Fund HoldingsOpaleye Management Inc.

Total Portfolio Value
$757.89M
Total Bought
$151.59M
Total Sold
$139.76M
Net Transaction
+$11.83M
Filing Period:
Securities
SharesValue ($K)
Q3 2025
Q4 2025
Change
Q3 2025
Q4 2025
Weight (%)
Change
LIQUIDIA CORPORATION(LQDA)2,615,0002,435,000-180,00059,46584,98211.21%+25,516
APOGEE THERAPEUTICS INC(APGE)363,257388,257+25,00014,43229,3063.87%+14,873
CRESCENT BIOPHARMA INC01,178,300+1,178,300013,9751.84%+13,975
SOL GEL TECHNOLOGIES
SHS NEW
204,835453,739+248,9045,97119,1212.52%+13,150
ALPHA COGNITION INC115,1422,070,784+1,955,64275013,4601.78%+12,711
KARYOPHARM THERAPEUTICS INC0930,000+930,00006,8450.90%+6,845
JADE BIOSCIENCES INC0427,608+427,60806,5980.87%+6,598
REZOLUTE INC903,4426,287,156+5,383,7148,49214,8381.96%+6,345
UROGEN PHARMA LTD(URGN)0268,423+268,42306,2860.83%+6,286
STOKE THERAPEUTICS INC(STOK)682,017695,000+12,98316,02722,0592.91%+6,032
ANNEXON INC(ANNX)2,600,0002,600,00007,93013,0521.72%+5,122
PERSPECTIVE THERAPEUTICS INC01,184,500+1,184,50004,9900.66%+4,990
VOYAGER THERAPEUTICS INC01,196,904+1,196,90404,7040.62%+4,704
RELMADA THERAPEUTICS INC0935,000+935,00004,5160.60%+4,516
TECTONIC THERAPEUTICS INC0214,747+214,74704,4800.59%+4,480
EDGEWISE THERAPEUTICS INC(EWTX)500,000500,00008,11012,4081.64%+4,298
FORTRESS BIOTECH INC01,090,000+1,090,00003,9890.53%+3,989
MBX BIOSCIENCES INC(MBX)253,000260,000+7,0004,4288,2001.08%+3,773
ROCKET PHARMACEUTICALS INC0955,000+955,00003,3520.44%+3,352
REVOLUTION MEDICINES INC(RVMD)100,000100,00004,6707,9651.05%+3,295
HARROW HEALTH INC(HROW)3,905,0003,905,0000188,143191,34525.25%+3,202
MEIRAGTX HOLDINGS PLC(MGTX)0390,844+390,84403,1070.41%+3,107
DISC MEDICINE INC(IRON)193,773200,000+6,22712,80515,8822.10%+3,077
ASSERTIO HOLDINGS INC0285,000+285,00002,5850.34%+2,585
ALUMIS INC665,000535,000-130,0002,6535,2220.69%+2,568
VENTYX BIOSCIENCES INC0251,932+251,93202,2750.30%+2,275
SUTRO BIOPHARMA INC0190,671+190,67102,2060.29%+2,206
PROTAGONIST THERAPEUTICS INC105,000105,00006,9759,1711.21%+2,196
RIGEL PHARMACEUTICALS INC37,78770,000+32,2131,0712,9980.40%+1,928
GENERATION BIO CO0310,000+310,00001,7610.23%+1,761
ZENTALIS PHARMACEUTICALS INC316,5501,400,906+1,084,3564781,8910.25%+1,413
BRIDGEBIO PHARMA INC(BBIO)018,319+18,31901,4010.18%+1,401
GOSSAMER BIO INC2,725,0002,720,000-5,0007,1678,4321.11%+1,265
ENANTA PHARMACEUTICALS INC075,000+75,00001,1830.16%+1,183
ZYMEWORKS INC(ZYME)100,000108,929+8,9291,7082,8680.38%+1,160
TREVI THERAPEUTICS INC(TRVI)390,000345,100-44,9003,5694,3210.57%+752
OCULAR THERAPEUTIX INC(OCUL)1,595,0001,595,000018,64619,3632.55%+718
Q32 BIO INC0213,363+213,36307080.09%+708
ATEA PHARMACEUTICALS INC0179,815+179,81506420.08%+642
JOURNEY MEDICAL CORP971,064975,000+3,9366,9147,5170.99%+603
CG ONCOLOGY INC(CGON)410,000410,000016,51517,0232.25%+508
SILENCE THERAPEUTICS PLC078,926+78,92604800.06%+480
OPUS GENETICS INC1,100,0001,120,000+20,0001,8152,2510.30%+436
RAPT THERAPEUTICS INC0150,000+150,00002130.03%+213
ALKERMES PLC(ALKS)450,000490,000+40,00013,50013,7101.81%+210
CABALETTA BIO INC808,882900,000+91,1181,8931,9710.26%+78
ADAGIO MED HLDGS INC110,57118,444-92,127215190.00%-195
IBIO INC375,0000-375,0003100-310
PEPGEN INC75,0000-75,0003470-346
SPYRE THERAPEUTICS INC(SYRE)65,0000-65,0001,0890-1,089
PROTALIX BIOTHERAPEUTICS INC2,580,5562,478,176-102,3805,7294,4610.59%-1,268
XOMA CORP DEL255,087292,590+37,5039,8317,7801.03%-2,051
ADC Therapeutics SA682,5290-682,5292,7300-2,730
TG THERAPEUTICS INC(TGTX)535,000535,000019,32715,9482.10%-3,379
KARYOPHARM THERAPEUTICS INC0004,6310-4,631
TREACE MEDICAL CONCEPTS INC702,2450-702,2454,7120-4,712
SANUWAVE HEALTH INC980,000981,267+1,26736,73029,2813.86%-7,449
ARVINAS INC987,8180-987,8188,4160-8,416
LARIMAR THERAPEUTICS INC3,720,8670-3,720,86710,5650-10,565
SAREPTA THERAPEUTICS INC(SRPT)585,0000-585,00011,2730-11,273
RHYTHM PHARMACEUTICALS INC(RYTM)461,700330,000-131,70046,62735,3234.66%-11,304
ETON PHARMACEUTICALS INC(ETON)2,860,0002,860,000062,14848,3636.38%-13,785
CODEXIS INC12,795,0006,789,738-6,005,26231,22011,0671.46%-20,153
IMMUNOME INC(IMNM)3,185,0000-3,185,00037,2960-37,296
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