Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2025 ▲▼ | Q1 2026 ▲▼ | Change ▲▼ | Q4 2025 ▲▼ | Q1 2026 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| ERASCA INC(ERAS) | 3,900,000 | 5,350,000 | +1,450,000 | 14,508 | 86,563 | 5.08% | +72,055 |
| XENON PHARMACEUTICALS INC(XENE) | 1,250,000 | 1,675,000 | +425,000 | 56,025 | 97,401 | 5.71% | +41,376 |
| ROIVANT SCIENCES LTD(ROIV) | 1,700,000 | 2,800,000 | +1,100,000 | 36,890 | 77,560 | 4.55% | +40,670 |
| CENTESSA PHARMACEUTICALS PLC | 600,552 | 1,400,000 | +799,448 | 15,020 | 55,608 | 3.26% | +40,588 |
| ANAPTYSBIO INC | 444,692 | 940,000 | +495,308 | 21,559 | 52,132 | 3.06% | +30,574 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 115,000 | 350,000 | +235,000 | 4,739 | 29,372 | 1.72% | +24,633 |
| ENLIVEN THERAPEUTICS INC | 0 | 586,904 | +586,904 | 0 | 23,007 | 1.35% | +23,007 |
| ALKERMES PLC(ALKS) | 1,000,000 | 1,350,000 | +350,000 | 27,980 | 47,736 | 2.80% | +19,756 |
| SUTRO BIOPHARMA INC(STRO) | 748,382 | 1,069,519 | +321,137 | 8,659 | 26,642 | 1.56% | +17,983 |
| SPYRE THERAPEUTICS INC(SYRE) | 1,432,591 | 1,279,134 | -153,457 | 46,932 | 64,520 | 3.78% | +17,588 |
| COGENT BIOSCIENCES INC(COGT) | 350,000 | 750,000 | +400,000 | 12,432 | 28,868 | 1.69% | +16,436 |
| ASCENDIS PHARMA A/S(ASND) | 30,000 | 95,000 | +65,000 | 6,397 | 21,729 | 1.27% | +15,332 |
| APOGEE THERAPEUTICS INC(APGE) | 1,234,926 | 1,284,926 | +50,000 | 93,212 | 108,152 | 6.34% | +14,940 |
| HELIX ACQUISITION CORP III(HLXC) | 0 | 1,250,000 | +1,250,000 | 0 | 12,700 | 0.74% | +12,700 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 300,000 | 3,164,582 | +2,864,582 | 825 | 13,196 | 0.77% | +12,371 |
| OVID THERAPEUTICS INC(OVID) | 7,150,000 | 10,636,318 | +3,486,318 | 11,655 | 23,613 | 1.38% | +11,958 |
| DAMORA THERAPEUTICS INC(DMRA) | 0 | 450,000 | +450,000 | 0 | 11,655 | 0.68% | +11,655 |
| ALTO NEUROSCIENCE INC(ANRO) | 0 | 500,000 | +500,000 | 0 | 11,240 | 0.66% | +11,240 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 31,131 | 55,000 | +23,869 | 18,129 | 28,791 | 1.69% | +10,662 |
| TYRA BIOSCIENCES INC(TYRA) | 0 | 257,512 | +257,512 | 0 | 9,863 | 0.58% | +9,863 |
| EUPRAXIA PHARMACEUTICALS INC(EPRX) | 300,000 | 1,589,005 | +1,289,005 | 2,265 | 11,504 | 0.67% | +9,239 |
| KORRO BIO INC(KRRO) | 0 | 706,904 | +706,904 | 0 | 8,002 | 0.47% | +8,002 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 70,000 | 200,000 | +130,000 | 4,647 | 12,540 | 0.74% | +7,893 |
| ARCELLX INC COMMON STOCK | 523,725 | 362,764 | -160,961 | 34,147 | 41,653 | 2.44% | +7,506 |
| TERNS PHARMACEUTICALS INC | 550,000 | 562,631 | +12,631 | 22,220 | 29,662 | 1.74% | +7,442 |
| COGENT BIOSCIENCES INC(COGT) | 0 | 0 | 0 | 1,176 | 8,586 | 0.50% | +7,410 |
| BELITE BIO INC(BLTE) | 20,000 | 65,000 | +45,000 | 3,199 | 10,364 | 0.61% | +7,164 |
| CRISPR THERAPEUTICS AG(CRSP) | 0 | 150,000 | +150,000 | 0 | 7,136 | 0.42% | +7,136 |
| SPYGLASS PHARMA INC(SGP) | 0 | 250,000 | +250,000 | 0 | 6,478 | 0.38% | +6,478 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 350,000 | 500,000 | +150,000 | 9,506 | 15,860 | 0.93% | +6,354 |
| ZURA BIO LTD(ZURA) | 1,813,671 | 2,564,303 | +750,632 | 9,504 | 15,258 | 0.89% | +5,754 |
| COMPASS PATHWAYS PLC(CMPS) | 200,000 | 1,108,483 | +908,483 | 1,380 | 6,130 | 0.36% | +4,750 |
| VERADERMICS INC(MANE) | 0 | 70,000 | +70,000 | 0 | 4,421 | 0.26% | +4,421 |
| GENERATE BIOMEDICINES INC(GENB) | 0 | 350,000 | +350,000 | 0 | 4,375 | 0.26% | +4,375 |
| RELAY THERAPEUTICS INC(RLAY) | 0 | 400,000 | +400,000 | 0 | 3,980 | 0.23% | +3,980 |
| PRECISION BIOSCIENCES INC(DTIL) | 0 | 597,946 | +597,946 | 0 | 3,289 | 0.19% | +3,289 |
| PROTAGONIST THERAPEUTICS INC | 172,125 | 172,125 | 0 | 15,033 | 18,142 | 1.06% | +3,109 |
| SOL-GEL TECHNOLOGIES LTD SHS NEW | 0 | 35,000 | +35,000 | 0 | 2,773 | 0.16% | +2,773 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 486,684 | 912,397 | +425,713 | 2,429 | 5,064 | 0.30% | +2,635 |
| EQUILLIUM INC(EQ) | 0 | 1,226,310 | +1,226,310 | 0 | 2,453 | 0.14% | +2,453 |
| SAB BIOTHERAPEUTICS INC(SABS) | 0 | 575,000 | +575,000 | 0 | 2,202 | 0.13% | +2,202 |
| CORCEPT THERAPEUTICS INC(CORT) | 0 | 50,000 | +50,000 | 0 | 2,016 | 0.12% | +2,016 |
| IBIO INC(IBIO) | 2,057,200 | 3,107,200 | +1,050,000 | 3,970 | 5,904 | 0.35% | +1,933 |
| REVOLUTION MEDICINES INC(RVMD) | 100,000 | 100,000 | 0 | 7,965 | 9,725 | 0.57% | +1,760 |
| ADLAI NORTYE LTD(ANL) | 0 | 164,748 | +164,748 | 0 | 1,140 | 0.07% | +1,140 |
| ALECTOR INC | 0 | 500,000 | +500,000 | 0 | 1,075 | 0.06% | +1,075 |
| ARRIVENT BIOPHARMA INC(AVBP) | 150,000 | 175,000 | +25,000 | 3,018 | 4,037 | 0.24% | +1,019 |
| ONKURE THERAPEUTICS INC(OKUR) | 0 | 240,963 | +240,963 | 0 | 998 | 0.06% | +998 |
| AVALO THERAPEUTICS INC(AVTX) | 1,051,054 | 1,340,840 | +289,786 | 19,087 | 20,019 | 1.17% | +932 |
| LENZ THERAPEUTICS INC(LENZ) | 0 | 100,000 | +100,000 | 0 | 915 | 0.05% | +915 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 6,516 | 7,314 | 0.43% | +798 |
| MACROGENICS INC(MGNX) | 484,308 | 500,000 | +15,692 | 780 | 1,445 | 0.08% | +665 |
| KEZAR LIFE SCIENCES INC COM NEW | 229,076 | 229,076 | 0 | 1,441 | 1,700 | 0.10% | +259 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 185,000 | 170,000 | -15,000 | 54,527 | 54,772 | 3.21% | +245 |
| ORUKA THERAPEUTICS INC(ORKA) | 802,342 | 499,673 | -302,669 | 24,319 | 24,509 | 1.44% | +190 |
| INSMED INC(INSM) | 450,000 | 480,000 | +30,000 | 78,318 | 78,490 | 4.60% | +172 |
| Q32 BIO INC(FIXX) | 27,777 | 27,777 | 0 | 92 | 178 | 0.01% | +86 |
| X4 PHARMACEUTICALS INC(XFOR) | 145,000 | 145,000 | 0 | 580 | 599 | 0.04% | +19 |
| OAKTREE ACQUISITION CORP III UNIT 10/04/2029 | 250,000 | 250,000 | 0 | 2,653 | 2,663 | 0.16% | +10 |
| ADAGIO MED HLDGS INC(ADGM) | 80,000 | 80,000 | 0 | 83 | 92 | 0.01% | +9 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 2 | 1 | 0.00% | -1 |
| CLIMB BIO INC(CLYM) | 1,300,000 | 700,000 | -600,000 | 5,200 | 4,795 | 0.28% | -405 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 50,000 | 0 | -50,000 | 652 | 0 | — | -651 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 572,804 | 402,550 | -170,254 | 2,377 | 1,711 | 0.10% | -666 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 245,000 | 245,000 | 0 | 5,635 | 4,910 | 0.29% | -725 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 75,000 | 75,000 | 0 | 3,491 | 2,724 | 0.16% | -767 |
| FORTE BIOSCIENCES INC(FBRX) | 989,490 | 1,011,890 | +22,400 | 26,983 | 26,208 | 1.54% | -775 |
| REZOLUTE INC(RZLT) | 2,351,144 | 1,547,641 | -803,503 | 5,549 | 4,720 | 0.28% | -828 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 275,000 | 275,000 | 0 | 9,647 | 8,803 | 0.52% | -844 |
| NEXTCURE INC | 247,294 | 241,826 | -5,468 | 3,509 | 2,583 | 0.15% | -926 |
| PROQR THRAPEUTICS N V SHS EURO | 2,454,278 | 2,454,278 | 0 | 4,958 | 3,976 | 0.23% | -982 |
| UNIQURE NV(QURE) | 50,000 | 0 | -50,000 | 1,197 | 0 | — | -1,196 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,400,000 | 1,400,000 | 0 | 43,694 | 42,168 | 2.47% | -1,526 |
| ENGENE HOLDINGS INC COM | 643,370 | 610,370 | -33,000 | 5,810 | 4,157 | 0.24% | -1,653 |
| NUVALENT INC | 322,633 | 300,000 | -22,633 | 32,454 | 30,735 | 1.80% | -1,719 |
| ULTRAGENYX PHARMACEUTICAL IN(RARE) | 75,000 | 0 | -75,000 | 1,725 | 0 | — | -1,725 |
| GERON CORP(GERN) | 1,500,000 | 0 | -1,500,000 | 1,980 | 0 | — | -1,980 |
| JADE BIOSCIENCES INC | 714,956 | 639,956 | -75,000 | 11,032 | 8,991 | 0.53% | -2,040 |
| VERRICA PHARMACEUTICALS INC(VRCA) | 707,338 | 707,338 | 0 | 5,878 | 3,742 | 0.22% | -2,136 |
| SAGIMET BIOSCIENCES INC(SGMT) | 1,148,245 | 868,020 | -280,225 | 6,798 | 4,535 | 0.27% | -2,262 |
| TRAVERE THERAPEUTICS INC(TVTX) | 300,000 | 300,000 | 0 | 11,463 | 8,913 | 0.52% | -2,550 |
| IMMUNOVANT INC(IMVT) | 200,000 | 100,000 | -100,000 | 5,084 | 2,484 | 0.15% | -2,600 |
| VERA THERAPEUTICS INC(VERA) | 250,000 | 250,000 | 0 | 12,660 | 10,058 | 0.59% | -2,602 |
| LEXEO THERAPEUTICS INC(LXEO) | 3,200,000 | 5,050,211 | +1,850,211 | 31,776 | 28,988 | 1.70% | -2,788 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 250,000 | 250,000 | 0 | 7,780 | 4,890 | 0.29% | -2,890 |
| MERSANA THERAPEUTICS INC | 100,000 | 0 | -100,000 | 2,893 | 0 | — | -2,893 |
| TREVI THERAPEUTICS INC(TRVI) | 2,150,172 | 2,000,172 | -150,000 | 26,920 | 23,862 | 1.40% | -3,058 |
| SAVARA INC(SVRA) | 2,797,153 | 2,512,153 | -285,000 | 16,867 | 13,716 | 0.80% | -3,150 |
| AMGEN INC(AMGN) | 10,000 | 0 | -10,000 | 3,273 | 0 | — | -3,273 |
| NURIX THERAPEUTICS INC(NRIX) | 967,620 | 967,620 | 0 | 18,356 | 14,998 | 0.88% | -3,358 |
| MBX BIOSCIENCES INC(MBX) | 250,000 | 150,000 | -100,000 | 7,885 | 4,478 | 0.26% | -3,407 |
| KARYOPHARM THERAPEUTICS INC(KPTI) | 889,575 | 500,000 | -389,575 | 6,547 | 2,785 | 0.16% | -3,762 |
| CYTOKINETICS INC(CYTK) | 800,000 | 700,483 | -99,517 | 50,832 | 46,169 | 2.71% | -4,663 |
| AVADEL PHARMACEUTICALS PLC | 250,000 | 0 | -250,000 | 5,388 | 0 | — | -5,387 |
| OMEROS CORP(OMER) | 0 | 0 | 0 | 19,384 | 13,219 | 0.78% | -6,165 |
| MINERALYS THERAPEUTICS INC(MLYS) | 730,000 | 750,000 | +20,000 | 26,492 | 20,318 | 1.19% | -6,174 |
| ARCUS BIOSCIENCES INC(RCUS) | 300,000 | 0 | -300,000 | 7,149 | 0 | — | -7,149 |
| TANGO THERAPEUTICS INC(TNGX) | 1,000,000 | 0 | -1,000,000 | 8,860 | 0 | — | -8,860 |
| CULLINAN THERAPEUTICS INC(CGEM) | 1,932,106 | 781,260 | -1,150,846 | 19,997 | 11,102 | 0.65% | -8,896 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 200,000 | 100,000 | -100,000 | 14,576 | 5,678 | 0.33% | -8,898 |