Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| United Therapeutics Corporation(UTHR) | 2,858,888 | 2,858,888 | 0 | $628.64M | $656.74M | 7.66% | +$28.10M |
| Apellis Pharmaceuticals Inc COM | 11,111,111 | 11,111,111 | 0 | $665.11M | $653.11M | 7.62% | -$12.00M |
| Ascendis Pharma A/SADR(ASND) | 3,755,555 | 3,966,666 | +211,111 | $473.01M | $599.64M | 6.99% | +$126.63M |
| Sarepta Therapeutics, Inc.(SRPT) | 4,344,444 | 4,344,444 | 0 | $418.93M | $562.43M | 6.56% | +$143.50M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,888,888 | 1,944,444 | +55,556 | $437.05M | $519.24M | 6.06% | +$82.19M |
| argenx SEADR(ARGX) | 1,234,567 | 1,238,467 | +3,900 | $469.67M | $487.61M | 5.69% | +$17.94M |
| Krystal Biotech, Inc.(KRYS) | 2,565,555 | 2,555,555 | -10,000 | $318.28M | $454.71M | 5.30% | +$136.43M |
| Spdr Series Trust - S&p BiotechETF ST STR SP BIOT | 4,444,444 | 4,300,000 | -144,444 | $396.84M | $408.03M | 4.76% | +$11.18M |
| BioMarin Pharmaceutical Inc.(BMRN) | 4,300,000 | 4,365,000 | +65,000 | $414.61M | $381.24M | 4.45% | -$33.37M |
| Amicus Therapeutics Inc COM | 27,400,000 | 27,400,000 | 0 | $388.81M | $322.77M | 3.76% | -$66.03M |
| Cerevel Therapeutics Hldng | 7,555,555 | 7,555,555 | 0 | $320.36M | $319.37M | 3.73% | -$982.2K |
| Viking Therapeutics, Inc.(VKTX) | 0 | 3,590,000 | +3,590,000 | $0 | $294.38M | 3.43% | +$294.38M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 1,130,000 | 8,555,555 | +7,425,555 | $34.58M | $244.69M | 2.85% | +$210.11M |
| Xenon Pharmaceuticals Inc.(XENE) | 5,666,666 | 5,666,666 | 0 | $261.01M | $243.95M | 2.85% | -$17.06M |
| Alpine Immune Sciences Inc | 0 | 5,775,000 | +5,775,000 | $0 | $228.92M | 2.67% | +$228.92M |
| Vera Therapeutics, Inc.(VERA) | 0 | 5,265,000 | +5,265,000 | $0 | $227.03M | 2.65% | +$227.03M |
| Iovance Biotherapeutics, Inc.(IOVA) | 6,700,000 | 11,700,000 | +5,000,000 | $54.47M | $173.39M | 2.02% | +$118.92M |
| Intra-Cellular Therapies Inc | 2,255,555 | 2,475,000 | +219,445 | $161.54M | $171.27M | 2.00% | +$9.73M |
| Kymera Therapeutics, Inc.(KYMR) | 3,775,000 | 3,888,888 | +113,888 | $96.11M | $156.33M | 1.82% | +$60.22M |
| Avidity Biosciences Inc | 2,510,000 | 5,825,000 | +3,315,000 | $22.72M | $148.65M | 1.73% | +$125.94M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 2,580,000 | 2,580,000 | 0 | $155.81M | $129.59M | 1.51% | -$26.21M |
| Syndax Pharmaceuticals, Inc.(SNDX) | 4,222,222 | 4,222,222 | 0 | $91.24M | $100.49M | 1.17% | +$9.25M |
| MacroGenics, Inc.(MGNX) | 0 | 6,150,000 | +6,150,000 | $0 | $90.53M | 1.06% | +$90.53M |
| Kura Oncology, Inc.(KURA) | 2,980,000 | 3,850,000 | +870,000 | $42.85M | $82.12M | 0.96% | +$39.27M |
| Autolus Therapeutics plcADR(AUTL) | 0 | 12,345,678 | +12,345,678 | $0 | $78.77M | 0.92% | +$78.77M |
| Spyre Therapeutics, Inc.(SYRE) | 1,839,138 | 1,839,138 | 0 | $39.58M | $69.76M | 0.81% | +$30.18M |
| Soleno Therapeutics Inc | 785,000 | 1,625,000 | +840,000 | $31.60M | $69.55M | 0.81% | +$37.95M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 13,050,000 | 13,050,000 | 0 | $78.17M | $66.29M | 0.77% | -$11.88M |
| Ocular Therapeutix, Inc.(OCUL) | 0 | 7,148,936 | +7,148,936 | $0 | $65.06M | 0.76% | +$65.06M |
| Taysha Gene Therapies, Inc.(TSHA) | 4,355,555 | 18,650,000 | +14,294,445 | $7.71M | $53.53M | 0.62% | +$45.82M |
| Tourmaline Bio Inc | 868,407 | 2,222,222 | +1,353,815 | $22.73M | $50.89M | 0.59% | +$28.15M |
| Roivant Sciences Ltd.(ROIV) | 4,651,162 | 4,651,162 | 0 | $52.23M | $49.02M | 0.57% | -$3.21M |
| Alnylam Pharmaceuticals, Inc.(ALNY) | 1,111,111 | 300,000 | -811,111 | $212.68M | $44.84M | 0.52% | -$167.84M |
| MannKind Corporation(MNKD) | 9,000,000 | 9,000,000 | 0 | $32.76M | $40.77M | 0.48% | +$8.01M |
| Merus N V | 888,888 | 888,888 | 0 | $24.44M | $40.03M | 0.47% | +$15.58M |
| Vaxcyte, Inc.(PCVX) | 0 | 575,000 | +575,000 | $0 | $39.28M | 0.46% | +$39.28M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 350,000 | 830,000 | +480,000 | $16.74M | $38.75M | 0.45% | +$22.02M |
| Marinus Pharmaceuticals Inc | 3,150,000 | 4,140,607 | +990,607 | $34.24M | $37.43M | 0.44% | +$3.19M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 1,260,900 | 1,260,900 | 0 | $37.79M | $33.97M | 0.40% | -$3.82M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 4,535,000 | 4,535,000 | 0 | $25.62M | $31.97M | 0.37% | +$6.35M |
| CG Oncology, Inc.(CGON) | 0 | 700,000 | +700,000 | $0 | $30.73M | 0.36% | +$30.73M |
| CRISPR Therapeutics AG(CRSP) | 0 | 419,580 | +419,580 | $0 | $28.60M | 0.33% | +$28.60M |
| Verrica Pharmaceuticals Inc.(VRCA) | 3,999,999 | 3,999,999 | 0 | $29.28M | $23.68M | 0.28% | -$5.60M |
| Kyverna Therapeutics, Inc.(KYTX) | 0 | 475,000 | +475,000 | $0 | $11.80M | 0.14% | +$11.80M |
| Whitehawk Therapeutics, Inc.(WHWK) | 2,849,402 | 2,849,402 | 0 | $5.76M | $6.67M | 0.08% | +$911.8K |
| Adverum Biotechnologies Inc | 0 | 416,666 | +416,666 | $0 | $5.89M | 0.07% | +$5.89M |
| Cymabay Therapeutics Inc | 11,111,111 | 0 | -11,111,111 | $262.44M | $0 | — | -$262.44M |
| Fennec Pharmaceuticals Inc.(FENC) | 1,200,000 | 0 | -1,200,000 | $13.46M | $0 | — | -$13.46M |
| Immunogen Inc | 875,000 | 0 | -875,000 | $25.94M | $0 | — | -$25.94M |
| Karuna Therapeutics Inc | 125,000 | 0 | -125,000 | $39.56M | $0 | — | -$39.56M |
| Mirati Therapeutics Inc | 4,886,840 | 0 | -4,886,840 | $287.10M | $0 | — | -$287.10M |
| Nuvalent Inc | 178,921 | 0 | -178,921 | $13.17M | $0 | — | -$13.17M |
| Structure Therapeutics IncADR | 2,333,333 | 0 | -2,333,333 | $95.11M | $0 | — | -$95.11M |