Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| IMMUNOGEN INC | 0 | 1,404,608 | +1,404,608 | 0 | 41,647 | 8.30% | +41,647 |
| CEREVEL THERAPEUTICS HLDNG I | 685,061 | 750,000 | +64,939 | 14,955 | 31,800 | 6.34% | +16,845 |
| LIANBIO(LIANY) | 672,357 | 3,779,694 | +3,107,337 | 1,002 | 16,895 | 3.37% | +15,893 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 150,000 | 400,000 | +250,000 | 4,128 | 15,864 | 3.16% | +11,736 |
| XENON PHARMACEUTICALS INC(XENE) | 300,438 | 460,000 | +159,562 | 10,263 | 21,188 | 4.22% | +10,925 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 85,000 | 100,000 | +15,000 | 12,413 | 23,138 | 4.61% | +10,725 |
| NUVALENT INC | 50,000 | 175,000 | +125,000 | 2,299 | 12,878 | 2.57% | +10,580 |
| CYMABAY THERAPEUTICS INC | 1,129,376 | 1,090,441 | -38,935 | 16,839 | 25,756 | 5.14% | +8,917 |
| SPYRE THERAPEUTICS INC(SYRE) | 242,297 | 517,554 | +275,257 | 2,968 | 11,138 | 2.22% | +8,170 |
| ALKERMES PLC(ALKS) | 100,000 | 356,384 | +256,384 | 2,801 | 9,886 | 1.97% | +7,085 |
| CYTOKINETICS INC(CYTK) | 230,366 | 160,000 | -70,366 | 6,787 | 13,358 | 2.66% | +6,572 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 1,992,466 | 1,550,408 | -442,058 | 4,642 | 9,985 | 1.99% | +5,342 |
| VERONA PHARMA PLC | 368,329 | 563,824 | +195,495 | 6,004 | 11,209 | 2.23% | +5,205 |
| NURIX THERAPEUTICS INC(NRIX) | 250,000 | 690,112 | +440,112 | 1,965 | 7,122 | 1.42% | +5,157 |
| COMPASS PATHWAYS PLC(CMPS) | 0 | 550,000 | +550,000 | 0 | 4,813 | 0.96% | +4,813 |
| ARCELLX INC COMMON STOCK | 400,000 | 340,000 | -60,000 | 14,352 | 18,870 | 3.76% | +4,518 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 0 | 0 | 16,408 | 20,579 | 4.10% | +4,171 |
| AXSOME THERAPEUTICS INC(AXSM) | 0 | 50,000 | +50,000 | 0 | 3,980 | 0.79% | +3,980 |
| ROIVANT SCIENCES LTD(ROIV) | 150,000 | 500,000 | +350,000 | 1,752 | 5,615 | 1.12% | +3,863 |
| ASTRIA THERAPEUTICS INC | 1,000,300 | 1,466,465 | +466,165 | 7,462 | 11,262 | 2.25% | +3,800 |
| OMEROS CORP | 0 | 0 | 0 | 0 | 3,600 | 0.72% | +3,600 |
| COHERUS BIOSCIENCES INC(CHRS) | 0 | 0 | 0 | 0 | 3,403 | 0.68% | +3,403 |
| RELAY THERAPEUTICS INC(RLAY) | 0 | 300,000 | +300,000 | 0 | 3,303 | 0.66% | +3,303 |
| MIRATI THERAPEUTICS INC | 60,426 | 100,049 | +39,623 | 2,632 | 5,878 | 1.17% | +3,246 |
| CULLINAN ONCOLOGY INC(CGEM) | 0 | 300,000 | +300,000 | 0 | 3,057 | 0.61% | +3,057 |
| IMMUNOVANT INC(IMVT) | 300,000 | 345,000 | +45,000 | 11,517 | 14,535 | 2.90% | +3,018 |
| APELLIS PHARMACEUTICALS INC COM | 40,000 | 75,000 | +35,000 | 1,522 | 4,490 | 0.90% | +2,968 |
| ARGENX SE(ARGX) | 0 | 7,500 | +7,500 | 0 | 2,853 | 0.57% | +2,853 |
| SPRINGWORKS THERAPEUTICS INC | 41,581 | 100,000 | +58,419 | 961 | 3,650 | 0.73% | +2,689 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 109,900 | +109,900 | 0 | 2,540 | 0.51% | +2,540 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 450,000 | 447,095 | -2,905 | 13,383 | 15,908 | 3.17% | +2,525 |
| BRIDGEBIO PHARMA INC(BBIO) | 30,000 | 80,000 | +50,000 | 791 | 3,230 | 0.64% | +2,439 |
| VIKING THERAPEUTICS INC(VKTX) | 300,000 | 300,000 | 0 | 3,321 | 5,583 | 1.11% | +2,262 |
| INOZYME PHARMA INC | 1,379,852 | 1,885,802 | +505,950 | 5,795 | 8,034 | 1.60% | +2,238 |
| PENUMBRA INC(PEN) | 0 | 7,500 | +7,500 | 0 | 1,887 | 0.38% | +1,887 |
| TOURMALINE BIO INC | 0 | 68,081 | +68,081 | 0 | 1,782 | 0.36% | +1,782 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 50,000 | 70,988 | +20,988 | 2,850 | 4,287 | 0.85% | +1,437 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 10,000 | +10,000 | 0 | 1,318 | 0.26% | +1,318 |
| INARI MED INC | 0 | 20,000 | +20,000 | 0 | 1,298 | 0.26% | +1,298 |
| ALLOGENE THERAPEUTICS INC | 0 | 400,000 | +400,000 | 0 | 1,284 | 0.26% | +1,284 |
| DYNAVAX TECHNOLOGIES CORP | 200,000 | 300,000 | +100,000 | 2,954 | 4,194 | 0.84% | +1,240 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 50,000 | +50,000 | 0 | 1,089 | 0.22% | +1,089 |
| SAVARA INC(SVRA) | 1,150,000 | 1,150,000 | 0 | 4,347 | 5,405 | 1.08% | +1,058 |
| FULCRUM THERAPEUTICS INC(FULC) | 0 | 125,000 | +125,000 | 0 | 844 | 0.17% | +844 |
| ADC THERAPEUTICS SA(ADCT) | 1,100,000 | 1,013,540 | -86,460 | 987 | 1,682 | 0.34% | +696 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 30,000 | 50,000 | +20,000 | 948 | 1,476 | 0.29% | +528 |
| PUMA BIOTECHNOLOGY INC(PBYI) | 202,349 | 202,349 | 0 | 532 | 876 | 0.17% | +344 |
| VAXCYTE INC(PCVX) | 25,000 | 25,000 | 0 | 1,275 | 1,570 | 0.31% | +296 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 125,000 | 125,000 | 0 | 1,156 | 1,396 | 0.28% | +240 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 137,000 | 137,000 | 0 | 260 | 429 | 0.09% | +169 |
| BIOHAVEN LTD(BHVN) | 30,156 | 20,866 | -9,290 | 784 | 893 | 0.18% | +109 |
| NUVATION BIO INC(NUVB) | 250,000 | 250,000 | 0 | 335 | 378 | 0.08% | +43 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 8 | 37 | 0.01% | +29 |
| ARAVIVE INC | 346,511 | 346,511 | 0 | 46 | 43 | 0.01% | -3 |
| ASTRAZENECA PLC(AZN) | 60,000 | 60,000 | 0 | 4,063 | 4,041 | 0.81% | -22 |
| AVROBIO INC | 500,000 | 500,000 | 0 | 770 | 680 | 0.14% | -90 |
| IMMATICS N.V | 187,204 | 187,204 | 0 | 663 | 547 | 0.11% | -116 |
| CONTEXT THERAPEUTICS INC(CNTX) | 328,817 | 328,817 | 0 | 497 | 372 | 0.07% | -125 |
| NLS PHARMACEUTICS LTD | 200,455 | 0 | -200,455 | 140 | 0 | — | -140 |
| IMMATICS N.V(IMTX) | 200,000 | 200,000 | 0 | 2,316 | 2,106 | 0.42% | -210 |
| PROMIS NEUROSCIENCES INC | 265,958 | 265,958 | 0 | 527 | 306 | 0.06% | -221 |
| CENTESSA PHARMACEUTICALS PLC | 1,018,091 | 795,729 | -222,362 | 6,587 | 6,334 | 1.26% | -253 |
| ALDEYRA THERAPEUTICS INC(ALDX) | 44,348 | 0 | -44,348 | 296 | 0 | — | -296 |
| BIOATLA INC(BCAB) | 180,000 | 0 | -180,000 | 306 | 0 | — | -306 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 2,000,000 | 1,900,000 | -100,000 | 20,400 | 19,836 | 3.95% | -564 |
| INFLARX NV(IFRX) | 325,097 | 200,097 | -125,000 | 969 | 326 | 0.07% | -643 |
| INSULET CORP(PODD) | 5,000 | 0 | -5,000 | 797 | 0 | — | -797 |
| TRAVERE THERAPEUTICS INC(TVTX) | 100,000 | 0 | -100,000 | 894 | 0 | — | -894 |
| TANGO THERAPEUTICS INC(TNGX) | 350,000 | 300,274 | -49,726 | 3,941 | 2,973 | 0.59% | -968 |
| MILESTONE PHARMACEUTICALS IN(MIST) | 335,068 | 0 | -335,068 | 1,039 | 0 | — | -1,039 |
| THESEUS PHARMACEUTICALS INC | 400,726 | 0 | -400,726 | 1,078 | 0 | — | -1,078 |
| TALARIS THERAPEUTICS INC | 400,000 | 0 | -400,000 | 1,124 | 0 | — | -1,124 |
| KALVISTA PHARMACEUTICALS INC | 278,292 | 125,969 | -152,323 | 2,680 | 1,543 | 0.31% | -1,137 |
| TERNS PHARMACEUTICALS INC | 325,000 | 66,000 | -259,000 | 1,635 | 428 | 0.09% | -1,206 |
| INSPIRE MED SYS INC(INSP) | 6,293 | 0 | -6,293 | 1,249 | 0 | — | -1,249 |
| MERSANA THERAPEUTICS INC | 2,850,000 | 1,000,000 | -1,850,000 | 3,620 | 2,320 | 0.46% | -1,299 |
| ASCENDIS PHARMA A/S(ASND) | 46,400 | 20,000 | -26,400 | 4,345 | 2,519 | 0.50% | -1,826 |
| LANTHEUS HLDGS INC(LNTH) | 30,000 | 0 | -30,000 | 2,084 | 0 | — | -2,084 |
| SEAGEN INC | 10,000 | 0 | -10,000 | 2,122 | 0 | — | -2,121 |
| KRYSTAL BIOTECH INC(KRYS) | 57,500 | 25,000 | -32,500 | 6,670 | 3,102 | 0.62% | -3,568 |
| PROTHENA CORP PLC SHS | 79,214 | 0 | -79,214 | 3,822 | 0 | — | -3,822 |
| MORPHIC HLDG INC | 270,000 | 42,670 | -227,330 | 6,186 | 1,232 | 0.25% | -4,953 |
| KURA ONCOLOGY INC(KURA) | 856,535 | 191,535 | -665,000 | 7,812 | 2,754 | 0.55% | -5,057 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 239,108 | 228,277 | -10,831 | 11,733 | 5,910 | 1.18% | -5,823 |
| APOGEE THERAPEUTICS INC(APGE) | 1,045,110 | 537,093 | -508,017 | 22,261 | 15,006 | 2.99% | -7,254 |