Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Ascendis Pharma A/SADR(ASND) | 4,980,000 | 5,110,000 | +130,000 | $859.55M | $1.02B | 13.14% | +$156.37M |
| United Therapeutics Corporation(UTHR) | 2,370,000 | 2,022,222 | -347,778 | $681.02M | $847.74M | 10.97% | +$166.72M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,875,000 | 1,833,000 | -42,000 | $567.45M | $840.72M | 10.88% | +$273.27M |
| argenx SEADR(ARGX) | 1,175,000 | 990,000 | -185,000 | $647.68M | $730.18M | 9.45% | +$82.50M |
| Krystal Biotech, Inc.(KRYS) | 2,660,000 | 2,777,777 | +117,777 | $365.64M | $490.36M | 6.34% | +$124.72M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 10,600,000 | 10,900,000 | +300,000 | $167.48M | $375.94M | 4.86% | +$208.46M |
| Kymera Therapeutics, Inc.(KYMR) | 6,555,555 | 6,350,000 | -205,555 | $286.08M | $359.41M | 4.65% | +$73.33M |
| Merus N V | 3,155,555 | 3,542,500 | +386,945 | $165.98M | $333.53M | 4.31% | +$167.54M |
| Avidity Biosciences Inc | 7,050,000 | 7,645,000 | +595,000 | $200.22M | $333.09M | 4.31% | +$132.87M |
| Apellis Pharmaceuticals Inc. COM | 12,222,222 | 12,222,222 | 0 | $211.57M | $276.59M | 3.58% | +$65.02M |
| Centessa Pharmaceuticals PlcADR | 5,000,000 | 10,808,080 | +5,808,080 | $65.70M | $262.10M | 3.39% | +$196.40M |
| uniQure N.V.(QURE) | 3,625,000 | 4,444,444 | +819,444 | $50.53M | $259.42M | 3.36% | +$208.89M |
| Xenon Pharmaceuticals Inc.(XENE) | 5,400,000 | 5,400,000 | 0 | $169.02M | $216.81M | 2.80% | +$47.79M |
| Akero Therapeutics Inc | 3,500,000 | 3,955,555 | +455,555 | $186.76M | $187.81M | 2.43% | +$1.05M |
| Vera Therapeutics, Inc.(VERA) | 6,300,000 | 6,210,000 | -90,000 | $148.43M | $180.46M | 2.33% | +$32.03M |
| Soleno Therapeutics Inc | 2,050,000 | 2,577,777 | +527,777 | $171.75M | $174.26M | 2.25% | +$2.51M |
| Structure Therapeutics Inc.ADS | 0 | 5,155,555 | +5,155,555 | $0 | $144.36M | 1.87% | +$144.36M |
| Tourmaline Bio Inc | 2,555,555 | 2,555,555 | 0 | $40.86M | $122.23M | 1.58% | +$81.37M |
| Ocular Therapeutix, Inc.(OCUL) | 7,400,000 | 10,250,000 | +2,850,000 | $68.67M | $119.82M | 1.55% | +$51.15M |
| Amicus Therapeutics Inc. COM | 18,000,000 | 15,025,000 | -2,975,000 | $103.14M | $118.40M | 1.53% | +$15.26M |
| 89bio Inc | 6,750,000 | 6,387,790 | -362,210 | $66.28M | $93.90M | 1.21% | +$27.62M |
| Taysha Gene Therapies, Inc.(TSHA) | 21,700,000 | 21,700,000 | 0 | $50.13M | $70.96M | 0.92% | +$20.83M |
| Alkermes plc(ALKS) | 2,900,000 | 2,240,000 | -660,000 | $82.97M | $67.20M | 0.87% | -$15.77M |
| Oruka Therapeutics, Inc.(ORKA) | 0 | 1,333,340 | +1,333,340 | $0 | $25.64M | 0.33% | +$25.64M |
| Septerna, Inc.(SEPN) | 1,237,500 | 1,337,500 | +100,000 | $13.08M | $25.16M | 0.33% | +$12.08M |
| MannKind Corporation(MNKD) | 5,850,000 | 4,468,877 | -1,381,123 | $21.88M | $24.00M | 0.31% | +$2.12M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 4,150,000 | 2,000,000 | -2,150,000 | $195.88M | $14.34M | 0.19% | -$181.54M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 4,500,000 | 1,250,000 | -3,250,000 | $40.32M | $9.49M | 0.12% | -$30.83M |
| Whitehawk Therapeutics, Inc.(WHWK) | 2,849,402 | 2,849,402 | 0 | $5.33M | $5.41M | 0.07% | +$85.5K |
| Tango Therapeutics, Inc.(TNGX) | 0 | 545,000 | +545,000 | $0 | $4.58M | 0.06% | +$4.58M |
| Blueprint Medicines Corp | 375,000 | 0 | -375,000 | $48.07M | $0 | — | -$48.07M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 3,725,000 | 0 | -3,725,000 | $16.80M | $0 | — | -$16.80M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 330,000 | 0 | -330,000 | $12.00M | $0 | — | -$12.00M |