Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Novo-Nordisk A S(NVO) | 0 | 611,884 | +611,884 | 0 | 78,566 | 4.64% | +78,566 |
| Vera Therapeutics Inc(VERA) | 3,467,156 | 2,793,987 | -673,169 | 53,325 | 120,477 | 7.11% | +67,152 |
| Incyte Corp(INCY) | 296,569 | 1,327,178 | +1,030,609 | 18,622 | 75,609 | 4.46% | +56,988 |
| Natera Inc(NTRA) | 1,550,280 | 1,550,280 | 0 | 97,110 | 141,789 | 8.37% | +44,679 |
| Argenx SE(ARGX) | 44,721 | 149,300 | +104,579 | 17,013 | 58,782 | 3.47% | +41,769 |
| Dyne Therapeutics Inc(DYN) | 1,013,505 | 1,936,650 | +923,145 | 13,480 | 54,981 | 3.24% | +41,502 |
| IDEXX Labs Inc(IDXX) | 0 | 75,224 | +75,224 | 0 | 40,616 | 2.40% | +40,616 |
| Insulet Corp(PODD) | 19,000 | 220,203 | +201,203 | 4,123 | 37,743 | 2.23% | +33,620 |
| Align Technology Inc | 0 | 95,478 | +95,478 | 0 | 31,309 | 1.85% | +31,309 |
| Arrivent Biopharma Inc(AVBP) | 0 | 1,696,752 | +1,696,752 | 0 | 30,304 | 1.79% | +30,304 |
| TG Therapeutics Inc(TGTX) | 0 | 1,984,962 | +1,984,962 | 0 | 30,191 | 1.78% | +30,191 |
| Sarepta Therapeutics Inc(SRPT) | 0 | 227,488 | +227,488 | 0 | 29,451 | 1.74% | +29,451 |
| Aerovate Therapeutics Inc | 3,758,686 | 3,758,686 | 0 | 85,059 | 111,144 | 6.56% | +26,085 |
| Elanco Animal Health Inc(ELAN) | 1,193,885 | 2,555,547 | +1,361,662 | 17,789 | 41,604 | 2.46% | +23,815 |
| Silk Rd Med Inc | 0 | 1,189,024 | +1,189,024 | 0 | 21,783 | 1.29% | +21,783 |
| Y-mAbs Therapeutics Inc | 2,194,278 | 2,194,278 | 0 | 14,965 | 35,679 | 2.11% | +20,714 |
| Ascendis Pharma A/S(ASND) | 754,032 | 754,032 | 0 | 94,970 | 113,987 | 6.73% | +19,017 |
| Boston Scientific Corp(BSX) | 131,000 | 353,851 | +222,851 | 7,573 | 24,235 | 1.43% | +16,662 |
| Inhibrx Inc | 772,957 | 1,302,645 | +529,688 | 29,372 | 45,540 | 2.69% | +16,168 |
| Cogent Biosciences Inc(COGT) | 0 | 2,400,771 | +2,400,771 | 0 | 16,133 | 0.95% | +16,133 |
| Exact Sciences Corp(EXK) | 0 | 229,481 | +229,481 | 0 | 15,848 | 0.94% | +15,848 |
| Alnylam Pharmaceuticals Inc(ALNY) | 0 | 103,036 | +103,036 | 0 | 15,399 | 0.91% | +15,399 |
| Syndax Pharmaceuticals Inc(SNDX) | 1,075,786 | 1,608,540 | +532,754 | 23,248 | 38,283 | 2.26% | +15,036 |
| Immunome Inc(IMNM) | 0 | 594,396 | +594,396 | 0 | 14,670 | 0.87% | +14,670 |
| Inozyme Pharma Inc | 4,280,308 | 4,280,308 | 0 | 18,234 | 32,787 | 1.93% | +14,553 |
| Intuitive Surgical Inc | 126,959 | 140,880 | +13,921 | 42,831 | 56,224 | 3.32% | +13,393 |
| Shockwave Med Inc | 0 | 35,000 | +35,000 | 0 | 11,397 | 0.67% | +11,397 |
| Roivant Sciences Ltd(ROIV) | 0 | 1,001,704 | +1,001,704 | 0 | 10,558 | 0.62% | +10,558 |
| Axonics Inc | 0 | 149,385 | +149,385 | 0 | 10,303 | 0.61% | +10,303 |
| PepGen Inc(PEPG) | 23,038 | 503,624 | +480,586 | 157 | 7,403 | 0.44% | +7,247 |
| Establishment Labs Hldgs Inc(ESTA) | 3,052 | 141,162 | +138,110 | 79 | 7,185 | 0.42% | +7,106 |
| Achieve Life Sciences Inc | 0 | 1,518,230 | +1,518,230 | 0 | 6,900 | 0.41% | +6,900 |
| Soleno Therapeutics Inc | 1,200 | 150,775 | +149,575 | 48 | 6,453 | 0.38% | +6,405 |
| 4D Molecular Therapeutics Inc | 0 | 198,186 | +198,186 | 0 | 6,314 | 0.37% | +6,314 |
| Avantor Inc(AVTR) | 0 | 232,446 | +232,446 | 0 | 5,944 | 0.35% | +5,944 |
| Madrigal Pharmaceuticals Inc(MDGL) | 0 | 19,029 | +19,029 | 0 | 5,082 | 0.30% | +5,082 |
| Nextcure Inc | 2,671,856 | 2,671,856 | 0 | 3,046 | 5,958 | 0.35% | +2,912 |
| Teleflex Incorporated(TFX) | 0 | 12,142 | +12,142 | 0 | 2,746 | 0.16% | +2,746 |
| Cooper Cos Inc(COO) | 0 | 21,236 | +21,236 | 0 | 2,155 | 0.13% | +2,155 |
| Fusion Pharmaceuticals Inc | 125,299 | 157,172 | +31,873 | 1,204 | 3,351 | 0.20% | +2,147 |
| Inspire Med Sys Inc(INSP) | 0 | 8,099 | +8,099 | 0 | 1,740 | 0.10% | +1,740 |
| Masimo Corp | 12,800 | 20,000 | +7,200 | 1,500 | 2,937 | 0.17% | +1,437 |
| LivaNova PLC(LIVN) | 0 | 20,456 | +20,456 | 0 | 1,144 | 0.07% | +1,144 |
| Amylyx Pharmaceuticals Inc(AMLX) | 0 | 306,729 | +306,729 | 0 | 871 | 0.05% | +871 |
| Baxter Intl Inc | 0 | 20,000 | +20,000 | 0 | 855 | 0.05% | +855 |
| Bolt Biotherapeutics Inc | 2,754,437 | 2,754,437 | 0 | 3,085 | 3,856 | 0.23% | +771 |
| Perspective Therapeutics Inc(CATX) | 0 | 430,105 | +430,105 | 0 | 512 | 0.03% | +512 |
| Inari Med Inc | 0 | 10,216 | +10,216 | 0 | 490 | 0.03% | +490 |
| Savara Inc(SVRA) | 2,382,835 | 2,347,261 | -35,574 | 11,199 | 11,689 | 0.69% | +490 |
| Disc Medicine Inc(IRON) | 0 | 6,173 | +6,173 | 0 | 384 | 0.02% | +384 |
| Kyverna Therapeutics Inc(KYTX) | 0 | 10,000 | +10,000 | 0 | 248 | 0.01% | +248 |
| Celldex Therapeutics Inc(CLDX) | 844,008 | 801,777 | -42,231 | 33,473 | 33,651 | 1.99% | +177 |
| Vir Biotechnology Inc(VIR) | 4,495 | 0 | -4,495 | 45 | 0 | — | -45 |
| Spruce Biosciences Inc | 22,767 | 0 | -22,767 | 67 | 0 | — | -67 |
| Immatics NV | 318,372 | 316,349 | -2,023 | 930 | 853 | 0.05% | -77 |
| PDS Biotechnology Corp(PDSB) | 142,635 | 142,635 | 0 | 709 | 565 | 0.03% | -144 |
| Ikena Oncology Inc | 363,479 | 382,616 | +19,137 | 716 | 543 | 0.03% | -173 |
| Fulcrum Therapeutics Inc(FULC) | 28,600 | 0 | -28,600 | 193 | 0 | — | -193 |
| Nucana PLC | 2,400,000 | 1,307,875 | -1,092,125 | 710 | 340 | 0.02% | -370 |
| Galera Therapeutics Inc | 3,083,712 | 0 | -3,083,712 | 448 | 0 | — | -448 |
| Nucana PLC | 4,684,120 | 3,400,739 | -1,283,381 | 1,386 | 884 | 0.05% | -501 |
| Penumbra Inc(PEN) | 2,000 | 0 | -2,000 | 503 | 0 | — | -503 |
| Pharvaris N V COM | 510,441 | 584,672 | +74,231 | 14,318 | 13,512 | 0.80% | -806 |
| Cooper Cos Inc(COO) | 4,000 | 0 | -4,000 | 1,514 | 0 | — | -1,514 |
| Cabaletta Bio Inc(CABA) | 429,395 | 429,746 | +351 | 9,747 | 7,331 | 0.43% | -2,416 |
| Dexcom Inc(DXCM) | 20,000 | 0 | -20,000 | 2,482 | 0 | — | -2,482 |
| Ironwood Pharmaceuticals Inc(IRWD) | 331,099 | 0 | -331,099 | 3,788 | 0 | — | -3,788 |
| Marinus Pharmaceuticals Inc | 1,772,699 | 1,401,053 | -371,646 | 19,269 | 12,666 | 0.75% | -6,604 |
| Structure Therapeutics Inc | 174,838 | 8,733 | -166,105 | 7,126 | 374 | 0.02% | -6,752 |
| MoonLake Immunotherapeutics(MLTX) | 113,757 | 0 | -113,757 | 6,870 | 0 | — | -6,870 |
| Merck & Co Inc(MRK) | 857,971 | 651,299 | -206,672 | 93,536 | 85,939 | 5.07% | -7,597 |
| Immatics NV(IMTX) | 2,969,039 | 2,163,646 | -805,393 | 31,264 | 22,740 | 1.34% | -8,524 |
| Immunovant Inc(IMVT) | 222,553 | 0 | -222,553 | 9,376 | 0 | — | -9,376 |
| Mirum Pharmaceuticals Inc(MIRM) | 352,397 | 3,012 | -349,385 | 10,403 | 76 | 0.00% | -10,327 |
| Agenus Inc(AGEN) | 15,656,234 | 0 | -15,656,234 | 12,962 | 0 | — | -12,962 |
| Kura Oncology Inc(KURA) | 1,667,321 | 501,940 | -1,165,381 | 23,976 | 10,706 | 0.63% | -13,270 |
| AstraZeneca PLC(AZN) | 850,577 | 596,713 | -253,864 | 57,286 | 40,427 | 2.39% | -16,859 |
| IDEAYA Biosciences Inc(IDYA) | 1,458,881 | 781,596 | -677,285 | 51,907 | 34,296 | 2.02% | -17,611 |
| Geron Corp(GERN) | 8,814,497 | 0 | -8,814,497 | 18,599 | 0 | — | -18,599 |
| Stryker Corporation(SYK) | 62,788 | 0 | -62,788 | 18,802 | 0 | — | -18,802 |
| Kenvue Inc(KVUE) | 1,206,939 | 0 | -1,206,939 | 25,985 | 0 | — | -25,985 |
| Sanofi(SNY) | 598,978 | 0 | -598,978 | 29,787 | 0 | — | -29,787 |
| CymaBay Therapeutics Inc | 1,411,769 | 0 | -1,411,769 | 33,346 | 0 | — | -33,346 |
| Cytokinetics Inc(CYTK) | 414,207 | 0 | -414,207 | 34,582 | 0 | — | -34,582 |
| Eli Lilly & Co(LLY) | 64,525 | 0 | -64,525 | 37,613 | 0 | — | -37,613 |
| ImmunoGen Inc | 1,546,902 | 0 | -1,546,902 | 45,866 | 0 | — | -45,866 |
| RayzeBio Inc | 2,419,528 | 0 | -2,419,528 | 150,422 | 0 | — | -150,422 |
| Karuna Therapeutics Inc | 1,381,149 | 0 | -1,381,149 | 437,147 | 0 | — | -437,147 |