Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| BLUEPRINT MEDICINES CORP | 1,185,000 | 3,850,000 | +2,665,000 | 103,356 | 340,764 | 5.32% | +237,408 |
| ASCENDIS PHARMA(ASND) | 5,103,055 | 5,218,000 | +114,945 | 702,538 | 813,277 | 12.69% | +110,740 |
| KRYSTAL BIOTECH INC(KRYS) | 2,628,822 | 2,731,000 | +102,178 | 411,831 | 492,399 | 7.69% | +80,568 |
| SOLENO THERAPEUTICS INC | 2,525,000 | 2,525,000 | 0 | 113,499 | 180,411 | 2.82% | +66,913 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 4,050,000 | +4,050,000 | 0 | 58,239 | 0.91% | +58,239 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 2,029,000 | 2,022,222 | -6,778 | 626,089 | 669,821 | 10.46% | +43,732 |
| MERUS N V | 2,125,000 | 3,000,000 | +875,000 | 89,356 | 126,270 | 1.97% | +36,914 |
| 89BIO INC | 4,100,000 | 6,350,000 | +2,250,000 | 32,062 | 46,165 | 0.72% | +14,103 |
| ALKERMES PLC(ALKS) | 2,450,000 | 2,450,000 | 0 | 70,462 | 80,899 | 1.26% | +10,437 |
| AVIDITY BIOSCIENCES INC | 7,500,000 | 7,625,000 | +125,000 | 218,100 | 225,090 | 3.51% | +6,990 |
| WHITEHAWK THERAPEUTICS INC | 2,849,402 | 2,849,402 | 0 | 8,990 | 5,072 | 0.08% | -3,918 |
| ULTRAGENYX PHARMACEUTICAL INC(RARE) | 830,000 | 830,000 | 0 | 34,918 | 30,054 | 0.47% | -4,864 |
| TAYSHA GENE THERAPIES INC(TSHA) | 19,999,999 | 19,999,999 | 0 | 34,600 | 27,800 | 0.43% | -6,800 |
| AUTOLUS THERAPEUTICS PLC | 9,910,642 | 9,910,642 | 0 | 23,290 | 15,361 | 0.24% | -7,929 |
| TOURMALINE BIO INC | 2,222,222 | 2,425,000 | +202,778 | 45,067 | 36,884 | 0.58% | -8,182 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 4,345,000 | 4,645,548 | +300,548 | 30,154 | 21,555 | 0.34% | -8,599 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 1,651,982 | 0 | -1,651,982 | 9,631 | 0 | — | -9,631 |
| OCULAR THERAPEUTIX INC(OCUL) | 8,060,000 | 8,060,000 | 0 | 68,832 | 59,080 | 0.92% | -9,753 |
| MANNKIND CORP(MNKD) | 8,750,000 | 8,750,000 | 0 | 56,263 | 44,013 | 0.69% | -12,250 |
| ROCKET PHARMACEUTICALS INC | 1,200,000 | 0 | -1,200,000 | 15,084 | 0 | — | -15,084 |
| UNIQURE NV(QURE) | 2,175,000 | 2,175,000 | 0 | 38,411 | 23,055 | 0.36% | -15,355 |
| SEPTERNA INC(SEPN) | 1,110,000 | 1,337,500 | +227,500 | 25,419 | 7,744 | 0.12% | -17,675 |
| KURA ONCOLOGY INC(KURA) | 2,250,000 | 0 | -2,250,000 | 19,598 | 0 | — | -19,597 |
| CG ONCOLOGY INC(CGON) | 700,000 | 0 | -700,000 | 20,076 | 0 | — | -20,076 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 11,865,000 | 8,700,000 | -3,165,000 | 89,225 | 65,250 | 1.02% | -23,975 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 3,500,000 | 0 | -3,500,000 | 25,900 | 0 | — | -25,900 |
| XENON PHARMACEUTICALS INC(XENE) | 5,666,666 | 5,741,666 | +75,000 | 222,133 | 192,633 | 3.01% | -29,500 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 2,275,000 | 0 | -2,275,000 | 30,076 | 0 | — | -30,075 |
| KYMERA THERAPEUTICS INC(KYMR) | 5,150,000 | 6,460,000 | +1,310,000 | 207,185 | 176,810 | 2.76% | -30,374 |
| ARGENX SE(ARGX) | 1,238,467 | 1,235,177 | -3,290 | 761,657 | 731,058 | 11.41% | -30,599 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 2,770,100 | 2,770,100 | 0 | 150,001 | 108,228 | 1.69% | -41,773 |
| AMICUS THERAPEUTICS INC. COM | 23,175,000 | 20,500,000 | -2,675,000 | 218,309 | 167,280 | 2.61% | -51,028 |
| VAXCYTE INC(PCVX) | 1,175,000 | 1,000,000 | -175,000 | 96,186 | 37,760 | 0.59% | -58,425 |
| ARROWHEAD PHARMACEUTICALS INC.(ARWR) | 11,111,111 | 11,111,111 | 0 | 208,889 | 141,556 | 2.21% | -67,333 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 1,462,500 | 0 | -1,462,500 | 96,130 | 0 | — | -96,130 |
| VERA THERAPEUTICS INC(VERA) | 5,610,000 | 5,701,900 | +91,900 | 237,247 | 136,960 | 2.14% | -100,287 |
| APELLIS PHARMACEUTICALS INC. COM | 12,222,222 | 12,222,222 | 0 | 390,011 | 267,300 | 4.17% | -122,711 |
| SAREPTA THERAPEUTICS INC(SRPT) | 2,555,555 | 2,674,835 | +119,280 | 310,730 | 170,708 | 2.66% | -140,022 |
| UNITED THERAPEUTICS CORP(UTHR) | 2,760,300 | 2,675,000 | -85,300 | 973,944 | 824,622 | 12.87% | -149,322 |
| INTRA-CELLULAR THERAPIES INC | 3,050,000 | 625,000 | -2,425,000 | 254,736 | 82,450 | 1.29% | -172,286 |