Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| NATERA INC(NTRA) | 1,550,280 | 1,550,280 | 0 | 249,549 | 355,154 | 15.31% | +105,605 |
| ASTRAZENECA PLC(AZN) | 823,933 | 1,632,334 | +808,401 | 63,212 | 150,060 | 6.47% | +86,848 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 588,828 | 959,860 | +371,032 | 77,608 | 163,176 | 7.04% | +85,569 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 0 | 1,512,994 | +1,512,994 | 0 | 81,611 | 3.52% | +81,611 |
| ELI LILLY & CO(LLY) | 0 | 61,652 | +61,652 | 0 | 66,256 | 2.86% | +66,256 |
| VERA THERAPEUTICS INC(VERA) | 2,793,987 | 2,793,987 | 0 | 81,193 | 141,488 | 6.10% | +60,294 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 0 | 697,133 | +697,133 | 0 | 41,431 | 1.79% | +41,431 |
| COGENT BIOSCIENCES INC(COGT) | 2,127,941 | 1,973,625 | -154,316 | 30,557 | 70,103 | 3.02% | +39,546 |
| ABBVIE INC(ABBV) | 150,966 | 317,783 | +166,817 | 34,955 | 72,610 | 3.13% | +37,656 |
| CIDARA THERAPEUTICS INC | 54,197 | 180,265 | +126,068 | 5,190 | 39,819 | 1.72% | +34,629 |
| DYNE THERAPEUTICS INC(DYN) | 985,828 | 2,254,161 | +1,268,333 | 12,471 | 44,091 | 1.90% | +31,621 |
| IMMUNOME INC(IMNM) | 436,051 | 1,618,477 | +1,182,426 | 5,106 | 34,765 | 1.50% | +29,659 |
| VERTEX PHARMACEUTICALS INC(VRTX) | 117,875 | 164,594 | +46,719 | 46,165 | 74,620 | 3.22% | +28,456 |
| PRAXIS PRECISION MEDICINES INC(PRAX) | 172,833 | 125,722 | -47,111 | 9,160 | 37,055 | 1.60% | +27,895 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 1,104,274 | +1,104,274 | 0 | 27,618 | 1.19% | +27,618 |
| ALCON AG(ALC) | 0 | 332,520 | +332,520 | 0 | 26,206 | 1.13% | +26,206 |
| INTUITIVE SURGICAL INC | 110,896 | 126,968 | +16,072 | 49,596 | 71,910 | 3.10% | +22,314 |
| INHIBRX BIOSCIENCES INC(INBX) | 440,092 | 454,657 | +14,565 | 14,822 | 35,918 | 1.55% | +21,096 |
| APOGEE THERAPEUTICS INC(APGE) | 565,417 | 534,845 | -30,572 | 22,464 | 40,370 | 1.74% | +17,906 |
| CELCUITY INC(CELC) | 253,375 | 299,417 | +46,042 | 12,517 | 29,864 | 1.29% | +17,347 |
| IMMATICS N.V(IMTX) | 2,227,837 | 3,435,542 | +1,207,705 | 18,981 | 36,073 | 1.56% | +17,092 |
| BIOAGE LABS INC | 2,293,788 | 2,293,788 | 0 | 13,487 | 30,347 | 1.31% | +16,859 |
| AVIDITY BIOSCIENCES INC | 875,925 | 745,116 | -130,809 | 38,164 | 53,745 | 2.32% | +15,581 |
| GE HEALTHCARE TECHNOLOGIES I(GEHC) | 0 | 160,876 | +160,876 | 0 | 13,195 | 0.57% | +13,195 |
| INSMED INC(INSM) | 104,339 | 156,801 | +52,462 | 15,026 | 27,290 | 1.18% | +12,264 |
| BRIDGEBIO PHARMA INC(BBIO) | 831,847 | 720,448 | -111,399 | 43,206 | 55,107 | 2.38% | +11,901 |
| NEKTAR THERAPEUTICS(NKTR) | 118,419 | 438,630 | +320,211 | 6,738 | 18,545 | 0.80% | +11,807 |
| COMPASS THERAPEUTICS INC | 2,028,886 | 3,365,446 | +1,336,560 | 7,101 | 18,072 | 0.78% | +10,971 |
| ARCUS BIOSCIENCES INC(RCUS) | 1,222,263 | 1,096,705 | -125,558 | 16,623 | 26,134 | 1.13% | +9,512 |
| SUPERNUS PHARMACEUTICALS INC(SUPN) | 377,066 | 553,095 | +176,029 | 18,020 | 27,489 | 1.19% | +9,469 |
| DISC MEDICINE INC(IRON) | 13,553 | 111,010 | +97,457 | 896 | 8,815 | 0.38% | +7,920 |
| GLAUKOS CORP(GKOS) | 312,994 | 288,128 | -24,866 | 25,525 | 32,533 | 1.40% | +7,008 |
| AMYLYX PHARMACEUTICALS INC(AMLX) | 0 | 527,099 | +527,099 | 0 | 6,367 | 0.27% | +6,367 |
| ANAPTYSBIO INC | 254,268 | 287,690 | +33,422 | 7,786 | 13,947 | 0.60% | +6,162 |
| MASIMO CORP | 0 | 46,201 | +46,201 | 0 | 6,009 | 0.26% | +6,009 |
| IDEAYA BIOSCIENCES INC(IDYA) | 922,695 | 885,121 | -37,574 | 25,107 | 30,599 | 1.32% | +5,492 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 246,966 | 271,394 | +24,428 | 24,941 | 29,050 | 1.25% | +4,109 |
| ARRIVENT BIOPHARMA INC(AVBP) | 1,696,752 | 1,696,752 | 0 | 31,305 | 34,139 | 1.47% | +2,834 |
| XENON PHARMACEUTICALS INC(XENE) | 0 | 59,900 | +59,900 | 0 | 2,685 | 0.12% | +2,685 |
| EVOMMUNE INC | 0 | 153,320 | +153,320 | 0 | 2,625 | 0.11% | +2,625 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 520,240 | 437,819 | -82,421 | 8,438 | 10,864 | 0.47% | +2,426 |
| PHARVARIS N V COM | 739,876 | 745,169 | +5,293 | 18,460 | 20,678 | 0.89% | +2,219 |
| ULTRAGENYX PHARMACEUTICAL INC(RARE) | 0 | 83,300 | +83,300 | 0 | 1,916 | 0.08% | +1,916 |
| NEXTCURE INC | 222,654 | 222,654 | 0 | 1,305 | 3,159 | 0.14% | +1,855 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 0 | 23,100 | +23,100 | 0 | 1,825 | 0.08% | +1,825 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 10,787 | 28,366 | +17,579 | 442 | 2,067 | 0.09% | +1,625 |
| WAVE LIFE SCIENCES LTD(WVE) | 170,943 | 158,182 | -12,761 | 1,251 | 2,689 | 0.12% | +1,438 |
| ACADIA PHARMACEUTICALS INC | 26,800 | 65,567 | +38,767 | 572 | 1,751 | 0.08% | +1,179 |
| JADE BIOSCIENCES INC | 107,391 | 107,391 | 0 | 927 | 1,657 | 0.07% | +730 |
| BOLT BIOTHERAPEUTICS INC | 137,721 | 137,721 | 0 | 733 | 753 | 0.03% | +20 |
| IMAGENEBIO INC | 31,884 | 31,884 | 0 | 260 | 220 | 0.01% | -40 |
| RAPPORT THERAPEUTICS INC(RAPP) | 1,947,579 | 1,904,408 | -43,171 | 57,843 | 57,780 | 2.49% | -63 |
| Scholar Rock Hldg Corp(SRRK) | 31,410 | 0 | -31,410 | 1,170 | 0 | — | -1,170 |
| UNITED THERAPEUTICS CORP(UTHR) | 190,626 | 157,641 | -32,985 | 79,912 | 76,811 | 3.31% | -3,102 |
| UNIQURE NV(QURE) | 136,862 | 176,513 | +39,651 | 7,989 | 4,224 | 0.18% | -3,765 |
| Liquidia Corporation(LQDA)(Put) | 250,000 | 0 | -250,000 | 5,685 | 0 | — | -5,685 |
| SAVARA INC(SVRA) | 2,427,724 | 304,770 | -2,122,954 | 8,667 | 1,838 | 0.08% | -6,829 |
| EXACT SCIENCES CORP(EXK) | 365,000 | 101,443 | -263,557 | 19,969 | 10,303 | 0.44% | -9,667 |
| SOLENO THERAPEUTICS INC | 166,281 | 12,414 | -153,867 | 11,241 | 575 | 0.02% | -10,666 |
| GE Healthcare Technologies Inc(GEHC) | 151,085 | 0 | -151,085 | 11,346 | 0 | — | -11,346 |
| PTC Therapeutics Inc(PTCT) | 186,932 | 0 | -186,932 | 11,472 | 0 | — | -11,472 |
| Merus N V | 166,729 | 0 | -166,729 | 15,698 | 0 | — | -15,698 |
| Uniqure NV(QURE)(Call) | 300,000 | 0 | -300,000 | 17,511 | 0 | — | -17,511 |
| Summit Therapeutics Inc(SMMT)(Call) | 900,000 | 0 | -900,000 | 18,594 | 0 | — | -18,594 |
| Akero Therapeutics Inc | 473,625 | 0 | -473,625 | 22,488 | 0 | — | -22,488 |
| DEXCOM INC(DXCM) | 779,616 | 378,219 | -401,397 | 52,460 | 25,102 | 1.08% | -27,358 |
| Uniqure NV(QURE)(Put) | 500,000 | 0 | -500,000 | 29,185 | 0 | — | -29,185 |
| ROIVANT SCIENCES LTD(ROIV) | 3,149,270 | 734,582 | -2,414,688 | 47,648 | 15,940 | 0.69% | -31,708 |
| SPDR Series Trust(Put) ST STR SP BIOT | 400,000 | 0 | -400,000 | 40,080 | 0 | — | -40,080 |
| United Therapeutics Corp(UTHR)(Put) | 97,100 | 0 | -97,100 | 40,705 | 0 | — | -40,705 |
| AXSOME THERAPEUTICS INC(AXSM) | 393,499 | 12,266 | -381,233 | 47,790 | 2,240 | 0.10% | -45,550 |
| iShares TR(Put) | 325,000 | 0 | -325,000 | 46,920 | 0 | — | -46,920 |
| Boston Scientific Corp(BSX) | 569,427 | 0 | -569,427 | 55,593 | 0 | — | -55,593 |
| Gilead Sciences Inc(GILD) | 1,252,312 | 0 | -1,252,312 | 139,007 | 0 | — | -139,007 |