Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2023 ▲▼ | Q4 2023 ▲▼ | Change ▲▼ | Q3 2023 ▲▼ | Q4 2023 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| IMMUNOGEN INC | 0 | 1,404,608 | +1,404,608 | 0 | 41,647 | 7.61% | +41,647 |
| CEREVEL THERAPEUTICS HLDNG I | 685,061 | 750,000 | +64,939 | 14,955 | 31,800 | 5.81% | +16,845 |
| LIANBIO | 672,357 | 3,779,694 | +3,107,337 | 1,002 | 16,895 | 3.09% | +15,893 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 150,000 | 400,000 | +250,000 | 4,128 | 15,864 | 2.90% | +11,736 |
| XENON PHARMACEUTICALS INC(XENE) | 300,438 | 460,000 | +159,562 | 10,263 | 21,188 | 3.87% | +10,925 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 0 | 100,000 | +100,000 | 0 | 23,138 | 4.23% | +23,138 |
| NUVALENT INC | 50,000 | 175,000 | +125,000 | 2,299 | 12,878 | 2.35% | +10,580 |
| CYMABAY THERAPEUTICS INC | 1,129,376 | 1,090,441 | -38,935 | 16,839 | 25,756 | 4.70% | +8,917 |
| SPYRE THERAPEUTICS INC(SYRE) | 242,297 | 517,554 | +275,257 | 2,968 | 11,138 | 2.03% | +8,170 |
| ALKERMES PLC(ALKS) | 100,000 | 356,384 | +256,384 | 2,801 | 9,886 | 1.81% | +7,085 |
| CYTOKINETICS INC(CYTK) | 230,366 | 160,000 | -70,366 | 6,787 | 13,358 | 2.44% | +6,572 |
| EYEPOINT PHARMACEUTICALS INC(EYPT)(Put) | 155,000 | 320,100 | +165,100 | 1,238 | 7,398 | — | +6,159 |
| ALNYLAM PHARMACEUTICALS INC(ALNY)(Call) | 0 | 30,000 | +30,000 | 0 | 5,742 | — | +5,742 |
| AUTOLUS THERAPEUTICS PLC | 1,992,466 | 1,550,408 | -442,058 | 4,642 | 9,985 | 1.82% | +5,342 |
| VERONA PHARMA PLC | 368,329 | 563,824 | +195,495 | 6,004 | 11,209 | 2.05% | +5,205 |
| NURIX THERAPEUTICS INC(NRIX) | 250,000 | 690,112 | +440,112 | 1,965 | 7,122 | 1.30% | +5,157 |
| COMPASS PATHWAYS PLC(CMPS) | 0 | 550,000 | +550,000 | 0 | 4,813 | 0.88% | +4,813 |
| ARCELLX INC COMMON STOCK | 400,000 | 340,000 | -60,000 | 14,352 | 18,870 | 3.45% | +4,518 |
| BRIDGEBIO PHARMA INC(BBIO) | 0 | 0 | 0 | 16,408 | 20,579 | 3.76% | +4,171 |
| STRUCTURE THERAPEUTICS INC(Call) | 0 | 100,000 | +100,000 | 0 | 4,076 | — | +4,076 |
| AXSOME THERAPEUTICS INC(AXSM) | 0 | 50,000 | +50,000 | 0 | 3,980 | 0.73% | +3,980 |
| ROIVANT SCIENCES LTD(ROIV) | 150,000 | 500,000 | +350,000 | 1,752 | 5,615 | 1.03% | +3,863 |
| ASTRIA THERAPEUTICS INC | 1,000,300 | 1,466,465 | +466,165 | 7,462 | 11,262 | 2.06% | +3,800 |
| OMEROS CORP | 0 | 0 | 0 | 0 | 3,600 | 0.66% | +3,600 |
| COHERUS BIOSCIENCES INC | 0 | 0 | 0 | 0 | 3,403 | 0.62% | +3,403 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA)(Call) | 1,100,000 | 1,400,000 | +300,000 | 11,220 | 14,616 | — | +3,396 |
| CRINETICS PHARMACEUTICALS IN(CRNX)(Put) | 0 | 94,300 | +94,300 | 0 | 3,355 | — | +3,355 |
| RELAY THERAPEUTICS INC(RLAY) | 0 | 300,000 | +300,000 | 0 | 3,303 | 0.60% | +3,303 |
| MIRATI THERAPEUTICS INC | 60,426 | 100,049 | +39,623 | 2,632 | 5,878 | 1.07% | +3,246 |
| CULLINAN ONCOLOGY INC(CGEM) | 0 | 300,000 | +300,000 | 0 | 3,057 | 0.56% | +3,057 |
| IMMUNOVANT INC(IMVT) | 300,000 | 345,000 | +45,000 | 11,517 | 14,535 | 2.65% | +3,018 |
| APELLIS PHARMACEUTICALS INC COM | 40,000 | 75,000 | +35,000 | 1,522 | 4,490 | 0.82% | +2,968 |
| ARGENX SE(ARGX) | 0 | 7,500 | +7,500 | 0 | 2,853 | 0.52% | +2,853 |
| CASSAVA SCIENCES INC(Call) | 0 | 121,000 | +121,000 | 0 | 2,724 | — | +2,724 |
| SPRINGWORKS THERAPEUTICS INC | 41,581 | 100,000 | +58,419 | 961 | 3,650 | 0.67% | +2,689 |
| EYEPOINT PHARMACEUTICALS INC(EYPT) | 0 | 109,900 | +109,900 | 0 | 2,540 | 0.46% | +2,540 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 450,000 | 447,095 | -2,905 | 13,383 | 15,908 | 2.91% | +2,525 |
| BRIDGEBIO PHARMA INC(BBIO) | 30,000 | 80,000 | +50,000 | 791 | 3,230 | 0.59% | +2,439 |
| VIKING THERAPEUTICS INC(VKTX) | 300,000 | 300,000 | 0 | 3,321 | 5,583 | 1.02% | +2,262 |
| INOZYME PHARMA INC | 1,379,852 | 1,885,802 | +505,950 | 5,795 | 8,034 | 1.47% | +2,238 |
| PENUMBRA INC(PEN) | 0 | 7,500 | +7,500 | 0 | 1,887 | 0.34% | +1,887 |
| TOURMALINE BIO INC | 0 | 68,081 | +68,081 | 0 | 1,782 | 0.33% | +1,782 |
| APELLIS PHARMACEUTICALS INC(Call) COM | 0 | 25,000 | +25,000 | 0 | 1,497 | — | +1,497 |
| MOONLAKE IMMUNOTHERAPEUTICS(MLTX) | 50,000 | 70,988 | +20,988 | 2,850 | 4,287 | 0.78% | +1,437 |
| NEUROCRINE BIOSCIENCES INC(NBIX) | 0 | 10,000 | +10,000 | 0 | 1,318 | 0.24% | +1,318 |
| INARI MED INC | 0 | 20,000 | +20,000 | 0 | 1,298 | 0.24% | +1,298 |
| ALLOGENE THERAPEUTICS INC | 0 | 400,000 | +400,000 | 0 | 1,284 | 0.23% | +1,284 |
| DYNAVAX TECHNOLOGIES CORP | 200,000 | 300,000 | +100,000 | 2,954 | 4,194 | 0.77% | +1,240 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 0 | 50,000 | +50,000 | 0 | 1,089 | 0.20% | +1,089 |
| SAVARA INC(SVRA) | 1,150,000 | 1,150,000 | 0 | 4,347 | 5,405 | 0.99% | +1,058 |
| FULCRUM THERAPEUTICS INC | 0 | 125,000 | +125,000 | 0 | 844 | 0.15% | +844 |
| ALKERMES PLC(ALKS)(Put) | 0 | 27,000 | +27,000 | 0 | 749 | — | +749 |
| ADC THERAPEUTICS SA | 1,100,000 | 1,013,540 | -86,460 | 987 | 1,682 | 0.31% | +696 |
| IMMATICS N.V | 0 | 187,204 | +187,204 | 0 | 547 | 0.10% | +547 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 30,000 | 50,000 | +20,000 | 948 | 1,476 | 0.27% | +528 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 0 | 137,000 | +137,000 | 0 | 429 | 0.08% | +429 |
| PUMA BIOTECHNOLOGY INC | 202,349 | 202,349 | 0 | 532 | 876 | 0.16% | +344 |
| VAXCYTE INC(PCVX) | 25,000 | 25,000 | 0 | 1,275 | 1,570 | 0.29% | +296 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 125,000 | 125,000 | 0 | 1,156 | 1,396 | 0.26% | +240 |
| BIOHAVEN LTD(BHVN) | 30,156 | 20,866 | -9,290 | 784 | 893 | 0.16% | +109 |
| NUVATION BIO INC(NUVB) | 250,000 | 250,000 | 0 | 335 | 378 | 0.07% | +43 |
| ROCKET PHARMACEUTICALS INC | 0 | 75,000 | +75,000 | 0 | 37 | 0.01% | +37 |
| ARAVIVE INC | 346,511 | 346,511 | 0 | 46 | 43 | 0.01% | -3 |
| ROCKET PHARMACEUTICALS INC | 75,000 | 0 | -75,000 | 8 | 0 | — | -7 |
| ASTRAZENECA PLC(AZN) | 60,000 | 60,000 | 0 | 4,063 | 4,041 | 0.74% | -22 |
| AVROBIO INC | 500,000 | 500,000 | 0 | 770 | 680 | 0.12% | -90 |
| CONTEXT THERAPEUTICS INC | 328,817 | 328,817 | 0 | 497 | 372 | 0.07% | -125 |
| NLS PHARMACEUTICS LTD | 200,455 | 0 | -200,455 | 140 | 0 | — | -140 |
| IMMATICS N.V(IMTX) | 200,000 | 200,000 | 0 | 2,316 | 2,106 | 0.38% | -210 |
| PROMIS NEUROSCIENCES INC | 265,958 | 265,958 | 0 | 527 | 306 | 0.06% | -221 |
| CENTESSA PHARMACEUTICALS PLC | 1,018,091 | 795,729 | -222,362 | 6,587 | 6,334 | 1.16% | -253 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 137,000 | 0 | -137,000 | 260 | 0 | — | -260 |
| ALDEYRA THERAPEUTICS INC | 44,348 | 0 | -44,348 | 296 | 0 | — | -296 |
| BIOATLA INC | 180,000 | 0 | -180,000 | 306 | 0 | — | -306 |
| MESOBLAST LTD(Put) | 400,000 | 0 | -400,000 | 492 | 0 | — | -492 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 2,000,000 | 1,900,000 | -100,000 | 20,400 | 19,836 | 3.62% | -564 |
| 89BIO INC(Call) | 37,300 | 0 | -37,300 | 576 | 0 | — | -576 |
| INFLARX NV | 325,097 | 200,097 | -125,000 | 969 | 326 | 0.06% | -643 |
| IMMATICS N.V | 187,204 | 0 | -187,204 | 663 | 0 | — | -663 |
| INSULET CORP(PODD) | 5,000 | 0 | -5,000 | 797 | 0 | — | -797 |
| TRAVERE THERAPEUTICS INC(TVTX) | 100,000 | 0 | -100,000 | 894 | 0 | — | -894 |
| TANGO THERAPEUTICS INC(TNGX) | 350,000 | 300,274 | -49,726 | 3,941 | 2,973 | 0.54% | -968 |
| MILESTONE PHARMACEUTICALS IN | 335,068 | 0 | -335,068 | 1,039 | 0 | — | -1,039 |
| ESTABLISHMENT LABS HLDGS INC(ESTA)(Call) | 140,000 | 225,000 | +85,000 | 6,870 | 5,825 | — | -1,045 |
| THESEUS PHARMACEUTICALS INC | 400,726 | 0 | -400,726 | 1,078 | 0 | — | -1,078 |
| TALARIS THERAPEUTICS INC | 400,000 | 0 | -400,000 | 1,124 | 0 | — | -1,124 |
| KALVISTA PHARMACEUTICALS INC | 278,292 | 125,969 | -152,323 | 2,680 | 1,543 | 0.28% | -1,137 |
| MORPHIC HLDG INC(Put) | 50,000 | 0 | -50,000 | 1,146 | 0 | — | -1,145 |
| TERNS PHARMACEUTICALS INC | 325,000 | 66,000 | -259,000 | 1,635 | 428 | 0.08% | -1,206 |
| INSPIRE MED SYS INC(INSP) | 6,293 | 0 | -6,293 | 1,249 | 0 | — | -1,249 |
| MERSANA THERAPEUTICS INC | 2,850,000 | 1,000,000 | -1,850,000 | 3,620 | 2,320 | 0.42% | -1,299 |
| ACLARIS THERAPEUTICS INC(ACRS)(Put) | 260,000 | 0 | -260,000 | 1,781 | 0 | — | -1,781 |
| ASCENDIS PHARMA A/S(ASND) | 46,400 | 20,000 | -26,400 | 4,345 | 2,519 | 0.46% | -1,826 |
| LANTHEUS HLDGS INC(LNTH) | 30,000 | 0 | -30,000 | 2,084 | 0 | — | -2,084 |
| SEAGEN INC | 10,000 | 0 | -10,000 | 2,122 | 0 | — | -2,121 |
| KRYSTAL BIOTECH INC(KRYS) | 57,500 | 25,000 | -32,500 | 6,670 | 3,102 | 0.57% | -3,568 |
| VIKING THERAPEUTICS INC(VKTX)(Put) | 332,600 | 0 | -332,600 | 3,682 | 0 | — | -3,682 |
| PROTHENA CORP PLC SHS | 79,214 | 0 | -79,214 | 3,822 | 0 | — | -3,822 |
| IMMUNOVANT INC(IMVT)(Put) | 128,100 | 0 | -128,100 | 4,918 | 0 | — | -4,918 |
| APELLIS PHARMACEUTICALS INC(Put) COM | 130,000 | 0 | -130,000 | 4,945 | 0 | — | -4,945 |