Fund Holdings — Opaleye Management Inc.

Total Portfolio Value:
$759.22M
Total Bought:
$146.70M
Total Sold:
$167.21M
Net Transaction:
-$20.51M
Notable People:
James Aaron Silverman
Securities
▲▼
SharesValue
Q4 2025
▲▼
Q1 2026
▲▼
Change
▲▼
Q4 2025
▲▼
Q1 2026
▲▼
Weight (%)
▲▼
Change
▲▼
Harrow, Inc.(HROW)3,905,0002,832,230-1,072,770$191.34M$99.86M13.15%-$91.48M
Liquidia Corporation(LQDA)2,435,0002,545,000+110,000$84.98M$88.82M11.70%+$3.84M
Eton Pharmaceuticals, Inc.(ETON)2,860,0002,860,0000$48.36M$70.58M9.30%+$22.22M
Sol-Gel Technologies LtdSHS NEW
SHS NEW
453,739500,000+46,261$19.12M$39.61M5.22%+$20.49M
Rhythm Pharmaceuticals, Inc.(RYTM)330,000123,000-207,000$35.32M$35.32M4.65%$0
Apogee Therapeutics Inc388,257390,000+1,743$29.31M$32.83M4.32%+$3.52M
Disc Medicine, Inc.(IRON)200,000421,000+221,000$15.88M$26.92M3.55%+$11.04M
UroGen Pharma Ltd.(URGN)268,4231,430,000+1,161,577$6.29M$25.71M3.39%+$19.42M
Crescent Biopharma, Inc.(CBIO)1,178,3001,312,615+134,315$13.97M$24.11M3.18%+$10.14M
Stoke Therapeutics, Inc.(STOK)695,000700,000+5,000$22.06M$22.79M3.00%+$732.7K
Perspective Therapeutics, Inc.(CATX)1,184,5004,675,000+3,490,500$4.99M$19.49M2.57%+$14.50M
Rezolute, Inc.(RZLT)6,287,1566,300,000+12,844$14.84M$19.21M2.53%+$4.38M
MeiraGTx Holdings plc(MGTX)390,8442,123,259+1,732,415$3.11M$18.39M2.42%+$15.28M
TG Therapeutics, Inc.(TGTX)535,000535,0000$15.95M$17.77M2.34%+$1.82M
SANUWAVE Health, Inc.(SNWV)981,267981,2670$29.28M$16.97M2.23%-$12.31M
Edgewise Therapeutics, Inc.(EWTX)500,000500,0000$12.41M$15.75M2.07%+$3.34M
Alpha Cognition Inc. Common Stock(ACOG)2,070,7842,561,950+491,166$13.46M$14.07M1.85%+$605.0K
Annexon, Inc.(ANNX)2,600,0002,331,761-268,239$13.05M$12.92M1.70%-$134.0K
Alumis Inc535,000550,000+15,000$5.22M$12.12M1.60%+$6.89M
Codexis, Inc.(CDXS)6,789,7386,785,000-4,738$11.07M$11.06M1.46%-$7.7K
Protagonist Therapeutics Inc105,000100,000-5,000$9.17M$10.54M1.39%+$1.37M
Revolution Medicines, Inc.(RVMD)100,000100,0000$7.96M$9.72M1.28%+$1.76M
Xoma Royalty Corporation292,590300,000+7,410$7.78M$9.41M1.24%+$1.63M
Q32 Bio Inc.(QTTB)213,3631,256,228+1,042,865$708.4K$8.06M1.06%+$7.36M
MBX Biosciences, Inc.(MBX)260,000260,0000$8.20M$7.76M1.02%-$439.4K
Relmada Therapeutics, Inc.(RLMD)935,000935,0000$4.52M$6.51M0.86%+$1.99M
CG Oncology, Inc.(CGON)410,00094,800-315,200$17.02M$6.42M0.85%-$10.61M
Jade Biosciences Inc427,608427,6080$6.60M$6.01M0.79%-$590.1K
Ocular Therapeutix, Inc.(OCUL)1,595,000600,000-995,000$19.36M$5.08M0.67%-$14.28M
Assertio Holdings Inc0265,707+265,707$0$5.06M0.67%+$5.06M
Editas Medicine, Inc.(EDIT)01,926,997+1,926,997$0$4.76M0.63%+$4.76M
Sutro Biopharma, Inc.(STRO)190,671190,6710$2.21M$4.75M0.63%+$2.54M
Journey Medical Corporation(DERM)975,000960,000-15,000$7.52M$4.50M0.59%-$3.01M
Voyager Therapeutics, Inc.(VYGR)1,196,9041,150,000-46,904$4.70M$4.44M0.58%-$264.8K
Trevi Therapeutics, Inc.(TRVI)345,100345,1000$4.32M$4.12M0.54%-$203.6K
Tectonic Therapeutic, Inc.(TECX)214,747123,000-91,747$4.48M$3.80M0.50%-$677.7K
Cabaletta Bio, Inc.(CABA)900,0001,380,000+480,000$1.97M$3.71M0.49%+$1.74M
Biodesix, Inc.(BDSX)0238,047+238,047$0$3.45M0.45%+$3.45M
Rocket Pharmaceuticals, Inc.(RCKT)955,000955,0000$3.35M$3.42M0.45%+$66.8K
Zentalis Pharmaceuticals, Inc.(ZNTL)1,400,9061,412,656+11,750$1.89M$3.31M0.44%+$1.41M
Intellia Therapeutics, Inc.(NTLA)0245,000+245,000$0$3.14M0.41%+$3.14M
Fortress Biotech, Inc.(FBIO)1,090,0001,042,000-48,000$3.99M$2.91M0.38%-$1.08M
Opus Genetics, Inc.(IRD)1,120,0001,120,0000$2.25M$2.25M0.30%$0
Rigel Pharmaceuticals, Inc.(RIGL)70,00070,0000$3.00M$1.89M0.25%-$1.11M
Atea Pharmaceuticals, Inc.(AVIR)179,815322,600+142,785$641.9K$1.74M0.23%+$1.09M
Lyell Immunopharma, Inc.(LYEL)079,097+79,097$0$1.59M0.21%+$1.59M
Enanta Pharmaceuticals, Inc.(ENTA)75,000125,000+50,000$1.18M$1.58M0.21%+$396.0K
Nextcure Inc0141,181+141,181$0$1.51M0.20%+$1.51M
4d Molecular Therapeutics In0112,291+112,291$0$1.05M0.14%+$1.05M
Perspective Therapeutics, Inc.CALL(CATX)0200,000+200,000$0$834.0K0.11%+$834.0K
Protalix BioTherapeutics, Inc.(PLX)2,478,176340,000-2,138,176$4.46M$737.8K0.10%-$3.72M
BridgeBio Oncology Therapeutics, Inc.(BBOT)053,282+53,282$0$476.9K0.06%+$476.9K
LB Pharmaceuticals Inc(LBRX)014,506+14,506$0$357.7K0.05%+$357.7K
Adagio Medical Holdings, Inc.(ADGM)18,44418,4440$19.2K$21.2K0.00%+$2.0K
Alkermes plcSHS(ALKS)490,0000-490,000$13.71M$0—-$13.71M
Assertio Holdings Inc285,0000-285,000$2.58M$0—-$2.58M
BridgeBio Pharma, Inc.(BBIO)18,3190-18,319$1.40M$0—-$1.40M
Generation Bio Co310,0000-310,000$1.76M$0—-$1.76M
Gossamer Bio, Inc.(GOSS)2,720,0000-2,720,000$8.43M$0—-$8.43M
Karyopharm Therapeutics Inc.(KPTI)930,0000-930,000$6.84M$0—-$6.84M
Rapt Therapeutics Inc150,0000-150,000$213.4K$0—-$213.4K
Silence Therapeutics plcADS(SLN)78,9260-78,926$479.9K$0—-$479.9K
Ventyx Biosciences Inc251,9320-251,932$2.27M$0—-$2.27M
Zymeworks Inc.(ZYME)108,9290-108,929$2.87M$0—-$2.87M
Page 1 of 1
Opaleye Management Inc. — 13F Holdings — Q1 2026 | TickerTrail