Fund Holdings

Sofinnova Investments, Inc.

Filing Period:
Securities
SharesValue ($K)
Q4 2025
Q1 2026
Change
Q4 2025
Q1 2026
Weight (%)
Change
iShares TR(Put)0600,000+600,0000148,800,000+148,800,000
SPDR Series Trust(Put)01,050,000+1,050,0000134,116,500+134,116,500
AstraZeneca PLC(AZN)0456,031+456,031089,938,4344.51%+89,938,434
Invesco QQQ TR(Put)0150,000+150,000086,577,000+86,577,000
iShares TR(Put)0475,000+475,000080,203,750+80,203,750
Ultragenyx Pharmaceutical Inc(RARE)03,145,888+3,145,888065,906,3543.30%+65,906,354
United Therapeutics Corp(UTHR)(Put)080,300+80,300047,616,294+47,616,294
Biogen Inc(BIIB)0229,521+229,521042,078,0852.11%+42,078,085
Bristol-Myers Squibb Co(BMY)01,988,721+1,988,7210120,615,9296.04%+120,615,929
Celcuity Inc(CELC)(Put)0300,000+300,000034,242,000+34,242,000
Axsome Therapeutics Inc.(AXSM)(Put)0200,000+200,000033,804,000+33,804,000
Axsome Therapeutics Inc.(AXSM)0212,747+212,747035,958,4981.80%+35,958,498
Insmed Inc(INSM)0346,075+346,075056,590,1842.84%+56,590,184
Alcon AG(ALC)0729,972+729,972055,003,3902.76%+55,003,390
Pfizer Inc(PFE)(Call)0800,000+800,000022,464,000+22,464,000
Supernus Pharmaceuticals(SUPN)0954,309+954,309049,328,2322.47%+49,328,232
Genmab A/S(GMAB)0752,261+752,261020,183,1631.01%+20,183,163
Liquidia Corporation(LQDA)(Put)0500,000+500,000018,870,000+18,870,000
Nektar Therapeutics(NKTR)0509,546+509,546036,661,8351.84%+36,661,835
United Therapeutics Corp(UTHR)0160,070+160,070094,918,3094.76%+94,918,309
Xenon Pharmaceuticals Inc(XENE)0305,216+305,216017,748,3100.89%+17,748,310
Stryker Corporation(SYK)044,480+44,480014,615,6830.73%+14,615,683
Celcuity Inc(CELC)0366,175+366,175041,795,2152.09%+41,795,215
Cogent Biosciences Inc(COGT)02,113,551+2,113,551081,350,5784.08%+81,350,578
Exelixis Inc(EXEL)(Put)0251,500+251,500010,786,835+10,786,835
Rhythm Pharmaceuticals Inc(RYTM)0450,096+450,096039,144,8491.96%+39,144,849
BioAge Labs Inc02,293,788+2,293,788040,118,3522.01%+40,118,352
Oric Pharmaceuticals Inc0679,578+679,57808,610,2530.43%+8,610,253
Tango Therapeutics Inc(TNGX)0395,081+395,08108,265,0950.41%+8,265,095
Tyra Biosciences Inc(TYRA)0204,015+204,01507,813,7750.39%+7,813,775
Replimune Group Inc(Call)01,015,400+1,015,40007,767,810+7,767,810
Ultragenyx Pharmaceutical Inc(RARE)(Call)0350,000+350,00007,332,500+7,332,500
IDEAYA Biosciences Inc(IDYA)01,131,786+1,131,786037,711,1101.89%+37,711,110
AxoGen Inc(AXGN)0210,665+210,66506,979,3310.35%+6,979,331
Definium Therapeutics Inc(DFTX)0344,166+344,16606,504,7370.33%+6,504,737
Cytokinetics Inc(CYTK)091,791+91,79106,049,9450.30%+6,049,945
Arrivent BioPharma Inc(AVBP)01,696,752+1,696,752039,144,0691.96%+39,144,069
Veradermics Inc(MANE)073,315+73,31504,629,8420.23%+4,629,842
Harmony Biosciences Hldgs Inc(HRMY)0152,695+152,69504,276,9870.21%+4,276,987
Vaxcyte Inc(PCVX)050,600+50,60002,940,3660.15%+2,940,366
BioMarin Pharmaceutical Inc(BMRN)0781,982+781,982044,174,1632.21%+44,174,163
Compass Therapeutics Inc(Call)0500,000+500,00002,645,000+2,645,000
Immunome Inc(IMNM)01,701,904+1,701,904037,220,6401.86%+37,220,640
Pharvaris N V0818,328+818,328023,117,7661.16%+23,117,766
Rapport Therapeutics Inc(RAPP)01,904,408+1,904,408059,588,9262.99%+59,588,926
Tenax Therapeutics Inc0104,400+104,40001,669,3560.08%+1,669,356
Edgewise Therapeutics Inc(EWTX)0386,498+386,498012,174,6870.61%+12,174,687
Septerna Inc(SEPN)047,506+47,50601,141,5690.06%+1,141,569
Mirum Pharmaceuticals Inc(MIRM)027,591+27,59102,548,8570.13%+2,548,857
Onkure Therapeutics Inc0141,700+141,7000586,6380.03%+586,638
Savara Inc(SVRA)0364,763+364,76301,991,6060.10%+1,991,606
Zymeworks Inc(ZYME)01,610+1,610040,3140.00%+40,314
Acadia Pharmaceuticals Inc078,551+78,55101,748,5450.09%+1,748,545
ImageneBio Inc031,884+31,8840159,4200.01%+159,420
Soleno Therapeutics Inc014,689+14,6890491,7880.02%+491,788
Establishment Labs Hldgs Inc(ESTA)033,930+33,93001,926,5450.10%+1,926,545
Jade Biosciences Inc0107,391+107,39101,508,8440.08%+1,508,844
AnaptysBio Inc0248,253+248,253013,768,1110.69%+13,768,111
Bolt Biotherapeutics Inc0137,721+137,7210556,3930.03%+556,393
Immatics N.V(IMTX)03,630,454+3,630,454035,723,6671.79%+35,723,667
Dexcom Inc(DXCM)0393,576+393,576024,716,5731.24%+24,716,573
Nextcure Inc0222,654+222,65402,377,9450.12%+2,377,945
Wave Life Sciences Ltd(WVE)0189,253+189,25301,372,0840.07%+1,372,084
EVOMMUNE INC000000
Roivant Sciences Ltd(ROIV)0477,995+477,995013,240,4620.66%+13,240,462
Disc Medicine Inc(IRON)078,320+78,32005,007,7810.25%+5,007,781
UNIQURE NV(QURE)000000
MASIMO CORP(MASI)000000
Arcus Biosciences Inc(RCUS)0923,086+923,086019,938,6581.00%+19,938,658
AMYLYX PHARMACEUTICALS INC(AMLX)000000
Compass Therapeutics Inc02,056,161+2,056,161010,877,0920.54%+10,877,092
Inhibrx Biosciences Inc(INBX)0406,029+406,029027,297,3301.37%+27,297,330
EXACT SCIENCES CORP(EXK)000000
GE HEALTHCARE TECHNOLOGIES I(GEHC)000000
Dyne Therapeutics Inc(DYN)01,633,897+1,633,897029,622,5531.48%+29,622,553
Praxis Precision Medicines Inc(PRAX)063,680+63,680020,517,0591.03%+20,517,059
BridgeBio Pharma Inc(BBIO)0409,183+409,183030,385,9301.52%+30,385,930
CENTESSA PHARMACEUTICALS PLC(CNTA)000000
Vera Therapeutics Inc(VERA)02,793,987+2,793,9870112,402,0975.63%+112,402,097
GLAUKOS CORP(GKOS)000000
CIDARA THERAPEUTICS INC000000
APOGEE THERAPEUTICS INC(APGE)000000
Natera Inc(NTRA)01,550,280+1,550,2800310,040,49715.53%+310,040,497
Jazz Pharmaceuticals PLC(JAZZ)0598,327+598,3270113,113,7195.67%+113,113,719
AVIDITY BIOSCIENCES INC000000
ELI LILLY & CO(LLY)000000
INTUITIVE SURGICAL INC000000
ABBVIE INC(ABBV)000000
VERTEX PHARMACEUTICALS INC(VRTX)000000
ASTRAZENECA PLC(AZN)000000
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