Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q2 2025 ▲▼ | Q3 2025 ▲▼ | Change ▲▼ | Q2 2025 ▲▼ | Q3 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| SPDR S&P 500 ETF TR(SPY) | 0 | 84,490 | +84,490 | 0 | 56,286 | 5.24% | +56,286 |
| ABIVAX SA(ABVX) | 100,000 | 360,000 | +260,000 | 765 | 30,564 | 2.84% | +29,799 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 80,000 | 115,000 | +35,000 | 24,211 | 52,746 | 4.91% | +28,535 |
| MERUS N V | 70,000 | 285,769 | +215,769 | 3,682 | 26,905 | 2.50% | +23,223 |
| XENON PHARMACEUTICALS INC(XENE) | 1,100,000 | 1,400,000 | +300,000 | 34,430 | 56,210 | 5.23% | +21,780 |
| CYTOKINETICS INC(CYTK) | 0 | 350,000 | +350,000 | 0 | 19,236 | 1.79% | +19,236 |
| INSMED INC(INSM) | 475,000 | 450,000 | -25,000 | 47,804 | 64,805 | 6.03% | +17,001 |
| APOGEE THERAPEUTICS INC(APGE) | 691,899 | 1,173,426 | +481,527 | 30,049 | 46,620 | 4.34% | +16,571 |
| MINERALYS THERAPEUTICS INC(MLYS) | 900,000 | 750,000 | -150,000 | 12,177 | 28,440 | 2.65% | +16,263 |
| UNIQURE NV(QURE) | 135,000 | 300,000 | +165,000 | 1,882 | 17,511 | 1.63% | +15,629 |
| CENTESSA PHARMACEUTICALS PLC | 900,162 | 1,107,162 | +207,000 | 11,828 | 26,849 | 2.50% | +15,021 |
| SPYRE THERAPEUTICS INC(SYRE) | 606,678 | 1,419,299 | +812,621 | 9,082 | 23,787 | 2.21% | +14,705 |
| SOLENO THERAPEUTICS INC | 0 | 200,000 | +200,000 | 0 | 13,520 | 1.26% | +13,520 |
| TREVI THERAPEUTICS INC(TRVI) | 2,534,058 | 2,800,000 | +265,942 | 13,861 | 25,620 | 2.38% | +11,759 |
| ORUKA THERAPEUTICS INC(ORKA) | 603,479 | 959,180 | +355,701 | 6,765 | 18,445 | 1.72% | +11,680 |
| LEXEO THERAPEUTICS INC(LXEO) | 3,589,355 | 3,870,527 | +281,172 | 14,429 | 25,700 | 2.39% | +11,271 |
| DIANTHUS THERAPEUTICS INC(DNTH) | 0 | 262,100 | +262,100 | 0 | 10,314 | 0.96% | +10,314 |
| REZOLUTE INC(RZLT) | 2,200,000 | 2,100,000 | -100,000 | 9,812 | 19,740 | 1.84% | +9,928 |
| AVALO THERAPEUTICS INC(AVTX) | 607,872 | 1,006,217 | +398,345 | 3,033 | 12,789 | 1.19% | +9,756 |
| TAYSHA GENE THERAPIES INC(TSHA) | 200,000 | 3,000,000 | +2,800,000 | 462 | 9,810 | 0.91% | +9,348 |
| VERONA PHARMA PLC | 610,000 | 625,000 | +15,000 | 57,694 | 66,694 | 6.21% | +9,000 |
| ALKERMES PLC(ALKS) | 1,000,000 | 1,250,000 | +250,000 | 28,610 | 37,500 | 3.49% | +8,890 |
| ARCELLX INC COMMON STOCK | 495,000 | 500,000 | +5,000 | 32,596 | 41,050 | 3.82% | +8,454 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 0 | 300,000 | +300,000 | 0 | 7,761 | 0.72% | +7,761 |
| ROIVANT SCIENCES LTD(ROIV) | 400,000 | 800,000 | +400,000 | 4,508 | 12,104 | 1.13% | +7,596 |
| TARSUS PHARMACEUTICALS INC(TARS) | 0 | 125,000 | +125,000 | 0 | 7,429 | 0.69% | +7,429 |
| ZURA BIO LTD(ZURA) | 223,335 | 1,274,351 | +1,051,016 | 235 | 5,518 | 0.51% | +5,283 |
| IMMUNOVANT INC(IMVT) | 0 | 300,000 | +300,000 | 0 | 4,836 | 0.45% | +4,836 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,400,000 | 1,400,000 | 0 | 23,464 | 28,280 | 2.63% | +4,816 |
| REVOLUTION MEDICINES INC(RVMD) | 0 | 100,000 | +100,000 | 0 | 4,670 | 0.43% | +4,670 |
| SAVARA INC(SVRA) | 500,000 | 1,500,000 | +1,000,000 | 1,140 | 5,355 | 0.50% | +4,215 |
| ERASCA INC(ERAS) | 4,085,787 | 4,285,787 | +200,000 | 5,189 | 9,343 | 0.87% | +4,154 |
| MONOPAR THERAPEUTICS INC(MNPR) | 67,500 | 79,483 | +11,983 | 2,415 | 6,491 | 0.60% | +4,076 |
| CELCUITY INC(CELC) | 0 | 0 | 0 | 0 | 3,998 | 0.37% | +3,998 |
| INSPIRE MED SYS INC(INSP) | 0 | 50,000 | +50,000 | 0 | 3,710 | 0.35% | +3,710 |
| OVID THERAPEUTICS INC(OVID) | 667,516 | 2,650,000 | +1,982,484 | 220 | 3,445 | 0.32% | +3,225 |
| MBX BIOSCIENCES INC(MBX) | 0 | 165,000 | +165,000 | 0 | 2,888 | 0.27% | +2,888 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 275,000 | 275,000 | 0 | 4,980 | 7,821 | 0.73% | +2,841 |
| OCULAR THERAPEUTIX INC(OCUL) | 0 | 239,000 | +239,000 | 0 | 2,794 | 0.26% | +2,794 |
| VENTYX BIOSCIENCES INC | 4,536,182 | 3,924,415 | -611,767 | 9,707 | 12,205 | 1.14% | +2,498 |
| SAGIMET BIOSCIENCES INC(SGMT) | 0 | 350,000 | +350,000 | 0 | 2,401 | 0.22% | +2,401 |
| WAVE LIFE SCIENCES LTD(WVE) | 2,000,308 | 2,100,000 | +99,692 | 13,002 | 15,372 | 1.43% | +2,370 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 245,000 | 245,000 | 0 | 1,960 | 4,192 | 0.39% | +2,232 |
| UNITED THERAPEUTICS CORP DEL(UTHR) | 0 | 5,000 | +5,000 | 0 | 2,096 | 0.20% | +2,096 |
| ORCHESTRA BIOMED HLDGS INC(OBIO) | 0 | 727,272 | +727,272 | 0 | 1,804 | 0.17% | +1,804 |
| EUPRAXIA PHARMACEUTICALS INC(EPRX) | 0 | 300,000 | +300,000 | 0 | 1,770 | 0.16% | +1,770 |
| NUVALENT INC | 415,000 | 384,417 | -30,583 | 31,665 | 33,244 | 3.09% | +1,580 |
| OLEMA PHARMACEUTICALS INC(OLMA) | 250,000 | 250,000 | 0 | 1,065 | 2,448 | 0.23% | +1,383 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 0 | 666,666 | +666,666 | 0 | 1,333 | 0.12% | +1,333 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 0 | 0 | 6,685 | 7,927 | 0.74% | +1,242 |
| COMPASS PATHWAYS PLC(CMPS) | 0 | 200,000 | +200,000 | 0 | 1,146 | 0.11% | +1,146 |
| NEXTCURE INC | 0 | 191,882 | +191,882 | 0 | 1,124 | 0.10% | +1,124 |
| KARYOPHARM THERAPEUTICS INC | 0 | 0 | 0 | 11,620 | 12,456 | 1.16% | +836 |
| CLIMB BIO INC(CLYM) | 1,500,000 | 1,300,000 | -200,000 | 1,860 | 2,613 | 0.24% | +753 |
| JAZZ PHARMACEUTICALS PLC(JAZZ) | 25,000 | 25,000 | 0 | 2,653 | 3,295 | 0.31% | +642 |
| ASTRIA THERAPEUTICS INC | 300,000 | 300,000 | 0 | 1,608 | 2,184 | 0.20% | +576 |
| PROQR THRAPEUTICS N V SHS EURO | 3,499,512 | 3,600,000 | +100,488 | 7,139 | 7,668 | 0.71% | +529 |
| VAXCYTE INC(PCVX) | 125,000 | 125,000 | 0 | 4,064 | 4,503 | 0.42% | +439 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 425,000 | 450,000 | +25,000 | 1,611 | 2,025 | 0.19% | +414 |
| ENGENE HOLDINGS INC COM | 77,000 | 77,000 | 0 | 280 | 526 | 0.05% | +246 |
| ENLIVEN THERAPEUTICS INC | 400,000 | 400,000 | 0 | 8,024 | 8,188 | 0.76% | +164 |
| SUTRO BIOPHARMA INC(STRO) | 752,722 | 752,722 | 0 | 537 | 654 | 0.06% | +116 |
| REPARE THERAPEUTICS INC | 200,000 | 200,000 | 0 | 278 | 352 | 0.03% | +74 |
| CONTEXT THERAPEUTICS INC(CNTX) | 518,025 | 402,653 | -115,372 | 339 | 390 | 0.04% | +51 |
| ADAGIO MED HLDGS INC(ADGM) | 80,000 | 80,000 | 0 | 108 | 155 | 0.01% | +47 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 350,000 | 350,000 | 0 | 3,714 | 3,756 | 0.35% | +42 |
| ARS PHARMACEUTICALS INC(SPRY) | 0 | 2,500 | +2,500 | 0 | 25 | 0.00% | +25 |
| Q32 BIO INC(FIXX) | 27,777 | 27,777 | 0 | 41 | 55 | 0.01% | +14 |
| OAKTREE ACQUISITION CORP III UNIT 10/04/2029 | 250,000 | 250,000 | 0 | 2,655 | 2,660 | 0.25% | +5 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 2 | 3 | 0.00% | +1 |
| IMMATICS N.V | 187,204 | 0 | -187,204 | 0 | 0 | — | -0 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 390,000 | 250,000 | -140,000 | 5,452 | 5,395 | 0.50% | -57 |
| GERON CORP(GERN) | 1,500,000 | 1,500,000 | 0 | 2,115 | 2,055 | 0.19% | -60 |
| JADE BIOSCIENCES INC | 65,317 | 65,317 | 0 | 653 | 564 | 0.05% | -89 |
| RADIOPHARM THERANOSTICS LTD(RADX) | 35,635 | 0 | -35,635 | 166 | 0 | — | -166 |
| AKEBIA THERAPEUTICS INC(AKBA) | 1,950,000 | 2,450,000 | +500,000 | 7,098 | 6,689 | 0.62% | -409 |
| CULLINAN THERAPEUTICS INC(CGEM) | 263,817 | 263,817 | 0 | 1,987 | 1,564 | 0.15% | -422 |
| ONKURE THERAPEUTICS INC(OKUR) | 347,990 | 0 | -347,990 | 832 | 0 | — | -832 |
| NEXTCURE INC | 2,302,598 | 0 | -2,302,598 | 1,059 | 0 | — | -1,059 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 152,252 | 75,000 | -77,252 | 4,379 | 3,124 | 0.29% | -1,255 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 24,692 | 0 | -24,692 | 1,257 | 0 | — | -1,257 |
| NKARTA INC(NKTX) | 800,000 | 0 | -800,000 | 1,328 | 0 | — | -1,328 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 334,863 | 310,000 | -24,863 | 14,302 | 12,707 | 1.18% | -1,595 |
| THIRD HARMONIC BIO INC | 370,000 | 0 | -370,000 | 2,009 | 0 | — | -2,009 |
| NURIX THERAPEUTICS INC(NRIX) | 967,620 | 967,620 | 0 | 11,021 | 8,941 | 0.83% | -2,080 |
| RAPPORT THERAPEUTICS INC(RAPP) | 199,643 | 0 | -199,643 | 2,270 | 0 | — | -2,270 |
| OMEROS CORP(OMER) | 0 | 0 | 0 | 7,069 | 4,713 | 0.44% | -2,355 |
| TRAVERE THERAPEUTICS INC(TVTX) | 970,000 | 500,000 | -470,000 | 14,356 | 11,950 | 1.11% | -2,406 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 1,050,000 | 300,000 | -750,000 | 3,612 | 1,029 | 0.10% | -2,583 |
| BRIDGEBIO PHARMA INC(BBIO) | 150,000 | 65,000 | -85,000 | 6,477 | 3,376 | 0.31% | -3,101 |
| VERA THERAPEUTICS INC(VERA) | 545,000 | 303,330 | -241,670 | 12,840 | 8,815 | 0.82% | -4,025 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 3,045,000 | 1,750,000 | -1,295,000 | 6,943 | 2,853 | 0.27% | -4,090 |
| CRESCENT BIOPHARMA INC.(CBIO) | 280,031 | 17,998 | -262,033 | 4,520 | 214 | 0.02% | -4,306 |
| AXSOME THERAPEUTICS INC(AXSM) | 50,000 | 0 | -50,000 | 5,220 | 0 | — | -5,219 |
| INOZYME PHARMA INC | 1,749,359 | 0 | -1,749,359 | 6,997 | 0 | — | -6,997 |
| PROTAGONIST THERAPEUTICS INC | 440,000 | 220,600 | -219,400 | 24,319 | 14,654 | 1.36% | -9,664 |
| BLUEPRINT MEDICINES CORP | 250,000 | 0 | -250,000 | 32,045 | 0 | — | -32,045 |