Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| United Therapeutics Corporation(UTHR) | 2,858,888 | 2,760,300 | -98,588 | $1.02B | $973.94M | 13.78% | -$50.54M |
| argenx SEADR(ARGX) | 1,238,467 | 1,238,467 | 0 | $671.35M | $761.66M | 10.77% | +$90.31M |
| Ascendis Pharma A/SADR(ASND) | 4,988,888 | 5,103,055 | +114,167 | $744.89M | $702.54M | 9.94% | -$42.35M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 2,029,000 | 2,029,000 | 0 | $430.59M | $626.09M | 8.86% | +$195.49M |
| Krystal Biotech, Inc.(KRYS) | 2,622,222 | 2,628,822 | +6,600 | $477.32M | $411.83M | 5.83% | -$65.49M |
| Apellis Pharmaceuticals Inc. COM | 11,111,111 | 12,222,222 | +1,111,111 | $320.44M | $390.01M | 5.52% | +$69.57M |
| Sarepta Therapeutics, Inc.(SRPT) | 2,555,555 | 2,555,555 | 0 | $319.16M | $310.73M | 4.40% | -$8.43M |
| Intra-Cellular Therapies Inc | 3,050,000 | 3,050,000 | 0 | $223.17M | $254.74M | 3.60% | +$31.57M |
| Vera Therapeutics, Inc.(VERA) | 4,309,590 | 5,610,000 | +1,300,410 | $190.48M | $237.25M | 3.36% | +$46.76M |
| Xenon Pharmaceuticals Inc.(XENE) | 5,666,666 | 5,666,666 | 0 | $223.10M | $222.13M | 3.14% | -$963.3K |
| Amicus Therapeutics Inc. COM | 23,175,000 | 23,175,000 | 0 | $247.51M | $218.31M | 3.09% | -$29.20M |
| Avidity Biosciences Inc | 6,875,000 | 7,500,000 | +625,000 | $315.77M | $218.10M | 3.08% | -$97.67M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 8,888,888 | 11,111,111 | +2,222,223 | $172.18M | $208.89M | 2.95% | +$36.71M |
| Kymera Therapeutics, Inc.(KYMR) | 4,500,000 | 5,150,000 | +650,000 | $212.99M | $207.18M | 2.93% | -$5.80M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 2,770,100 | 2,770,100 | 0 | $139.67M | $150.00M | 2.12% | +$10.33M |
| Soleno Therapeutics Inc | 2,181,000 | 2,525,000 | +344,000 | $110.12M | $113.50M | 1.61% | +$3.38M |
| Blueprint Medicines Corp | 0 | 1,185,000 | +1,185,000 | $0 | $103.36M | 1.46% | +$103.36M |
| Vaxcyte, Inc.(PCVX) | 1,175,000 | 1,175,000 | 0 | $134.27M | $96.19M | 1.36% | -$38.08M |
| BioMarin Pharmaceutical Inc.(BMRN) | 2,038,015 | 1,462,500 | -575,515 | $143.25M | $96.13M | 1.36% | -$47.12M |
| Merus N V | 1,355,000 | 2,125,000 | +770,000 | $67.70M | $89.36M | 1.26% | +$21.66M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 11,865,000 | 11,865,000 | 0 | $90.17M | $89.22M | 1.26% | -$949.2K |
| Alkermes plc(ALKS) | 0 | 2,450,000 | +2,450,000 | $0 | $70.46M | 1.00% | +$70.46M |
| Ocular Therapeutix, Inc.(OCUL) | 8,060,000 | 8,060,000 | 0 | $70.12M | $68.83M | 0.97% | -$1.29M |
| MannKind Corporation(MNKD) | 8,750,000 | 8,750,000 | 0 | $55.04M | $56.26M | 0.80% | +$1.23M |
| Tourmaline Bio Inc | 2,222,222 | 2,222,222 | 0 | $57.13M | $45.07M | 0.64% | -$12.07M |
| uniQure N.V.(QURE) | 0 | 2,175,000 | +2,175,000 | $0 | $38.41M | 0.54% | +$38.41M |
| Ultragenyx Pharmaceutical Inc.(RARE) | 830,000 | 830,000 | 0 | $46.11M | $34.92M | 0.49% | -$11.19M |
| Taysha Gene Therapies, Inc.(TSHA) | 18,650,000 | 19,999,999 | +1,349,999 | $37.49M | $34.60M | 0.49% | -$2.89M |
| 89bio Inc | 0 | 4,100,000 | +4,100,000 | $0 | $32.06M | 0.45% | +$32.06M |
| Monte Rosa Therapeutics, Inc.(GLUE) | 5,790,236 | 4,345,000 | -1,445,236 | $30.69M | $30.15M | 0.43% | -$534.0K |
| Syndax Pharmaceuticals, Inc.(SNDX) | 3,888,437 | 2,275,000 | -1,613,437 | $74.85M | $30.08M | 0.43% | -$44.78M |
| Iovance Biotherapeutics, Inc.(IOVA) | 4,240,000 | 3,500,000 | -740,000 | $39.81M | $25.90M | 0.37% | -$13.91M |
| Septerna, Inc.(SEPN) | 0 | 1,110,000 | +1,110,000 | $0 | $25.42M | 0.36% | +$25.42M |
| Autolus Therapeutics plcADR(AUTL) | 12,345,678 | 9,910,642 | -2,435,036 | $44.81M | $23.29M | 0.33% | -$21.52M |
| CG Oncology, Inc.(CGON) | 700,000 | 700,000 | 0 | $26.41M | $20.08M | 0.28% | -$6.33M |
| Kura Oncology, Inc.(KURA) | 3,541,505 | 2,250,000 | -1,291,505 | $69.20M | $19.60M | 0.28% | -$49.60M |
| Rocket Pharmaceuticals, Inc.(RCKT) | 0 | 1,200,000 | +1,200,000 | $0 | $15.08M | 0.21% | +$15.08M |
| Olema Pharmaceuticals, Inc.(OLMA) | 0 | 1,651,982 | +1,651,982 | $0 | $9.63M | 0.14% | +$9.63M |
| Whitehawk Therapeutics, Inc.(WHWK) | 2,849,402 | 2,849,402 | 0 | $5.87M | $8.99M | 0.13% | +$3.12M |
| Dyne Therapeutics, Inc.(DYN) | 650,000 | 0 | -650,000 | $23.35M | $0 | — | -$23.35M |
| Neurogene Inc.(NGNE) | 22,029 | 0 | -22,029 | $924.3K | $0 | — | -$924.3K |
| Spyre Therapeutics, Inc.(SYRE) | 598,600 | 0 | -598,600 | $17.60M | $0 | — | -$17.60M |