Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Natera, Inc.(NTRA) | 1,550,280 | 1,550,280 | 0 | $249.55M | $355.15M | 15.31% | +$105.61M |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 588,828 | 959,860 | +371,032 | $77.61M | $163.18M | 7.04% | +$85.57M |
| AstraZeneca PLCADR(AZN) | 823,933 | 1,632,334 | +808,401 | $63.21M | $150.06M | 6.47% | +$86.85M |
| Vera Therapeutics, Inc.CL A(VERA) | 2,793,987 | 2,793,987 | 0 | $81.19M | $141.49M | 6.10% | +$60.29M |
| Bristol-Myers Squibb Company(BMY) | 0 | 1,512,994 | +1,512,994 | $0 | $81.61M | 3.52% | +$81.61M |
| United Therapeutics Corporation(UTHR) | 190,626 | 157,641 | -32,985 | $79.91M | $76.81M | 3.31% | -$3.10M |
| Vertex Pharmaceuticals Incorporated(VRTX) | 117,875 | 164,594 | +46,719 | $46.16M | $74.62M | 3.22% | +$28.46M |
| AbbVie Inc.(ABBV) | 150,966 | 317,783 | +166,817 | $34.95M | $72.61M | 3.13% | +$37.66M |
| Intuitive Surgical, Inc.(ISRG) | 110,896 | 126,968 | +16,072 | $49.60M | $71.91M | 3.10% | +$22.31M |
| Cogent Biosciences, Inc.(COGT) | 2,127,941 | 1,973,625 | -154,316 | $30.56M | $70.10M | 3.02% | +$39.55M |
| Eli Lilly and Company(LLY) | 0 | 61,652 | +61,652 | $0 | $66.26M | 2.86% | +$66.26M |
| Rapport Therapeutics, Inc.(RAPP) | 1,947,579 | 1,904,408 | -43,171 | $57.84M | $57.78M | 2.49% | -$63.4K |
| BridgeBio Pharma, Inc.(BBIO) | 831,847 | 720,448 | -111,399 | $43.21M | $55.11M | 2.38% | +$11.90M |
| Avidity Biosciences Inc | 875,925 | 745,116 | -130,809 | $38.16M | $53.75M | 2.32% | +$15.58M |
| Dyne Therapeutics, Inc.(DYN) | 985,828 | 2,254,161 | +1,268,333 | $12.47M | $44.09M | 1.90% | +$31.62M |
| BioMarin Pharmaceutical Inc.(BMRN) | 0 | 697,133 | +697,133 | $0 | $41.43M | 1.79% | +$41.43M |
| Apogee Therapeutics Inc | 565,417 | 534,845 | -30,572 | $22.46M | $40.37M | 1.74% | +$17.91M |
| Cidara Therapeutics Inc | 54,197 | 180,265 | +126,068 | $5.19M | $39.82M | 1.72% | +$34.63M |
| Praxis Precision Medicines, Inc.(PRAX) | 172,833 | 125,722 | -47,111 | $9.16M | $37.06M | 1.60% | +$27.90M |
| Immatics N.V.SHS(IMTX) | 2,227,837 | 3,435,542 | +1,207,705 | $18.98M | $36.07M | 1.56% | +$17.09M |
| Inhibrx Biosciences, Inc.(INBX) | 440,092 | 454,657 | +14,565 | $14.82M | $35.92M | 1.55% | +$21.10M |
| Immunome, Inc.(IMNM) | 436,051 | 1,618,477 | +1,182,426 | $5.11M | $34.76M | 1.50% | +$29.66M |
| ArriVent BioPharma, Inc.(AVBP) | 1,696,752 | 1,696,752 | 0 | $31.31M | $34.14M | 1.47% | +$2.83M |
| Glaukos Corporation(GKOS) | 312,994 | 288,128 | -24,866 | $25.52M | $32.53M | 1.40% | +$7.01M |
| IDEAYA Biosciences, Inc.(IDYA) | 922,695 | 885,121 | -37,574 | $25.11M | $30.60M | 1.32% | +$5.49M |
| BioAge Labs, Inc.(BIOA) | 2,293,788 | 2,293,788 | 0 | $13.49M | $30.35M | 1.31% | +$16.86M |
| Celcuity Inc.(CELC) | 253,375 | 299,417 | +46,042 | $12.52M | $29.86M | 1.29% | +$17.35M |
| Rhythm Pharmaceuticals, Inc.(RYTM) | 246,966 | 271,394 | +24,428 | $24.94M | $29.05M | 1.25% | +$4.11M |
| Centessa Pharmaceuticals PlcADS | 0 | 1,104,274 | +1,104,274 | $0 | $27.62M | 1.19% | +$27.62M |
| Supernus Pharmaceuticals, Inc.(SUPN) | 377,066 | 553,095 | +176,029 | $18.02M | $27.49M | 1.19% | +$9.47M |
| Insmed Incorporated(INSM) | 104,339 | 156,801 | +52,462 | $15.03M | $27.29M | 1.18% | +$12.26M |
| Alcon Inc.(ALC) | 0 | 332,520 | +332,520 | $0 | $26.21M | 1.13% | +$26.21M |
| Arcus Biosciences, Inc.(RCUS) | 1,222,263 | 1,096,705 | -125,558 | $16.62M | $26.13M | 1.13% | +$9.51M |
| DexCom, Inc.(DXCM) | 779,616 | 378,219 | -401,397 | $52.46M | $25.10M | 1.08% | -$27.36M |
| Pharvaris N V COM | 739,876 | 745,169 | +5,293 | $18.46M | $20.68M | 0.89% | +$2.22M |
| Nektar Therapeutics(NKTR) | 118,419 | 438,630 | +320,211 | $6.74M | $18.55M | 0.80% | +$11.81M |
| Compass Therapeutics, Inc.(CMPX) | 2,028,886 | 3,365,446 | +1,336,560 | $7.10M | $18.07M | 0.78% | +$10.97M |
| Roivant Sciences Ltd.SHS(ROIV) | 3,149,270 | 734,582 | -2,414,688 | $47.65M | $15.94M | 0.69% | -$31.71M |
| Anaptysbio Inc | 254,268 | 287,690 | +33,422 | $7.79M | $13.95M | 0.60% | +$6.16M |
| GE HealthCare Technologies Inc.(GEHC) | 151,085 | 160,876 | +9,791 | $11.35M | $13.20M | 0.57% | +$1.85M |
| Edgewise Therapeutics, Inc.(EWTX) | 520,240 | 437,819 | -82,421 | $8.44M | $10.86M | 0.47% | +$2.43M |
| Endeavour Silver Corp.(EXK) | 365,000 | 101,443 | -263,557 | $19.97M | $10.30M | 0.44% | -$9.67M |
| Disc Medicine, Inc.(IRON) | 13,553 | 111,010 | +97,457 | $895.6K | $8.82M | 0.38% | +$7.92M |
| Amylyx Pharmaceuticals, Inc.(AMLX) | 0 | 527,099 | +527,099 | $0 | $6.37M | 0.27% | +$6.37M |
| Masimo Corp | 0 | 46,201 | +46,201 | $0 | $6.01M | 0.26% | +$6.01M |
| uniQure N.V.SHS(QURE) | 136,862 | 176,513 | +39,651 | $7.99M | $4.22M | 0.18% | -$3.76M |
| Nextcure Inc | 222,654 | 222,654 | 0 | $1.30M | $3.16M | 0.14% | +$1.85M |
| Wave Life Sciences, Inc.SHS(WVE) | 170,943 | 158,182 | -12,761 | $1.25M | $2.69M | 0.12% | +$1.44M |
| Xenon Pharmaceuticals Inc.(XENE) | 0 | 59,900 | +59,900 | $0 | $2.68M | 0.12% | +$2.68M |
| Evommune, Inc.(EVMN) | 0 | 153,320 | +153,320 | $0 | $2.62M | 0.11% | +$2.62M |
| Axsome Therapeutics, Inc.(AXSM) | 393,499 | 12,266 | -381,233 | $47.79M | $2.24M | 0.10% | -$45.55M |
| Establishment Labs Holdings Inc.(ESTA) | 10,787 | 28,366 | +17,579 | $442.2K | $2.07M | 0.09% | +$1.63M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 0 | 83,300 | +83,300 | $0 | $1.92M | 0.08% | +$1.92M |
| Savara Inc.(SVRA) | 2,427,724 | 304,770 | -2,122,954 | $8.67M | $1.84M | 0.08% | -$6.83M |
| Mirum Pharmaceuticals, Inc.(MIRM) | 0 | 23,100 | +23,100 | $0 | $1.82M | 0.08% | +$1.82M |
| Acadia Pharmaceuticals Inc | 26,800 | 65,567 | +38,767 | $571.9K | $1.75M | 0.08% | +$1.18M |
| Jade Biosciences Inc | 107,391 | 107,391 | 0 | $926.8K | $1.66M | 0.07% | +$730.3K |
| Bolt Biotherapeutics Inc | 137,721 | 137,721 | 0 | $732.7K | $753.1K | 0.03% | +$20.4K |
| Soleno Therapeutics Inc | 166,281 | 12,414 | -153,867 | $11.24M | $574.8K | 0.02% | -$10.67M |
| ImageneBio, Inc.(IMA) | 31,884 | 31,884 | 0 | $259.9K | $220.0K | 0.01% | -$39.9K |
| Akero Therapeutics Inc | 473,625 | 0 | -473,625 | $22.49M | $0 | — | -$22.49M |
| Boston Scientific Corporation(BSX) | 569,427 | 0 | -569,427 | $55.59M | $0 | — | -$55.59M |
| Gilead Sciences, Inc.(GILD) | 1,252,312 | 0 | -1,252,312 | $139.01M | $0 | — | -$139.01M |
| Merus N V | 166,729 | 0 | -166,729 | $15.70M | $0 | — | -$15.70M |
| PTC Therapeutics, Inc.(PTCT) | 186,932 | 0 | -186,932 | $11.47M | $0 | — | -$11.47M |
| Scholar Rock Holding Corporation(SRRK) | 31,410 | 0 | -31,410 | $1.17M | $0 | — | -$1.17M |