Opaleye Management Inc.
Comparing Q4 2025 vs Q3 2025
Sorting applies to all holdings for this quarter on the server, then the page is sliced. Prior-quarter values come from the full prior-quarter filing.
Issuer ▲▼ | Shares | Value ($K) | ||||
|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | |
| LIQUIDIA CORPORATION | 2,615,000 | 2,435,000 | -180,000 | 59,465,100 | 84,981,500 | +25,516,400 |
| APOGEE THERAPEUTICS INC | 363,257 | 388,257 | +25,000 | 14,432,201 | 29,305,638 | +14,873,437 |
| CRESCENT BIOPHARMA INC | 0 | 1,178,300 | +1,178,300 | 0 | 13,974,638 | +13,974,638 |
| SOL GEL TECHNOLOGIES | 204,835 | 453,739 | +248,904 | 5,970,940 | 19,120,561 | +13,149,621 |
| ALPHA COGNITION INC | 115,142 | 2,070,784 | +1,955,642 | 749,574 | 13,460,096 | +12,710,522 |
| KARYOPHARM THERAPEUTICS INC | 0 | 930,000 | +930,000 | 0 | 6,844,800 | +6,844,800 |
| JADE BIOSCIENCES INC | 0 | 427,608 | +427,608 | 0 | 6,597,991 | +6,597,991 |
| REZOLUTE INC | 903,442 | 6,287,156 | +5,383,714 | 8,492,355 | 14,837,688 | +6,345,333 |
| UROGEN PHARMA LTD | 0 | 268,423 | +268,423 | 0 | 6,286,467 | +6,286,467 |
| STOKE THERAPEUTICS INC | 682,017 | 695,000 | +12,983 | 16,027,400 | 22,059,300 | +6,031,900 |
| ANNEXON INC | 2,600,000 | 2,600,000 | 0 | 7,930,000 | 13,052,000 | +5,122,000 |
| PERSPECTIVE THERAPEUTICS INC | 0 | 1,184,500 | +1,184,500 | 0 | 4,989,875 | +4,989,875 |
| VOYAGER THERAPEUTICS INC | 0 | 1,196,904 | +1,196,904 | 0 | 4,703,833 | +4,703,833 |
| RELMADA THERAPEUTICS INC | 0 | 935,000 | +935,000 | 0 | 4,516,050 | +4,516,050 |
| TECTONIC THERAPEUTICS INC | 0 | 214,747 | +214,747 | 0 | 4,479,622 | +4,479,622 |
| EDGEWISE THERAPEUTICS INC | 500,000 | 500,000 | 0 | 8,110,000 | 12,407,500 | +4,297,500 |
| FORTRESS BIOTECH INC | 0 | 1,090,000 | +1,090,000 | 0 | 3,989,400 | +3,989,400 |
| MBX BIOSCIENCES INC | 253,000 | 260,000 | +7,000 | 4,427,500 | 8,200,400 | +3,772,900 |
| ROCKET PHARMACEUTICALS INC | 0 | 955,000 | +955,000 | 0 | 3,352,050 | +3,352,050 |
| REVOLUTION MEDICINES INC | 100,000 | 100,000 | 0 | 4,670,000 | 7,965,000 | +3,295,000 |
| HARROW HEALTH INC | 3,905,000 | 3,905,000 | 0 | 188,142,900 | 191,345,000 | +3,202,100 |
| MEIRAGTX HOLDINGS PLC | 0 | 390,844 | +390,844 | 0 | 3,107,210 | +3,107,210 |
| DISC MEDICINE INC | 193,773 | 200,000 | +6,227 | 12,804,520 | 15,882,000 | +3,077,480 |
| ASSERTIO HOLDINGS INC | 0 | 285,000 | +285,000 | 0 | 2,584,950 | +2,584,950 |
| ALUMIS INC | 665,000 | 535,000 | -130,000 | 2,653,350 | 5,221,600 | +2,568,250 |
| VENTYX BIOSCIENCES INC | 0 | 251,932 | +251,932 | 0 | 2,274,946 | +2,274,946 |
| SUTRO BIOPHARMA INC | 0 | 190,671 | +190,671 | 0 | 2,206,063 | +2,206,063 |
| PROTAGONIST THERAPEUTICS INC | 105,000 | 105,000 | 0 | 6,975,150 | 9,170,700 | +2,195,550 |
| RIGEL PHARMACEUTICALS INC | 37,787 | 70,000 | +32,213 | 1,070,506 | 2,998,100 | +1,927,594 |
| GENERATION BIO CO | 0 | 310,000 | +310,000 | 0 | 1,760,800 | +1,760,800 |
| ZENTALIS PHARMACEUTICALS INC | 316,550 | 1,400,906 | +1,084,356 | 477,991 | 1,891,223 | +1,413,232 |
| BRIDGEBIO PHARMA INC | 0 | 18,319 | +18,319 | 0 | 1,401,220 | +1,401,220 |
| GOSSAMER BIO INC | 2,725,000 | 2,720,000 | -5,000 | 7,166,750 | 8,432,000 | +1,265,250 |
| ENANTA PHARMACEUTICALS INC | 0 | 75,000 | +75,000 | 0 | 1,182,750 | +1,182,750 |
| ZYMEWORKS INC | 100,000 | 108,929 | +8,929 | 1,708,000 | 2,868,101 | +1,160,101 |
| TREVI THERAPEUTICS INC | 390,000 | 345,100 | -44,900 | 3,568,500 | 4,320,652 | +752,152 |
| OCULAR THERAPEUTIX INC | 1,595,000 | 1,595,000 | 0 | 18,645,550 | 19,363,300 | +717,750 |
| Q32 BIO INC | 0 | 213,363 | +213,363 | 0 | 708,365 | +708,365 |
| ATEA PHARMACEUTICALS INC | 0 | 179,815 | +179,815 | 0 | 641,940 | +641,940 |
| JOURNEY MEDICAL CORP | 971,064 | 975,000 | +3,936 | 6,913,976 | 7,517,250 | +603,274 |
| CG ONCOLOGY INC | 410,000 | 410,000 | 0 | 16,514,800 | 17,023,200 | +508,400 |
| SILENCE THERAPEUTICS PLC | 0 | 78,926 | +78,926 | 0 | 479,870 | +479,870 |
| OPUS GENETICS INC | 1,100,000 | 1,120,000 | +20,000 | 1,815,000 | 2,251,200 | +436,200 |
| RAPT THERAPEUTICS INC | 0 | 150,000 | +150,000 | 0 | 213,363 | +213,363 |
| ALKERMES PLC | 450,000 | 490,000 | +40,000 | 13,500,000 | 13,710,200 | +210,200 |
| CABALETTA BIO INC | 808,882 | 900,000 | +91,118 | 1,892,784 | 1,971,000 | +78,216 |
| ADAGIO MED HLDGS INC | 110,571 | 110,571 | 0 | 214,508 | 114,994 | -99,514 |
| PROTALIX BIOTHERAPEUTICS INC | 2,580,556 | 2,478,176 | -102,380 | 5,728,834 | 4,460,717 | -1,268,117 |
| XOMA CORP DEL | 255,087 | 292,590 | +37,503 | 9,831,053 | 7,779,968 | -2,051,085 |
| TG THERAPEUTICS INC | 535,000 | 535,000 | 0 | 19,326,875 | 15,948,350 | -3,378,525 |
| SANUWAVE HEALTH INC | 980,000 | 981,267 | +1,267 | 36,730,400 | 29,281,007 | -7,449,393 |
| RHYTHM PHARMACEUTICALS INC | 461,700 | 330,000 | -131,700 | 46,627,083 | 35,323,200 | -11,303,883 |
| ETON PHARMACEUTICALS INC | 2,860,000 | 2,860,000 | 0 | 62,147,800 | 48,362,600 | -13,785,200 |
| CODEXIS INC | 12,795,000 | 6,789,738 | -6,005,262 | 31,219,800 | 11,067,273 | -20,152,527 |