Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| United Therapeutics Corporation(UTHR) | 2,022,222 | 2,606,060 | +583,838 | $847.74M | $1.27B | 12.48% | +$422.07M |
| Ascendis Pharma A/SADR(ASND) | 5,110,000 | 5,111,111 | +1,111 | $1.02B | $1.09B | 10.71% | +$73.97M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 1,833,000 | 1,807,500 | -25,500 | $840.72M | $1.05B | 10.35% | +$211.86M |
| argenx SEADR(ARGX) | 990,000 | 990,000 | 0 | $730.18M | $832.54M | 8.18% | +$102.36M |
| Krystal Biotech, Inc.(KRYS) | 2,777,777 | 2,888,888 | +111,111 | $490.36M | $712.23M | 7.00% | +$221.87M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 10,900,000 | 10,625,000 | -275,000 | $375.94M | $705.39M | 6.93% | +$329.45M |
| Kymera Therapeutics, Inc.(KYMR) | 6,350,000 | 7,474,747 | +1,124,747 | $359.41M | $581.61M | 5.72% | +$222.20M |
| Structure Therapeutics IncADS | 5,155,555 | 6,555,555 | +1,400,000 | $144.36M | $455.94M | 4.48% | +$311.58M |
| Avidity Biosciences Inc | 7,645,000 | 5,455,000 | -2,190,000 | $333.09M | $393.47M | 3.87% | +$60.38M |
| Centessa Pharmaceuticals PlcADS | 10,808,080 | 14,555,555 | +3,747,475 | $262.10M | $364.03M | 3.58% | +$101.94M |
| Celcuity Inc.(CELC) | 0 | 3,111,111 | +3,111,111 | $0 | $310.30M | 3.05% | +$310.30M |
| Apellis Pharmaceuticals Inc COM | 12,222,222 | 12,222,222 | 0 | $276.59M | $307.02M | 3.02% | +$30.43M |
| Vera Therapeutics, Inc.(VERA) | 6,210,000 | 5,888,888 | -321,112 | $180.46M | $298.21M | 2.93% | +$117.75M |
| Spdr Series Trust - S&p BiotechETF ST STR SP BIOT | 0 | 2,100,000 | +2,100,000 | $0 | $256.05M | 2.52% | +$256.05M |
| Xenon Pharmaceuticals Inc.(XENE) | 5,400,000 | 5,424,444 | +24,444 | $216.81M | $243.12M | 2.39% | +$26.31M |
| Terns Pharmaceuticals Inc | 0 | 4,350,000 | +4,350,000 | $0 | $175.74M | 1.73% | +$175.74M |
| Revolution Medicines, Inc.(RVMD) | 0 | 2,170,000 | +2,170,000 | $0 | $172.84M | 1.70% | +$172.84M |
| uniQure N.V.(QURE) | 4,444,444 | 6,150,000 | +1,705,556 | $259.42M | $147.17M | 1.45% | -$112.25M |
| Soleno Therapeutics Inc | 2,577,777 | 2,900,000 | +322,223 | $174.26M | $134.27M | 1.32% | -$39.99M |
| Ocular Therapeutix, Inc.(OCUL) | 10,250,000 | 10,777,777 | +527,777 | $119.82M | $130.84M | 1.29% | +$11.02M |
| Taysha Gene Therapies, Inc.(TSHA) | 21,700,000 | 21,700,000 | 0 | $70.96M | $119.35M | 1.17% | +$48.39M |
| Mind Medicine (Mindmed) Inc | 0 | 5,000,000 | +5,000,000 | $0 | $66.95M | 0.66% | +$66.95M |
| PTC Therapeutics, Inc.(PTCT) | 0 | 685,000 | +685,000 | $0 | $52.03M | 0.51% | +$52.03M |
| Viridian Therapeutics, Inc.(VRDN) | 0 | 1,500,000 | +1,500,000 | $0 | $46.68M | 0.46% | +$46.68M |
| Oruka Therapeutics, Inc.(ORKA) | 1,333,340 | 1,333,340 | 0 | $25.64M | $40.41M | 0.40% | +$14.77M |
| Alkermes plc(ALKS) | 2,240,000 | 1,400,000 | -840,000 | $67.20M | $39.17M | 0.39% | -$28.03M |
| Apogee Therapeutics Inc | 0 | 500,000 | +500,000 | $0 | $37.74M | 0.37% | +$37.74M |
| Septerna, Inc.(SEPN) | 1,337,500 | 1,337,500 | 0 | $25.16M | $37.29M | 0.37% | +$12.13M |
| Lexeo Therapeutics, Inc.(LXEO) | 0 | 3,300,000 | +3,300,000 | $0 | $32.77M | 0.32% | +$32.77M |
| MannKind Corporation(MNKD) | 4,468,877 | 4,444,444 | -24,433 | $24.00M | $25.20M | 0.25% | +$1.20M |
| GH Research PLC(GHRS) | 0 | 1,800,000 | +1,800,000 | $0 | $22.86M | 0.22% | +$22.86M |
| Incyte Corporation(INCY) | 0 | 135,000 | +135,000 | $0 | $13.33M | 0.13% | +$13.33M |
| Whitehawk Therapeutics, Inc.(WHWK) | 2,849,402 | 2,849,402 | 0 | $5.41M | $6.90M | 0.07% | +$1.48M |
| 89bio Inc | 6,387,790 | 0 | -6,387,790 | $93.90M | $0 | — | -$93.90M |
| Akero Therapeutics Inc | 3,955,555 | 0 | -3,955,555 | $187.81M | $0 | — | -$187.81M |
| Amicus Therapeutics Inc. COM | 15,025,000 | 0 | -15,025,000 | $118.40M | $0 | — | -$118.40M |
| BioCryst Pharmaceuticals, Inc.(BCRX) | 1,250,000 | 0 | -1,250,000 | $9.49M | $0 | — | -$9.49M |
| Merus N V | 3,542,500 | 0 | -3,542,500 | $333.53M | $0 | — | -$333.53M |
| MoonLake ImmunotherapeuticsCL A(MLTX) | 2,000,000 | 0 | -2,000,000 | $14.34M | $0 | — | -$14.34M |
| Tango Therapeutics, Inc.(TNGX) | 545,000 | 0 | -545,000 | $4.58M | $0 | — | -$4.58M |
| Tourmaline Bio Inc | 2,555,555 | 0 | -2,555,555 | $122.23M | $0 | — | -$122.23M |