Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SPDR SERIES TRUST - S&P BIOTECH ST STR SP BIOT | 0 | 4,444,444 | +4,444,444 | 0 | 396,844 | 5.48% | +396,844 |
| CEREVEL THERAPEUTICS HLDNG | 955,555 | 7,555,555 | +6,600,000 | 20,860 | 320,356 | 4.42% | +299,496 |
| APELLIS PHARMACEUTICALS INC COM | 11,111,111 | 11,111,111 | 0 | 422,667 | 665,111 | 9.19% | +242,444 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 1,555,000 | 1,888,888 | +333,888 | 227,092 | 437,051 | 6.04% | +209,959 |
| INTRA-CELLULAR THERAPIES INC | 0 | 2,255,555 | +2,255,555 | 0 | 161,543 | 2.23% | +161,543 |
| ASCENDIS PHARMA(ASND) | 3,670,000 | 3,755,555 | +85,555 | 343,659 | 473,012 | 6.53% | +129,353 |
| CYMABAY THERAPEUTICS INC | 10,300,000 | 11,111,111 | +811,111 | 153,573 | 262,444 | 3.63% | +108,871 |
| XENON PHARMACEUTICALS INC(XENE) | 4,900,000 | 5,666,666 | +766,666 | 167,384 | 261,007 | 3.61% | +93,623 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 3,850,000 | 4,300,000 | +450,000 | 340,648 | 414,606 | 5.73% | +73,958 |
| AMICUS THERAPEUTICS INC COM | 27,400,000 | 27,400,000 | 0 | 333,184 | 388,806 | 5.37% | +55,622 |
| SYNDAX PHARMACEUTICALS INC(SNDX) | 2,555,555 | 4,222,222 | +1,666,667 | 37,107 | 91,242 | 1.26% | +54,136 |
| STRUCTURE THERAPEUTICS INC | 1,000,000 | 2,333,333 | +1,333,333 | 50,420 | 95,107 | 1.31% | +44,687 |
| KYMERA THERAPEUTICS INC(KYMR) | 3,855,000 | 3,775,000 | -80,000 | 53,585 | 96,112 | 1.33% | +42,527 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 1,999,999 | 2,580,000 | +580,001 | 114,000 | 155,806 | 2.15% | +41,806 |
| KARUNA THERAPEUTICS INC | 0 | 125,000 | +125,000 | 0 | 39,564 | 0.55% | +39,564 |
| SPYRE THERAPEUTICS INC(SYRE) | 11,458 | 1,839,138 | +1,827,680 | 140 | 39,578 | 0.55% | +39,438 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 1,011,111 | 1,111,111 | +100,000 | 179,068 | 212,678 | 2.94% | +33,610 |
| SOLENO THERAPEUTICS INC | 0 | 785,000 | +785,000 | 0 | 31,596 | 0.44% | +31,596 |
| IMMUNOGEN INC | 0 | 875,000 | +875,000 | 0 | 25,944 | 0.36% | +25,944 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 6,700,000 | 6,700,000 | 0 | 30,485 | 54,471 | 0.75% | +23,986 |
| TOURMALINE BIO INC | 0 | 868,407 | +868,407 | 0 | 22,735 | 0.31% | +22,735 |
| KRYSTAL BIOTECH INC(KRYS) | 2,565,555 | 2,565,555 | 0 | 297,604 | 318,283 | 4.40% | +20,678 |
| ARROWHEAD PHARMACEUTICALS INC(ARWR) | 565,000 | 1,130,000 | +565,000 | 15,182 | 34,578 | 0.48% | +19,396 |
| VERRICA PHARMACEUTICALS INC | 2,954,064 | 3,999,999 | +1,045,935 | 11,477 | 29,280 | 0.40% | +17,803 |
| KURA ONCOLOGY INC(KURA) | 2,980,000 | 2,980,000 | 0 | 27,178 | 42,852 | 0.59% | +15,675 |
| MERUS N V | 444,444 | 888,888 | +444,444 | 10,480 | 24,444 | 0.34% | +13,964 |
| ROCKET PHARMACEUTICALS INC | 1,250,000 | 1,260,900 | +10,900 | 25,613 | 37,789 | 0.52% | +12,177 |
| MARINUS PHARMACEUTICALS INC | 3,150,000 | 3,150,000 | 0 | 25,358 | 34,241 | 0.47% | +8,883 |
| AVIDITY BIOSCIENCES INC | 2,510,000 | 2,510,000 | 0 | 16,014 | 22,716 | 0.31% | +6,702 |
| FENNEC PHARMACEUTICALS INC | 1,200,000 | 1,200,000 | 0 | 9,012 | 13,464 | 0.19% | +4,452 |
| MONTE ROSA THERAPEUTICS INC(GLUE) | 4,535,000 | 4,535,000 | 0 | 21,723 | 25,623 | 0.35% | +3,900 |
| Invesco QQQ Trust(Put) | 500,000 | 0 | -500,000 | 1,220 | 0 | — | -1,220 |
| TALARIS THERAPEUTICS INC | 500,000 | 0 | -500,000 | 1,405 | 0 | — | -1,405 |
| ROIVANT SCIENCES LTD(ROIV) | 4,651,162 | 4,651,162 | 0 | 54,326 | 52,233 | 0.72% | -2,093 |
| IO BIOTECH INC | 2,055,883 | 0 | -2,055,883 | 2,837 | 0 | — | -2,837 |
| MIRATI THERAPEUTICS INC | 6,666,666 | 4,886,840 | -1,779,826 | 290,400 | 287,102 | 3.97% | -3,298 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 11,550,000 | 13,050,000 | +1,500,000 | 81,774 | 78,170 | 1.08% | -3,604 |
| MANNKIND CORP(MNKD) | 9,000,000 | 9,000,000 | 0 | 37,170 | 32,760 | 0.45% | -4,410 |
| TAYSHA GENE THERAPIES INC(TSHA) | 3,925,000 | 4,355,555 | +430,555 | 12,403 | 7,709 | 0.11% | -4,694 |
| SERES THERAPEUTICS INC | 2,500,000 | 0 | -2,500,000 | 5,950 | 0 | — | -5,950 |
| IKENA ONCOLOGY INC | 1,640,000 | 0 | -1,640,000 | 7,101 | 0 | — | -7,101 |
| AADI BIOSCIENCES INC | 2,849,402 | 2,849,402 | 0 | 13,791 | 5,756 | 0.08% | -8,035 |
| UNITED THERAPEUTICS CORP(UTHR) | 2,852,500 | 2,858,888 | +6,388 | 644,294 | 628,641 | 8.68% | -15,653 |
| PMV PHARMACEUTICALS INC | 3,000,000 | 0 | -3,000,000 | 18,420 | 0 | — | -18,420 |
| ARGENX SE(ARGX) | 1,000,000 | 1,234,567 | +234,567 | 491,630 | 469,666 | 6.49% | -21,964 |
| NUVALENT INC | 812,500 | 178,921 | -633,579 | 37,351 | 13,167 | 0.18% | -24,184 |
| TANGO THERAPEUTICS INC(TNGX) | 2,222,222 | 0 | -2,222,222 | 25,022 | 0 | — | -25,022 |
| AKERO THERAPEUTICS ORD | 555,555 | 0 | -555,555 | 28,100 | 0 | — | -28,100 |
| ULTRAGENYX PHARMACEUTICAL INC(RARE) | 1,500,000 | 350,000 | -1,150,000 | 53,475 | 16,737 | 0.23% | -36,738 |
| SAREPTA THERAPEUTICS INC(SRPT) | 4,025,000 | 4,344,444 | +319,444 | 487,911 | 418,935 | 5.79% | -68,976 |
| SEAGEN INC | 1,759,606 | 0 | -1,759,606 | 373,300 | 0 | — | -373,300 |
| HORIZON THERAPEUTICS PLC | 7,000,000 | 0 | -7,000,000 | 809,830 | 0 | — | -809,830 |