Fund Holdings — Opaleye Management Inc.

Total Portfolio Value
$707.32M
Total Bought
$123.42M
Total Sold
$65.20M
Net Transaction
+$58.22M
Filing Period:
Securities
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SharesValue ($K)
Q2 2025
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Q3 2025
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Change
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Q2 2025
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Q3 2025
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Weight (%)
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Change
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HARROW HEALTH INC(HROW)3,905,0003,905,0000119,259188,14326.60%+68,884
LIQUIDIA CORPORATION(LQDA)2,475,0002,615,000+140,00030,83959,4658.41%+28,627
ETON PHARMACEUTICALS INC(ETON)2,860,0002,860,000040,75562,1488.79%+21,393
RHYTHM PHARMACEUTICALS INC(RYTM)475,000461,700-13,30030,01546,6276.59%+16,612
APOGEE THERAPEUTICS INC(APGE)0363,257+363,257014,4322.04%+14,432
ALKERMES PLC(ALKS)0450,000+450,000013,5001.91%+13,500
STOKE THERAPEUTICS INC(STOK)562,120682,017+119,8976,38016,0272.27%+9,647
CG ONCOLOGY INC(CGON)266,000410,000+144,0006,91616,5152.33%+9,599
ANNEXON INC(ANNX)02,600,000+2,600,00007,9301.12%+7,930
JOURNEY MEDICAL CORP(DERM)95,000971,064+876,0646826,9140.98%+6,232
SOL GEL TECHNOLOGIES
SHS NEW
0204,835+204,83505,9710.84%+5,971
PROTALIX BIOTHERAPEUTICS INC(PLX)02,580,556+2,580,55605,7290.81%+5,729
TREACE MEDICAL CONCEPTS INC(TMCI)0702,245+702,24504,7120.67%+4,712
SANUWAVE HEALTH INC(SNWV)980,000980,000032,20336,7305.19%+4,528
IMMUNOME INC(IMNM)3,529,5813,185,000-344,58132,82537,2965.27%+4,471
REZOLUTE INC(RZLT)903,442903,44204,0298,4921.20%+4,463
OCULAR THERAPEUTIX INC(OCUL)1,595,0001,595,000014,80218,6462.64%+3,844
XOMA CORP DEL255,087255,08706,4289,8311.39%+3,403
DISC MEDICINE INC(IRON)186,418193,773+7,3559,87312,8051.81%+2,932
GOSSAMER BIO INC(GOSS)3,545,0002,725,000-820,0004,3607,1671.01%+2,806
ADC Therapeutics SA(ADCT)0682,529+682,52902,7300.39%+2,730
SAREPTA THERAPEUTICS INC(SRPT)500,000585,000+85,0008,55011,2731.59%+2,723
CABALETTA BIO INC(CABA)0808,882+808,88201,8930.27%+1,893
MBX BIOSCIENCES INC(MBX)239,319253,000+13,6812,7314,4280.63%+1,697
EDGEWISE THERAPEUTICS INC(EWTX)490,000500,000+10,0006,4248,1101.15%+1,686
TREVI THERAPEUTICS INC(TRVI)390,000390,00002,1333,5690.50%+1,435
PROTAGONIST THERAPEUTICS INC105,000105,00005,8036,9750.99%+1,172
SPYRE THERAPEUTICS INC(SYRE)065,000+65,00001,0890.15%+1,089
RIGEL PHARMACEUTICALS(RIGL)037,787+37,78701,0710.15%+1,071
REVOLUTION MEDICINES INC(RVMD)105,000100,000-5,0003,8634,6700.66%+807
ALPHA COGNITION INC(ACOG)0115,142+115,14207500.11%+750
OPUS GENETICS INC(IRD)1,220,0001,100,000-120,0001,1491,8150.26%+666
CODEXIS INC(CDXS)12,600,00012,795,000+195,00030,74431,2204.41%+476
ALUMIS INC775,000665,000-110,0002,3252,6530.38%+328
PEPGEN INC(PEPG)240,00075,000-165,0002663470.05%+80
KARYOPHARM THERAPEUTICS INC0004,5564,6310.65%+75
TG THERAPEUTICS INC(TGTX)535,000535,000019,25519,3272.73%+72
ADAGIO MED HLDGS INC(ADGM)110,571110,57101442150.03%+71
IBIO INC(IBIO)375,000375,00002853100.04%+25
ELEVATION ONCOLOGY INC1,442,0610-1,442,0615290—-529
ZYMEWORKS INC(ZYME)210,000100,000-110,0002,6361,7080.24%-927
LARIMAR THERAPEUTICS INC(LRMR)4,110,0003,720,867-389,13311,87810,5651.49%-1,313
ZENTALIS PHARMACEUTICALS INC(ZNTL)1,924,300316,550-1,607,7502,2324780.07%-1,754
AVITA MEDICAL INC(RCEL)389,5190-389,5192,0610—-2,061
PROTARA THERAPEUTICS INC(TARA)855,0000-855,0002,5910—-2,591
CARGO THERAPEUTICS INC666,5030-666,5032,7460—-2,746
ESSA PHARMA INC2,209,9980-2,209,9983,7570—-3,757
ARVINAS INC(ARVN)1,680,000987,818-692,18212,3658,4161.19%-3,949
GINKGO BIOWORKS HOLDINGS(DNA)500,0000-500,0005,6250—-5,625
GOSSAMER BIO INC(GOSS)0005,9490—-5,949
ANIKA THERAPEUTICS INC588,7970-588,7976,2290—-6,229
VIGIL NEUROSCIENCES INC1,000,0000-1,000,0007,9500—-7,950
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