Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q1 2025 ▲▼ | Q2 2025 ▲▼ | Change ▲▼ | Q1 2025 ▲▼ | Q2 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Verona Pharma PlcADS | 615,000 | 610,000 | -5,000 | $39.05M | $57.69M | 8.53% | +$18.65M |
| Insmed Incorporated(INSM) | 140,000 | 475,000 | +335,000 | $10.68M | $47.80M | 7.07% | +$37.12M |
| Xenon Pharmaceuticals Inc.(XENE) | 1,328,175 | 1,100,000 | -228,175 | $44.56M | $34.43M | 5.09% | -$10.13M |
| Arcellx Inc COMMON STOCK | 530,000 | 495,000 | -35,000 | $34.77M | $32.60M | 4.82% | -$2.17M |
| Blueprint Medicines Corp | 0 | 250,000 | +250,000 | $0 | $32.05M | 4.74% | +$32.05M |
| Nuvalent Inc | 460,000 | 415,000 | -45,000 | $32.62M | $31.66M | 4.68% | -$958.7K |
| Apogee Therapeutics Inc | 1,151,199 | 691,899 | -459,300 | $43.01M | $30.05M | 4.44% | -$12.96M |
| Alkermes plcSHS(ALKS) | 1,000,000 | 1,000,000 | 0 | $33.02M | $28.61M | 4.23% | -$4.41M |
| Protagonist Therapeutics Inc | 400,000 | 440,000 | +40,000 | $19.34M | $24.32M | 3.60% | +$4.97M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 80,000 | 80,000 | 0 | $26.50M | $24.21M | 3.58% | -$2.29M |
| Teva Pharmaceutical Industries LimitedADS(TEVA) | 1,400,000 | 1,400,000 | 0 | $21.52M | $23.46M | 3.47% | +$1.95M |
| Lexeo Therapeutics, Inc.(LXEO) | 1,480,881 | 3,589,355 | +2,108,474 | $5.14M | $14.43M | 2.13% | +$9.29M |
| Travere Therapeutics, Inc.(TVTX) | 1,070,000 | 970,000 | -100,000 | $19.17M | $14.36M | 2.12% | -$4.82M |
| Establishment Labs Holdings Inc.(ESTA) | 280,000 | 334,863 | +54,863 | $11.43M | $14.30M | 2.11% | +$2.88M |
| Trevi Therapeutics, Inc.(TRVI) | 1,250,000 | 2,534,058 | +1,284,058 | $7.86M | $13.86M | 2.05% | +$6.00M |
| Wave Life Sciences, Inc.SHS(WVE) | 1,825,000 | 2,000,308 | +175,308 | $14.75M | $13.00M | 1.92% | -$1.74M |
| Vera Therapeutics, Inc.CL A(VERA) | 355,143 | 545,000 | +189,857 | $8.53M | $12.84M | 1.90% | +$4.31M |
| Mineralys Therapeutics, Inc.(MLYS) | 1,100,000 | 900,000 | -200,000 | $17.47M | $12.18M | 1.80% | -$5.29M |
| Centessa Pharmaceuticals PlcADS | 1,546,662 | 900,162 | -646,500 | $22.24M | $11.83M | 1.75% | -$10.41M |
| Karyopharm Therapeutics IncNOTE 3 000 10 1 | 0 | 0 | 0 | $11.61M | $11.62M | 1.72% | +$9.2K |
| Nurix Therapeutics, Inc.(NRIX) | 810,669 | 967,620 | +156,951 | $9.63M | $11.02M | 1.63% | +$1.39M |
| Rezolute, Inc.(RZLT) | 1,700,000 | 2,200,000 | +500,000 | $4.93M | $9.81M | 1.45% | +$4.88M |
| Ventyx Biosciences Inc | 0 | 4,536,182 | +4,536,182 | $0 | $9.71M | 1.44% | +$9.71M |
| Spyre Therapeutics, Inc.(SYRE) | 481,678 | 606,678 | +125,000 | $7.77M | $9.08M | 1.34% | +$1.31M |
| Enliven Therapeutics Inc | 0 | 400,000 | +400,000 | $0 | $8.02M | 1.19% | +$8.02M |
| Proqr Thrapeutics N VSHS EURO SHS EURO | 3,284,512 | 3,499,512 | +215,000 | $4.37M | $7.14M | 1.06% | +$2.77M |
| Akebia Therapeutics, Inc.(AKBA) | 1,500,000 | 1,950,000 | +450,000 | $2.88M | $7.10M | 1.05% | +$4.22M |
| Omeros CorporationNOTE 9 500 6 1(OMER) | 0 | 0 | 0 | $0 | $7.07M | 1.05% | +$7.07M |
| Inozyme Pharma Inc | 3,867,710 | 1,749,359 | -2,118,351 | $3.52M | $7.00M | 1.03% | +$3.48M |
| Autolus Therapeutics plcADS(AUTL) | 3,045,000 | 3,045,000 | 0 | $4.72M | $6.94M | 1.03% | +$2.22M |
| Oruka Therapeutics, Inc.(ORKA) | 545,362 | 603,479 | +58,117 | $5.60M | $6.76M | 1.00% | +$1.17M |
| Travere Therapeutics, Inc.NOTE 2 250 3 0(TVTX) | 0 | 0 | 0 | $6.99M | $6.69M | 0.99% | -$307.9K |
| BridgeBio Pharma, Inc.(BBIO) | 300,000 | 150,000 | -150,000 | $10.37M | $6.48M | 0.96% | -$3.89M |
| Viridian Therapeutics, Inc.(VRDN) | 390,000 | 390,000 | 0 | $5.26M | $5.45M | 0.81% | +$195.0K |
| Axsome Therapeutics, Inc.(AXSM) | 100,000 | 50,000 | -50,000 | $11.66M | $5.22M | 0.77% | -$6.44M |
| Erasca, Inc.(ERAS) | 3,341,519 | 4,085,787 | +744,268 | $4.58M | $5.19M | 0.77% | +$611.1K |
| Newamsterdam Pharma Company ORDINARY SHARES | 325,000 | 275,000 | -50,000 | $6.65M | $4.98M | 0.74% | -$1.67M |
| Crescent Biopharma, Inc.(CBIO) | 0 | 280,031 | +280,031 | $0 | $4.52M | 0.67% | +$4.52M |
| Roivant Sciences Ltd.SHS(ROIV) | 150,000 | 400,000 | +250,000 | $1.51M | $4.51M | 0.67% | +$2.99M |
| Crinetics Pharmaceuticals In | 152,252 | 152,252 | 0 | $5.11M | $4.38M | 0.65% | -$727.8K |
| Vaxcyte, Inc.(PCVX) | 25,000 | 125,000 | +100,000 | $944.0K | $4.06M | 0.60% | +$3.12M |
| Perceptive Cap Solutions CorCL A CL A ORD SHS | 350,000 | 350,000 | 0 | $3.62M | $3.71M | 0.55% | +$94.5K |
| Merus N V | 321,962 | 70,000 | -251,962 | $13.55M | $3.68M | 0.54% | -$9.87M |
| Perspective Therapeutics, Inc.(CATX) | 2,224,196 | 1,050,000 | -1,174,196 | $4.74M | $3.61M | 0.53% | -$1.13M |
| Avalo Therapeutics, Inc.(AVTX) | 657,154 | 607,872 | -49,282 | $5.26M | $3.03M | 0.45% | -$2.23M |
| Oaktree Acquisition Corp IiiUNIT 10 04 2029 UNIT 10/04/2029 | 250,000 | 250,000 | 0 | $2.60M | $2.65M | 0.39% | +$60.0K |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 0 | 25,000 | +25,000 | $0 | $2.65M | 0.39% | +$2.65M |
| Monopar Therapeutics Inc.(MNPR) | 62,000 | 67,500 | +5,500 | $2.26M | $2.42M | 0.36% | +$157.7K |
| Rapport Therapeutics, Inc.(RAPP) | 0 | 199,643 | +199,643 | $0 | $2.27M | 0.34% | +$2.27M |
| Geron Corporation(GERN) | 1,500,000 | 1,500,000 | 0 | $2.38M | $2.12M | 0.31% | -$270.0K |
| Third Harmonic Bio Inc | 370,000 | 370,000 | 0 | $1.28M | $2.01M | 0.30% | +$725.2K |
| Cullinan Therapeutics, Inc.(CGEM) | 263,817 | 263,817 | 0 | $2.00M | $1.99M | 0.29% | -$10.6K |
| Newamsterdam Pharma CompanyW EXP 99 99 999 *W EXP 99/99/999 | 241,957 | 245,000 | +3,043 | $2.75M | $1.96M | 0.29% | -$786.2K |
| uniQure N.V.SHS(QURE) | 400,000 | 135,000 | -265,000 | $4.24M | $1.88M | 0.28% | -$2.36M |
| Climb Bio, Inc.(CLYM) | 1,500,000 | 1,500,000 | 0 | $1.83M | $1.86M | 0.28% | +$30.0K |
| Anteris Technologies Global Corp.(AVR) | 390,000 | 425,000 | +35,000 | $1.42M | $1.61M | 0.24% | +$191.2K |
| Astria Therapeutics Inc | 0 | 300,000 | +300,000 | $0 | $1.61M | 0.24% | +$1.61M |
| Nkarta, Inc.(NKTX) | 800,000 | 800,000 | 0 | $1.47M | $1.33M | 0.20% | -$144.0K |
| Mirum Pharmaceuticals, Inc.(MIRM) | 49,692 | 24,692 | -25,000 | $2.24M | $1.26M | 0.19% | -$982.0K |
| Savara Inc.(SVRA) | 0 | 500,000 | +500,000 | $0 | $1.14M | 0.17% | +$1.14M |
| Olema Pharmaceuticals, Inc.(OLMA) | 325,000 | 250,000 | -75,000 | $1.22M | $1.06M | 0.16% | -$157.0K |
| Nextcure Inc | 2,302,598 | 2,302,598 | 0 | $1.11M | $1.06M | 0.16% | -$46.7K |
| OnKure Therapeutics, Inc.CL A(OKUR) | 394,159 | 347,990 | -46,169 | $1.69M | $831.7K | 0.12% | -$863.2K |
| ABIVAX Société AnonymeADS(ABVX) | 200,000 | 100,000 | -100,000 | $1.25M | $765.0K | 0.11% | -$485.0K |
| Jade Biosciences Inc | 0 | 65,317 | +65,317 | $0 | $652.5K | 0.10% | +$652.5K |
| Sutro Biopharma, Inc.(STRO) | 752,722 | 752,722 | 0 | $489.7K | $537.4K | 0.08% | +$47.6K |
| Taysha Gene Therapies, Inc.(TSHA) | 0 | 200,000 | +200,000 | $0 | $462.0K | 0.07% | +$462.0K |
| Context Therapeutics Inc.(CNTX) | 660,589 | 518,025 | -142,564 | $404.3K | $339.4K | 0.05% | -$64.9K |
| Engene Holdings Inc COM | 0 | 77,000 | +77,000 | $0 | $280.3K | 0.04% | +$280.3K |
| Repare Therapeutics Inc | 200,000 | 200,000 | 0 | $197.2K | $278.0K | 0.04% | +$80.8K |
| Zura Bio LimitedCL A(ZURA) | 223,335 | 223,335 | 0 | $288.1K | $234.5K | 0.03% | -$53.6K |
| Ovid Therapeutics Inc.(OVID) | 667,516 | 667,516 | 0 | $208.2K | $220.2K | 0.03% | +$12.0K |
| Radiopharm Theranostics LimitedADS(RADX) | 64,600 | 35,635 | -28,965 | $310.7K | $166.1K | 0.02% | -$144.7K |
| Adagio Medical Holdings, Inc.(ADGM) | 213,235 | 80,000 | -133,235 | $169.5K | $108.0K | 0.02% | -$61.5K |
| Q32 Bio Inc.(QTTB) | 27,777 | 27,777 | 0 | $45.8K | $41.4K | 0.01% | -$4.4K |
| Rocket Pharmaceuticals, Inc.W EXP 09 02 202(RCKT) | 75,000 | 75,000 | 0 | $3.5K | $2.2K | 0.00% | -$1.4K |
| Immatics N.VW EXP 07 01 202 | 187,204 | 187,204 | 0 | $3.0K | $112 | 0.00% | -$2.8K |
| 89bio Inc | 175,000 | 0 | -175,000 | $1.27M | $0 | — | -$1.27M |
| Aerovate Therapeutics Inc | 800,000 | 0 | -800,000 | $2.01M | $0 | — | -$2.01M |
| Allakos Inc | 250,000 | 0 | -250,000 | $56.9K | $0 | — | -$56.9K |
| Black Diamond Therapeutics I | 250,000 | 0 | -250,000 | $387.5K | $0 | — | -$387.5K |
| Compass Therapeutics, Inc.(CMPX) | 130,807 | 0 | -130,807 | $248.5K | $0 | — | -$248.5K |
| Immunovant, Inc.(IMVT) | 430,000 | 0 | -430,000 | $7.35M | $0 | — | -$7.35M |
| Kymera Therapeutics, Inc.(KYMR) | 100,000 | 0 | -100,000 | $2.74M | $0 | — | -$2.74M |
| Maze Therapeutics, Inc.(MAZE) | 250,000 | 0 | -250,000 | $2.75M | $0 | — | -$2.75M |
| MBX Biosciences, Inc.(MBX) | 175,000 | 0 | -175,000 | $1.29M | $0 | — | -$1.29M |
| MeiraGTx Holdings plc(MGTX) | 150,000 | 0 | -150,000 | $1.02M | $0 | — | -$1.02M |
| Neurocrine Biosciences, Inc.(NBIX) | 50,000 | 0 | -50,000 | $5.53M | $0 | — | -$5.53M |
| Omeros Corporation(OMER) | 9,958 | 0 | -9,958 | $81.9K | $0 | — | -$81.9K |
| Omeros CorpNOTE 5 250 2 1 | 0 | 0 | 0 | $14.28M | $0 | — | -$14.28M |
| Soleno Therapeutics Inc | 50,000 | 0 | -50,000 | $3.57M | $0 | — | -$3.57M |
| State Street SPDR S&P 500 ETF TrustTR UNIT(SPY) | 30,000 | 0 | -30,000 | $16.78M | $0 | — | -$16.78M |
| Viking Therapeutics, Inc.(VKTX) | 25,000 | 0 | -25,000 | $603.8K | $0 | — | -$603.8K |