Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| INSMED INC(INSM) | 140,000 | 475,000 | +335,000 | 10,681 | 47,804 | 7.07% | +37,123 |
| BLUEPRINT MEDICINES CORP | 0 | 250,000 | +250,000 | 0 | 32,045 | 4.74% | +32,045 |
| VERONA PHARMA PLC | 615,000 | 610,000 | -5,000 | 39,046 | 57,694 | 8.53% | +18,647 |
| VENTYX BIOSCIENCES INC | 0 | 4,536,182 | +4,536,182 | 0 | 9,707 | 1.44% | +9,707 |
| LEXEO THERAPEUTICS INC(LXEO) | 1,480,881 | 3,589,355 | +2,108,474 | 5,139 | 14,429 | 2.13% | +9,291 |
| ENLIVEN THERAPEUTICS INC | 0 | 400,000 | +400,000 | 0 | 8,024 | 1.19% | +8,024 |
| OMEROS CORP(OMER) | 0 | 0 | 0 | 0 | 7,069 | 1.05% | +7,069 |
| TREVI THERAPEUTICS INC(TRVI) | 1,250,000 | 2,534,058 | +1,284,058 | 7,863 | 13,861 | 2.05% | +5,999 |
| PROTAGONIST THERAPEUTICS INC | 400,000 | 440,000 | +40,000 | 19,344 | 24,319 | 3.60% | +4,975 |
| REZOLUTE INC(RZLT) | 1,700,000 | 2,200,000 | +500,000 | 4,930 | 9,812 | 1.45% | +4,882 |
| CRESCENT BIOPHARMA INC.(CBIO) | 0 | 280,031 | +280,031 | 0 | 4,520 | 0.67% | +4,520 |
| VERA THERAPEUTICS INC(VERA) | 355,143 | 545,000 | +189,857 | 8,531 | 12,840 | 1.90% | +4,310 |
| AKEBIA THERAPEUTICS INC(AKBA) | 1,500,000 | 1,950,000 | +450,000 | 2,880 | 7,098 | 1.05% | +4,218 |
| INOZYME PHARMA INC | 3,867,710 | 1,749,359 | -2,118,351 | 3,520 | 6,997 | 1.03% | +3,478 |
| VAXCYTE INC(PCVX) | 25,000 | 125,000 | +100,000 | 944 | 4,064 | 0.60% | +3,120 |
| ROIVANT SCIENCES LTD(ROIV) | 150,000 | 400,000 | +250,000 | 1,514 | 4,508 | 0.67% | +2,995 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 280,000 | 334,863 | +54,863 | 11,425 | 14,302 | 2.11% | +2,877 |
| PROQR THRAPEUTICS N V SHS EURO | 3,284,512 | 3,499,512 | +215,000 | 4,368 | 7,139 | 1.06% | +2,771 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 0 | 25,000 | +25,000 | 0 | 2,653 | 0.39% | +2,653 |
| RAPPORT THERAPEUTICS INC(RAPP) | 0 | 199,643 | +199,643 | 0 | 2,270 | 0.34% | +2,270 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 3,045,000 | 3,045,000 | 0 | 4,720 | 6,943 | 1.03% | +2,223 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,400,000 | 1,400,000 | 0 | 21,518 | 23,464 | 3.47% | +1,946 |
| ASTRIA THERAPEUTICS INC | 0 | 300,000 | +300,000 | 0 | 1,608 | 0.24% | +1,608 |
| NURIX THERAPEUTICS INC(NRIX) | 810,669 | 967,620 | +156,951 | 9,631 | 11,021 | 1.63% | +1,390 |
| SPYRE THERAPEUTICS INC(SYRE) | 481,678 | 606,678 | +125,000 | 7,772 | 9,082 | 1.34% | +1,310 |
| ORUKA THERAPEUTICS INC(ORKA) | 545,362 | 603,479 | +58,117 | 5,595 | 6,765 | 1.00% | +1,170 |
| SAVARA INC(SVRA) | 0 | 500,000 | +500,000 | 0 | 1,140 | 0.17% | +1,140 |
| THIRD HARMONIC BIO INC | 370,000 | 370,000 | 0 | 1,284 | 2,009 | 0.30% | +725 |
| JADE BIOSCIENCES INC | 0 | 65,317 | +65,317 | 0 | 653 | 0.10% | +653 |
| ERASCA INC(ERAS) | 3,341,519 | 4,085,787 | +744,268 | 4,578 | 5,189 | 0.77% | +611 |
| TAYSHA GENE THERAPIES INC(TSHA) | 0 | 200,000 | +200,000 | 0 | 462 | 0.07% | +462 |
| ENGENE HOLDINGS INC COM | 0 | 77,000 | +77,000 | 0 | 280 | 0.04% | +280 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 390,000 | 390,000 | 0 | 5,257 | 5,452 | 0.81% | +195 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 390,000 | 425,000 | +35,000 | 1,420 | 1,611 | 0.24% | +191 |
| MONOPAR THERAPEUTICS INC(MNPR) | 62,000 | 67,500 | +5,500 | 2,257 | 2,415 | 0.36% | +158 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 350,000 | 350,000 | 0 | 3,619 | 3,714 | 0.55% | +95 |
| REPARE THERAPEUTICS INC | 200,000 | 200,000 | 0 | 197 | 278 | 0.04% | +81 |
| OAKTREE ACQUISITION CORP III UNIT 10/04/2029 | 250,000 | 250,000 | 0 | 2,595 | 2,655 | 0.39% | +60 |
| SUTRO BIOPHARMA INC(STRO) | 752,722 | 752,722 | 0 | 490 | 537 | 0.08% | +48 |
| CLIMB BIO INC(CLYM) | 1,500,000 | 1,500,000 | 0 | 1,830 | 1,860 | 0.28% | +30 |
| OVID THERAPEUTICS INC(OVID) | 667,516 | 667,516 | 0 | 208 | 220 | 0.03% | +12 |
| KARYOPHARM THERAPEUTICS INC | 0 | 0 | 0 | 11,611 | 11,620 | 1.72% | +9 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 4 | 2 | 0.00% | -1 |
| IMMATICS N.V | 187,204 | 187,204 | 0 | 3 | 0 | 0.00% | -3 |
| Q32 BIO INC(FIXX) | 27,777 | 27,777 | 0 | 46 | 41 | 0.01% | -4 |
| CULLINAN THERAPEUTICS INC(CGEM) | 263,817 | 263,817 | 0 | 1,997 | 1,987 | 0.29% | -11 |
| NEXTCURE INC | 2,302,598 | 2,302,598 | 0 | 1,106 | 1,059 | 0.16% | -47 |
| ZURA BIO LTD(ZURA) | 223,335 | 223,335 | 0 | 288 | 235 | 0.03% | -54 |
| ALLAKOS INC | 250,000 | 0 | -250,000 | 57 | 0 | — | -57 |
| ADAGIO MED HLDGS INC(ADGM) | 213,235 | 80,000 | -133,235 | 170 | 108 | 0.02% | -62 |
| CONTEXT THERAPEUTICS INC(CNTX) | 660,589 | 518,025 | -142,564 | 404 | 339 | 0.05% | -65 |
| OMEROS CORP(OMER) | 9,958 | 0 | -9,958 | 82 | 0 | — | -82 |
| NKARTA INC(NKTX) | 800,000 | 800,000 | 0 | 1,472 | 1,328 | 0.20% | -144 |
| RADIOPHARM THERANOSTICS LTD(RADX) | 64,600 | 35,635 | -28,965 | 311 | 166 | 0.02% | -145 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 325,000 | 250,000 | -75,000 | 1,222 | 1,065 | 0.16% | -157 |
| COMPASS THERAPEUTICS INC(CMPX) | 130,807 | 0 | -130,807 | 249 | 0 | — | -249 |
| GERON CORP(GERN) | 1,500,000 | 1,500,000 | 0 | 2,385 | 2,115 | 0.31% | -270 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 0 | 0 | 6,993 | 6,685 | 0.99% | -308 |
| BLACK DIAMOND THERAPEUTICS I | 250,000 | 0 | -250,000 | 388 | 0 | — | -387 |
| ABIVAX SA(ABVX) | 200,000 | 100,000 | -100,000 | 1,250 | 765 | 0.11% | -485 |
| VIKING THERAPEUTICS INC(VKTX) | 25,000 | 0 | -25,000 | 604 | 0 | — | -604 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 152,252 | 152,252 | 0 | 5,107 | 4,379 | 0.65% | -728 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 241,957 | 245,000 | +3,043 | 2,746 | 1,960 | 0.29% | -786 |
| ONKURE THERAPEUTICS INC(OKUR) | 394,159 | 347,990 | -46,169 | 1,695 | 832 | 0.12% | -863 |
| NUVALENT INC | 460,000 | 415,000 | -45,000 | 32,623 | 31,665 | 4.68% | -959 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 49,692 | 24,692 | -25,000 | 2,239 | 1,257 | 0.19% | -982 |
| MEIRAGTX HOLDINGS PLC(MGTX) | 150,000 | 0 | -150,000 | 1,017 | 0 | — | -1,017 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 2,224,196 | 1,050,000 | -1,174,196 | 4,738 | 3,612 | 0.53% | -1,126 |
| 89BIO INC | 175,000 | 0 | -175,000 | 1,272 | 0 | — | -1,272 |
| MBX BIOSCIENCES INC(MBX) | 175,000 | 0 | -175,000 | 1,292 | 0 | — | -1,291 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 325,000 | 275,000 | -50,000 | 6,653 | 4,980 | 0.74% | -1,672 |
| WAVE LIFE SCIENCES LTD(WVE) | 1,825,000 | 2,000,308 | +175,308 | 14,746 | 13,002 | 1.92% | -1,744 |
| AEROVATE THERAPEUTICS INC | 800,000 | 0 | -800,000 | 2,008 | 0 | — | -2,008 |
| ARCELLX INC COMMON STOCK | 530,000 | 495,000 | -35,000 | 34,768 | 32,596 | 4.82% | -2,172 |
| AVALO THERAPEUTICS INC(AVTX) | 657,154 | 607,872 | -49,282 | 5,264 | 3,033 | 0.45% | -2,231 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 80,000 | 80,000 | 0 | 26,498 | 24,211 | 3.58% | -2,287 |
| UNIQURE NV(QURE) | 400,000 | 135,000 | -265,000 | 4,240 | 1,882 | 0.28% | -2,358 |
| KYMERA THERAPEUTICS INC(KYMR) | 100,000 | 0 | -100,000 | 2,737 | 0 | — | -2,737 |
| MAZE THERAPEUTICS INC(MAZE) | 250,000 | 0 | -250,000 | 2,753 | 0 | — | -2,752 |
| SOLENO THERAPEUTICS INC | 50,000 | 0 | -50,000 | 3,573 | 0 | — | -3,572 |
| BRIDGEBIO PHARMA INC(BBIO) | 300,000 | 150,000 | -150,000 | 10,371 | 6,477 | 0.96% | -3,894 |
| ALKERMES PLC(ALKS) | 1,000,000 | 1,000,000 | 0 | 33,020 | 28,610 | 4.23% | -4,410 |
| TRAVERE THERAPEUTICS INC(TVTX) | 1,070,000 | 970,000 | -100,000 | 19,174 | 14,356 | 2.12% | -4,818 |
| MINERALYS THERAPEUTICS INC(MLYS) | 1,100,000 | 900,000 | -200,000 | 17,468 | 12,177 | 1.80% | -5,291 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 50,000 | 0 | -50,000 | 5,530 | 0 | — | -5,530 |
| AXSOME THERAPEUTICS INC(AXSM) | 100,000 | 50,000 | -50,000 | 11,663 | 5,220 | 0.77% | -6,443 |
| IMMUNOVANT INC(IMVT) | 430,000 | 0 | -430,000 | 7,349 | 0 | — | -7,349 |
| MERUS N V | 321,962 | 70,000 | -251,962 | 13,551 | 3,682 | 0.54% | -9,869 |
| XENON PHARMACEUTICALS INC(XENE) | 1,328,175 | 1,100,000 | -228,175 | 44,560 | 34,430 | 5.09% | -10,130 |
| CENTESSA PHARMACEUTICALS PLC | 1,546,662 | 900,162 | -646,500 | 22,241 | 11,828 | 1.75% | -10,413 |
| APOGEE THERAPEUTICS INC(APGE) | 1,151,199 | 691,899 | -459,300 | 43,009 | 30,049 | 4.44% | -12,960 |
| OMEROS CORP | 0 | 0 | 0 | 14,275 | 0 | — | -14,275 |
| SPDR S&P 500 ETF TR(SPY) | 30,000 | 0 | -30,000 | 16,782 | 0 | — | -16,782 |