Fund Holdings — Sofinnova Investments, Inc.

Total Portfolio Value
$1.63B
Total Bought
$381.56M
Total Sold
$361.76M
Net Transaction
+$19.80M
Filing Period:
Securities
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SharesValue ($K)
Q2 2025
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Q3 2025
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Change
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Q2 2025
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Q3 2025
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Weight (%)
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Change
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Vertex Pharmaceuticals Inc(VRTX)0117,875+117,875046,1652.83%+46,165
United Therapeutics Corp(UTHR)118,513190,626+72,11334,05579,9124.90%+45,858
AstraZeneca PLC(AZN)293,661823,933+530,27220,52163,2123.88%+42,691
Axsome Therapeutics Inc(AXSM)93,610393,499+299,8899,77247,7902.93%+38,019
Rapport Therapeutics Inc(RAPP)1,995,5941,947,579-48,01522,69057,8433.55%+35,153
Glaukos Corp(GKOS)0312,994+312,994025,5251.57%+25,525
Gilead Sciences Inc(GILD)1,050,3081,252,312+202,004116,448139,0078.53%+22,559
Avidity Biosciences Inc584,801875,925+291,12416,60838,1642.34%+21,556
Apogee Therapeutics Inc(APGE)76,180565,417+489,2373,30822,4641.38%+19,156
Vera Therapeutics Inc(VERA)2,793,9872,793,987065,82681,1934.98%+15,367
Cogent Biosciences Inc(COGT)2,355,5052,127,941-227,56416,91330,5571.87%+13,645
Roivant Sciences Ltd(ROIV)3,088,8143,149,270+60,45634,81147,6482.92%+12,838
Celcuity Inc(CELC)0253,375+253,375012,5170.77%+12,517
GE Healthcare Technologies Inc(GEHC)0151,085+151,085011,3460.70%+11,346
Intuitive Surgical Inc70,642110,896+40,25438,38849,5963.04%+11,208
Boston Scientific Corp(BSX)431,200569,427+138,22746,31555,5933.41%+9,278
Exact Sciences Corp(EXK)208,300365,000+156,70011,06919,9691.22%+8,900
Praxis Precision Medicines Inc(PRAX)15,717172,833+157,1166619,1600.56%+8,499
Pharvaris N V
COM
585,532739,876+154,34410,30518,4601.13%+8,155
Compass Therapeutics Inc(CMPX)02,028,886+2,028,88607,1010.44%+7,101
Immatics N.V(IMTX)2,240,5282,227,837-12,69112,05418,9811.16%+6,927
Dexcom Inc(DXCM)523,694779,616+255,92245,71352,4603.22%+6,747
Nektar Therapeutics(NKTR)0118,419+118,41906,7380.41%+6,738
Arcus Biosciences Inc(RCUS)1,216,0161,222,263+6,2479,89816,6231.02%+6,724
Dyne Therapeutics Inc(DYN)614,865985,828+370,9635,85412,4710.77%+6,617
Inhibrx Biosciences Inc(INBX)708,678440,092-268,58610,11314,8220.91%+4,709
BioAge Labs Inc(BIOA)2,304,9012,293,788-11,1139,51913,4870.83%+3,968
Jazz Pharmaceuticals PLC(JAZZ)694,096588,828-105,26873,65777,6084.76%+3,950
Savara Inc(SVRA)2,457,3522,427,724-29,6285,6038,6670.53%+3,064
Nextcure Inc0222,654+222,65401,3050.08%+1,305
Acadia Pharmaceuticals Inc026,800+26,80005720.04%+572
Disc Medicine Inc(IRON)7,31213,553+6,2413878960.05%+508
Wave Life Sciences Ltd(WVE)117,903170,943+53,0407661,2510.08%+485
BridgeBio Pharma Inc(BBIO)993,093831,847-161,24642,88243,2062.65%+324
ImageneBio Inc(IMA)031,884+31,88402600.02%+260
Scholar Rock Hldg Corp(SRRK)26,44031,410+4,9709371,1700.07%+233
Bolt Biotherapeutics Inc137,721137,72107957330.04%-62
Jade Biosciences Inc107,391107,39101,0739270.06%-146
Ikena Oncology Inc382,6160-382,6165130—-513
Structure Therapeutics Inc34,3530-34,3537120—-712
Establishment Labs Hldgs Inc(ESTA)28,12010,787-17,3331,2014420.03%-759
Edgewise Therapeutics Inc(EWTX)716,873520,240-196,6339,3988,4380.52%-960
Metsera Inc36,1910-36,1911,0300—-1,030
Nextcure Inc2,671,8560-2,671,8561,2290—-1,229
Immunome Inc(IMNM)778,476436,051-342,4257,2405,1060.31%-2,134
Merus N V404,562166,729-237,83321,28015,6980.96%-5,582
Arrivent BioPharma Inc(AVBP)1,696,7521,696,752036,93831,3051.92%-5,633
Akero Therapeutics Inc548,788473,625-75,16329,28322,4881.38%-6,796
PTC Therapeutics Inc(PTCT)375,939186,932-189,00718,36111,4720.70%-6,889
Cidara Therapeutics Inc251,03154,197-196,83412,2285,1900.32%-7,038
Supernus Pharmaceuticals Inc(SUPN)799,253377,066-422,18725,19218,0201.11%-7,172
Y-mAbs Therapeutics Inc2,194,2780-2,194,2789,8960—-9,896
Rhythm Pharmaceuticals Inc(RYTM)586,010246,966-339,04437,03024,9411.53%-12,089
Natera Inc(NTRA)1,550,2801,550,2800261,904249,54915.31%-12,356
Uniqure NV(QURE)1,558,356136,862-1,421,49421,7237,9890.49%-13,735
Syndax Pharmaceuticals Inc(SNDX)1,524,4400-1,524,44014,2760—-14,276
AbbVie Inc(ABBV)265,850150,966-114,88449,34734,9552.14%-14,392
AnaptysBio Inc1,032,362254,268-778,09422,9187,7860.48%-15,133
Insmed Inc(INSM)313,923104,339-209,58431,59315,0260.92%-16,567
Replimune Group Inc(REPL)1,806,5290-1,806,52916,7830—-16,783
Inozyme Pharma Inc4,280,3080-4,280,30817,1210—-17,121
IDEAYA Biosciences Inc(IDYA)2,147,795922,695-1,225,10045,14725,1071.54%-20,040
Soleno Therapeutics Inc415,219166,281-248,93834,78711,2410.69%-23,546
Eli Lilly and Co(LLY)97,0180-97,01875,6280—-75,628
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