Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| United Therapeutics Corporation(UTHR) | 2,606,060 | 2,630,000 | +23,940 | $1.27B | $1.56B | 15.36% | +$289.73M |
| Ascendis Pharma A/SADR(ASND) | 5,111,111 | 5,062,500 | -48,611 | $1.09B | $1.16B | 11.41% | +$68.05M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,807,500 | 1,818,181 | +10,681 | $1.05B | $951.76M | 9.38% | -$100.82M |
| Krystal Biotech, Inc.(KRYS) | 2,888,888 | 2,888,888 | 0 | $712.23M | $746.26M | 7.35% | +$34.03M |
| argenx SEADR(ARGX) | 990,000 | 1,000,000 | +10,000 | $832.54M | $730.25M | 7.19% | -$102.29M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 10,625,000 | 10,699,999 | +74,999 | $705.39M | $670.89M | 6.61% | -$34.50M |
| Kymera Therapeutics, Inc.(KYMR) | 7,474,747 | 7,474,747 | 0 | $581.61M | $622.57M | 6.13% | +$40.96M |
| Apellis Pharmaceuticals Inc COM | 12,222,222 | 12,222,222 | 0 | $307.02M | $491.70M | 4.84% | +$184.68M |
| Centessa Pharmaceuticals PlcADS | 14,555,555 | 11,430,455 | -3,125,100 | $364.03M | $454.02M | 4.47% | +$89.98M |
| Celcuity Inc.(CELC) | 3,111,111 | 3,375,000 | +263,889 | $310.30M | $385.22M | 3.79% | +$74.92M |
| Xenon Pharmaceuticals Inc.(XENE) | 5,424,444 | 5,777,777 | +353,333 | $243.12M | $335.98M | 3.31% | +$92.85M |
| Structure Therapeutics IncADS | 6,555,555 | 6,555,555 | 0 | $455.94M | $315.98M | 3.11% | -$139.96M |
| Terns Pharmaceuticals Inc | 4,350,000 | 5,695,000 | +1,345,000 | $175.74M | $300.24M | 2.96% | +$124.50M |
| Vera Therapeutics, Inc.(VERA) | 5,888,888 | 5,888,888 | 0 | $298.21M | $236.91M | 2.33% | -$61.30M |
| Revolution Medicines, Inc.(RVMD) | 2,170,000 | 2,344,444 | +174,444 | $172.84M | $228.00M | 2.25% | +$55.16M |
| Cytokinetics, Incorporated(CYTK) | 0 | 3,333,333 | +3,333,333 | $0 | $219.70M | 2.16% | +$219.70M |
| Ocular Therapeutix, Inc.(OCUL) | 10,777,777 | 12,315,000 | +1,537,223 | $130.84M | $104.31M | 1.03% | -$26.53M |
| Damora Therapeutics, Inc.(DMRA) | 0 | 3,783,000 | +3,783,000 | $0 | $97.98M | 0.97% | +$97.98M |
| uniQure N.V.(QURE) | 6,150,000 | 5,959,595 | -190,405 | $147.17M | $97.44M | 0.96% | -$49.73M |
| Taysha Gene Therapies, Inc.(TSHA) | 21,700,000 | 21,700,000 | 0 | $119.35M | $97.00M | 0.96% | -$22.35M |
| Definium Therapeutics, Inc.(DFTX) | 0 | 5,000,000 | +5,000,000 | $0 | $94.50M | 0.93% | +$94.50M |
| Soleno Therapeutics Inc | 2,900,000 | 2,300,000 | -600,000 | $134.27M | $77.00M | 0.76% | -$57.27M |
| Alkermes plc(ALKS) | 1,400,000 | 1,200,000 | -200,000 | $39.17M | $42.43M | 0.42% | +$3.26M |
| Septerna, Inc.(SEPN) | 1,337,500 | 1,337,500 | 0 | $37.29M | $32.14M | 0.32% | -$5.15M |
| Viridian Therapeutics, Inc.(VRDN) | 1,500,000 | 1,500,000 | 0 | $46.68M | $29.34M | 0.29% | -$17.34M |
| GH Research PLC(GHRS) | 1,800,000 | 1,800,000 | 0 | $22.86M | $25.31M | 0.25% | +$2.45M |
| Avalo Therapeutics, Inc.(AVTX) | 0 | 1,410,000 | +1,410,000 | $0 | $21.05M | 0.21% | +$21.05M |
| Lexeo Therapeutics, Inc.(LXEO) | 3,300,000 | 1,875,000 | -1,425,000 | $32.77M | $10.76M | 0.11% | -$22.01M |
| Whitehawk Therapeutics, Inc.(WHWK) | 2,849,402 | 2,849,402 | 0 | $6.90M | $9.83M | 0.10% | +$2.93M |
| MannKind Corporation(MNKD) | 4,444,444 | 2,200,000 | -2,244,444 | $25.20M | $5.39M | 0.05% | -$19.81M |
| Apogee Therapeutics Inc | 500,000 | 0 | -500,000 | $37.74M | $0 | — | -$37.74M |
| Avidity Biosciences Inc | 5,455,000 | 0 | -5,455,000 | $393.47M | $0 | — | -$393.47M |
| Incyte Corporation(INCY) | 135,000 | 0 | -135,000 | $13.33M | $0 | — | -$13.33M |
| Mind Medicine (Mindmed) Inc | 5,000,000 | 0 | -5,000,000 | $66.95M | $0 | — | -$66.95M |
| Oruka Therapeutics, Inc.(ORKA) | 1,333,340 | 0 | -1,333,340 | $40.41M | $0 | — | -$40.41M |
| PTC Therapeutics, Inc.(PTCT) | 685,000 | 0 | -685,000 | $52.03M | $0 | — | -$52.03M |
| Spdr Series Trust - S&p BiotechETF ST STR SP BIOT | 2,100,000 | 0 | -2,100,000 | $256.05M | $0 | — | -$256.05M |