Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| APOGEE THERAPEUTICS INC(APGE) | 537,093 | 592,093 | +55,000 | 15,006 | 39,345 | 6.40% | +24,338 |
| VERA THERAPEUTICS INC(VERA) | 0 | 470,000 | +470,000 | 0 | 20,266 | 3.29% | +20,266 |
| XENON PHARMACEUTICALS INC(XENE) | 460,000 | 837,387 | +377,387 | 21,188 | 36,050 | 5.86% | +14,862 |
| BEIGENE LTD(ONC) | 0 | 82,143 | +82,143 | 0 | 12,846 | 2.09% | +12,846 |
| KURA ONCOLOGY INC(KURA) | 191,535 | 730,492 | +538,957 | 2,754 | 15,581 | 2.53% | +12,827 |
| INOZYME PHARMA INC | 1,885,802 | 2,642,519 | +756,717 | 8,034 | 20,242 | 3.29% | +12,208 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 1,550,408 | 3,375,000 | +1,824,592 | 9,985 | 21,533 | 3.50% | +11,548 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 0 | 0 | 0 | 9,449 | 1.54% | +9,449 |
| GERON CORP(GERN) | 0 | 2,500,000 | +2,500,000 | 0 | 8,250 | 1.34% | +8,250 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 100,000 | 115,000 | +15,000 | 23,138 | 30,710 | 4.99% | +7,572 |
| AXSOME THERAPEUTICS INC(AXSM) | 50,000 | 139,758 | +89,758 | 3,980 | 11,153 | 1.81% | +7,173 |
| INARI MED INC | 20,000 | 175,000 | +155,000 | 1,298 | 8,397 | 1.37% | +7,098 |
| MORPHIC HLDG INC | 42,670 | 225,000 | +182,330 | 1,232 | 7,920 | 1.29% | +6,688 |
| ELEVATION ONCOLOGY INC | 0 | 1,268,825 | +1,268,825 | 0 | 6,509 | 1.06% | +6,509 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 447,095 | 470,000 | +22,905 | 15,908 | 22,001 | 3.58% | +6,093 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 0 | 5,100,000 | +5,100,000 | 0 | 6,069 | 0.99% | +6,069 |
| ABSCI CORPORATION | 0 | 1,025,000 | +1,025,000 | 0 | 5,822 | 0.95% | +5,822 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 400,000 | 510,000 | +110,000 | 15,864 | 21,405 | 3.48% | +5,541 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 125,000 | 286,200 | +161,200 | 1,396 | 6,769 | 1.10% | +5,372 |
| APELLIS PHARMACEUTICALS INC COM | 75,000 | 165,000 | +90,000 | 4,490 | 9,699 | 1.58% | +5,209 |
| NURIX THERAPEUTICS INC(NRIX) | 690,112 | 810,253 | +120,141 | 7,122 | 11,911 | 1.94% | +4,789 |
| SPYRE THERAPEUTICS INC(SYRE) | 517,554 | 410,000 | -107,554 | 11,138 | 15,551 | 2.53% | +4,414 |
| FULCRUM THERAPEUTICS INC(FULC) | 125,000 | 550,339 | +425,339 | 844 | 5,195 | 0.84% | +4,351 |
| MINERALYS THERAPEUTICS INC(MLYS) | 0 | 327,959 | +327,959 | 0 | 4,234 | 0.69% | +4,234 |
| REZOLUTE INC(RZLT) | 0 | 1,600,000 | +1,600,000 | 0 | 4,080 | 0.66% | +4,080 |
| OMEROS CORP | 0 | 0 | 0 | 3,600 | 7,632 | 1.24% | +4,032 |
| VAXCYTE INC(PCVX) | 25,000 | 80,000 | +55,000 | 1,570 | 5,465 | 0.89% | +3,895 |
| COMPASS PATHWAYS PLC(CMPS) | 550,000 | 1,027,868 | +477,868 | 4,813 | 8,552 | 1.39% | +3,739 |
| INTRA-CELLULAR THERAPIES INC | 0 | 50,000 | +50,000 | 0 | 3,460 | 0.56% | +3,460 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 0 | 120,000 | +120,000 | 0 | 3,432 | 0.56% | +3,432 |
| CENTESSA PHARMACEUTICALS PLC | 795,729 | 830,546 | +34,817 | 6,334 | 9,385 | 1.53% | +3,051 |
| NEXTCURE INC | 0 | 1,359,037 | +1,359,037 | 0 | 3,031 | 0.49% | +3,031 |
| PROTAGONIST THERAPEUTICS INC | 0 | 100,000 | +100,000 | 0 | 2,893 | 0.47% | +2,893 |
| HELIX ACQUISITION CORP II | 0 | 250,000 | +250,000 | 0 | 2,588 | 0.42% | +2,588 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 50,000 | 160,000 | +110,000 | 1,476 | 4,019 | 0.65% | +2,543 |
| TERNS PHARMACEUTICALS INC | 66,000 | 450,000 | +384,000 | 428 | 2,952 | 0.48% | +2,524 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 228,277 | 164,589 | -63,688 | 5,910 | 8,378 | 1.36% | +2,467 |
| COHERUS BIOSCIENCES INC(CHRS) | 0 | 0 | 0 | 3,403 | 5,785 | 0.94% | +2,382 |
| REGENXBIO INC(RGNX) | 0 | 110,000 | +110,000 | 0 | 2,318 | 0.38% | +2,318 |
| MERSANA THERAPEUTICS INC | 1,000,000 | 1,000,000 | 0 | 2,320 | 4,480 | 0.73% | +2,160 |
| ARCELLX INC COMMON STOCK | 340,000 | 300,000 | -40,000 | 18,870 | 20,865 | 3.39% | +1,995 |
| VERONA PHARMA PLC | 563,824 | 817,833 | +254,009 | 11,209 | 13,159 | 2.14% | +1,950 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 137,000 | 202,599 | +65,599 | 429 | 2,237 | 0.36% | +1,808 |
| WAVE LIFE SCIENCES LTD(WVE) | 0 | 286,585 | +286,585 | 0 | 1,768 | 0.29% | +1,768 |
| BOSTON SCIENTIFIC CORP(BSX) | 0 | 25,000 | +25,000 | 0 | 1,712 | 0.28% | +1,712 |
| KRYSTAL BIOTECH INC(KRYS) | 25,000 | 26,746 | +1,746 | 3,102 | 4,759 | 0.77% | +1,657 |
| KEZAR LIFE SCIENCES INC | 0 | 1,761,778 | +1,761,778 | 0 | 1,588 | 0.26% | +1,588 |
| IMMATICS N.V(IMTX) | 200,000 | 350,000 | +150,000 | 2,106 | 3,679 | 0.60% | +1,573 |
| ARYA SCIENCES ACQU CORP IV | 0 | 133,500 | +133,500 | 0 | 1,505 | 0.24% | +1,505 |
| CULLINAN ONCOLOGY INC(CGEM) | 300,000 | 258,588 | -41,412 | 3,057 | 4,406 | 0.72% | +1,349 |
| SPRINGWORKS THERAPEUTICS INC | 100,000 | 100,000 | 0 | 3,650 | 4,922 | 0.80% | +1,272 |
| ZURA BIO LTD(ZURA) | 0 | 450,009 | +450,009 | 0 | 1,157 | 0.19% | +1,157 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 125,000 | +125,000 | 0 | 964 | 0.16% | +964 |
| ASTRIA THERAPEUTICS INC | 1,466,465 | 845,606 | -620,859 | 11,262 | 11,902 | 1.94% | +639 |
| Q32 BIO INC(FIXX) | 0 | 27,777 | +27,777 | 0 | 473 | 0.08% | +473 |
| PASSAGE BIO INC(PASG) | 0 | 264,266 | +264,266 | 0 | 357 | 0.06% | +357 |
| SAVARA INC(SVRA) | 1,150,000 | 1,150,000 | 0 | 5,405 | 5,727 | 0.93% | +322 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 10,000 | +10,000 | 0 | 218 | 0.04% | +218 |
| AVROBIO INC | 500,000 | 700,000 | +200,000 | 680 | 896 | 0.15% | +216 |
| PROMIS NEUROSCIENCES INC | 265,958 | 265,958 | 0 | 306 | 508 | 0.08% | +202 |
| CASSAVA SCIENCES INC | 0 | 24,200 | +24,200 | 0 | 98 | 0.02% | +98 |
| CONTEXT THERAPEUTICS INC(CNTX) | 328,817 | 328,817 | 0 | 372 | 454 | 0.07% | +82 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 37 | 22 | 0.00% | -14 |
| ARAVIVE INC | 346,511 | 0 | -346,511 | 43 | 0 | — | -43 |
| IMMATICS N.V | 187,204 | 187,204 | 0 | 547 | 487 | 0.08% | -60 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,900,000 | 1,400,000 | -500,000 | 19,836 | 19,754 | 3.21% | -82 |
| INFLARX NV(IFRX) | 200,097 | 0 | -200,097 | 326 | 0 | — | -326 |
| ROIVANT SCIENCES LTD(ROIV) | 500,000 | 500,000 | 0 | 5,615 | 5,270 | 0.86% | -345 |
| NUVATION BIO INC(NUVB) | 250,000 | 0 | -250,000 | 378 | 0 | — | -377 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 70,988 | 75,000 | +4,012 | 4,287 | 3,767 | 0.61% | -520 |
| TOURMALINE BIO INC | 68,081 | 50,000 | -18,081 | 1,782 | 1,145 | 0.19% | -637 |
| PUMA BIOTECHNOLOGY INC(PBYI) | 202,349 | 0 | -202,349 | 876 | 0 | — | -876 |
| BIOHAVEN LTD(BHVN) | 20,866 | 0 | -20,866 | 893 | 0 | — | -893 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 50,000 | 0 | -50,000 | 1,089 | 0 | — | -1,089 |
| ALLOGENE THERAPEUTICS INC | 400,000 | 0 | -400,000 | 1,284 | 0 | — | -1,284 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 10,000 | 0 | -10,000 | 1,318 | 0 | — | -1,318 |
| VIKING THERAPEUTICS INC(VKTX) | 300,000 | 50,000 | -250,000 | 5,583 | 4,100 | 0.67% | -1,483 |
| KALVISTA PHARMACEUTICALS INC | 125,969 | 0 | -125,969 | 1,543 | 0 | — | -1,543 |
| NUVALENT INC | 175,000 | 150,000 | -25,000 | 12,878 | 11,264 | 1.83% | -1,615 |
| ADC THERAPEUTICS SA(ADCT) | 1,013,540 | 0 | -1,013,540 | 1,682 | 0 | — | -1,682 |
| BRIDGEBIO PHARMA INC(BBIO) | 80,000 | 50,000 | -30,000 | 3,230 | 1,546 | 0.25% | -1,684 |
| TANGO THERAPEUTICS INC(TNGX) | 300,274 | 150,274 | -150,000 | 2,973 | 1,193 | 0.19% | -1,780 |
| PENUMBRA INC(PEN) | 7,500 | 0 | -7,500 | 1,887 | 0 | — | -1,887 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 0 | 0 | 20,579 | 18,298 | 2.97% | -2,280 |
| ASCENDIS PHARMA A/S(ASND) | 20,000 | 0 | -20,000 | 2,519 | 0 | — | -2,519 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 109,900 | 0 | -109,900 | 2,540 | 0 | — | -2,540 |
| ARGENX SE(ARGX) | 7,500 | 0 | -7,500 | 2,853 | 0 | — | -2,853 |
| RELAY THERAPEUTICS INC(RLAY) | 300,000 | 0 | -300,000 | 3,303 | 0 | — | -3,303 |
| ASTRAZENECA PLC(AZN) | 60,000 | 0 | -60,000 | 4,041 | 0 | — | -4,041 |
| DYNAVAX TECHNOLOGIES CORP | 300,000 | 0 | -300,000 | 4,194 | 0 | — | -4,194 |
| IMMUNOVANT INC(IMVT) | 345,000 | 285,000 | -60,000 | 14,535 | 9,208 | 1.50% | -5,326 |
| MIRATI THERAPEUTICS INC | 100,049 | 0 | -100,049 | 5,878 | 0 | — | -5,878 |
| CYTOKINETICS INC(CYTK) | 160,000 | 80,000 | -80,000 | 13,358 | 5,609 | 0.91% | -7,750 |
| ALKERMES PLC(ALKS) | 356,384 | 75,000 | -281,384 | 9,886 | 2,030 | 0.33% | -7,856 |
| LIANBIO(LIANY) | 3,779,694 | 0 | -3,779,694 | 16,895 | 0 | — | -16,895 |
| CEREVEL THERAPEUTICS HLDNG I | 750,000 | 300,000 | -450,000 | 31,800 | 12,681 | 2.06% | -19,119 |
| CYMABAY THERAPEUTICS INC | 1,090,441 | 0 | -1,090,441 | 25,756 | 0 | — | -25,756 |
| IMMUNOGEN INC | 1,404,608 | 0 | -1,404,608 | 41,647 | 0 | — | -41,647 |