Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2024 ▲▼ | Q3 2024 ▲▼ | Change ▲▼ | Q2 2024 ▲▼ | Q3 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| NUVALENT INC | 200,000 | 337,500 | +137,500 | 15,172 | 34,526 | 5.36% | +19,354 |
| ALKERMES PLC(ALKS) | 650,000 | 1,000,000 | +350,000 | 15,665 | 27,990 | 4.34% | +12,325 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 150,000 | 525,000 | +375,000 | 1,952 | 11,944 | 1.85% | +9,992 |
| WAVE LIFE SCIENCES LTD(WVE) | 375,000 | 1,400,000 | +1,025,000 | 1,871 | 11,480 | 1.78% | +9,609 |
| VERONA PHARMA PLC | 700,000 | 650,000 | -50,000 | 10,122 | 18,701 | 2.90% | +8,579 |
| ORUKA THERAPEUTICS INC(ORKA) | 0 | 349,836 | +349,836 | 0 | 8,574 | 1.33% | +8,574 |
| ARCELLX INC COMMON STOCK | 460,000 | 400,000 | -60,000 | 25,387 | 33,404 | 5.18% | +8,017 |
| OMEROS CORP | 0 | 0 | 0 | 8,083 | 14,637 | 2.27% | +6,554 |
| XENON PHARMACEUTICALS INC(XENE) | 994,227 | 1,144,021 | +149,794 | 38,765 | 45,040 | 6.99% | +6,275 |
| APOGEE THERAPEUTICS INC(APGE) | 836,283 | 664,198 | -172,085 | 32,908 | 39,015 | 6.05% | +6,107 |
| VERA THERAPEUTICS INC(VERA) | 375,000 | 435,000 | +60,000 | 13,568 | 19,227 | 2.98% | +5,660 |
| ARVINAS INC(ARVN) | 0 | 225,000 | +225,000 | 0 | 5,542 | 0.86% | +5,542 |
| CENTESSA PHARMACEUTICALS PLC | 1,135,702 | 965,612 | -170,090 | 10,255 | 15,440 | 2.40% | +5,185 |
| BRIDGEBIO PHARMA INC(BBIO) | 100,000 | 300,000 | +200,000 | 2,533 | 7,638 | 1.19% | +5,105 |
| TERNS PHARMACEUTICALS INC | 0 | 600,000 | +600,000 | 0 | 5,004 | 0.78% | +5,004 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 50,000 | 325,000 | +275,000 | 1,300 | 6,295 | 0.98% | +4,996 |
| COHERUS BIOSCIENCES INC(CHRS) | 0 | 0 | 0 | 8,636 | 13,051 | 2.02% | +4,414 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 0 | 0 | 0 | 4,320 | 0.67% | +4,320 |
| KARYOPHARM THERAPEUTICS INC | 0 | 0 | 0 | 6,296 | 9,616 | 1.49% | +3,320 |
| SPYRE THERAPEUTICS INC(SYRE) | 513,420 | 498,420 | -15,000 | 12,071 | 14,659 | 2.27% | +2,588 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 223,407 | 290,447 | +67,040 | 10,152 | 12,568 | 1.95% | +2,416 |
| SPRINGWORKS THERAPEUTICS INC | 69,999 | 147,500 | +77,501 | 2,637 | 4,726 | 0.73% | +2,089 |
| INOZYME PHARMA INC | 2,856,252 | 2,822,318 | -33,934 | 12,739 | 14,761 | 2.29% | +2,022 |
| NKARTA INC(NKTX) | 200,000 | 650,000 | +450,000 | 1,182 | 2,938 | 0.46% | +1,756 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,450,000 | 1,400,000 | -50,000 | 23,563 | 25,228 | 3.91% | +1,666 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 4,300,000 | 4,500,000 | +200,000 | 14,964 | 16,335 | 2.53% | +1,371 |
| SOLENO THERAPEUTICS INC | 0 | 25,000 | +25,000 | 0 | 1,262 | 0.20% | +1,262 |
| VERASTEM INC(VSTM) | 0 | 400,000 | +400,000 | 0 | 1,196 | 0.19% | +1,196 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 550,000 | 500,000 | -50,000 | 5,484 | 6,675 | 1.04% | +1,192 |
| VAXCYTE INC(PCVX) | 60,000 | 50,000 | -10,000 | 4,531 | 5,714 | 0.89% | +1,183 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 0 | 15,000 | +15,000 | 0 | 1,054 | 0.16% | +1,054 |
| ERASCA INC(ERAS) | 2,499,431 | 2,499,431 | 0 | 5,899 | 6,823 | 1.06% | +925 |
| AEROVATE THERAPEUTICS INC | 200,000 | 600,000 | +400,000 | 332 | 1,254 | 0.19% | +922 |
| KEZAR LIFE SCIENCES INC | 1,761,778 | 2,511,778 | +750,000 | 1,057 | 1,942 | 0.30% | +885 |
| TECTONIC THERAPEUTIC INC(TECX) | 58,331 | 58,331 | 0 | 961 | 1,767 | 0.27% | +807 |
| AXSOME THERAPEUTICS INC(AXSM) | 80,000 | 80,000 | 0 | 6,440 | 7,190 | 1.12% | +750 |
| Q32 BIO INC(FIXX) | 27,777 | 27,777 | 0 | 499 | 1,239 | 0.19% | +741 |
| MERUS N V | 125,000 | 161,741 | +36,741 | 7,396 | 8,081 | 1.25% | +684 |
| REPARE THERAPEUTICS INC | 0 | 173,351 | +173,351 | 0 | 596 | 0.09% | +596 |
| ADAGIO MED HLDGS INC(ADGM) | 0 | 213,235 | +213,235 | 0 | 550 | 0.09% | +550 |
| NEXTCURE INC | 1,687,955 | 2,302,598 | +614,643 | 2,684 | 3,155 | 0.49% | +471 |
| GERON CORP(GERN) | 1,500,000 | 1,500,000 | 0 | 6,360 | 6,810 | 1.06% | +450 |
| MINERALYS THERAPEUTICS INC(MLYS) | 327,959 | 350,000 | +22,041 | 3,837 | 4,239 | 0.66% | +401 |
| VOYAGER THERAPEUTICS INC(VYGR) | 0 | 51,727 | +51,727 | 0 | 303 | 0.05% | +303 |
| NURIX THERAPEUTICS INC(NRIX) | 912,000 | 860,399 | -51,601 | 19,033 | 19,333 | 3.00% | +300 |
| REZOLUTE INC(RZLT) | 1,850,000 | 1,700,000 | -150,000 | 7,955 | 8,245 | 1.28% | +290 |
| ZURA BIO LTD(ZURA) | 223,335 | 223,335 | 0 | 782 | 907 | 0.14% | +125 |
| AADI BIOSCIENCE INC(WHWK) | 0 | 47,019 | +47,019 | 0 | 97 | 0.02% | +97 |
| HELIX ACQUISITION CORP II | 250,000 | 250,000 | 0 | 2,555 | 2,613 | 0.41% | +58 |
| KURA ONCOLOGY INC(KURA) | 650,000 | 687,785 | +37,785 | 13,384 | 13,439 | 2.09% | +56 |
| GENELUX CORPORATION(GNLX) | 100,000 | 100,000 | 0 | 195 | 237 | 0.04% | +42 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 5 | 5 | 0.00% | +1 |
| IOVANCE BIOTHERAPEUTICS INC(IOVA) | 100 | 0 | -100 | 1 | 0 | — | -1 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 350,000 | 350,000 | 0 | 3,521 | 3,511 | 0.54% | -10 |
| IMMATICS N.V | 187,204 | 187,204 | 0 | 485 | 431 | 0.07% | -54 |
| AVALO THERAPEUTICS INC(AVTX) | 45,000 | 45,000 | 0 | 561 | 426 | 0.07% | -135 |
| NEUROBO PHARMACEUTICALS IN | 89,222 | 89,222 | 0 | 432 | 283 | 0.04% | -149 |
| PUMA BIOTECHNOLOGY INC(PBYI) | 250,000 | 250,000 | 0 | 815 | 638 | 0.10% | -177 |
| CULLINAN THERAPEUTICS INC(CGEM) | 263,817 | 263,817 | 0 | 4,601 | 4,416 | 0.69% | -185 |
| PASSAGE BIO INC(PASG) | 264,266 | 0 | -264,266 | 210 | 0 | — | -210 |
| RAPT THERAPEUTICS INC | 75,000 | 0 | -75,000 | 229 | 0 | — | -229 |
| ARCA BIOPHARMA INC | 72,484 | 0 | -72,484 | 278 | 0 | — | -278 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 423,155 | 472,390 | +49,235 | 8,129 | 7,842 | 1.22% | -287 |
| PROMIS NEUROSCIENCES INC | 265,958 | 30,643 | -235,315 | 399 | 38 | 0.01% | -361 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 202,599 | 212,974 | +10,375 | 1,917 | 1,491 | 0.23% | -426 |
| IMMATICS N.V(IMTX) | 300,000 | 250,000 | -50,000 | 3,486 | 2,853 | 0.44% | -633 |
| CONTEXT THERAPEUTICS INC(CNTX) | 1,619,140 | 1,321,153 | -297,987 | 3,246 | 2,589 | 0.40% | -657 |
| ASTRIA THERAPEUTICS INC | 975,606 | 725,106 | -250,500 | 8,878 | 7,983 | 1.24% | -895 |
| KYVERNA THERAPEUTICS INC(KYTX) | 200,000 | 119,900 | -80,100 | 1,500 | 586 | 0.09% | -914 |
| COMPASS PATHWAYS PLC(CMPS) | 500,512 | 300,512 | -200,000 | 3,023 | 1,893 | 0.29% | -1,130 |
| TANGO THERAPEUTICS INC(TNGX) | 150,274 | 0 | -150,274 | 1,289 | 0 | — | -1,289 |
| ROIVANT SCIENCES LTD(ROIV) | 351,587 | 201,587 | -150,000 | 3,716 | 2,326 | 0.36% | -1,390 |
| ADC THERAPEUTICS SA(ADCT) | 474,744 | 0 | -474,744 | 1,500 | 0 | — | -1,500 |
| ARYA SCIENCES ACQU CORP IV | 133,500 | 0 | -133,500 | 1,530 | 0 | — | -1,530 |
| MERSANA THERAPEUTICS INC | 767,000 | 0 | -767,000 | 1,542 | 0 | — | -1,542 |
| ZYMEWORKS INC(ZYME) | 191,127 | 0 | -191,127 | 1,626 | 0 | — | -1,626 |
| VIR BIOTECHNOLOGY INC(VIR) | 200,000 | 0 | -200,000 | 1,780 | 0 | — | -1,780 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 155,000 | 75,000 | -80,000 | 5,299 | 2,925 | 0.45% | -2,374 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 515,000 | 400,000 | -115,000 | 23,067 | 20,440 | 3.17% | -2,627 |
| IMMUNOVANT INC(IMVT) | 346,088 | 225,000 | -121,088 | 9,137 | 6,415 | 1.00% | -2,722 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 275,000 | 0 | -275,000 | 2,976 | 0 | — | -2,975 |
| BLACK DIAMOND THERAPEUTICS I | 650,000 | 0 | -650,000 | 3,029 | 0 | — | -3,029 |
| SAVARA INC(SVRA) | 1,546,850 | 700,000 | -846,850 | 6,234 | 2,968 | 0.46% | -3,266 |
| SPDR SER TR ST STR SP BIOT | 37,550 | 0 | -37,550 | 3,481 | 0 | — | -3,481 |
| DYNE THERAPEUTICS INC(DYN) | 100,000 | 0 | -100,000 | 3,529 | 0 | — | -3,529 |
| HILLEVAX INC | 265,859 | 0 | -265,859 | 3,844 | 0 | — | -3,844 |
| ELEVATION ONCOLOGY INC | 1,468,825 | 0 | -1,468,825 | 3,966 | 0 | — | -3,966 |
| ELIEM THERAPEUTICS INC(CLYM) | 1,670,661 | 1,500,000 | -170,661 | 11,878 | 7,635 | 1.18% | -4,243 |
| INSMED INC(INSM) | 125,000 | 50,000 | -75,000 | 8,375 | 3,650 | 0.57% | -4,725 |
| INARI MED INC | 200,000 | 60,000 | -140,000 | 9,630 | 2,474 | 0.38% | -7,156 |
| BEIGENE LTD(ONC) | 110,000 | 35,000 | -75,000 | 15,694 | 7,858 | 1.22% | -7,836 |
| MORPHIC HLDG INC | 250,573 | 0 | -250,573 | 8,537 | 0 | — | -8,537 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 110,000 | 100,000 | -10,000 | 30,818 | 21,222 | 3.29% | -9,596 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 475,400 | 125,000 | -350,400 | 17,595 | 4,249 | 0.66% | -13,346 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 0 | 0 | 16,200 | 0 | — | -16,200 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 0 | 0 | 17,257 | 0 | — | -17,257 |
| CEREVEL THERAPEUTICS HLDNG I | 500,000 | 0 | -500,000 | 20,445 | 0 | — | -20,445 |