Fund Holdings — Opaleye Management Inc.

Total Portfolio Value:
$494.14M
Total Bought:
$65.36M
Total Sold:
$62.32M
Net Transaction:
+$3.04M
Notable People:
James Aaron Silverman
Securities
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SharesValue
Q1 2025
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Q2 2025
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Change
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Q1 2025
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Q2 2025
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Weight (%)
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Change
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Harrow, Inc.(HROW)3,955,0003,905,000-50,000$105.20M$119.26M24.13%+$14.06M
Eton Pharmaceuticals, Inc.(ETON)2,852,0702,860,000+7,930$37.02M$40.76M8.25%+$3.74M
Immunome, Inc.(IMNM)3,550,0003,529,581-20,419$23.89M$32.83M6.64%+$8.93M
SANUWAVE Health, Inc.(SNWV)972,002980,000+7,998$34.38M$32.20M6.52%-$2.18M
Liquidia Corporation(LQDA)2,260,0002,475,000+215,000$33.34M$30.84M6.24%-$2.50M
Codexis, Inc.(CDXS)9,500,00012,600,000+3,100,000$25.55M$30.74M6.22%+$5.19M
Rhythm Pharmaceuticals, Inc.(RYTM)490,000475,000-15,000$25.96M$30.02M6.07%+$4.06M
TG Therapeutics, Inc.(TGTX)535,000535,0000$21.10M$19.25M3.90%-$1.84M
Ocular Therapeutix, Inc.(OCUL)1,595,0001,595,0000$11.69M$14.80M3.00%+$3.11M
Arvinas, Inc.(ARVN)1,975,0001,680,000-295,000$13.86M$12.36M2.50%-$1.50M
Larimar Therapeutics, Inc.(LRMR)1,914,0774,110,000+2,195,923$4.12M$11.88M2.40%+$7.76M
Disc Medicine, Inc.(IRON)85,000186,418+101,418$4.22M$9.87M2.00%+$5.65M
Sarepta Therapeutics, Inc.(SRPT)0500,000+500,000$0$8.55M1.73%+$8.55M
Vigil Neurosciences Inc01,000,000+1,000,000$0$7.95M1.61%+$7.95M
CG Oncology, Inc.(CGON)163,988266,000+102,012$4.02M$6.92M1.40%+$2.90M
Xoma Corp Del253,043255,087+2,044$5.04M$6.43M1.30%+$1.39M
Edgewise Therapeutics, Inc.(EWTX)395,000490,000+95,000$8.69M$6.42M1.30%-$2.27M
Stoke Therapeutics, Inc.(STOK)300,000562,120+262,120$2.00M$6.38M1.29%+$4.39M
Anika Therapeutics Inc395,000588,797+193,797$5.94M$6.23M1.26%+$292.6K
Gossamer Bio, Inc.NOTE 5 000 6 0(GOSS)000$6.32M$5.95M1.20%-$370.4K
Protagonist Therapeutics Inc105,000105,0000$5.08M$5.80M1.17%+$725.5K
Ginkgo Bioworks Holdings, Inc.CL A(DNA)1,195,000500,000-695,000$6.81M$5.63M1.14%-$1.19M
Karyopharm Therapeutics IncNOTE 3 000 10 1000$4.56M$4.56M0.92%-$840
Gossamer Bio, Inc.(GOSS)4,287,4153,545,000-742,415$4.72M$4.36M0.88%-$355.8K
Rezolute, Inc.(RZLT)465,000903,442+438,442$1.35M$4.03M0.82%+$2.68M
Revolution Medicines, Inc.(RVMD)0105,000+105,000$0$3.86M0.78%+$3.86M
Essa Pharma Inc2,209,9982,209,9980$3.49M$3.76M0.76%+$265.2K
Cargo Therapeutics Inc666,503666,5030$2.71M$2.75M0.56%+$33.3K
MBX Biosciences, Inc.(MBX)250,000239,319-10,681$1.84M$2.73M0.55%+$885.6K
Zymeworks Inc.(ZYME)175,000210,000+35,000$2.08M$2.64M0.53%+$551.3K
Protara Therapeutics, Inc.(TARA)1,730,000855,000-875,000$7.37M$2.59M0.52%-$4.78M
Alumis Inc0775,000+775,000$0$2.33M0.47%+$2.33M
Zentalis Pharmaceuticals, Inc.(ZNTL)1,985,0001,924,300-60,700$3.16M$2.23M0.45%-$924.0K
Trevi Therapeutics, Inc.(TRVI)795,000390,000-405,000$5.00M$2.13M0.43%-$2.87M
AVITA Medical, Inc.(RCEL)440,000389,519-50,481$3.58M$2.06M0.42%-$1.52M
Opus Genetics, Inc.(IRD)1,175,0001,220,000+45,000$1.55M$1.15M0.23%-$397.0K
Journey Medical Corporation(DERM)69,32395,000+25,677$409.0K$682.1K0.14%+$273.1K
Elevation Oncology Inc01,442,061+1,442,061$0$529.4K0.11%+$529.4K
iBio, Inc.(IBIO)375,000375,0000$1.51M$285.0K0.06%-$1.22M
PepGen Inc.(PEPG)420,000240,000-180,000$590.1K$266.4K0.05%-$323.7K
Adagio Medical Holdings, Inc.(ADGM)110,571110,5710$92.1K$143.7K0.03%+$51.6K
Acelyrin Inc1,615,0000-1,615,000$3.99M$0—-$3.99M
Anaptys Bio Inc250,9330-250,933$4.66M$0—-$4.66M
Biodesix, Inc.(BDSX)3,225,0000-3,225,000$2.02M$0—-$2.02M
Kiniksa Pharmaceuticals International, plcCL A(KNSA)62,5010-62,501$1.39M$0—-$1.39M
Nurix Therapeutics, Inc.(NRIX)115,0000-115,000$1.37M$0—-$1.37M
Optinose Inc193,0390-193,039$1.77M$0—-$1.77M
Palvella Therapeutics, Inc.(PVLA)172,3570-172,357$4.82M$0—-$4.82M
Sangamo Therapeutics, Inc.(SGMOQ)1,055,0000-1,055,000$691.9K$0—-$691.9K
Ventyx Biosciences Inc190,0000-190,000$218.5K$0—-$218.5K
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Opaleye Management Inc. — 13F Holdings — Q2 2025 | TickerTrail