Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| UNITED THERAPEUTICS CORP(UTHR) | 2,022,222 | 2,606,060 | +583,838 | 847,736 | 1,269,803 | 12.48% | +422,067 |
| CENTESSA PHARMACEUTICALS PLC | 0 | 14,555,555 | +14,555,555 | 0 | 364,034 | 3.58% | +364,034 |
| ARROWHEAD PHARMACEUTICALS INC(ARWR) | 10,900,000 | 10,625,000 | -275,000 | 375,941 | 705,394 | 6.93% | +329,453 |
| STRUCTURE THERAPEUTICS INC | 5,155,555 | 6,555,555 | +1,400,000 | 144,356 | 455,939 | 4.48% | +311,583 |
| CELCUITY INC(CELC) | 0 | 3,111,111 | +3,111,111 | 0 | 310,302 | 3.05% | +310,302 |
| SPDR SERIES TRUST - S&P BIOTECH ST STR SP BIOT | 0 | 2,100,000 | +2,100,000 | 0 | 256,053 | 2.52% | +256,053 |
| KYMERA THERAPEUTICS INC(KYMR) | 6,350,000 | 7,474,747 | +1,124,747 | 359,410 | 581,610 | 5.72% | +222,200 |
| KRYSTAL BIOTECH INC(KRYS) | 2,777,777 | 2,888,888 | +111,111 | 490,361 | 712,226 | 7.00% | +221,865 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 1,833,000 | 1,807,500 | -25,500 | 840,724 | 1,052,580 | 10.35% | +211,856 |
| TERNS PHARMACEUTICALS INC | 0 | 4,350,000 | +4,350,000 | 0 | 175,740 | 1.73% | +175,740 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 2,170,000 | +2,170,000 | 0 | 172,841 | 1.70% | +172,841 |
| VERA THERAPEUTICS INC(VERA) | 6,210,000 | 5,888,888 | -321,112 | 180,463 | 298,213 | 2.93% | +117,751 |
| ARGENX SE(ARGX) | 990,000 | 990,000 | 0 | 730,184 | 832,541 | 8.18% | +102,356 |
| ASCENDIS PHARMA(ASND) | 5,110,000 | 5,111,111 | +1,111 | 1,015,919 | 1,089,893 | 10.71% | +73,974 |
| MIND MEDICINE (MINDMED) INC | 0 | 5,000,000 | +5,000,000 | 0 | 66,950 | 0.66% | +66,950 |
| AVIDITY BIOSCIENCES INC | 7,645,000 | 5,455,000 | -2,190,000 | 333,093 | 393,469 | 3.87% | +60,377 |
| PTC THERAPEUTICS INC(PTCT) | 0 | 685,000 | +685,000 | 0 | 52,033 | 0.51% | +52,033 |
| TAYSHA GENE THERAPIES INC(TSHA) | 21,700,000 | 21,700,000 | 0 | 70,959 | 119,350 | 1.17% | +48,391 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 1,500,000 | +1,500,000 | 0 | 46,680 | 0.46% | +46,680 |
| APOGEE THERAPEUTICS INC(APGE) | 0 | 500,000 | +500,000 | 0 | 37,740 | 0.37% | +37,740 |
| LEXEO THERAPEUTICS INC | 0 | 3,300,000 | +3,300,000 | 0 | 32,769 | 0.32% | +32,769 |
| APELLIS PHARMACEUTICALS INC COM | 12,222,222 | 12,222,222 | 0 | 276,589 | 307,022 | 3.02% | +30,433 |
| XENON PHARMACEUTICALS INC(XENE) | 5,400,000 | 5,424,444 | +24,444 | 216,810 | 243,124 | 2.39% | +26,314 |
| GH RESEARCH PLC(GHRS) | 0 | 1,800,000 | +1,800,000 | 0 | 22,860 | 0.22% | +22,860 |
| ORUKA THERAPEUTICS INC(ORKA) | 1,333,340 | 1,333,340 | 0 | 25,640 | 40,414 | 0.40% | +14,773 |
| INCYTE CORP(INCY) | 0 | 135,000 | +135,000 | 0 | 13,334 | 0.13% | +13,334 |
| SEPTERNA INC(SEPN) | 1,337,500 | 1,337,500 | 0 | 25,158 | 37,290 | 0.37% | +12,131 |
| OCULAR THERAPEUTIX INC(OCUL) | 10,250,000 | 10,777,777 | +527,777 | 119,823 | 130,842 | 1.29% | +11,020 |
| WHITEHAWK THERAPEUTICS INC | 2,849,402 | 2,849,402 | 0 | 5,414 | 6,896 | 0.07% | +1,482 |
| MANNKIND CORP(MNKD) | 4,468,877 | 4,444,444 | -24,433 | 23,998 | 25,200 | 0.25% | +1,202 |
| ASCENDIS PHARMA(ASND)(Call) | 0 | 50,000 | +50,000 | 0 | 625 | — | +625 |
| STRUCTURE THERAPEUTICS INC.(Call) | 250,000 | 0 | -250,000 | 2,238 | 0 | — | -2,237 |
| UNITED THERAPEUTICS CORP(UTHR)(Call) | 200,000 | 0 | -200,000 | 4,440 | 0 | — | -4,440 |
| TANGO THERAPEUTICS INC(TNGX) | 545,000 | 0 | -545,000 | 4,578 | 0 | — | -4,578 |
| BIOCRYST PHARMACEUTICALS INC(BCRX) | 1,250,000 | 0 | -1,250,000 | 9,488 | 0 | — | -9,487 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 2,000,000 | 0 | -2,000,000 | 14,340 | 0 | — | -14,340 |
| ALKERMES PLC(ALKS) | 2,240,000 | 1,400,000 | -840,000 | 67,200 | 39,172 | 0.39% | -28,028 |
| SOLENO THERAPEUTICS INC | 2,577,777 | 2,900,000 | +322,223 | 174,258 | 134,270 | 1.32% | -39,988 |
| 89BIO INC | 6,387,790 | 0 | -6,387,790 | 93,901 | 0 | — | -93,901 |
| UNIQURE NV(QURE) | 4,444,444 | 6,150,000 | +1,705,556 | 259,422 | 147,170 | 1.45% | -112,253 |
| AMICUS THERAPEUTICS INC. COM | 15,025,000 | 0 | -15,025,000 | 118,397 | 0 | — | -118,397 |
| TOURMALINE BIO INC | 2,555,555 | 0 | -2,555,555 | 122,232 | 0 | — | -122,232 |
| AKERO THERAPEUTICS INC | 3,955,555 | 0 | -3,955,555 | 187,810 | 0 | — | -187,810 |
| CENTESSA PHARMACEUTICALS PLC | 10,808,080 | 0 | -10,808,080 | 262,096 | 0 | — | -262,096 |
| MERUS N V | 3,542,500 | 0 | -3,542,500 | 333,526 | 0 | — | -333,526 |