Sofinnova Investments, Inc.
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| iShares TR(Put) | 0 | 600,000 | +600,000 | 0 | 148,800,000 | — | +148,800,000 |
| SPDR Series Trust(Put) ST STR SP BIOT | 0 | 1,050,000 | +1,050,000 | 0 | 134,116,500 | — | +134,116,500 |
| AstraZeneca PLC(AZN) | 0 | 456,031 | +456,031 | 0 | 89,938,434 | 4.51% | +89,938,434 |
| Invesco QQQ TR(Put) | 0 | 150,000 | +150,000 | 0 | 86,577,000 | — | +86,577,000 |
| iShares TR(Put) | 0 | 475,000 | +475,000 | 0 | 80,203,750 | — | +80,203,750 |
| Ultragenyx Pharmaceutical Inc(RARE) | 83,300 | 3,145,888 | +3,062,588 | 1,915,900 | 65,906,354 | 3.30% | +63,990,454 |
| United Therapeutics Corp(UTHR)(Put) | 0 | 80,300 | +80,300 | 0 | 47,616,294 | — | +47,616,294 |
| Biogen Inc(BIIB) | 0 | 229,521 | +229,521 | 0 | 42,078,085 | 2.11% | +42,078,085 |
| Bristol-Myers Squibb Co(BMY) | 1,512,994 | 1,988,721 | +475,727 | 81,610,896 | 120,615,929 | 6.04% | +39,005,033 |
| Celcuity Inc(CELC)(Put) | 0 | 300,000 | +300,000 | 0 | 34,242,000 | — | +34,242,000 |
| Axsome Therapeutics Inc.(AXSM)(Put) | 0 | 200,000 | +200,000 | 0 | 33,804,000 | — | +33,804,000 |
| Axsome Therapeutics Inc.(AXSM) | 12,266 | 212,747 | +200,481 | 2,240,262 | 35,958,498 | 1.80% | +33,718,236 |
| Insmed Inc(INSM) | 156,801 | 346,075 | +189,274 | 27,289,646 | 56,590,184 | 2.84% | +29,300,538 |
| Alcon AG(ALC) | 332,520 | 729,972 | +397,452 | 26,205,901 | 55,003,390 | 2.76% | +28,797,489 |
| Pfizer Inc(PFE)(Call) | 0 | 800,000 | +800,000 | 0 | 22,464,000 | — | +22,464,000 |
| Supernus Pharmaceuticals(SUPN) | 553,095 | 954,309 | +401,214 | 27,488,822 | 49,328,232 | 2.47% | +21,839,410 |
| Genmab A/S(GMAB) | 0 | 752,261 | +752,261 | 0 | 20,183,163 | 1.01% | +20,183,163 |
| Liquidia Corporation(LQDA)(Put) | 0 | 500,000 | +500,000 | 0 | 18,870,000 | — | +18,870,000 |
| Nektar Therapeutics(NKTR) | 438,630 | 509,546 | +70,916 | 18,545,276 | 36,661,835 | 1.84% | +18,116,559 |
| United Therapeutics Corp(UTHR) | 157,641 | 160,070 | +2,429 | 76,810,577 | 94,918,309 | 4.76% | +18,107,732 |
| Xenon Pharmaceuticals Inc(XENE) | 59,900 | 305,216 | +245,316 | 2,684,718 | 17,748,310 | 0.89% | +15,063,592 |
| Stryker Corporation(SYK) | 0 | 44,480 | +44,480 | 0 | 14,615,683 | 0.73% | +14,615,683 |
| Celcuity Inc(CELC) | 299,417 | 366,175 | +66,758 | 29,863,852 | 41,795,215 | 2.09% | +11,931,363 |
| Cogent Biosciences Inc(COGT) | 1,973,625 | 2,113,551 | +139,926 | 70,103,160 | 81,350,578 | 4.08% | +11,247,418 |
| Exelixis Inc(EXEL)(Put) | 0 | 251,500 | +251,500 | 0 | 10,786,835 | — | +10,786,835 |
| Rhythm Pharmaceuticals Inc(RYTM) | 271,394 | 450,096 | +178,702 | 29,050,014 | 39,144,849 | 1.96% | +10,094,835 |
| BioAge Labs Inc(BIOA) | 2,293,788 | 2,293,788 | 0 | 30,346,815 | 40,118,352 | 2.01% | +9,771,537 |
| Oric Pharmaceuticals Inc(ORIC) | 0 | 679,578 | +679,578 | 0 | 8,610,253 | 0.43% | +8,610,253 |
| Tango Therapeutics Inc(TNGX) | 0 | 395,081 | +395,081 | 0 | 8,265,095 | 0.41% | +8,265,095 |
| Tyra Biosciences Inc(TYRA) | 0 | 204,015 | +204,015 | 0 | 7,813,775 | 0.39% | +7,813,775 |
| Replimune Group Inc(REPL)(Call) | 0 | 1,015,400 | +1,015,400 | 0 | 7,767,810 | — | +7,767,810 |
| Ultragenyx Pharmaceutical Inc(RARE)(Call) | 0 | 350,000 | +350,000 | 0 | 7,332,500 | — | +7,332,500 |
| IDEAYA Biosciences Inc(IDYA) | 885,121 | 1,131,786 | +246,665 | 30,598,633 | 37,711,110 | 1.89% | +7,112,477 |
| AxoGen Inc(AXGN) | 0 | 210,665 | +210,665 | 0 | 6,979,331 | 0.35% | +6,979,331 |
| Definium Therapeutics Inc(DFTX) | 0 | 344,166 | +344,166 | 0 | 6,504,737 | 0.33% | +6,504,737 |
| Cytokinetics Inc(CYTK) | 0 | 91,791 | +91,791 | 0 | 6,049,945 | 0.30% | +6,049,945 |
| Arrivent BioPharma Inc(AVBP) | 1,696,752 | 1,696,752 | 0 | 34,138,650 | 39,144,069 | 1.96% | +5,005,419 |
| Veradermics Inc(MANE) | 0 | 73,315 | +73,315 | 0 | 4,629,842 | 0.23% | +4,629,842 |
| Harmony Biosciences Hldgs Inc(HRMY) | 0 | 152,695 | +152,695 | 0 | 4,276,987 | 0.21% | +4,276,987 |
| Vaxcyte Inc(PCVX) | 0 | 50,600 | +50,600 | 0 | 2,940,366 | 0.15% | +2,940,366 |
| BioMarin Pharmaceutical Inc(BMRN) | 697,133 | 781,982 | +84,849 | 41,430,614 | 44,174,163 | 2.21% | +2,743,549 |
| Compass Therapeutics Inc(Call) | 0 | 500,000 | +500,000 | 0 | 2,645,000 | — | +2,645,000 |
| Immunome Inc(IMNM) | 1,618,477 | 1,701,904 | +83,427 | 34,764,886 | 37,220,640 | 1.86% | +2,455,754 |
| Pharvaris N V COM | 745,169 | 818,328 | +73,159 | 20,678,440 | 23,117,766 | 1.16% | +2,439,326 |
| Rapport Therapeutics Inc(RAPP) | 1,904,408 | 1,904,408 | 0 | 57,779,739 | 59,588,926 | 2.99% | +1,809,187 |
| Tenax Therapeutics Inc | 0 | 104,400 | +104,400 | 0 | 1,669,356 | 0.08% | +1,669,356 |
| Edgewise Therapeutics Inc(EWTX) | 437,819 | 386,498 | -51,321 | 10,864,478 | 12,174,687 | 0.61% | +1,310,209 |
| Septerna Inc(SEPN) | 0 | 47,506 | +47,506 | 0 | 1,141,569 | 0.06% | +1,141,569 |
| Mirum Pharmaceuticals Inc(MIRM) | 23,100 | 27,591 | +4,491 | 1,824,669 | 2,548,857 | 0.13% | +724,188 |
| Onkure Therapeutics Inc | 0 | 141,700 | +141,700 | 0 | 586,638 | 0.03% | +586,638 |
| Savara Inc(SVRA) | 304,770 | 364,763 | +59,993 | 1,837,763 | 1,991,606 | 0.10% | +153,843 |
| Zymeworks Inc(ZYME) | 0 | 1,610 | +1,610 | 0 | 40,314 | 0.00% | +40,314 |
| Acadia Pharmaceuticals Inc | 65,567 | 78,551 | +12,984 | 1,751,295 | 1,748,545 | 0.09% | -2,750 |
| ImageneBio Inc | 31,884 | 31,884 | 0 | 220,000 | 159,420 | 0.01% | -60,580 |
| Soleno Therapeutics Inc | 12,414 | 14,689 | +2,275 | 574,768 | 491,788 | 0.02% | -82,980 |
| Establishment Labs Hldgs Inc(ESTA) | 28,366 | 33,930 | +5,564 | 2,067,314 | 1,926,545 | 0.10% | -140,769 |
| Jade Biosciences Inc | 107,391 | 107,391 | 0 | 1,657,043 | 1,508,844 | 0.08% | -148,199 |
| AnaptysBio Inc | 287,690 | 248,253 | -39,437 | 13,947,211 | 13,768,111 | 0.69% | -179,100 |
| Bolt Biotherapeutics Inc | 137,721 | 137,721 | 0 | 753,058 | 556,393 | 0.03% | -196,665 |
| Immatics N.V(IMTX) | 3,435,542 | 3,630,454 | +194,912 | 36,073,191 | 35,723,667 | 1.79% | -349,524 |
| Dexcom Inc(DXCM) | 378,219 | 393,576 | +15,357 | 25,102,395 | 24,716,573 | 1.24% | -385,822 |
| Nextcure Inc | 222,654 | 222,654 | 0 | 3,159,460 | 2,377,945 | 0.12% | -781,515 |
| Wave Life Sciences Ltd(WVE) | 158,182 | 189,253 | +31,071 | 2,689,094 | 1,372,084 | 0.07% | -1,317,010 |
| EVOMMUNE INC | 153,320 | 0 | -153,320 | 2,624,838 | 0 | — | -2,624,838 |
| Roivant Sciences Ltd(ROIV) | 734,582 | 477,995 | -256,587 | 15,940,429 | 13,240,462 | 0.66% | -2,699,967 |
| Disc Medicine Inc(IRON) | 111,010 | 78,320 | -32,690 | 8,815,304 | 5,007,781 | 0.25% | -3,807,523 |
| UNIQURE NV(QURE) | 176,513 | 0 | -176,513 | 4,223,956 | 0 | — | -4,223,956 |
| MASIMO CORP | 46,201 | 0 | -46,201 | 6,008,902 | 0 | — | -6,008,902 |
| Arcus Biosciences Inc(RCUS) | 1,096,705 | 923,086 | -173,619 | 26,134,480 | 19,938,658 | 1.00% | -6,195,822 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 527,099 | 0 | -527,099 | 6,367,356 | 0 | — | -6,367,356 |
| Compass Therapeutics Inc | 3,365,446 | 2,056,161 | -1,309,285 | 18,072,445 | 10,877,092 | 0.54% | -7,195,353 |
| Inhibrx Biosciences Inc(INBX) | 454,657 | 406,029 | -48,628 | 35,917,903 | 27,297,330 | 1.37% | -8,620,573 |
| EXACT SCIENCES CORP(EXK) | 101,443 | 0 | -101,443 | 10,302,551 | 0 | — | -10,302,551 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 160,876 | 0 | -160,876 | 13,195,050 | 0 | — | -13,195,050 |
| Dyne Therapeutics Inc(DYN) | 2,254,161 | 1,633,897 | -620,264 | 44,091,389 | 29,622,553 | 1.48% | -14,468,836 |
| Praxis Precision Medicines Inc(PRAX) | 125,722 | 63,680 | -62,042 | 37,055,302 | 20,517,059 | 1.03% | -16,538,243 |
| BridgeBio Pharma Inc(BBIO) | 720,448 | 409,183 | -311,265 | 55,107,068 | 30,385,930 | 1.52% | -24,721,138 |
| CENTESSA PHARMACEUTICALS PLC | 1,104,274 | 0 | -1,104,274 | 27,617,893 | 0 | — | -27,617,893 |
| Vera Therapeutics Inc(VERA) | 2,793,987 | 2,793,987 | 0 | 141,487,502 | 112,402,097 | 5.63% | -29,085,405 |
| GLAUKOS CORP(GKOS) | 288,128 | 0 | -288,128 | 32,532,532 | 0 | — | -32,532,532 |
| CIDARA THERAPEUTICS INC | 180,265 | 0 | -180,265 | 39,818,736 | 0 | — | -39,818,736 |
| APOGEE THERAPEUTICS INC(APGE) | 534,845 | 0 | -534,845 | 40,370,101 | 0 | — | -40,370,101 |
| Natera Inc(NTRA) | 1,550,280 | 1,550,280 | 0 | 355,153,645 | 310,040,497 | 15.53% | -45,113,148 |
| Jazz Pharmaceuticals PLC(JAZZ) | 959,860 | 598,327 | -361,533 | 163,176,200 | 113,113,719 | 5.67% | -50,062,481 |
| AVIDITY BIOSCIENCES INC | 745,116 | 0 | -745,116 | 53,745,217 | 0 | — | -53,745,217 |
| ELI LILLY & CO(LLY) | 61,652 | 0 | -61,652 | 66,256,171 | 0 | — | -66,256,171 |
| INTUITIVE SURGICAL INC | 126,968 | 0 | -126,968 | 71,909,596 | 0 | — | -71,909,596 |
| ABBVIE INC(ABBV) | 317,783 | 0 | -317,783 | 72,610,238 | 0 | — | -72,610,238 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 164,594 | 0 | -164,594 | 74,620,336 | 0 | — | -74,620,336 |
| ASTRAZENECA PLC(AZN) | 1,632,334 | 0 | -1,632,334 | 150,060,465 | 0 | — | -150,060,465 |