Fund Holdings — Opaleye Management Inc.

Total Portfolio Value:
$707.32M
Total Bought:
$123.42M
Total Sold:
$65.20M
Net Transaction:
+$58.22M
Notable People:
James Aaron Silverman
Securities
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SharesValue
Q2 2025
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Q3 2025
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Change
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Q2 2025
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Q3 2025
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Weight (%)
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Change
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Harrow, Inc.(HROW)3,905,0003,905,0000$119.26M$188.14M26.60%+$68.88M
Eton Pharmaceuticals, Inc.(ETON)2,860,0002,860,0000$40.76M$62.15M8.79%+$21.39M
Liquidia Corporation(LQDA)2,475,0002,615,000+140,000$30.84M$59.47M8.41%+$28.63M
Rhythm Pharmaceuticals, Inc.(RYTM)475,000461,700-13,300$30.02M$46.63M6.59%+$16.61M
Immunome, Inc.(IMNM)3,529,5813,185,000-344,581$32.83M$37.30M5.27%+$4.47M
SANUWAVE Health, Inc.(SNWV)980,000980,0000$32.20M$36.73M5.19%+$4.53M
Codexis, Inc.(CDXS)12,600,00012,795,000+195,000$30.74M$31.22M4.41%+$475.8K
TG Therapeutics, Inc.(TGTX)535,000535,0000$19.25M$19.33M2.73%+$72.2K
Ocular Therapeutix, Inc.(OCUL)1,595,0001,595,0000$14.80M$18.65M2.64%+$3.84M
CG Oncology, Inc.(CGON)266,000410,000+144,000$6.92M$16.51M2.33%+$9.60M
Stoke Therapeutics, Inc.(STOK)562,120682,017+119,897$6.38M$16.03M2.27%+$9.65M
Apogee Therapeutics Inc0363,257+363,257$0$14.43M2.04%+$14.43M
Alkermes plcSHS(ALKS)0450,000+450,000$0$13.50M1.91%+$13.50M
Disc Medicine, Inc.(IRON)186,418193,773+7,355$9.87M$12.80M1.81%+$2.93M
Sarepta Therapeutics, Inc.(SRPT)500,000585,000+85,000$8.55M$11.27M1.59%+$2.72M
Larimar Therapeutics, Inc.(LRMR)4,110,0003,720,867-389,133$11.88M$10.56M1.49%-$1.31M
Xoma Corp Del255,087255,0870$6.43M$9.83M1.39%+$3.40M
Rezolute, Inc.(RZLT)903,442903,4420$4.03M$8.49M1.20%+$4.46M
Arvinas, Inc.(ARVN)1,680,000987,818-692,182$12.36M$8.42M1.19%-$3.95M
Edgewise Therapeutics, Inc.(EWTX)490,000500,000+10,000$6.42M$8.11M1.15%+$1.69M
Annexon, Inc.(ANNX)02,600,000+2,600,000$0$7.93M1.12%+$7.93M
Gossamer Bio, Inc.(GOSS)3,545,0002,725,000-820,000$4.36M$7.17M1.01%+$2.81M
Protagonist Therapeutics Inc105,000105,0000$5.80M$6.98M0.99%+$1.17M
Journey Medical Corporation(DERM)95,000971,064+876,064$682.1K$6.91M0.98%+$6.23M
Sol Gel TechnologiesSHS NEW
SHS NEW
0204,835+204,835$0$5.97M0.84%+$5.97M
Protalix BioTherapeutics, Inc.(PLX)02,580,556+2,580,556$0$5.73M0.81%+$5.73M
Treace Medical Concepts, Inc.(TMCI)0702,245+702,245$0$4.71M0.67%+$4.71M
Revolution Medicines, Inc.(RVMD)105,000100,000-5,000$3.86M$4.67M0.66%+$807.0K
Karyopharm Therapeutics IncNOTE 3 000 10 1000$4.56M$4.63M0.65%+$74.8K
MBX Biosciences, Inc.(MBX)239,319253,000+13,681$2.73M$4.43M0.63%+$1.70M
Trevi Therapeutics, Inc.(TRVI)390,000390,0000$2.13M$3.57M0.50%+$1.44M
ADC Therapeutics SASHS(ADCT)0682,529+682,529$0$2.73M0.39%+$2.73M
Alumis Inc775,000665,000-110,000$2.33M$2.65M0.38%+$328.4K
Cabaletta Bio, Inc.(CABA)0808,882+808,882$0$1.89M0.27%+$1.89M
Opus Genetics, Inc.(IRD)1,220,0001,100,000-120,000$1.15M$1.81M0.26%+$665.6K
Zymeworks Inc.(ZYME)210,000100,000-110,000$2.64M$1.71M0.24%-$927.5K
Spyre Therapeutics, Inc.(SYRE)065,000+65,000$0$1.09M0.15%+$1.09M
Rigel Pharmaceuticals, Inc.(RIGL)037,787+37,787$0$1.07M0.15%+$1.07M
Alpha Cognition Inc. Common Stock(ACOG)0115,142+115,142$0$749.6K0.11%+$749.6K
Zentalis Pharmaceuticals, Inc.(ZNTL)1,924,300316,550-1,607,750$2.23M$478.0K0.07%-$1.75M
PepGen Inc.(PEPG)240,00075,000-165,000$266.4K$346.5K0.05%+$80.1K
iBio, Inc.(IBIO)375,000375,0000$285.0K$310.4K0.04%+$25.4K
Adagio Medical Holdings, Inc.(ADGM)110,571110,5710$143.7K$214.5K0.03%+$70.8K
Anika Therapeutics Inc588,7970-588,797$6.23M$0—-$6.23M
AVITA Medical, Inc.(RCEL)389,5190-389,519$2.06M$0—-$2.06M
Cargo Therapeutics Inc666,5030-666,503$2.75M$0—-$2.75M
Elevation Oncology Inc1,442,0610-1,442,061$529.4K$0—-$529.4K
Essa Pharma Inc2,209,9980-2,209,998$3.76M$0—-$3.76M
Ginkgo Bioworks Holdings, Inc.CL A(DNA)500,0000-500,000$5.63M$0—-$5.63M
Gossamer Bio, Inc.NOTE 5 000 6 0(GOSS)000$5.95M$0—-$5.95M
Protara Therapeutics, Inc.(TARA)855,0000-855,000$2.59M$0—-$2.59M
Vigil Neurosciences Inc1,000,0000-1,000,000$7.95M$0—-$7.95M
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Opaleye Management Inc. — 13F Holdings — Q3 2025 | TickerTrail