Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q3 2024 ▲▼ | Q4 2024 ▲▼ | Change ▲▼ | Q3 2024 ▲▼ | Q4 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| VERONA PHARMA PLC | 650,000 | 660,000 | +10,000 | 18,701 | 30,650 | 4.79% | +11,950 |
| MERUS N V | 161,741 | 389,241 | +227,500 | 8,081 | 16,368 | 2.56% | +8,287 |
| PROQR THRAPEUTICS N V SHS EURO | 0 | 2,825,000 | +2,825,000 | 0 | 7,486 | 1.17% | +7,486 |
| WAVE LIFE SCIENCES LTD(WVE) | 1,400,000 | 1,500,000 | +100,000 | 11,480 | 18,555 | 2.90% | +7,075 |
| ARVINAS INC(ARVN) | 225,000 | 630,000 | +405,000 | 5,542 | 12,077 | 1.89% | +6,535 |
| TEVA PHARMACEUTICAL INDS LTD(TEVA) | 1,400,000 | 1,400,000 | 0 | 25,228 | 30,856 | 4.82% | +5,628 |
| PROTAGONIST THERAPEUTICS INC | 0 | 130,000 | +130,000 | 0 | 5,018 | 0.78% | +5,018 |
| SOLENO THERAPEUTICS INC | 25,000 | 130,000 | +105,000 | 1,262 | 5,844 | 0.91% | +4,581 |
| SPYRE THERAPEUTICS INC(SYRE) | 498,420 | 824,328 | +325,908 | 14,659 | 19,190 | 3.00% | +4,532 |
| MADRIGAL PHARMACEUTICALS INC(MDGL) | 100,000 | 82,500 | -17,500 | 21,222 | 25,457 | 3.98% | +4,235 |
| AVALO THERAPEUTICS INC(AVTX) | 45,000 | 550,765 | +505,765 | 426 | 4,092 | 0.64% | +3,666 |
| ALKERMES PLC(ALKS) | 1,000,000 | 1,100,000 | +100,000 | 27,990 | 31,636 | 4.94% | +3,646 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 200,000 | +200,000 | 0 | 3,484 | 0.54% | +3,484 |
| APOGEE THERAPEUTICS INC(APGE) | 664,198 | 931,728 | +267,530 | 39,015 | 42,207 | 6.59% | +3,192 |
| COHERUS BIOSCIENCES INC(CHRS) | 0 | 0 | 0 | 13,051 | 16,189 | 2.53% | +3,139 |
| NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES | 472,390 | 425,000 | -47,390 | 7,842 | 10,923 | 1.71% | +3,081 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 400,000 | 460,000 | +60,000 | 20,440 | 23,520 | 3.67% | +3,080 |
| CENTESSA PHARMACEUTICALS PLC | 965,612 | 1,095,924 | +130,312 | 15,440 | 18,357 | 2.87% | +2,917 |
| CG ONCOLOGY INC(CGON) | 0 | 100,000 | +100,000 | 0 | 2,868 | 0.45% | +2,868 |
| OAKTREE ACQUISITION CORP III UNIT 10/04/2029 | 0 | 250,000 | +250,000 | 0 | 2,538 | 0.40% | +2,538 |
| KARYOPHARM THERAPEUTICS INC | 0 | 0 | 0 | 9,616 | 11,868 | 1.85% | +2,251 |
| NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 | 212,974 | 237,935 | +24,961 | 1,491 | 3,331 | 0.52% | +1,840 |
| ANTERIS TECHNOLOGIES GLOBAL(AVR) | 0 | 300,000 | +300,000 | 0 | 1,674 | 0.26% | +1,674 |
| KYMERA THERAPEUTICS INC(KYMR) | 0 | 40,000 | +40,000 | 0 | 1,609 | 0.25% | +1,609 |
| APELLIS PHARMACEUTICALS INC COM | 0 | 50,000 | +50,000 | 0 | 1,596 | 0.25% | +1,596 |
| RAPT THERAPEUTICS INC | 0 | 1,000,000 | +1,000,000 | 0 | 1,580 | 0.25% | +1,580 |
| TRAVERE THERAPEUTICS INC(TVTX) | 0 | 0 | 0 | 4,320 | 5,744 | 0.90% | +1,424 |
| COMPASS PATHWAYS PLC(CMPS) | 300,512 | 850,512 | +550,000 | 1,893 | 3,215 | 0.50% | +1,322 |
| ONKURE THERAPEUTICS INC(OKUR) | 0 | 144,159 | +144,159 | 0 | 1,240 | 0.19% | +1,240 |
| BLACK DIAMOND THERAPEUTICS I | 0 | 559,163 | +559,163 | 0 | 1,197 | 0.19% | +1,197 |
| GERON CORP(GERN) | 1,500,000 | 2,250,000 | +750,000 | 6,810 | 7,965 | 1.24% | +1,155 |
| KEZAR LIFE SCIENCES INC COM NEW | 0 | 142,316 | +142,316 | 0 | 956 | 0.15% | +956 |
| TECTONIC THERAPEUTIC INC(TECX) | 58,331 | 58,331 | 0 | 1,767 | 2,693 | 0.42% | +926 |
| AEROVATE THERAPEUTICS INC | 600,000 | 800,000 | +200,000 | 1,254 | 2,120 | 0.33% | +866 |
| RADIOPHARM THERANOSTICS LTD(RADX) | 0 | 156,171 | +156,171 | 0 | 684 | 0.11% | +684 |
| XENON PHARMACEUTICALS INC(XENE) | 1,144,021 | 1,161,237 | +17,216 | 45,040 | 45,520 | 7.11% | +480 |
| ESTABLISHMENT LABS HLDGS INC(ESTA) | 290,447 | 279,445 | -11,002 | 12,568 | 12,874 | 2.01% | +306 |
| OMEROS CORP(OMER) | 0 | 9,958 | +9,958 | 0 | 98 | 0.02% | +98 |
| MINERALYS THERAPEUTICS INC(MLYS) | 350,000 | 350,000 | 0 | 4,239 | 4,309 | 0.67% | +70 |
| PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS | 350,000 | 350,000 | 0 | 3,511 | 3,563 | 0.56% | +53 |
| SYROS PHARMACEUTICALS INC | 0 | 150,000 | +150,000 | 0 | 34 | 0.01% | +34 |
| HELIX ACQUISITION CORP II | 250,000 | 250,000 | 0 | 2,613 | 2,625 | 0.41% | +13 |
| MIRUM PHARMACEUTICALS INC(MIRM) | 75,000 | 70,742 | -4,258 | 2,925 | 2,925 | 0.46% | 0 |
| ROCKET PHARMACEUTICALS INC(RCKT) | 75,000 | 75,000 | 0 | 5 | 3 | 0.00% | -3 |
| OMEROS CORP | 0 | 0 | 0 | 14,637 | 14,615 | 2.28% | -22 |
| PROMIS NEUROSCIENCES INC | 30,643 | 0 | -30,643 | 38 | 0 | — | -38 |
| AADI BIOSCIENCE INC(WHWK) | 47,019 | 0 | -47,019 | 97 | 0 | — | -97 |
| INSMED INC(INSM) | 50,000 | 50,000 | 0 | 3,650 | 3,452 | 0.54% | -198 |
| GENELUX CORPORATION(GNLX) | 100,000 | 0 | -100,000 | 237 | 0 | — | -237 |
| NEUROBO PHARMACEUTICALS IN | 89,222 | 0 | -89,222 | 283 | 0 | — | -283 |
| VOYAGER THERAPEUTICS INC(VYGR) | 51,727 | 0 | -51,727 | 303 | 0 | — | -303 |
| ADAGIO MED HLDGS INC(ADGM) | 213,235 | 213,235 | 0 | 550 | 224 | 0.03% | -326 |
| ZURA BIO LTD(ZURA) | 223,335 | 223,335 | 0 | 907 | 558 | 0.09% | -348 |
| IMMATICS N.V | 187,204 | 187,204 | 0 | 431 | 47 | 0.01% | -383 |
| REPARE THERAPEUTICS INC | 173,351 | 100,000 | -73,351 | 596 | 131 | 0.02% | -465 |
| REZOLUTE INC(RZLT) | 1,700,000 | 1,575,000 | -125,000 | 8,245 | 7,718 | 1.21% | -527 |
| ERASCA INC(ERAS) | 2,499,431 | 2,499,431 | 0 | 6,823 | 6,274 | 0.98% | -550 |
| KYVERNA THERAPEUTICS INC(KYTX) | 119,900 | 0 | -119,900 | 586 | 0 | — | -586 |
| PUMA BIOTECHNOLOGY INC(PBYI) | 250,000 | 0 | -250,000 | 638 | 0 | — | -637 |
| ARROWHEAD PHARMACEUTICALS IN(ARWR) | 325,000 | 300,000 | -25,000 | 6,295 | 5,640 | 0.88% | -655 |
| ARCELLX INC COMMON STOCK | 400,000 | 425,000 | +25,000 | 33,404 | 32,593 | 5.09% | -811 |
| AXSOME THERAPEUTICS INC(AXSM) | 80,000 | 75,000 | -5,000 | 7,190 | 6,346 | 0.99% | -844 |
| NKARTA INC(NKTX) | 650,000 | 800,000 | +150,000 | 2,938 | 1,992 | 0.31% | -946 |
| BIOMARIN PHARMACEUTICAL INC(BMRN) | 15,000 | 0 | -15,000 | 1,054 | 0 | — | -1,054 |
| Q32 BIO INC(FIXX) | 27,777 | 27,777 | 0 | 1,239 | 96 | 0.01% | -1,144 |
| VERASTEM INC(VSTM) | 400,000 | 0 | -400,000 | 1,196 | 0 | — | -1,196 |
| INARI MED INC | 60,000 | 25,000 | -35,000 | 2,474 | 1,276 | 0.20% | -1,198 |
| CULLINAN THERAPEUTICS INC(CGEM) | 263,817 | 263,817 | 0 | 4,416 | 3,213 | 0.50% | -1,203 |
| VERA THERAPEUTICS INC(VERA) | 435,000 | 425,000 | -10,000 | 19,227 | 17,973 | 2.81% | -1,254 |
| NEXTCURE INC | 2,302,598 | 2,302,598 | 0 | 3,155 | 1,775 | 0.28% | -1,379 |
| ORUKA THERAPEUTICS INC(ORKA) | 349,836 | 368,698 | +18,862 | 8,574 | 7,149 | 1.12% | -1,425 |
| CONTEXT THERAPEUTICS INC(CNTX) | 1,321,153 | 1,015,340 | -305,813 | 2,589 | 1,066 | 0.17% | -1,523 |
| NURIX THERAPEUTICS INC(NRIX) | 860,399 | 940,083 | +79,684 | 19,333 | 17,711 | 2.77% | -1,622 |
| SAVARA INC(SVRA) | 700,000 | 410,586 | -289,414 | 2,968 | 1,260 | 0.20% | -1,708 |
| KEZAR LIFE SCIENCES INC | 2,511,778 | 0 | -2,511,778 | 1,942 | 0 | — | -1,942 |
| BRIDGEBIO PHARMA INC(BBIO) | 300,000 | 200,000 | -100,000 | 7,638 | 5,488 | 0.86% | -2,150 |
| ROIVANT SCIENCES LTD(ROIV) | 201,587 | 0 | -201,587 | 2,326 | 0 | — | -2,326 |
| PERSPECTIVE THERAPEUTICS INC(CATX) | 500,000 | 1,300,000 | +800,000 | 6,675 | 4,147 | 0.65% | -2,528 |
| IMMATICS N.V(IMTX) | 250,000 | 0 | -250,000 | 2,853 | 0 | — | -2,852 |
| VAXCYTE INC(PCVX) | 50,000 | 25,000 | -25,000 | 5,714 | 2,047 | 0.32% | -3,667 |
| INOZYME PHARMA INC | 2,822,318 | 3,972,318 | +1,150,000 | 14,761 | 11,003 | 1.72% | -3,757 |
| IMMUNOVANT INC(IMVT) | 225,000 | 100,000 | -125,000 | 6,415 | 2,477 | 0.39% | -3,938 |
| CELLDEX THERAPEUTICS INC NEW(CLDX) | 125,000 | 9,992 | -115,008 | 4,249 | 252 | 0.04% | -3,996 |
| SPRINGWORKS THERAPEUTICS INC | 147,500 | 0 | -147,500 | 4,726 | 0 | — | -4,726 |
| TERNS PHARMACEUTICALS INC | 600,000 | 0 | -600,000 | 5,004 | 0 | — | -5,004 |
| AUTOLUS THERAPEUTICS PLC(AUTL) | 4,500,000 | 4,500,000 | 0 | 16,335 | 10,575 | 1.65% | -5,760 |
| CLIMB BIO INC(CLYM) | 1,500,000 | 500,000 | -1,000,000 | 7,635 | 900 | 0.14% | -6,735 |
| BEIGENE LTD(ONC) | 35,000 | 0 | -35,000 | 7,858 | 0 | — | -7,858 |
| ASTRIA THERAPEUTICS INC | 725,106 | 0 | -725,106 | 7,983 | 0 | — | -7,983 |
| VIRIDIAN THERAPEUTICS INC(VRDN) | 525,000 | 159,614 | -365,386 | 11,944 | 3,060 | 0.48% | -8,884 |
| NUVALENT INC | 337,500 | 285,000 | -52,500 | 34,526 | 22,310 | 3.49% | -12,216 |
| KURA ONCOLOGY INC(KURA) | 687,785 | 0 | -687,785 | 13,439 | 0 | — | -13,439 |