Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2024 ▲▼ | Q1 2025 ▲▼ | Change ▲▼ | Q4 2024 ▲▼ | Q1 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SPDR S&P 500 ETF TR(SPY) | 0 | 30,000 | +30,000 | 0 | 16,782 | 2.63% | +16,782 |
| TRAVERE THERAPEUTICS INC(TVTX) | 200,000 | 1,070,000 | +870,000 | 3,484 | 19,174 | 3.00% | +15,690 |
| PROTAGONIST THERAPEUTICS INC | 130,000 | 400,000 | +270,000 | 5,018 | 19,344 | 3.03% | +14,326 |
| MINERALYS THERAPEUTICS INC(MLYS) | 350,000 | 1,100,000 | +750,000 | 4,309 | 17,468 | 2.73% | +13,160 |
| NUVALENT INC | 285,000 | 460,000 | +175,000 | 22,310 | 32,623 | 5.11% | +10,313 |
| VERONA PHARMA PLC | 660,000 | 615,000 | -45,000 | 30,650 | 39,046 | 6.11% | +8,396 |
| TREVI THERAPEUTICS INC(TRVI) | 0 | 1,250,000 | +1,250,000 | 0 | 7,863 | 1.23% | +7,863 |
| INSMED INC(INSM) | 50,000 | 140,000 | +90,000 | 3,452 | 10,681 | 1.67% | +7,229 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 50,000 | +50,000 | 0 | 5,530 | 0.87% | +5,530 |
| AXSOME THERAPEUTICS INC(AXSM) | 75,000 | 100,000 | +25,000 | 6,346 | 11,663 | 1.83% | +5,317 |
| LEXEO THERAPEUTICS INC(LXEO) | 0 | 1,480,881 | +1,480,881 | 0 | 5,139 | 0.80% | +5,139 |
| BRIDGEBIO PHARMA INC(BBIO) | 200,000 | 300,000 | +100,000 | 5,488 | 10,371 | 1.62% | +4,883 |
| IMMUNOVANT INC(IMVT) | 100,000 | 430,000 | +330,000 | 2,477 | 7,349 | 1.15% | +4,872 |
| UNIQURE NV(QURE) | 0 | 400,000 | +400,000 | 0 | 4,240 | 0.66% | +4,240 |
| CENTESSA PHARMACEUTICALS PLC | 1,095,924 | 1,546,662 | +450,738 | 18,357 | 22,241 | 3.48% | +3,884 |
| AKEBIA THERAPEUTICS INC(AKBA) | 0 | 1,500,000 | +1,500,000 | 0 | 2,880 | 0.45% | +2,880 |
| MAZE THERAPEUTICS INC(MAZE) | 0 | 250,000 | +250,000 | 0 | 2,753 | 0.43% | +2,753 |
| MONOPAR THERAPEUTICS INC(MNPR) | 0 | 62,000 | +62,000 | 0 | 2,257 | 0.35% | +2,257 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 159,614 | 390,000 | +230,386 | 3,060 | 5,257 | 0.82% | +2,197 |
| ARCELLX INC COMMON STOCK | 425,000 | 530,000 | +105,000 | 32,593 | 34,768 | 5.44% | +2,175 |
| ROIVANT SCIENCES LTD(ROIV) | 0 | 150,000 | +150,000 | 0 | 1,514 | 0.24% | +1,514 |
| ALKERMES PLC(ALKS) | 1,100,000 | 1,000,000 | -100,000 | 31,636 | 33,020 | 5.17% | +1,384 |
| MBX BIOSCIENCES INC(MBX) | 0 | 175,000 | +175,000 | 0 | 1,292 | 0.20% | +1,292 |
| THIRD HARMONIC BIO INC | 0 | 370,000 | +370,000 | 0 | 1,284 | 0.20% | +1,284 |
| 89BIO INC | 0 | 175,000 | +175,000 | 0 | 1,272 | 0.20% | +1,272 |
| ABIVAX SA(ABVX) | 0 | 200,000 | +200,000 | 0 | 1,250 | 0.20% | +1,250 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 0 | 0 | 5,744 | 6,993 | 1.09% | +1,249 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 0 | 325,000 | +325,000 | 0 | 1,222 | 0.19% | +1,222 |
| AVALO THERAPEUTICS INC(AVTX) | 550,765 | 657,154 | +106,389 | 4,092 | 5,264 | 0.82% | +1,172 |
| KYMERA THERAPEUTICS INC(KYMR) | 40,000 | 100,000 | +60,000 | 1,609 | 2,737 | 0.43% | +1,128 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 82,500 | 80,000 | -2,500 | 25,457 | 26,498 | 4.15% | +1,041 |
| MEIRAGTX HOLDINGS PLC(MGTX) | 0 | 150,000 | +150,000 | 0 | 1,017 | 0.16% | +1,017 |
| CLIMB BIO INC(CLYM) | 500,000 | 1,500,000 | +1,000,000 | 900 | 1,830 | 0.29% | +930 |
| APOGEE THERAPEUTICS INC(APGE) | 931,728 | 1,151,199 | +219,471 | 42,207 | 43,009 | 6.73% | +802 |
| VIKING THERAPEUTICS INC(VKTX) | 0 | 25,000 | +25,000 | 0 | 604 | 0.09% | +604 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 1,300,000 | 2,224,196 | +924,196 | 4,147 | 4,738 | 0.74% | +591 |
| SUTRO BIOPHARMA INC(STRO) | 0 | 752,722 | +752,722 | 0 | 490 | 0.08% | +490 |
| ONKURE THERAPEUTICS INC(OKUR) | 144,159 | 394,159 | +250,000 | 1,240 | 1,695 | 0.27% | +455 |
| COMPASS THERAPEUTICS INC(CMPX) | 0 | 130,807 | +130,807 | 0 | 249 | 0.04% | +249 |
| OVID THERAPEUTICS INC(OVID) | 0 | 667,516 | +667,516 | 0 | 208 | 0.03% | +208 |
| REPARE THERAPEUTICS INC | 100,000 | 200,000 | +100,000 | 131 | 197 | 0.03% | +66 |
| OAKTREE ACQUISITION CORP III UNIT 10/04/2029 | 250,000 | 250,000 | 0 | 2,538 | 2,595 | 0.41% | +58 |
| ALLAKOS INC | 0 | 250,000 | +250,000 | 0 | 57 | 0.01% | +57 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 350,000 | 350,000 | 0 | 3,563 | 3,619 | 0.57% | +56 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 3 | 4 | 0.00% | +1 |
| OMEROS CORP(OMER) | 9,958 | 9,958 | 0 | 98 | 82 | 0.01% | -17 |
| SYROS PHARMACEUTICALS INC | 150,000 | 0 | -150,000 | 34 | 0 | — | -34 |
| IMMATICS N.V | 187,204 | 187,204 | 0 | 47 | 3 | 0.00% | -44 |
| Q32 BIO INC(FIXX) | 27,777 | 27,777 | 0 | 96 | 46 | 0.01% | -50 |
| ADAGIO MED HLDGS INC(ADGM) | 213,235 | 213,235 | 0 | 224 | 170 | 0.03% | -54 |
| AEROVATE THERAPEUTICS INC | 800,000 | 800,000 | 0 | 2,120 | 2,008 | 0.31% | -112 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 9,992 | 0 | -9,992 | 252 | 0 | — | -252 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 300,000 | 390,000 | +90,000 | 1,674 | 1,420 | 0.22% | -254 |
| KARYOPHARM THERAPEUTICS INC | 0 | 0 | 0 | 11,868 | 11,611 | 1.82% | -256 |
| ZURA BIO LTD(ZURA) | 223,335 | 223,335 | 0 | 558 | 288 | 0.05% | -270 |
| OMEROS CORP | 0 | 0 | 0 | 14,615 | 14,275 | 2.23% | -340 |
| RADIOPHARM THERANOSTICS LTD(RADX) | 156,171 | 64,600 | -91,571 | 684 | 311 | 0.05% | -373 |
| NKARTA INC(NKTX) | 800,000 | 800,000 | 0 | 1,992 | 1,472 | 0.23% | -520 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 237,935 | 241,957 | +4,022 | 3,331 | 2,746 | 0.43% | -585 |
| CONTEXT THERAPEUTICS INC(CNTX) | 1,015,340 | 660,589 | -354,751 | 1,066 | 404 | 0.06% | -662 |
| NEXTCURE INC | 2,302,598 | 2,302,598 | 0 | 1,775 | 1,106 | 0.17% | -669 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 70,742 | 49,692 | -21,050 | 2,925 | 2,239 | 0.35% | -687 |
| BLACK DIAMOND THERAPEUTICS I | 559,163 | 250,000 | -309,163 | 1,197 | 388 | 0.06% | -809 |
| KEZAR LIFE SCIENCES INC COM NEW | 142,316 | 0 | -142,316 | 956 | 0 | — | -956 |
| XENON PHARMACEUTICALS INC(XENE) | 1,161,237 | 1,328,175 | +166,938 | 45,520 | 44,560 | 6.98% | -960 |
| VAXCYTE INC(PCVX) | 25,000 | 25,000 | 0 | 2,047 | 944 | 0.15% | -1,102 |
| CULLINAN THERAPEUTICS INC(CGEM) | 263,817 | 263,817 | 0 | 3,213 | 1,997 | 0.31% | -1,216 |
| SAVARA INC(SVRA) | 410,586 | 0 | -410,586 | 1,260 | 0 | — | -1,260 |
| INARI MED INC | 25,000 | 0 | -25,000 | 1,276 | 0 | — | -1,276 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 279,445 | 280,000 | +555 | 12,874 | 11,425 | 1.79% | -1,449 |
| ORUKA THERAPEUTICS INC(ORKA) | 368,698 | 545,362 | +176,664 | 7,149 | 5,595 | 0.88% | -1,554 |
| RAPT THERAPEUTICS INC | 1,000,000 | 0 | -1,000,000 | 1,580 | 0 | — | -1,580 |
| APELLIS PHARMACEUTICALS INC COM | 50,000 | 0 | -50,000 | 1,596 | 0 | — | -1,595 |
| ERASCA INC(ERAS) | 2,499,431 | 3,341,519 | +842,088 | 6,274 | 4,578 | 0.72% | -1,696 |
| SOLENO THERAPEUTICS INC | 130,000 | 50,000 | -80,000 | 5,844 | 3,573 | 0.56% | -2,271 |
| HELIX ACQUISITION CORP II | 250,000 | 0 | -250,000 | 2,625 | 0 | — | -2,625 |
| TECTONIC THERAPEUTIC INC(TECX) | 58,331 | 0 | -58,331 | 2,693 | 0 | — | -2,693 |
| REZOLUTE INC(RZLT) | 1,575,000 | 1,700,000 | +125,000 | 7,718 | 4,930 | 0.77% | -2,787 |
| MERUS N V | 389,241 | 321,962 | -67,279 | 16,368 | 13,551 | 2.12% | -2,816 |
| CG ONCOLOGY INC(CGON) | 100,000 | 0 | -100,000 | 2,868 | 0 | — | -2,868 |
| PROQR THRAPEUTICS N V SHS EURO | 2,825,000 | 3,284,512 | +459,512 | 7,486 | 4,368 | 0.68% | -3,118 |
| COMPASS PATHWAYS PLC(CMPS) | 850,512 | 0 | -850,512 | 3,215 | 0 | — | -3,215 |
| WAVE LIFE SCIENCES LTD(WVE) | 1,500,000 | 1,825,000 | +325,000 | 18,555 | 14,746 | 2.31% | -3,809 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 425,000 | 325,000 | -100,000 | 10,923 | 6,653 | 1.04% | -4,270 |
| GERON CORP(GERN) | 2,250,000 | 1,500,000 | -750,000 | 7,965 | 2,385 | 0.37% | -5,580 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 300,000 | 0 | -300,000 | 5,640 | 0 | — | -5,640 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 4,500,000 | 3,045,000 | -1,455,000 | 10,575 | 4,720 | 0.74% | -5,855 |
| INOZYME PHARMA INC | 3,972,318 | 3,867,710 | -104,608 | 11,003 | 3,520 | 0.55% | -7,484 |
| NURIX THERAPEUTICS INC(NRIX) | 940,083 | 810,669 | -129,414 | 17,711 | 9,631 | 1.51% | -8,080 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,400,000 | 1,400,000 | 0 | 30,856 | 21,518 | 3.37% | -9,338 |
| VERA THERAPEUTICS INC(VERA) | 425,000 | 355,143 | -69,857 | 17,973 | 8,531 | 1.34% | -9,443 |
| SPYRE THERAPEUTICS INC(SYRE) | 824,328 | 481,678 | -342,650 | 19,190 | 7,772 | 1.22% | -11,418 |
| ARVINAS INC(ARVN) | 630,000 | 0 | -630,000 | 12,077 | 0 | — | -12,077 |
| COHERUS BIOSCIENCES INC(CHRS) | 0 | 0 | 0 | 16,189 | 0 | — | -16,189 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 460,000 | 152,252 | -307,748 | 23,520 | 5,107 | 0.80% | -18,413 |