Fund Holdings

Opaleye Management Inc.

Filing Period:
Securities
SharesValue ($K)
Q2 2025
Q3 2025
Change
Q2 2025
Q3 2025
Weight (%)
Change
HARROW HEALTH INC(HROW)3,905,0003,905,0000119,258,700188,142,90026.60%+68,884,200
LIQUIDIA CORPORATION(LQDA)2,475,0002,615,000+140,00030,838,50059,465,1008.41%+28,626,600
ETON PHARMACEUTICALS INC(ETON)2,860,0002,860,000040,755,00062,147,8008.79%+21,392,800
RHYTHM PHARMACEUTICALS INC(RYTM)475,000461,700-13,30030,015,25046,627,0836.59%+16,611,833
APOGEE THERAPEUTICS INC(APGE)0363,257+363,257014,432,2012.04%+14,432,201
ALKERMES PLC(ALKS)0450,000+450,000013,500,0001.91%+13,500,000
STOKE THERAPEUTICS INC(STOK)562,120682,017+119,8976,380,06216,027,4002.27%+9,647,338
CG ONCOLOGY INC(CGON)266,000410,000+144,0006,916,00016,514,8002.33%+9,598,800
ANNEXON INC(ANNX)02,600,000+2,600,00007,930,0001.12%+7,930,000
JOURNEY MEDICAL CORP95,000971,064+876,064682,1006,913,9760.98%+6,231,876
SOL GEL TECHNOLOGIES0204,835+204,83505,970,9400.84%+5,970,940
PROTALIX BIOTHERAPEUTICS INC02,580,556+2,580,55605,728,8340.81%+5,728,834
TREACE MEDICAL CONCEPTS INC0702,245+702,24504,712,0640.67%+4,712,064
SANUWAVE HEALTH INC980,000980,000032,202,80036,730,4005.19%+4,527,600
IMMUNOME INC(IMNM)3,529,5813,185,000-344,58132,825,10337,296,3505.27%+4,471,247
REZOLUTE INC903,442903,44204,029,3518,492,3551.20%+4,463,004
OCULAR THERAPEUTIX INC(OCUL)1,595,0001,595,000014,801,60018,645,5502.64%+3,843,950
XOMA CORP DEL255,087255,08706,428,1929,831,0531.39%+3,402,861
DISC MEDICINE INC(IRON)186,418193,773+7,3559,872,69712,804,5201.81%+2,931,823
GOSSAMER BIO INC3,545,0002,725,000-820,0004,360,3507,166,7501.01%+2,806,400
ADC Therapeutics SA0682,529+682,52902,730,1160.39%+2,730,116
SAREPTA THERAPEUTICS INC(SRPT)500,000585,000+85,0008,550,00011,272,9501.59%+2,722,950
CABALETTA BIO INC0808,882+808,88201,892,7840.27%+1,892,784
MBX BIOSCIENCES INC(MBX)239,319253,000+13,6812,730,6304,427,5000.63%+1,696,870
EDGEWISE THERAPEUTICS INC(EWTX)490,000500,000+10,0006,423,9008,110,0001.15%+1,686,100
TREVI THERAPEUTICS INC(TRVI)390,000390,00002,133,3003,568,5000.50%+1,435,200
PROTAGONIST THERAPEUTICS INC105,000105,00005,803,3506,975,1500.99%+1,171,800
SPYRE THERAPEUTICS INC(SYRE)065,000+65,00001,089,4000.15%+1,089,400
RIGEL PHARMACEUTICALS037,787+37,78701,070,5060.15%+1,070,506
REVOLUTION MEDICINES INC(RVMD)105,000100,000-5,0003,862,9504,670,0000.66%+807,050
ALPHA COGNITION INC0115,142+115,1420749,5740.11%+749,574
OPUS GENETICS INC1,220,0001,100,000-120,0001,149,3621,815,0000.26%+665,638
CODEXIS INC12,600,00012,795,000+195,00030,744,00031,219,8004.41%+475,800
ALUMIS INC775,000665,000-110,0002,325,0002,653,3500.38%+328,350
PEPGEN INC240,00075,000-165,000266,400346,5000.05%+80,100
KARYOPHARM THERAPEUTICS INC0004,556,0524,630,8420.65%+74,790
TG THERAPEUTICS INC(TGTX)535,000535,000019,254,65019,326,8752.73%+72,225
ADAGIO MED HLDGS INC110,571110,5710143,742214,5080.03%+70,766
IBIO INC375,000375,0000285,000310,4250.04%+25,425
ELEVATION ONCOLOGY INC1,442,0610-1,442,061529,3810-529,381
ZYMEWORKS INC(ZYME)210,000100,000-110,0002,635,5001,708,0000.24%-927,500
LARIMAR THERAPEUTICS INC4,110,0003,720,867-389,13311,877,90010,564,9001.49%-1,313,000
ZENTALIS PHARMACEUTICALS INC1,924,300316,550-1,607,7502,232,188477,9910.07%-1,754,197
AVITA MEDICAL INC389,5190-389,5192,060,5560-2,060,556
PROTARA THERAPEUTICS INC855,0000-855,0002,590,6500-2,590,650
CARGO THERAPEUTICS INC666,5030-666,5032,745,9920-2,745,992
ESSA PHARMA INC2,209,9980-2,209,9983,756,9970-3,756,997
ARVINAS INC1,680,000987,818-692,18212,364,8008,416,2091.19%-3,948,591
GINKGO BIOWORKS HOLDINGS500,0000-500,0005,625,0000-5,625,000
GOSSAMER BIO INC0005,948,9730-5,948,973
ANIKA THERAPEUTICS INC588,7970-588,7976,229,4720-6,229,472
VIGIL NEUROSCIENCES INC1,000,0000-1,000,0007,950,0000-7,950,000
Page 1 of 1