Sofinnova Investments, Inc.
Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Vertex Pharmaceuticals Inc(VRTX) | 0 | 117,875 | +117,875 | 0 | 46,164,565 | 2.83% | +46,164,565 |
| United Therapeutics Corp(UTHR) | 118,513 | 190,626 | +72,113 | 34,054,711 | 79,912,325 | 4.90% | +45,857,614 |
| AstraZeneca PLC(AZN) | 293,661 | 823,933 | +530,272 | 20,521,031 | 63,212,140 | 3.88% | +42,691,109 |
| United Therapeutics Corp(UTHR)(Put) | 0 | 97,100 | +97,100 | 0 | 40,705,291 | — | +40,705,291 |
| SPDR Series Trust(Put) | 0 | 400,000 | +400,000 | 0 | 40,080,000 | — | +40,080,000 |
| Axsome Therapeutics Inc(AXSM) | 93,610 | 393,499 | +299,889 | 9,771,948 | 47,790,454 | 2.93% | +38,018,506 |
| Rapport Therapeutics Inc(RAPP) | 1,995,594 | 1,947,579 | -48,015 | 22,689,904 | 57,843,096 | 3.55% | +35,153,192 |
| Uniqure NV(QURE)(Put) | 0 | 500,000 | +500,000 | 0 | 29,185,000 | — | +29,185,000 |
| Glaukos Corp(GKOS) | 0 | 312,994 | +312,994 | 0 | 25,524,661 | 1.57% | +25,524,661 |
| Gilead Sciences Inc(GILD) | 1,050,308 | 1,252,312 | +202,004 | 116,447,648 | 139,006,632 | 8.53% | +22,558,984 |
| Avidity Biosciences Inc | 584,801 | 875,925 | +291,124 | 16,608,348 | 38,164,052 | 2.34% | +21,555,704 |
| Apogee Therapeutics Inc(APGE) | 76,180 | 565,417 | +489,237 | 3,308,497 | 22,464,017 | 1.38% | +19,155,520 |
| Uniqure NV(QURE)(Call) | 0 | 300,000 | +300,000 | 0 | 17,511,000 | — | +17,511,000 |
| Vera Therapeutics Inc(VERA) | 2,793,987 | 2,793,987 | 0 | 65,826,334 | 81,193,262 | 4.98% | +15,366,928 |
| Cogent Biosciences Inc(COGT) | 2,355,505 | 2,127,941 | -227,564 | 16,912,526 | 30,557,233 | 1.87% | +13,644,707 |
| Roivant Sciences Ltd(ROIV) | 3,088,814 | 3,149,270 | +60,456 | 34,810,934 | 47,648,455 | 2.92% | +12,837,521 |
| Celcuity Inc(CELC) | 0 | 253,375 | +253,375 | 0 | 12,516,725 | 0.77% | +12,516,725 |
| GE Healthcare Technologies Inc(GEHC) | 0 | 151,085 | +151,085 | 0 | 11,346,484 | 0.70% | +11,346,484 |
| Intuitive Surgical Inc | 70,642 | 110,896 | +40,254 | 38,387,569 | 49,596,018 | 3.04% | +11,208,449 |
| Boston Scientific Corp(BSX) | 431,200 | 569,427 | +138,227 | 46,315,192 | 55,593,158 | 3.41% | +9,277,966 |
| Exact Sciences Corp(EXK) | 208,300 | 365,000 | +156,700 | 11,069,062 | 19,969,150 | 1.22% | +8,900,088 |
| Praxis Precision Medicines Inc(PRAX) | 15,717 | 172,833 | +157,116 | 660,900 | 9,160,149 | 0.56% | +8,499,249 |
| Pharvaris N V | 585,532 | 739,876 | +154,344 | 10,305,363 | 18,459,906 | 1.13% | +8,154,543 |
| Compass Therapeutics Inc | 0 | 2,028,886 | +2,028,886 | 0 | 7,101,101 | 0.44% | +7,101,101 |
| Immatics N.V(IMTX) | 2,240,528 | 2,227,837 | -12,691 | 12,054,041 | 18,981,171 | 1.16% | +6,927,130 |
| Dexcom Inc(DXCM) | 523,694 | 779,616 | +255,922 | 45,713,249 | 52,460,361 | 3.22% | +6,747,112 |
| Nektar Therapeutics(NKTR) | 0 | 118,419 | +118,419 | 0 | 6,738,041 | 0.41% | +6,738,041 |
| Arcus Biosciences Inc(RCUS) | 1,216,016 | 1,222,263 | +6,247 | 9,898,370 | 16,622,777 | 1.02% | +6,724,407 |
| Dyne Therapeutics Inc(DYN) | 614,865 | 985,828 | +370,963 | 5,853,515 | 12,470,724 | 0.77% | +6,617,209 |
| Liquidia Corporation(LQDA)(Put) | 0 | 250,000 | +250,000 | 0 | 5,685,000 | — | +5,685,000 |
| Inhibrx Biosciences Inc(INBX) | 708,678 | 440,092 | -268,586 | 10,112,835 | 14,822,299 | 0.91% | +4,709,464 |
| BioAge Labs Inc(BIOA) | 2,304,901 | 2,293,788 | -11,113 | 9,519,241 | 13,487,473 | 0.83% | +3,968,232 |
| Jazz Pharmaceuticals PLC(JAZZ) | 694,096 | 588,828 | -105,268 | 73,657,468 | 77,607,530 | 4.76% | +3,950,062 |
| Summit Therapeutics Inc(SMMT)(Call) | 700,000 | 900,000 | +200,000 | 14,896,000 | 18,594,000 | — | +3,698,000 |
| Savara Inc(SVRA) | 2,457,352 | 2,427,724 | -29,628 | 5,602,763 | 8,666,975 | 0.53% | +3,064,212 |
| Nextcure Inc | 0 | 222,654 | +222,654 | 0 | 1,304,752 | 0.08% | +1,304,752 |
| Acadia Pharmaceuticals Inc | 0 | 26,800 | +26,800 | 0 | 571,912 | 0.04% | +571,912 |
| Disc Medicine Inc(IRON) | 7,312 | 13,553 | +6,241 | 387,244 | 895,582 | 0.05% | +508,338 |
| Wave Life Sciences Ltd(WVE) | 117,903 | 170,943 | +53,040 | 766,370 | 1,251,303 | 0.08% | +484,933 |
| BridgeBio Pharma Inc(BBIO) | 993,093 | 831,847 | -161,246 | 42,881,756 | 43,206,133 | 2.65% | +324,377 |
| ImageneBio Inc | 0 | 31,884 | +31,884 | 0 | 259,855 | 0.02% | +259,855 |
| Scholar Rock Hldg Corp(SRRK) | 26,440 | 31,410 | +4,970 | 936,505 | 1,169,708 | 0.07% | +233,203 |
| Bolt Biotherapeutics Inc | 137,721 | 137,721 | 0 | 794,650 | 732,676 | 0.04% | -61,974 |
| Jade Biosciences Inc | 107,391 | 107,391 | 0 | 1,072,836 | 926,784 | 0.06% | -146,052 |
| Ikena Oncology Inc | 382,616 | 0 | -382,616 | 512,705 | 0 | — | -512,705 |
| iShares TR(Put) | 375,000 | 325,000 | -50,000 | 47,441,250 | 46,920,250 | — | -521,000 |
| Structure Therapeutics Inc | 34,353 | 0 | -34,353 | 712,481 | 0 | — | -712,481 |
| Establishment Labs Hldgs Inc(ESTA) | 28,120 | 10,787 | -17,333 | 1,201,005 | 442,159 | 0.03% | -758,846 |
| Edgewise Therapeutics Inc(EWTX) | 716,873 | 520,240 | -196,633 | 9,398,205 | 8,438,293 | 0.52% | -959,912 |
| Metsera Inc | 36,191 | 0 | -36,191 | 1,029,634 | 0 | — | -1,029,634 |
| Nextcure Inc | 2,671,856 | 0 | -2,671,856 | 1,229,054 | 0 | — | -1,229,054 |
| Immunome Inc(IMNM) | 778,476 | 436,051 | -342,425 | 7,239,827 | 5,106,157 | 0.31% | -2,133,670 |
| Cogent Biosciences Inc(COGT)(Call) | 660,000 | 0 | -660,000 | 4,738,800 | 0 | — | -4,738,800 |
| Cidara Therapeutics Inc(Call) | 100,000 | 0 | -100,000 | 4,871,000 | 0 | — | -4,871,000 |
| Merus N V | 404,562 | 166,729 | -237,833 | 21,279,961 | 15,697,535 | 0.96% | -5,582,426 |
| Arrivent BioPharma Inc(AVBP) | 1,696,752 | 1,696,752 | 0 | 36,938,291 | 31,305,074 | 1.92% | -5,633,217 |
| Akero Therapeutics Inc | 548,788 | 473,625 | -75,163 | 29,283,328 | 22,487,715 | 1.38% | -6,795,613 |
| PTC Therapeutics Inc(PTCT) | 375,939 | 186,932 | -189,007 | 18,360,861 | 11,472,017 | 0.70% | -6,888,844 |
| Cidara Therapeutics Inc | 251,031 | 54,197 | -196,834 | 12,227,720 | 5,189,905 | 0.32% | -7,037,815 |
| Supernus Pharmaceuticals Inc(SUPN) | 799,253 | 377,066 | -422,187 | 25,192,455 | 18,019,984 | 1.11% | -7,172,471 |
| Y-mAbs Therapeutics Inc | 2,194,278 | 0 | -2,194,278 | 9,896,194 | 0 | — | -9,896,194 |
| Roivant Sciences Ltd(ROIV)(Call) | 1,000,000 | 0 | -1,000,000 | 11,270,000 | 0 | — | -11,270,000 |
| Rhythm Pharmaceuticals Inc(RYTM) | 586,010 | 246,966 | -339,044 | 37,029,972 | 24,941,096 | 1.53% | -12,088,876 |
| Natera Inc(NTRA) | 1,550,280 | 1,550,280 | 0 | 261,904,303 | 249,548,572 | 15.31% | -12,355,731 |
| Uniqure NV(QURE) | 1,558,356 | 136,862 | -1,421,494 | 21,723,483 | 7,988,635 | 0.49% | -13,734,848 |
| Replimune Group Inc(REPL)(Put) | 1,500,000 | 0 | -1,500,000 | 13,935,000 | 0 | — | -13,935,000 |
| Rhythm Pharmaceuticals Inc(RYTM)(Put) | 225,000 | 0 | -225,000 | 14,217,750 | 0 | — | -14,217,750 |
| Syndax Pharmaceuticals Inc(SNDX) | 1,524,440 | 0 | -1,524,440 | 14,276,381 | 0 | — | -14,276,381 |
| AbbVie Inc(ABBV) | 265,850 | 150,966 | -114,884 | 49,347,077 | 34,954,668 | 2.14% | -14,392,409 |
| AnaptysBio Inc | 1,032,362 | 254,268 | -778,094 | 22,918,436 | 7,785,686 | 0.48% | -15,132,750 |
| Insmed Inc(INSM) | 313,923 | 104,339 | -209,584 | 31,593,211 | 15,025,859 | 0.92% | -16,567,352 |
| Replimune Group Inc(REPL) | 1,806,529 | 0 | -1,806,529 | 16,782,654 | 0 | — | -16,782,654 |
| Inozyme Pharma Inc | 4,280,308 | 0 | -4,280,308 | 17,121,232 | 0 | — | -17,121,232 |
| IDEAYA Biosciences Inc(IDYA) | 2,147,795 | 922,695 | -1,225,100 | 45,146,651 | 25,106,531 | 1.54% | -20,040,120 |
| Soleno Therapeutics Inc | 415,219 | 166,281 | -248,938 | 34,787,048 | 11,240,596 | 0.69% | -23,546,452 |
| iShares TR(Put) | 250,000 | 0 | -250,000 | 53,947,500 | 0 | — | -53,947,500 |
| Eli Lilly and Co(LLY) | 97,018 | 0 | -97,018 | 75,628,442 | 0 | — | -75,628,442 |