Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Stryker Corporation(SYK) | 116,005 | 298,567 | +182,562 | 41,768 | 111,142 | 8.38% | +69,374 |
| Medtronic PLC(MDT) | 0 | 562,992 | +562,992 | 0 | 50,590 | 3.82% | +50,590 |
| Eli Lilly & Co(LLY) | 14,364 | 52,800 | +38,436 | 11,089 | 43,608 | 3.29% | +32,519 |
| PTC Therapeutics Inc(PTCT) | 0 | 579,339 | +579,339 | 0 | 29,523 | 2.23% | +29,523 |
| BridgeBio Pharma Inc(BBIO) | 0 | 734,227 | +734,227 | 0 | 25,382 | 1.91% | +25,382 |
| Blueprint Medicines Corp | 0 | 261,039 | +261,039 | 0 | 23,105 | 1.74% | +23,105 |
| Bristol-Myers Squibb Co(BMY) | 0 | 371,497 | +371,497 | 0 | 22,658 | 1.71% | +22,658 |
| Alnylam Pharmaceuticals Inc(ALNY) | 110,157 | 176,181 | +66,024 | 25,921 | 47,572 | 3.59% | +21,651 |
| Akero Therapeutics Inc | 0 | 510,020 | +510,020 | 0 | 20,646 | 1.56% | +20,646 |
| AnaptysBio Inc | 132,927 | 1,160,033 | +1,027,106 | 1,760 | 21,565 | 1.63% | +19,805 |
| Syndax Pharmaceuticals Inc(SNDX) | 658,627 | 2,275,223 | +1,616,596 | 8,707 | 27,951 | 2.11% | +19,244 |
| Supernus Pharmaceuticals Inc(SUPN) | 0 | 520,678 | +520,678 | 0 | 17,052 | 1.29% | +17,052 |
| IDEAYA Biosciences Inc(IDYA) | 1,069,090 | 2,622,192 | +1,553,102 | 27,476 | 42,952 | 3.24% | +15,476 |
| Roivant Sciences Ltd(ROIV) | 0 | 1,279,510 | +1,279,510 | 0 | 12,910 | 0.97% | +12,910 |
| Penumbra Inc(PEN) | 0 | 42,936 | +42,936 | 0 | 11,482 | 0.87% | +11,482 |
| Avidity Biosciences Inc | 13,789 | 379,931 | +366,142 | 401 | 11,216 | 0.85% | +10,815 |
| Danaher Corporation(DHR) | 10,000 | 58,606 | +48,606 | 2,296 | 12,014 | 0.91% | +9,719 |
| Arcus Biosciences Inc(RCUS) | 0 | 1,037,776 | +1,037,776 | 0 | 8,147 | 0.61% | +8,147 |
| Cogent Biosciences Inc(COGT) | 823,160 | 2,182,121 | +1,358,961 | 6,421 | 13,071 | 0.99% | +6,650 |
| Praxis Precision Medicines I(PRAX) | 0 | 157,640 | +157,640 | 0 | 5,970 | 0.45% | +5,970 |
| Uniqure NV(QURE) | 0 | 545,771 | +545,771 | 0 | 5,785 | 0.44% | +5,785 |
| Insmed Inc(INSM) | 256,281 | 304,254 | +47,973 | 17,694 | 23,212 | 1.75% | +5,518 |
| Kura Oncology Inc(KURA) | 0 | 791,667 | +791,667 | 0 | 5,225 | 0.39% | +5,225 |
| Immatics N.V(IMTX) | 343,206 | 1,554,304 | +1,211,098 | 2,440 | 7,010 | 0.53% | +4,570 |
| Dexcom Inc(DXCM) | 290,210 | 395,975 | +105,765 | 22,570 | 27,041 | 2.04% | +4,472 |
| Scholar Rock Hldg Corp(SRRK) | 0 | 116,117 | +116,117 | 0 | 3,733 | 0.28% | +3,733 |
| Inhibrx Biosciences Inc(INBX) | 527,190 | 697,916 | +170,726 | 8,119 | 9,764 | 0.74% | +1,645 |
| Rhythm Pharmaceuticals(RYTM) | 397,428 | 446,839 | +49,411 | 22,248 | 23,669 | 1.78% | +1,421 |
| Jazz Pharmaceuticals PLC(JAZZ) | 504,193 | 510,050 | +5,857 | 62,091 | 63,323 | 4.78% | +1,231 |
| Metsera Inc | 0 | 36,800 | +36,800 | 0 | 1,002 | 0.08% | +1,002 |
| Soleno Therapeutics Inc | 757,248 | 484,471 | -272,777 | 34,038 | 34,615 | 2.61% | +577 |
| Structure Therapeutics Inc | 20,892 | 34,952 | +14,060 | 567 | 605 | 0.05% | +38 |
| Enliven Therapeutics Inc | 34,025 | 33,547 | -478 | 766 | 660 | 0.05% | -105 |
| Ikena Oncology Inc | 382,616 | 382,616 | 0 | 627 | 490 | 0.04% | -138 |
| Vir Biotechnology Inc(VIR) | 114,131 | 83,010 | -31,121 | 838 | 538 | 0.04% | -300 |
| Bolt Biotherapeutics Inc | 2,754,437 | 2,754,437 | 0 | 1,474 | 1,102 | 0.08% | -372 |
| Pulmonx Corp(LUNG) | 61,326 | 0 | -61,326 | 416 | 0 | — | -416 |
| Aerovate Therapeutics Inc | 3,758,686 | 3,758,686 | 0 | 9,961 | 9,434 | 0.71% | -526 |
| Travere Therapeutics Inc(TVTX) | 32,616 | 0 | -32,616 | 568 | 0 | — | -568 |
| ICU Med Inc(ICUI) | 5,000 | 0 | -5,000 | 776 | 0 | — | -776 |
| Nextcure Inc | 2,671,856 | 2,671,856 | 0 | 2,060 | 1,283 | 0.10% | -777 |
| Disc Medicine Inc(IRON) | 22,752 | 7,485 | -15,267 | 1,442 | 372 | 0.03% | -1,071 |
| Becton Dickinson & Co(BDX) | 4,951 | 0 | -4,951 | 1,123 | 0 | — | -1,123 |
| Pharvaris N V COM | 560,723 | 593,403 | +32,680 | 10,749 | 9,316 | 0.70% | -1,433 |
| Keros Therapeutics Inc(KROS) | 95,375 | 0 | -95,375 | 1,510 | 0 | — | -1,510 |
| Savara Inc(SVRA) | 5,471,299 | 5,481,666 | +10,367 | 16,797 | 15,184 | 1.15% | -1,613 |
| Erasca Inc(ERAS) | 1,795,880 | 1,877,085 | +81,205 | 4,508 | 2,572 | 0.19% | -1,936 |
| Immunome Inc(IMNM) | 746,824 | 788,666 | +41,842 | 7,931 | 5,308 | 0.40% | -2,624 |
| Exact Sciences Corp(EXK) | 52,042 | 0 | -52,042 | 2,924 | 0 | — | -2,924 |
| Edwards Lifesciences Corp | 40,000 | 0 | -40,000 | 2,961 | 0 | — | -2,961 |
| Establishment Labs Hldgs Inc(ESTA) | 95,305 | 28,675 | -66,630 | 4,391 | 1,170 | 0.09% | -3,221 |
| Edgewise Therapeutics Inc(EWTX) | 402,773 | 342,218 | -60,555 | 10,754 | 7,529 | 0.57% | -3,225 |
| Avantor Inc(AVTR) | 200,000 | 0 | -200,000 | 4,214 | 0 | — | -4,214 |
| Achieve Life Sciences Inc | 1,306,482 | 0 | -1,306,482 | 4,599 | 0 | — | -4,599 |
| BioAge Labs Inc(BIOA) | 2,304,901 | 2,304,901 | 0 | 13,345 | 8,666 | 0.65% | -4,679 |
| Y-mAbs Therapeutics Inc | 2,194,278 | 2,194,278 | 0 | 17,181 | 9,721 | 0.73% | -7,461 |
| Inozyme Pharma Inc | 4,280,308 | 4,280,308 | 0 | 11,856 | 3,895 | 0.29% | -7,961 |
| Inari Med Inc | 180,456 | 0 | -180,456 | 9,212 | 0 | — | -9,212 |
| Janux Therapeutics Inc(JANX) | 253,262 | 0 | -253,262 | 13,560 | 0 | — | -13,560 |
| Arrivent BioPharma Inc(AVBP) | 1,696,752 | 1,696,752 | 0 | 45,201 | 31,373 | 2.37% | -13,829 |
| Intuitive Surgical Inc | 37,896 | 11,984 | -25,912 | 19,780 | 5,935 | 0.45% | -13,845 |
| Replimune Group Inc(REPL) | 3,149,522 | 2,479,939 | -669,583 | 38,141 | 24,179 | 1.82% | -13,961 |
| Incyte Corp(INCY) | 524,267 | 357,800 | -166,467 | 36,211 | 21,665 | 1.63% | -14,546 |
| Rapport Therapeutics Inc(RAPP) | 1,995,594 | 1,995,594 | 0 | 35,402 | 20,016 | 1.51% | -15,386 |
| Dyne Therapeutics Inc(DYN) | 1,071,498 | 716,896 | -354,602 | 25,244 | 7,499 | 0.57% | -17,746 |
| Globus Med Inc(GMED) | 244,700 | 0 | -244,700 | 20,239 | 0 | — | -20,239 |
| Axsome Therapeutics Inc(AXSM) | 491,726 | 175,317 | -316,409 | 41,605 | 20,447 | 1.54% | -21,158 |
| Gilead Sciences Inc(GILD) | 774,227 | 418,900 | -355,327 | 71,515 | 46,938 | 3.54% | -24,578 |
| Alkermes Plc(ALKS) | 894,266 | 0 | -894,266 | 25,719 | 0 | — | -25,719 |
| Natera Inc(NTRA) | 1,550,280 | 1,550,280 | 0 | 245,409 | 219,225 | 16.53% | -26,184 |
| Boston Scientific Corp(BSX) | 346,571 | 0 | -346,571 | 30,956 | 0 | — | -30,956 |
| Sarepta Therapeutics Inc(SRPT) | 428,771 | 327,618 | -101,153 | 52,134 | 20,909 | 1.58% | -31,226 |
| AstraZeneca PLC(AZN) | 651,344 | 0 | -651,344 | 42,676 | 0 | — | -42,676 |
| Vera Therapeutics Inc(VERA) | 2,793,987 | 2,793,987 | 0 | 118,158 | 67,112 | 5.06% | -51,046 |
| AbbVie Inc(ABBV) | 359,393 | 0 | -359,393 | 63,864 | 0 | — | -63,864 |