Opaleye Management Inc.
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ETON PHARMACEUTICALS INC(ETON) | 2,860,000 | 2,860,000 | 0 | 48,362,600 | 70,584,800 | 9.30% | +22,222,200 |
| SOL-GEL TECHNOLOGIES LTD SHS NEW | 453,739 | 500,000 | +46,261 | 19,120,561 | 39,610,000 | 5.22% | +20,489,439 |
| PERSPECTIVE THERAPEUTICS INC | 0 | 4,675,000 | +4,675,000 | 0 | 19,494,750 | 2.57% | +19,494,750 |
| UROGEN PHARMA LTD(URGN) | 268,423 | 1,430,000 | +1,161,577 | 6,286,467 | 25,711,400 | 3.39% | +19,424,933 |
| MEIRAGTX HLDGS PLC(MGTX) | 390,844 | 2,123,259 | +1,732,415 | 3,107,210 | 18,387,423 | 2.42% | +15,280,213 |
| DISC MEDICINE INC(IRON) | 200,000 | 421,000 | +221,000 | 15,882,000 | 26,918,740 | 3.55% | +11,036,740 |
| CRESCENT BIOPHARMA INC. | 1,178,300 | 1,312,615 | +134,315 | 13,974,638 | 24,112,738 | 3.18% | +10,138,100 |
| Q32 BIO INC | 213,363 | 1,256,228 | +1,042,865 | 708,365 | 8,064,984 | 1.06% | +7,356,619 |
| ALUMIS INC | 535,000 | 550,000 | +15,000 | 5,221,600 | 12,116,500 | 1.60% | +6,894,900 |
| ASSERTIO HOLDINGS INC | 0 | 265,707 | +265,707 | 0 | 5,064,375 | 0.67% | +5,064,375 |
| EDITAS MEDICINE INC | 0 | 1,926,997 | +1,926,997 | 0 | 4,759,683 | 0.63% | +4,759,683 |
| REZOLUTE INC | 6,287,156 | 6,300,000 | +12,844 | 14,837,688 | 19,215,000 | 2.53% | +4,377,312 |
| LIQUIDIA CORPORATION(LQDA) | 2,435,000 | 2,545,000 | +110,000 | 84,981,500 | 88,820,500 | 11.70% | +3,839,000 |
| APOGEE THERAPEUTICS INC(APGE) | 388,257 | 390,000 | +1,743 | 29,305,638 | 32,826,300 | 4.32% | +3,520,662 |
| BIODESIX INC | 0 | 238,047 | +238,047 | 0 | 3,451,682 | 0.45% | +3,451,682 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 500,000 | 500,000 | 0 | 12,407,500 | 15,750,000 | 2.07% | +3,342,500 |
| INTELLIA THERAPEUTICS INC(NTLA) | 0 | 245,000 | +245,000 | 0 | 3,140,900 | 0.41% | +3,140,900 |
| SUTRO BIOPHARMA INC | 190,671 | 190,671 | 0 | 2,206,063 | 4,749,615 | 0.63% | +2,543,552 |
| RELMADA THERAPEUTICS INC | 935,000 | 935,000 | 0 | 4,516,050 | 6,507,600 | 0.86% | +1,991,550 |
| TG THERAPEUTICS INC(TGTX) | 535,000 | 535,000 | 0 | 15,948,350 | 17,772,700 | 2.34% | +1,824,350 |
| REVOLUTION MEDICINES INC(RVMD) | 100,000 | 100,000 | 0 | 7,965,000 | 9,725,000 | 1.28% | +1,760,000 |
| CABALETTA BIO INC | 900,000 | 1,380,000 | +480,000 | 1,971,000 | 3,712,200 | 0.49% | +1,741,200 |
| XOMA ROYALTY CORPORATION | 292,590 | 300,000 | +7,410 | 7,779,968 | 9,411,000 | 1.24% | +1,631,032 |
| LYELL IMMUNOPHARMA INC | 0 | 79,097 | +79,097 | 0 | 1,586,686 | 0.21% | +1,586,686 |
| NEXTCURE INC | 0 | 141,181 | +141,181 | 0 | 1,507,813 | 0.20% | +1,507,813 |
| ZENTALIS PHARMACEUTICALS INC | 1,400,906 | 1,412,656 | +11,750 | 1,891,223 | 3,305,615 | 0.44% | +1,414,392 |
| PROTAGONIST THERAPEUTICS INC | 105,000 | 100,000 | -5,000 | 9,170,700 | 10,540,000 | 1.39% | +1,369,300 |
| ATEA PHARMACEUTICALS INC | 179,815 | 322,600 | +142,785 | 641,940 | 1,735,588 | 0.23% | +1,093,648 |
| 4D MOLECULAR THERAPEUTICS IN | 0 | 112,291 | +112,291 | 0 | 1,045,429 | 0.14% | +1,045,429 |
| PERSPECTIVE THERAPEUTICS INC | 0 | 200,000 | +200,000 | 0 | 834,000 | 0.11% | +834,000 |
| STOKE THERAPEUTICS INC(STOK) | 695,000 | 700,000 | +5,000 | 22,059,300 | 22,792,000 | 3.00% | +732,700 |
| ALPHA COGNITION INC | 2,070,784 | 2,561,950 | +491,166 | 13,460,096 | 14,065,106 | 1.85% | +605,010 |
| BRIDGEBIO ONCOLOGY THERAPEUT | 0 | 53,282 | +53,282 | 0 | 476,874 | 0.06% | +476,874 |
| ENANTA PHARMACEUTICALS INC | 75,000 | 125,000 | +50,000 | 1,182,750 | 1,578,750 | 0.21% | +396,000 |
| LB PHARMACEUTICALS INC(LBRX) | 0 | 14,506 | +14,506 | 0 | 357,718 | 0.05% | +357,718 |
| ROCKET PHARMACEUTICALS INC | 955,000 | 955,000 | 0 | 3,352,050 | 3,418,900 | 0.45% | +66,850 |
| ADAGIO MED HLDGS INC | 18,444 | 18,444 | 0 | 19,182 | 21,211 | 0.00% | +2,029 |
| OPUS GENETICS INC | 1,120,000 | 1,120,000 | 0 | 2,251,200 | 2,251,200 | 0.30% | 0 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 330,000 | 123,000 | -207,000 | 35,323,200 | 35,323,200 | 4.65% | 0 |
| CODEXIS INC | 6,789,738 | 6,785,000 | -4,738 | 11,067,273 | 11,059,550 | 1.46% | -7,723 |
| ANNEXON INC(ANNX) | 2,600,000 | 2,331,761 | -268,239 | 13,052,000 | 12,917,956 | 1.70% | -134,044 |
| TREVI THERAPEUTICS INC(TRVI) | 345,100 | 345,100 | 0 | 4,320,652 | 4,117,043 | 0.54% | -203,609 |
| RAPT THERAPEUTICS INC | 150,000 | 0 | -150,000 | 213,363 | 0 | — | -213,363 |
| VOYAGER THERAPEUTICS INC | 1,196,904 | 1,150,000 | -46,904 | 4,703,833 | 4,439,000 | 0.58% | -264,833 |
| MBX BIOSCIENCES INC(MBX) | 260,000 | 260,000 | 0 | 8,200,400 | 7,761,000 | 1.02% | -439,400 |
| SILENCE THERAPEUTICS PLC | 78,926 | 0 | -78,926 | 479,870 | 0 | — | -479,870 |
| JADE BIOSCIENCES INC | 427,608 | 427,608 | 0 | 6,597,991 | 6,007,892 | 0.79% | -590,099 |
| TECTONIC THERAPEUTIC INC | 214,747 | 123,000 | -91,747 | 4,479,622 | 3,801,930 | 0.50% | -677,692 |
| FORTRESS BIOTECH INC | 1,090,000 | 1,042,000 | -48,000 | 3,989,400 | 2,907,180 | 0.38% | -1,082,220 |
| RIGEL PHARMACEUTICALS INC | 70,000 | 70,000 | 0 | 2,998,100 | 1,892,800 | 0.25% | -1,105,300 |
| BRIDGEBIO PHARMA INC(BBIO) | 18,319 | 0 | -18,319 | 1,401,220 | 0 | — | -1,401,220 |
| GENERATION BIO CO | 310,000 | 0 | -310,000 | 1,760,800 | 0 | — | -1,760,800 |
| VENTYX BIOSCIENCES INC | 251,932 | 0 | -251,932 | 2,274,946 | 0 | — | -2,274,946 |
| ASSERTIO HOLDINGS INC | 285,000 | 0 | -285,000 | 2,584,950 | 0 | — | -2,584,950 |
| ZYMEWORKS INC(ZYME) | 108,929 | 0 | -108,929 | 2,868,101 | 0 | — | -2,868,101 |
| JOURNEY MED CORP | 975,000 | 960,000 | -15,000 | 7,517,250 | 4,502,400 | 0.59% | -3,014,850 |
| PROTALIX BIOTHERAPEUTICS INC | 2,478,176 | 340,000 | -2,138,176 | 4,460,717 | 737,800 | 0.10% | -3,722,917 |
| PERSPECTIVE THERAPEUTICS INC | 1,184,500 | 0 | -1,184,500 | 4,989,875 | 0 | — | -4,989,875 |
| KARYOPHARM THERAPEUTICS INC | 930,000 | 0 | -930,000 | 6,844,800 | 0 | — | -6,844,800 |
| GOSSAMER BIO INC | 2,720,000 | 0 | -2,720,000 | 8,432,000 | 0 | — | -8,432,000 |
| CG ONCOLOGY INC(CGON) | 410,000 | 94,800 | -315,200 | 17,023,200 | 6,416,064 | 0.85% | -10,607,136 |
| SANUWAVE HEALTH INC | 981,267 | 981,267 | 0 | 29,281,007 | 16,966,106 | 2.23% | -12,314,901 |
| ALKERMES PLC(ALKS) | 490,000 | 0 | -490,000 | 13,710,200 | 0 | — | -13,710,200 |
| OCULAR THERAPEUTIX INC(OCUL) | 1,595,000 | 600,000 | -995,000 | 19,363,300 | 5,082,000 | 0.67% | -14,281,300 |
| HARROW INC(HROW) | 3,905,000 | 2,832,230 | -1,072,770 | 191,345,000 | 99,864,430 | 13.15% | -91,480,570 |