Fund Holdings — Opaleye Management Inc.

Total Portfolio Value
$759.22M
Total Bought
$146.70M
Total Sold
$167.21M
Net Transaction
-$20.51M
Filing Period:
Securities
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SharesValue ($K)
Q4 2025
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Q1 2026
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Change
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Q4 2025
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Q1 2026
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Weight (%)
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Change
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ETON PHARMACEUTICALS INC(ETON)2,860,0002,860,000048,36370,5859.30%+22,222
SOL-GEL TECHNOLOGIES LTD
SHS NEW
453,739500,000+46,26119,12139,6105.22%+20,489
UROGEN PHARMA LTD(URGN)268,4231,430,000+1,161,5776,28625,7113.39%+19,425
MEIRAGTX HLDGS PLC(MGTX)390,8442,123,259+1,732,4153,10718,3872.42%+15,280
PERSPECTIVE THERAPEUTICS INC(CATX)1,184,5004,675,000+3,490,5004,99019,4952.57%+14,505
DISC MEDICINE INC(IRON)200,000421,000+221,00015,88226,9193.55%+11,037
CRESCENT BIOPHARMA INC.(CBIO)1,178,3001,312,615+134,31513,97524,1133.18%+10,138
Q32 BIO INC(FIXX)213,3631,256,228+1,042,8657088,0651.06%+7,357
ALUMIS INC535,000550,000+15,0005,22212,1171.60%+6,895
ASSERTIO HOLDINGS INC0265,707+265,70705,0640.67%+5,064
EDITAS MEDICINE INC(EDIT)01,926,997+1,926,99704,7600.63%+4,760
REZOLUTE INC(RZLT)6,287,1566,300,000+12,84414,83819,2152.53%+4,377
LIQUIDIA CORPORATION(LQDA)2,435,0002,545,000+110,00084,98288,82111.70%+3,839
APOGEE THERAPEUTICS INC(APGE)388,257390,000+1,74329,30632,8264.32%+3,521
BIODESIX INC(BDSX)0238,047+238,04703,4520.45%+3,452
EDGEWISE THERAPEUTICS INC(EWTX)500,000500,000012,40815,7502.07%+3,343
INTELLIA THERAPEUTICS INC(NTLA)0245,000+245,00003,1410.41%+3,141
SUTRO BIOPHARMA INC(STRO)190,671190,67102,2064,7500.63%+2,544
RELMADA THERAPEUTICS INC(RLMD)935,000935,00004,5166,5080.86%+1,992
TG THERAPEUTICS INC(TGTX)535,000535,000015,94817,7732.34%+1,824
REVOLUTION MEDICINES INC(RVMD)100,000100,00007,9659,7251.28%+1,760
CABALETTA BIO INC(CABA)900,0001,380,000+480,0001,9713,7120.49%+1,741
XOMA ROYALTY CORPORATION292,590300,000+7,4107,7809,4111.24%+1,631
LYELL IMMUNOPHARMA INC(LYEL)079,097+79,09701,5870.21%+1,587
NEXTCURE INC0141,181+141,18101,5080.20%+1,508
ZENTALIS PHARMACEUTICALS INC(ZNTL)1,400,9061,412,656+11,7501,8913,3060.44%+1,414
PROTAGONIST THERAPEUTICS INC105,000100,000-5,0009,17110,5401.39%+1,369
ATEA PHARMACEUTICALS INC(AVIR)179,815322,600+142,7856421,7360.23%+1,094
4D MOLECULAR THERAPEUTICS IN0112,291+112,29101,0450.14%+1,045
PERSPECTIVE THERAPEUTICS INC(CATX)0200,000+200,00008340.11%+834
STOKE THERAPEUTICS INC(STOK)695,000700,000+5,00022,05922,7923.00%+733
ALPHA COGNITION INC(ACOG)2,070,7842,561,950+491,16613,46014,0651.85%+605
BRIDGEBIO ONCOLOGY THERAPEUT(BBOT)053,282+53,28204770.06%+477
ENANTA PHARMACEUTICALS INC(ENTA)75,000125,000+50,0001,1831,5790.21%+396
LB PHARMACEUTICALS INC(LBRX)014,506+14,50603580.05%+358
ROCKET PHARMACEUTICALS INC(RCKT)955,000955,00003,3523,4190.45%+67
ADAGIO MED HLDGS INC(ADGM)18,44418,444019210.00%+2
OPUS GENETICS INC(IRD)1,120,0001,120,00002,2512,2510.30%0
RHYTHM PHARMACEUTICALS INC(RYTM)330,000123,000-207,00035,32335,3234.65%0
CODEXIS INC(CDXS)6,789,7386,785,000-4,73811,06711,0601.46%-8
ANNEXON INC(ANNX)2,600,0002,331,761-268,23913,05212,9181.70%-134
TREVI THERAPEUTICS INC(TRVI)345,100345,10004,3214,1170.54%-204
RAPT THERAPEUTICS INC150,0000-150,0002130—-213
VOYAGER THERAPEUTICS INC(VYGR)1,196,9041,150,000-46,9044,7044,4390.58%-265
MBX BIOSCIENCES INC(MBX)260,000260,00008,2007,7611.02%-439
SILENCE THERAPEUTICS PLC(SLN)78,9260-78,9264800—-480
JADE BIOSCIENCES INC427,608427,60806,5986,0080.79%-590
TECTONIC THERAPEUTIC INC(TECX)214,747123,000-91,7474,4803,8020.50%-678
FORTRESS BIOTECH INC(FBIO)1,090,0001,042,000-48,0003,9892,9070.38%-1,082
RIGEL PHARMACEUTICALS INC(RIGL)70,00070,00002,9981,8930.25%-1,105
BRIDGEBIO PHARMA INC(BBIO)18,3190-18,3191,4010—-1,401
GENERATION BIO CO310,0000-310,0001,7610—-1,761
VENTYX BIOSCIENCES INC251,9320-251,9322,2750—-2,275
ASSERTIO HOLDINGS INC285,0000-285,0002,5850—-2,585
ZYMEWORKS INC(ZYME)108,9290-108,9292,8680—-2,868
JOURNEY MED CORP(DERM)975,000960,000-15,0007,5174,5020.59%-3,015
PROTALIX BIOTHERAPEUTICS INC(PLX)2,478,176340,000-2,138,1764,4617380.10%-3,723
KARYOPHARM THERAPEUTICS INC(KPTI)930,0000-930,0006,8450—-6,845
GOSSAMER BIO INC(GOSS)2,720,0000-2,720,0008,4320—-8,432
CG ONCOLOGY INC(CGON)410,00094,800-315,20017,0236,4160.85%-10,607
SANUWAVE HEALTH INC(SNWV)981,267981,267029,28116,9662.23%-12,315
ALKERMES PLC(ALKS)490,0000-490,00013,7100—-13,710
OCULAR THERAPEUTIX INC(OCUL)1,595,000600,000-995,00019,3635,0820.67%-14,281
HARROW INC(HROW)3,905,0002,832,230-1,072,770191,34599,86413.15%-91,481
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Opaleye Management Inc. — 13F Holdings — Q1 2026 | TickerTrail