Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| AstraZeneca PLC(AZN) | 0 | 456,031 | +456,031 | 0 | 89,938 | 4.51% | +89,938 |
| Ultragenyx Pharmaceutical Inc(RARE) | 83,300 | 3,145,888 | +3,062,588 | 1,916 | 65,906 | 3.30% | +63,990 |
| Biogen Inc(BIIB) | 0 | 229,521 | +229,521 | 0 | 42,078 | 2.11% | +42,078 |
| Bristol-Myers Squibb Co(BMY) | 1,512,994 | 1,988,721 | +475,727 | 81,611 | 120,616 | 6.04% | +39,005 |
| Axsome Therapeutics Inc.(AXSM) | 12,266 | 212,747 | +200,481 | 2,240 | 35,958 | 1.80% | +33,718 |
| Insmed Inc(INSM) | 156,801 | 346,075 | +189,274 | 27,290 | 56,590 | 2.84% | +29,301 |
| Alcon AG(ALC) | 332,520 | 729,972 | +397,452 | 26,206 | 55,003 | 2.76% | +28,797 |
| Supernus Pharmaceuticals(SUPN) | 553,095 | 954,309 | +401,214 | 27,489 | 49,328 | 2.47% | +21,839 |
| Genmab A/S(GMAB) | 0 | 752,261 | +752,261 | 0 | 20,183 | 1.01% | +20,183 |
| Nektar Therapeutics(NKTR) | 438,630 | 509,546 | +70,916 | 18,545 | 36,662 | 1.84% | +18,117 |
| United Therapeutics Corp(UTHR) | 157,641 | 160,070 | +2,429 | 76,811 | 94,918 | 4.76% | +18,108 |
| Xenon Pharmaceuticals Inc(XENE) | 59,900 | 305,216 | +245,316 | 2,685 | 17,748 | 0.89% | +15,064 |
| Stryker Corporation(SYK) | 0 | 44,480 | +44,480 | 0 | 14,616 | 0.73% | +14,616 |
| Celcuity Inc(CELC) | 299,417 | 366,175 | +66,758 | 29,864 | 41,795 | 2.09% | +11,931 |
| Cogent Biosciences Inc(COGT) | 1,973,625 | 2,113,551 | +139,926 | 70,103 | 81,351 | 4.08% | +11,247 |
| Rhythm Pharmaceuticals Inc(RYTM) | 271,394 | 450,096 | +178,702 | 29,050 | 39,145 | 1.96% | +10,095 |
| BioAge Labs Inc(BIOA) | 2,293,788 | 2,293,788 | 0 | 30,347 | 40,118 | 2.01% | +9,772 |
| Oric Pharmaceuticals Inc(ORIC) | 0 | 679,578 | +679,578 | 0 | 8,610 | 0.43% | +8,610 |
| Tango Therapeutics Inc(TNGX) | 0 | 395,081 | +395,081 | 0 | 8,265 | 0.41% | +8,265 |
| Tyra Biosciences Inc(TYRA) | 0 | 204,015 | +204,015 | 0 | 7,814 | 0.39% | +7,814 |
| IDEAYA Biosciences Inc(IDYA) | 885,121 | 1,131,786 | +246,665 | 30,599 | 37,711 | 1.89% | +7,112 |
| AxoGen Inc(AXGN) | 0 | 210,665 | +210,665 | 0 | 6,979 | 0.35% | +6,979 |
| Definium Therapeutics Inc(DFTX) | 0 | 344,166 | +344,166 | 0 | 6,505 | 0.33% | +6,505 |
| Cytokinetics Inc(CYTK) | 0 | 91,791 | +91,791 | 0 | 6,050 | 0.30% | +6,050 |
| Arrivent BioPharma Inc(AVBP) | 1,696,752 | 1,696,752 | 0 | 34,139 | 39,144 | 1.96% | +5,005 |
| Veradermics Inc(MANE) | 0 | 73,315 | +73,315 | 0 | 4,630 | 0.23% | +4,630 |
| Harmony Biosciences Hldgs Inc(HRMY) | 0 | 152,695 | +152,695 | 0 | 4,277 | 0.21% | +4,277 |
| Vaxcyte Inc(PCVX) | 0 | 50,600 | +50,600 | 0 | 2,940 | 0.15% | +2,940 |
| BioMarin Pharmaceutical Inc(BMRN) | 697,133 | 781,982 | +84,849 | 41,431 | 44,174 | 2.21% | +2,744 |
| Immunome Inc(IMNM) | 1,618,477 | 1,701,904 | +83,427 | 34,765 | 37,221 | 1.86% | +2,456 |
| Pharvaris N V COM | 745,169 | 818,328 | +73,159 | 20,678 | 23,118 | 1.16% | +2,439 |
| Rapport Therapeutics Inc(RAPP) | 1,904,408 | 1,904,408 | 0 | 57,780 | 59,589 | 2.99% | +1,809 |
| Tenax Therapeutics Inc(TENX) | 0 | 104,400 | +104,400 | 0 | 1,669 | 0.08% | +1,669 |
| Edgewise Therapeutics Inc(EWTX) | 437,819 | 386,498 | -51,321 | 10,864 | 12,175 | 0.61% | +1,310 |
| Septerna Inc(SEPN) | 0 | 47,506 | +47,506 | 0 | 1,142 | 0.06% | +1,142 |
| Mirum Pharmaceuticals Inc(MIRM) | 23,100 | 27,591 | +4,491 | 1,825 | 2,549 | 0.13% | +724 |
| Onkure Therapeutics Inc(OKUR) | 0 | 141,700 | +141,700 | 0 | 587 | 0.03% | +587 |
| Savara Inc(SVRA) | 304,770 | 364,763 | +59,993 | 1,838 | 1,992 | 0.10% | +154 |
| Zymeworks Inc(ZYME) | 0 | 1,610 | +1,610 | 0 | 40 | 0.00% | +40 |
| Acadia Pharmaceuticals Inc | 65,567 | 78,551 | +12,984 | 1,751 | 1,749 | 0.09% | -3 |
| ImageneBio Inc(IMA) | 31,884 | 31,884 | 0 | 220 | 159 | 0.01% | -61 |
| Soleno Therapeutics Inc | 12,414 | 14,689 | +2,275 | 575 | 492 | 0.02% | -83 |
| Establishment Labs Hldgs Inc(ESTA) | 28,366 | 33,930 | +5,564 | 2,067 | 1,927 | 0.10% | -141 |
| Jade Biosciences Inc | 107,391 | 107,391 | 0 | 1,657 | 1,509 | 0.08% | -148 |
| AnaptysBio Inc | 287,690 | 248,253 | -39,437 | 13,947 | 13,768 | 0.69% | -179 |
| Bolt Biotherapeutics Inc | 137,721 | 137,721 | 0 | 753 | 556 | 0.03% | -197 |
| Immatics N.V(IMTX) | 3,435,542 | 3,630,454 | +194,912 | 36,073 | 35,724 | 1.79% | -350 |
| Dexcom Inc(DXCM) | 378,219 | 393,576 | +15,357 | 25,102 | 24,717 | 1.24% | -386 |
| Nextcure Inc | 222,654 | 222,654 | 0 | 3,159 | 2,378 | 0.12% | -782 |
| Wave Life Sciences Ltd(WVE) | 158,182 | 189,253 | +31,071 | 2,689 | 1,372 | 0.07% | -1,317 |
| EVOMMUNE INC(EVMN) | 153,320 | 0 | -153,320 | 2,625 | 0 | — | -2,625 |
| Roivant Sciences Ltd(ROIV) | 734,582 | 477,995 | -256,587 | 15,940 | 13,240 | 0.66% | -2,700 |
| Disc Medicine Inc(IRON) | 111,010 | 78,320 | -32,690 | 8,815 | 5,008 | 0.25% | -3,808 |
| UNIQURE NV(QURE) | 176,513 | 0 | -176,513 | 4,224 | 0 | — | -4,224 |
| MASIMO CORP | 46,201 | 0 | -46,201 | 6,009 | 0 | — | -6,009 |
| Arcus Biosciences Inc(RCUS) | 1,096,705 | 923,086 | -173,619 | 26,134 | 19,939 | 1.00% | -6,196 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 527,099 | 0 | -527,099 | 6,367 | 0 | — | -6,367 |
| Compass Therapeutics Inc(CMPX) | 3,365,446 | 2,056,161 | -1,309,285 | 18,072 | 10,877 | 0.54% | -7,195 |
| Inhibrx Biosciences Inc(INBX) | 454,657 | 406,029 | -48,628 | 35,918 | 27,297 | 1.37% | -8,621 |
| EXACT SCIENCES CORP(EXK) | 101,443 | 0 | -101,443 | 10,303 | 0 | — | -10,303 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 160,876 | 0 | -160,876 | 13,195 | 0 | — | -13,195 |
| Dyne Therapeutics Inc(DYN) | 2,254,161 | 1,633,897 | -620,264 | 44,091 | 29,623 | 1.48% | -14,469 |
| Praxis Precision Medicines Inc(PRAX) | 125,722 | 63,680 | -62,042 | 37,055 | 20,517 | 1.03% | -16,538 |
| BridgeBio Pharma Inc(BBIO) | 720,448 | 409,183 | -311,265 | 55,107 | 30,386 | 1.52% | -24,721 |
| CENTESSA PHARMACEUTICALS PLC | 1,104,274 | 0 | -1,104,274 | 27,618 | 0 | — | -27,618 |
| Vera Therapeutics Inc(VERA) | 2,793,987 | 2,793,987 | 0 | 141,488 | 112,402 | 5.63% | -29,085 |
| GLAUKOS CORP(GKOS) | 288,128 | 0 | -288,128 | 32,533 | 0 | — | -32,533 |
| CIDARA THERAPEUTICS INC | 180,265 | 0 | -180,265 | 39,819 | 0 | — | -39,819 |
| APOGEE THERAPEUTICS INC(APGE) | 534,845 | 0 | -534,845 | 40,370 | 0 | — | -40,370 |
| Natera Inc(NTRA) | 1,550,280 | 1,550,280 | 0 | 355,154 | 310,040 | 15.53% | -45,113 |
| Jazz Pharmaceuticals PLC(JAZZ) | 959,860 | 598,327 | -361,533 | 163,176 | 113,114 | 5.67% | -50,062 |
| AVIDITY BIOSCIENCES INC | 745,116 | 0 | -745,116 | 53,745 | 0 | — | -53,745 |
| ELI LILLY & CO(LLY) | 61,652 | 0 | -61,652 | 66,256 | 0 | — | -66,256 |
| INTUITIVE SURGICAL INC | 126,968 | 0 | -126,968 | 71,910 | 0 | — | -71,910 |
| ABBVIE INC(ABBV) | 317,783 | 0 | -317,783 | 72,610 | 0 | — | -72,610 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 164,594 | 0 | -164,594 | 74,620 | 0 | — | -74,620 |
| ASTRAZENECA PLC(AZN) | 1,632,334 | 0 | -1,632,334 | 150,060 | 0 | — | -150,060 |