Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SCHOLAR ROCK HLDG CORP(SRRK) | 2,161,203 | 2,510,690 | +349,487 | 17,311 | 108,512 | 2.09% | +91,201 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 1,863,800 | 1,820,000 | -43,800 | 214,747 | 248,430 | 4.78% | +33,683 |
| INTRA-CELLULAR THERAPIES INC | 2,485,627 | 2,440,240 | -45,387 | 181,873 | 203,809 | 3.92% | +21,936 |
| ARGENX SE(ARGX) | 632,829 | 593,184 | -39,645 | 343,044 | 364,808 | 7.02% | +21,764 |
| MERCK & CO INC(MRK) | 42,233 | 264,226 | +221,993 | 4,796 | 26,285 | 0.51% | +21,489 |
| BRUKER CORP(BRKR) | 0 | 359,588 | +359,588 | 0 | 21,079 | 0.41% | +21,079 |
| WAVE LIFE SCIENCES LTD(WVE) | 4,094,458 | 4,094,458 | 0 | 33,575 | 50,648 | 0.97% | +17,074 |
| ENCOMPASS HEALTH CORP(EHC) | 19,233 | 188,522 | +169,289 | 1,859 | 17,410 | 0.34% | +15,551 |
| AMGEN INC(AMGN) | 25,152 | 89,240 | +64,088 | 8,104 | 23,260 | 0.45% | +15,155 |
| DEXCOM INC(DXCM) | 1,017,038 | 1,045,044 | +28,006 | 68,182 | 81,273 | 1.56% | +13,091 |
| TENET HEALTHCARE CORP(THC) | 5,625 | 110,230 | +104,605 | 935 | 13,914 | 0.27% | +12,979 |
| INCYTE CORP(INCY) | 2,150,551 | 2,157,478 | +6,927 | 142,151 | 149,017 | 2.87% | +6,866 |
| EDWARDS LIFESCIENCES CORP | 1,134,076 | 1,097,848 | -36,228 | 74,838 | 81,274 | 1.56% | +6,436 |
| NATERA INC(NTRA) | 138,459 | 145,676 | +7,217 | 17,577 | 23,061 | 0.44% | +5,483 |
| ESPERION THERAPEUTICS INC NE | 9,944,064 | 9,944,064 | 0 | 16,408 | 21,877 | 0.42% | +5,469 |
| MASIMO CORP | 0 | 24,166 | +24,166 | 0 | 3,995 | 0.08% | +3,995 |
| PENUMBRA INC(PEN) | 272,683 | 238,053 | -34,630 | 52,985 | 56,533 | 1.09% | +3,548 |
| SPDR S&P 500 ETF TR(SPY) | 0 | 5,660 | +5,660 | 0 | 3,317 | 0.06% | +3,317 |
| BRIGHTSPRING HEALTH SVCS INC(BTSG) | 0 | 174,152 | +174,152 | 0 | 2,966 | 0.06% | +2,966 |
| SUMMIT THERAPEUTICS INC(SMMT) | 64,094 | 170,594 | +106,500 | 1,404 | 3,044 | 0.06% | +1,641 |
| WAYSTAR HLDG CORP(WAY) | 150,202 | 157,898 | +7,696 | 4,189 | 5,795 | 0.11% | +1,606 |
| ALTIMMUNE INC(ALT) | 863,660 | 945,446 | +81,786 | 5,303 | 6,817 | 0.13% | +1,514 |
| CENCORA INC | 72,053 | 77,522 | +5,469 | 16,218 | 17,418 | 0.34% | +1,200 |
| GLAUKOS CORP(GKOS) | 62,983 | 60,875 | -2,108 | 8,205 | 9,128 | 0.18% | +922 |
| VANECK ETF TRUST GOLD MINERS ETF | 0 | 26,200 | +26,200 | 0 | 888 | 0.02% | +888 |
| MOLINA HEALTHCARE INC(MOH) | 67,562 | 82,151 | +14,589 | 23,279 | 23,910 | 0.46% | +631 |
| GILEAD SCIENCES INC(GILD) | 46,027 | 48,429 | +2,402 | 3,859 | 4,473 | 0.09% | +614 |
| PHREESIA INC(PHR) | 422,406 | 405,693 | -16,713 | 9,627 | 10,207 | 0.20% | +581 |
| ZOETIS INC(ZTS) | 5,284 | 9,779 | +4,495 | 1,032 | 1,593 | 0.03% | +561 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 7,700 | 25,000 | +17,300 | 128 | 643 | 0.01% | +515 |
| RHYTHM PHARMACEUTICALS INC(RYTM) | 15,700 | 23,596 | +7,896 | 823 | 1,321 | 0.03% | +498 |
| BEAM THERAPEUTICS INC(BEAM) | 1,518,121 | 1,518,121 | 0 | 37,194 | 37,649 | 0.72% | +455 |
| STERIS PLC(STE) | 91,282 | 109,887 | +18,605 | 22,140 | 22,588 | 0.43% | +449 |
| UNIQURE NV(QURE) | 0 | 22,500 | +22,500 | 0 | 397 | 0.01% | +397 |
| PROTAGONIST THERAPEUTICS INC | 12,346 | 23,718 | +11,372 | 556 | 916 | 0.02% | +360 |
| ASCENDIS PHARMA A/S(ASND) | 0 | 2,500 | +2,500 | 0 | 344 | 0.01% | +344 |
| ZAI LAB LTD(ZLAB) | 0 | 13,000 | +13,000 | 0 | 340 | 0.01% | +340 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 24,000 | +24,000 | 0 | 284 | 0.01% | +284 |
| BRISTOL-MYERS SQUIBB CO(BMY) | 36,825 | 38,113 | +1,288 | 1,905 | 2,156 | 0.04% | +250 |
| DOXIMITY INC(DOCS) | 29,060 | 27,911 | -1,149 | 1,266 | 1,490 | 0.03% | +224 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 39,500 | 39,500 | 0 | 367 | 550 | 0.01% | +183 |
| PTC THERAPEUTICS INC(PTCT) | 0 | 3,800 | +3,800 | 0 | 172 | 0.00% | +172 |
| OCULIS HOLDING AG(OCS) | 0 | 10,000 | +10,000 | 0 | 170 | 0.00% | +170 |
| KINIKSA PHARMACEUTICALS INTL(KNSA) | 0 | 8,100 | +8,100 | 0 | 160 | 0.00% | +160 |
| AMNEAL PHARMACEUTICALS INC(AMRX) | 76,414 | 100,414 | +24,000 | 636 | 795 | 0.02% | +160 |
| ALPHABET INC(GOOG) | 6,000 | 6,000 | 0 | 1,003 | 1,143 | 0.02% | +140 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 1,100 | 1,100 | 0 | 233 | 339 | 0.01% | +106 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 70,821 | 60,598 | -10,223 | 1,276 | 1,336 | 0.03% | +59 |
| GARMIN LTD(GRMN) | 1,050 | 1,050 | 0 | 185 | 217 | 0.00% | +32 |
| BRIDGEBIO PHARMA INC(BBIO) | 10,400 | 10,400 | 0 | 265 | 285 | 0.01% | +21 |
| VERACYTE INC(VCYT) | 3,600 | 3,600 | 0 | 123 | 143 | 0.00% | +20 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 4,400 | 4,400 | 0 | 222 | 238 | 0.00% | +16 |
| EDGEWISE THERAPEUTICS INC(EWTX) | 1,428,929 | 1,428,929 | 0 | 38,138 | 38,152 | 0.73% | +14 |
| NVIDIA CORPORATION(NVDA) | 716 | 751 | +35 | 87 | 101 | 0.00% | +14 |
| LABCORP HOLDINGS INC(LH) | 206 | 216 | +10 | 46 | 50 | 0.00% | +3 |
| MINERALYS THERAPEUTICS INC(MLYS) | 16,499 | 16,499 | 0 | 200 | 203 | 0.00% | +3 |
| ORACLE CORP(ORCL) | 624 | 654 | +30 | 106 | 109 | 0.00% | +3 |
| MICROSOFT CORP(MSFT) | 194 | 203 | +9 | 83 | 86 | 0.00% | +2 |
| XENON PHARMACEUTICALS INC(XENE) | 8,200 | 8,200 | 0 | 323 | 321 | 0.01% | -1 |
| QUALCOMM INC(QCOM) | 427 | 447 | +20 | 73 | 69 | 0.00% | -4 |
| AGILENT TECHNOLOGIES INC(A) | 769 | 806 | +37 | 114 | 108 | 0.00% | -6 |
| METTLER TOLEDO INTERNATIONAL(MTD) | 41 | 42 | +1 | 61 | 51 | 0.00% | -10 |
| BLUEPRINT MEDICINES CORP | 3,200 | 3,200 | 0 | 296 | 279 | 0.01% | -17 |
| TEMPUS AI INC(TEM) | 516 | 237 | -279 | 29 | 8 | 0.00% | -21 |
| NURIX THERAPEUTICS INC(NRIX) | 8,000 | 8,000 | 0 | 180 | 151 | 0.00% | -29 |
| TRAVERE THERAPEUTICS INC(TVTX) | 31,000 | 23,100 | -7,900 | 434 | 402 | 0.01% | -31 |
| RECURSION PHARMACEUTICALS IN(RXRX) | 392,881 | 377,806 | -15,075 | 2,589 | 2,554 | 0.05% | -35 |
| BAIDU INC | 2,000 | 2,000 | 0 | 211 | 169 | 0.00% | -42 |
| OMNIAB INC(OABI) | 11,456 | 0 | -11,456 | 48 | 0 | — | -48 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 41,500 | 41,500 | 0 | 151 | 98 | 0.00% | -53 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 4,000 | 4,000 | 0 | 222 | 168 | 0.00% | -54 |
| ILLUMINA INC(ILMN) | 45,196 | 43,703 | -1,493 | 5,894 | 5,840 | 0.11% | -54 |
| CYTOKINETICS INC(CYTK) | 10,941 | 10,941 | 0 | 578 | 515 | 0.01% | -63 |
| MERUS N V | 8,000 | 8,000 | 0 | 400 | 336 | 0.01% | -63 |
| KRYSTAL BIOTECH INC(KRYS) | 4,779 | 5,047 | +268 | 870 | 791 | 0.02% | -79 |
| BIONTECH SE(BNTX) | 8,721 | 8,332 | -389 | 1,036 | 949 | 0.02% | -86 |
| DR REDDYS LABS LTD(RDY) | 20,595 | 97,900 | +77,305 | 1,636 | 1,546 | 0.03% | -90 |
| ARCELLX INC COMMON STOCK | 4,000 | 3,000 | -1,000 | 334 | 230 | 0.00% | -104 |
| BIOGEN INC(BIIB) | 2,634 | 2,652 | +18 | 511 | 406 | 0.01% | -105 |
| DENALI THERAPEUTICS INC(DNLI) | 15,700 | 15,700 | 0 | 457 | 320 | 0.01% | -137 |
| CERTARA INC(CERT) | 95,924 | 92,129 | -3,795 | 1,123 | 981 | 0.02% | -142 |
| KURA ONCOLOGY INC(KURA) | 13,600 | 13,600 | 0 | 266 | 118 | 0.00% | -147 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 9,300 | 0 | -9,300 | 172 | 0 | — | -172 |
| ADMA BIOLOGICS INC | 25,900 | 16,900 | -9,000 | 518 | 290 | 0.01% | -228 |
| IDEAYA BIOSCIENCES INC(IDYA) | 7,200 | 0 | -7,200 | 228 | 0 | — | -228 |
| ASTRAZENECA PLC(AZN) | 33,500 | 35,700 | +2,200 | 2,610 | 2,339 | 0.05% | -271 |
| NIKE INC(NKE) | 3,500 | 0 | -3,500 | 309 | 0 | — | -309 |
| PFIZER INC(PFE) | 141,075 | 141,560 | +485 | 4,083 | 3,756 | 0.07% | -327 |
| ACCOLADE INC | 640,865 | 615,509 | -25,356 | 2,467 | 2,105 | 0.04% | -362 |
| VAXCYTE INC(PCVX) | 11,981 | 12,038 | +57 | 1,369 | 985 | 0.02% | -384 |
| MACROGENICS INC(MGNX) | 9,929,963 | 9,929,963 | 0 | 32,670 | 32,272 | 0.62% | -397 |
| CVS HEALTH CORP(CVS) | 22,066 | 21,844 | -222 | 1,388 | 981 | 0.02% | -407 |
| JOHNSON & JOHNSON(JNJ) | 51,242 | 54,557 | +3,315 | 8,304 | 7,890 | 0.15% | -414 |
| ABBVIE INC(ABBV) | 42,886 | 45,259 | +2,373 | 8,469 | 8,043 | 0.15% | -427 |
| VIATRIS INC(VTRS) | 39,283 | 0 | -39,283 | 456 | 0 | — | -456 |
| HUTCHMED CHINA LTD(HCM) | 24,015 | 0 | -24,015 | 469 | 0 | — | -469 |
| VIKING THERAPEUTICS INC(VKTX) | 16,179 | 12,939 | -3,240 | 1,024 | 521 | 0.01% | -504 |
| APELLIS PHARMACEUTICALS INC COM | 19,046 | 0 | -19,046 | 549 | 0 | — | -549 |
| PRIVIA HEALTH GROUP INC(PRVA) | 1,059,171 | 953,164 | -106,007 | 19,288 | 18,634 | 0.36% | -653 |
| CARDINAL HEALTH INC(CAH) | 30,224 | 22,298 | -7,926 | 3,340 | 2,637 | 0.05% | -703 |