Fund Holdings — Opaleye Management Inc.

Total Portfolio Value:
$1.10B
Total Bought:
$211.12M
Total Sold:
$202.44M
Net Transaction:
+$8.68M
Notable People:
James Aaron Silverman
Securities
▲▼
SharesValue
Q1 2026
▲▼
Q2 2026
▲▼
Change
▲▼
Q1 2026
▲▼
Q2 2026
▲▼
Weight (%)
▲▼
Change
▲▼
Liquidia Corporation(LQDA)2,545,0002,447,500-97,500$88.82M$195.14M17.67%+$106.32M
Eton Pharmaceuticals, Inc.(ETON)2,860,0002,860,0000$70.58M$103.53M9.38%+$32.95M
Harrow, Inc.(HROW)2,832,2302,400,000-432,230$99.86M$101.93M9.23%+$2.06M
Disc Medicine, Inc.(IRON)421,000855,000+434,000$26.92M$62.53M5.66%+$35.62M
UroGen Pharma Ltd.(URGN)1,430,0001,439,996+9,996$25.71M$52.99M4.80%+$27.28M
Apogee Therapeutics Inc390,000390,0000$32.83M$51.76M4.69%+$18.94M
MeiraGTx Holdings plc(MGTX)2,123,2593,550,000+1,426,741$18.39M$47.96M4.34%+$29.57M
Sol-Gel Technologies LtdSHS NEW
SHS NEW
500,000500,0000$39.61M$37.07M3.36%-$2.54M
Rezolute, Inc.(RZLT)6,300,0006,300,0000$19.21M$32.76M2.97%+$13.54M
TG Therapeutics, Inc.(TGTX)535,000535,0000$17.77M$29.39M2.66%+$11.62M
Immix Biopharma, Inc.(IMMX)02,345,000+2,345,000$0$24.18M2.19%+$24.18M
Crescent Biopharma, Inc.(CBIO)1,312,6151,319,351+6,736$24.11M$23.75M2.15%-$364.4K
Stoke Therapeutics, Inc.(STOK)700,000700,0000$22.79M$22.90M2.07%+$112.0K
Alpha Cognition Inc. Common Stock(ACOG)2,561,9502,895,467+333,517$14.07M$20.91M1.89%+$6.84M
Edgewise Therapeutics, Inc.(EWTX)500,000500,0000$15.75M$20.32M1.84%+$4.57M
Revolution Medicines, Inc.(RVMD)100,000100,0000$9.72M$18.73M1.70%+$9.00M
Monte Rosa Therapeutics, Inc.(GLUE)0745,000+745,000$0$18.03M1.63%+$18.03M
Alumis Inc550,000550,0000$12.12M$15.48M1.40%+$3.36M
Codexis, Inc.(CDXS)6,785,0006,785,0000$11.06M$15.33M1.39%+$4.27M
Replimune Group, Inc.(REPL)01,384,993+1,384,993$0$15.33M1.39%+$15.33M
Xoma Royalty Corporation300,000338,374+38,374$9.41M$14.38M1.30%+$4.97M
MBX Biosciences, Inc.(MBX)260,000260,0000$7.76M$14.35M1.30%+$6.59M
Rhythm Pharmaceuticals, Inc.(RYTM)123,000122,500-500$35.32M$13.60M1.23%-$21.72M
Editas Medicine, Inc.(EDIT)1,926,9973,861,930+1,934,933$4.76M$12.51M1.13%+$7.75M
Protagonist Therapeutics Inc100,000100,0000$10.54M$12.26M1.11%+$1.72M
Cabaletta Bio, Inc.(CABA)1,380,0003,863,800+2,483,800$3.71M$12.02M1.09%+$8.30M
Q32 Bio Inc.(QTTB)1,256,228931,000-325,228$8.06M$11.86M1.07%+$3.80M
Annexon, Inc.(ANNX)2,331,7611,714,451-617,310$12.92M$9.79M0.89%-$3.13M
Verastem, Inc.(VSTM)01,800,000+1,800,000$0$6.88M0.62%+$6.88M
Zentalis Pharmaceuticals, Inc.(ZNTL)1,412,6561,412,6560$3.31M$6.85M0.62%+$3.55M
Relmada Therapeutics, Inc.(RLMD)935,000935,0000$6.51M$6.47M0.59%-$37.4K
Ocular Therapeutix, Inc.(OCUL)600,000600,0000$5.08M$5.89M0.53%+$810.0K
Trevi Therapeutics, Inc.(TRVI)345,100310,000-35,100$4.12M$5.78M0.52%+$1.66M
BridgeBio Oncology Therapeutics, Inc.(BBOT)53,282700,000+646,718$476.9K$5.33M0.48%+$4.86M
Lyell Immunopharma, Inc.(LYEL)79,097344,025+264,928$1.59M$4.83M0.44%+$3.25M
Opus Genetics, Inc.(IRD)1,120,0001,125,000+5,000$2.25M$4.62M0.42%+$2.37M
4d Molecular Therapeutics In112,291334,437+222,146$1.05M$4.45M0.40%+$3.40M
Intellia Therapeutics, Inc.(NTLA)245,000250,000+5,000$3.14M$4.23M0.38%+$1.09M
Voyager Therapeutics, Inc.(VYGR)1,150,0001,185,000+35,000$4.44M$4.15M0.38%-$291.5K
Biodesix, Inc.(BDSX)238,047180,000-58,047$3.45M$4.06M0.37%+$607.3K
Rocket Pharmaceuticals, Inc.(RCKT)955,0001,000,000+45,000$3.42M$3.42M0.31%+$1.1K
Jade Biosciences Inc427,608145,000-282,608$6.01M$3.22M0.29%-$2.79M
SANUWAVE Health, Inc.(SNWV)981,267306,140-675,127$16.97M$3.06M0.28%-$13.90M
Fortress Biotech, Inc.(FBIO)1,042,000890,000-152,000$2.91M$2.72M0.25%-$183.8K
Journey Medical Corporation(DERM)960,000350,000-610,000$4.50M$2.48M0.22%-$2.02M
Phathom Pharmaceuticals, Inc.(PHAT)0185,589+185,589$0$2.01M0.18%+$2.01M
Inhibrx Biosciences, Inc.(INBX)020,291+20,291$0$1.92M0.17%+$1.92M
Enanta Pharmaceuticals, Inc.(ENTA)125,000125,0000$1.58M$1.82M0.17%+$243.8K
Hemab Therapeutics Hldgs Inc047,652+47,652$0$1.75M0.16%+$1.75M
First Tracks Biotherapeutics065,000+65,000$0$1.31M0.12%+$1.31M
CG Oncology, Inc.(CGON)94,80017,789-77,011$6.42M$1.26M0.11%-$5.15M
Biohaven Ltd.(BHVN)077,915+77,915$0$1.16M0.10%+$1.16M
Atea Pharmaceuticals, Inc.(AVIR)322,600235,000-87,600$1.74M$1.09M0.10%-$642.8K
Pasithea Therapeutics Corp.(KTTA)02,050,000+2,050,000$0$1.06M0.10%+$1.06M
ADC Therapeutics SASHS(ADCT)0700,000+700,000$0$749.0K0.07%+$749.0K
OKYO Pharma LimitedSHS NEW(OKYO)0375,204+375,204$0$562.8K0.05%+$562.8K
Palatin Technologies, Inc.(PTN)020,500+20,500$0$221.2K0.02%+$221.2K
Adagio Medical Holdings, Inc.(ADGM)18,44418,4440$21.2K$13.4K0.00%-$7.9K
Assertio Holdings Inc265,7070-265,707$5.06M$0—-$5.06M
LB Pharmaceuticals Inc(LBRX)14,5060-14,506$357.7K$0—-$357.7K
Nextcure Inc141,1810-141,181$1.51M$0—-$1.51M
Perspective Therapeutics, Inc.(CATX)4,675,0000-4,675,000$19.49M$0—-$19.49M
Perspective Therapeutics, Inc.CALL(CATX)200,0000-200,000$834.0K$0—-$834.0K
Protalix BioTherapeutics, Inc.(PLX)340,0000-340,000$737.8K$0—-$737.8K
Rigel Pharmaceuticals, Inc.(RIGL)70,0000-70,000$1.89M$0—-$1.89M
Sutro Biopharma, Inc.(STRO)190,6710-190,671$4.75M$0—-$4.75M
Tectonic Therapeutic, Inc.(TECX)123,0000-123,000$3.80M$0—-$3.80M
Page 1 of 1
Opaleye Management Inc. — 13F Holdings — Q2 2026 | TickerTrail