789,500 |
| PTC THERAPEUTICS INC | 0 | 61,879 | +61,879 | 0 | 4,700,329 | +4,700,329 |
| ACLARIS THERAPEUTICS INC | 4,609,309 | 4,453,741 | -155,568 | 8,757,687 | 13,405,760 | +4,648,073 |
| MIRUM PHARMACEUTICALS INC | 761,126 | 762,294 | +1,168 | 55,798,147 | 60,213,603 | +4,415,456 |
| TERNS PHARMACEUTICALS INC | 0 | 108,481 | +108,481 | 0 | 4,382,632 | +4,382,632 |
| ARCUS BIOSCIENCES INC | 0 | 180,000 | +180,000 | 0 | 4,289,400 | +4,289,400 |
| EYEPOINT INC | 31,655 | 258,739 | +227,084 | 450,767 | 4,727,162 | +4,276,395 |
| TARSUS PHARMACEUTICALS INC | 288,344 | 260,344 | -28,000 | 17,136,284 | 21,316,967 | +4,180,683 |
| MBX BIOSCIENCES INC | 282,624 | 282,624 | 0 | 4,945,920 | 8,913,961 | +3,968,041 |
| THERAVANCE BIOPHARMA INC | 0 | 208,771 | +208,771 | 0 | 3,906,105 | +3,906,105 |
| INSPIRE MED SYS INC | 110,500 | 131,000 | +20,500 | 8,199,100 | 12,082,130 | +3,883,030 |
| INDIVIOR PLC | 0 | 105,100 | +105,100 | 0 | 3,770,988 | +3,770,988 |
| ERASCA INC | 0 | 951,710 | +951,710 | 0 | 3,540,361 | +3,540,361 |
| BRIDGEBIO PHARMA INC | 85,000 | 103,500 | +18,500 | 4,414,900 | 7,916,715 | +3,501,815 |
| TANGO THERAPEUTICS INC | 0 | 386,915 | +386,915 | 0 | 3,428,067 | +3,428,067 |
| AZENTA INC | 540,400 | 569,100 | +28,700 | 15,520,288 | 18,928,266 | +3,407,978 |
| MERSANA THERAPEUTICS INC | 152,586 | 152,586 | 0 | 1,184,067 | 4,414,313 | +3,230,246 |
| BOSTON SCIENTIFIC CORP | 360,250 | 399,050 | +38,800 | 35,171,208 | 38,049,418 | +2,878,210 |
| SCHOLAR ROCK HLDG CORP | 794,133 | 733,477 | -60,656 | 29,573,513 | 32,309,662 | +2,736,149 |
| NEWAMSTERDAM PHARMA COMPANY | 595,929 | 557,194 | -38,735 | 16,948,221 | 19,546,366 | +2,598,145 |
| OLEMA PHARMACEUTICALS INC | 0 | 98,240 | +98,240 | 0 | 2,456,000 | +2,456,000 |
| CYTOKINETICS INC | 0 | 35,853 | +35,853 | 0 | 2,278,100 | +2,278,100 |
| RHYTHM PHARMACEUTICALS INC | 717,102 | 695,010 | -22,092 | 72,420,131 | 74,393,870 | +1,973,739 |
| ALPHATEC HLDGS INC | 302,500 | 302,500 | 0 | 4,398,350 | 6,364,600 | +1,966,250 |
| ROIVANT SCIENCES LTD | 0 | 88,750 | +88,750 | 0 | 1,925,875 | +1,925,875 |
| DANAHER CORPORATION | 61,500 | 61,500 | 0 | 12,192,990 | 14,078,580 | +1,885,590 |
| VAXCYTE INC | 11,100 | 47,000 | +35,900 | 399,822 | 2,168,580 | +1,768,758 |
| CORCEPT THERAPEUTICS INC | 0 | 50,250 | +50,250 | 0 | 1,748,700 | +1,748,700 |
| PHARVARIS N V | 623,402 | 623,402 | 0 | 15,553,880 | 17,299,406 | +1,745,526 |
| DEXCOM INC | 316,900 | 347,300 | +30,400 | 21,324,201 | 23,050,301 | +1,726,100 |
| APELLIS PHARMACEUTICALS INC | 92,000 | 150,500 | +58,500 | 2,081,960 | 3,780,560 | +1,698,600 |
| GOSSAMER BIO INC | 3,266,960 | 3,266,960 | 0 | 8,592,105 | 10,127,576 | +1,535,471 |
| REGENERON PHARMACEUTICALS | 11,300 | 10,100 | -1,200 | 6,353,651 | 7,795,887 | +1,442,236 |
| TEVA PHARMACEUTICAL INDS LTD | 0 | 45,500 | +45,500 | 0 | 1,420,055 | +1,420,055 |
| BICARA THERAPEUTICS INC | 370,666 | 429,095 | +58,429 | 5,852,816 | 7,221,669 | +1,368,853 |
| EDAP TMS S A | 1,270,000 | 1,286,500 | +16,500 | 2,908,300 | 4,232,585 | +1,324,285 |
| IRHYTHM TECHNOLOGIES INC | 235,000 | 235,000 | 0 | 40,417,650 | 41,698,400 | +1,280,750 |
| SIONNA THERAPEUTICS INC | 99,429 | 99,429 | 0 | 2,924,207 | 4,090,509 | +1,166,302 |
| XENON PHARMACEUTICALS INC | 851,744 | 787,788 | -63,956 | 34,197,522 | 35,308,658 | +1,111,136 |
| SOLENO THERAPEUTICS INC | 154,528 | 247,053 | +92,525 | 10,446,093 | 11,438,554 | +992,461 |
| THERMO FISHER SCIENTIFIC INC | 10,000 | 10,000 | 0 | 4,850,200 | 5,794,500 | +944,300 |
| TALPHERA INC | 3,589,186 | 3,589,186 | 0 | 3,205,861 | 4,091,672 | +885,811 |
| ARDELYX INC | 2,286,273 | 2,299,473 | +13,200 | 12,597,364 | 13,405,928 | +808,564 |
| ASCENDIS PHARMA A/S | 214,500 | 203,500 | -11,000 | 42,644,745 | 43,394,340 | +749,595 |
| LEGEND BIOTECH CORP | 0 | 33,800 | +33,800 | 0 | 734,812 | +734,812 |
| ALKERMES PLC | 106,537 | 139,228 | +32,691 | 3,196,110 | 3,895,599 | +699,489 |
| OCULAR THERAPEUTIX INC | 300,000 | 345,820 | +45,820 | 3,507,000 | 4,198,255 | +691,255 |
| MOONLAKE IMMUNOTHERAPEUTICS | 28,200 | 61,700 | +33,500 | 202,194 | 813,206 | +611,012 |
| NEUROGENE INC | 104,339 | 104,339 | 0 | 1,808,195 | 2,149,383 | +341,188 |
| JAZZ PHARMACEUTICALS PLC | 0 | 1,750 | +1,750 | 0 | 297,500 | +297,500 |
| NEWAMSTERDAM PHARMA COMPANY(Call) | 31,600 | 31,600 | 0 | 898,704 | 1,108,528 | +209,824 |
| EDWARDS LIFESCIENCES CORP | 88,000 | 82,500 | -5,500 | 6,843,760 | 7,033,125 | +189,365 |
| CELLDEX THERAPEUTICS INC NEW | 721,538 | 692,538 | -29,000 | 18,666,188 | 18,809,332 | +143,144 |
| INSMED INC | 385,000 | 319,250 | -65,750 | 55,443,850 | 55,562,270 | +118,420 |
| MINERALYS THERAPEUTICS INC | 408,313 | 427,596 | +19,283 | 15,483,229 | 15,517,459 | +34,230 |
| NUVATION BIO INC | 134,028 | 134,028 | 0 | 27,087 | 44,229 | +17,142 |
| GOSSAMER BIO INC | 0 | 0 | 0 | 6,718,513 | 6,559,037 | -159,476 |
| JANUX THERAPEUTICS INC | 210,366 | 358,798 | +148,432 | 5,141,345 | 4,951,412 | -189,933 |
| HEARTFLOW INC | 250,000 | 277,700 | +27,700 | 8,415,000 | 8,094,955 | -320,045 |
| TENET HEALTHCARE CORP | 125,000 | 125,000 | 0 | 25,380,000 | 24,840,000 | -540,000 |
| JASPER THERAPEUTICS INC | 1,100,726 | 1,100,726 | 0 | 2,619,728 | 2,014,329 | -605,399 |
| AMYLYX PHARMACEUTICALS INC | 499,764 | 499,764 | 0 | 6,791,793 | 6,037,149 | -754,644 |
| ENLIVEN THERAPEUTICS INC | 686,107 | 798,405 | +112,298 | 14,044,610 | 12,295,437 | -1,749,173 |
| SUMMIT THERAPEUTICS INC | 710,000 | 710,000 | 0 | 14,668,600 | 12,417,900 | -2,250,700 |
| ACADIA HEALTHCARE COMPANY IN | 170,000 | 120,000 | -50,000 | 4,209,200 | 1,702,800 | -2,506,400 |
| AGILON HEALTH INC | 6,966,300 | 6,500,000 | -466,300 | 7,175,289 | 4,476,550 | -2,698,739 |
| PHREESIA INC | 749,116 | 876,600 | +127,484 | 17,619,208 | 14,832,072 | -2,787,136 |
| ARCELLX INC | 178,982 | 169,859 | -9,123 | 14,694,422 | 11,074,807 | -3,619,615 |
| CARIS LIFE SCIENCES INC | 793,651 | 687,500 | -106,151 | 24,007,943 | 18,548,750 | -5,459,193 |
| ALNYLAM PHARMACEUTICALS INC | 74,250 | 71,250 | -3,000 | 33,858,000 | 28,332,563 | -5,525,437 |
| LENZ THERAPEUTICS INC | 236,227 | 257,460 | +21,233 | 11,003,454 | 4,119,360 | -6,884,094 |
| ULTRAGENYX PHARMACEUTICAL IN | 1,246,341 | 1,267,241 | +20,900 | 37,489,937 | 29,146,543 | -8,343,394 |
| OMADA HEALTH INC | 919,950 | 740,000 | -179,950 | 20,340,095 | 11,677,200 | -8,662,895 |
| ZAI LAB LTD | 791,193 | 811,546 | +20,353 | 26,813,531 | 14,315,671 | -12,497,860 |
| EVOLENT HEALTH INC | 2,950,000 | 2,675,000 | -275,000 | 24,957,000 | 10,700,000 | -14,257,000 |
| AGIOS PHARMACEUTICALS INC | 958,542 | 799,163 | -159,379 | 38,475,876 | 21,753,217 | -16,722,659 |
| ARGENX SE | 142,750 | 103,250 | -39,500 | 105,286,690 | 86,828,088 | -18,458,602 |