Securities ▲▼ | Shares | Value | |||||
|---|---|---|---|---|---|---|---|
Q3 2025 ▲▼ | Q4 2025 ▲▼ | Change ▲▼ | Q3 2025 ▲▼ | Q4 2025 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| Apogee Therapeutics Inc | 1,173,426 | 1,234,926 | +61,500 | $46.62M | $93.21M | 6.70% | +$46.59M |
| Insmed Incorporated(INSM) | 450,000 | 450,000 | 0 | $64.80M | $78.32M | 5.63% | +$13.51M |
| ABIVAX Société AnonymeADS(ABVX) | 360,000 | 505,000 | +145,000 | $30.56M | $68.10M | 4.89% | +$37.54M |
| Ventyx Biosciences Inc | 3,924,415 | 6,484,558 | +2,560,143 | $12.20M | $58.56M | 4.21% | +$46.35M |
| Xenon Pharmaceuticals Inc.(XENE) | 1,400,000 | 1,250,000 | -150,000 | $56.21M | $56.02M | 4.03% | -$185.0K |
| Praxis Precision Medicines, Inc.(PRAX) | 0 | 185,000 | +185,000 | $0 | $54.53M | 3.92% | +$54.53M |
| Cytokinetics, Incorporated(CYTK) | 350,000 | 800,000 | +450,000 | $19.24M | $50.83M | 3.65% | +$31.60M |
| Spyre Therapeutics, Inc.(SYRE) | 1,419,299 | 1,432,591 | +13,292 | $23.79M | $46.93M | 3.37% | +$23.14M |
| Wave Life Sciences, Inc.SHS(WVE) | 2,100,000 | 2,700,000 | +600,000 | $15.37M | $45.90M | 3.30% | +$30.53M |
| Teva Pharmaceutical Industries LimitedADS(TEVA) | 1,400,000 | 1,400,000 | 0 | $28.28M | $43.69M | 3.14% | +$15.41M |
| Roivant Sciences Ltd.SHS(ROIV) | 800,000 | 1,700,000 | +900,000 | $12.10M | $36.89M | 2.65% | +$24.79M |
| Arcellx Inc COMMON STOCK | 500,000 | 523,725 | +23,725 | $41.05M | $34.15M | 2.45% | -$6.90M |
| Nuvalent Inc | 384,417 | 322,633 | -61,784 | $33.24M | $32.45M | 2.33% | -$790.7K |
| Lexeo Therapeutics, Inc.(LXEO) | 3,870,527 | 3,200,000 | -670,527 | $25.70M | $31.78M | 2.28% | +$6.08M |
| Alkermes plcSHS(ALKS) | 1,250,000 | 1,000,000 | -250,000 | $37.50M | $27.98M | 2.01% | -$9.52M |
| Forte Biosciences Inc | 0 | 989,490 | +989,490 | $0 | $26.98M | 1.94% | +$26.98M |
| Trevi Therapeutics, Inc.(TRVI) | 2,800,000 | 2,150,172 | -649,828 | $25.62M | $26.92M | 1.93% | +$1.30M |
| Mineralys Therapeutics, Inc.(MLYS) | 750,000 | 730,000 | -20,000 | $28.44M | $26.49M | 1.90% | -$1.95M |
| BridgeBio Pharma, Inc.(BBIO) | 65,000 | 320,000 | +255,000 | $3.38M | $24.48M | 1.76% | +$21.10M |
| Oruka Therapeutics, Inc.(ORKA) | 959,180 | 802,342 | -156,838 | $18.45M | $24.32M | 1.75% | +$5.87M |
| Terns Pharmaceuticals Inc | 0 | 550,000 | +550,000 | $0 | $22.22M | 1.60% | +$22.22M |
| Anaptysbio Inc | 0 | 444,692 | +444,692 | $0 | $21.56M | 1.55% | +$21.56M |
| Cullinan Therapeutics, Inc.(CGEM) | 263,817 | 1,932,106 | +1,668,289 | $1.56M | $20.00M | 1.44% | +$18.43M |
| Omeros CorporationNOTE 9 500 6 1(OMER) | 0 | 0 | 0 | $4.71M | $19.38M | 1.39% | +$14.67M |
| Avalo Therapeutics, Inc.(AVTX) | 1,006,217 | 1,051,054 | +44,837 | $12.79M | $19.09M | 1.37% | +$6.30M |
| Nurix Therapeutics, Inc.(NRIX) | 967,620 | 967,620 | 0 | $8.94M | $18.36M | 1.32% | +$9.41M |
| Taysha Gene Therapies, Inc.(TSHA) | 3,000,000 | 3,300,000 | +300,000 | $9.81M | $18.15M | 1.30% | +$8.34M |
| Madrigal Pharmaceuticals, Inc.(MDGL) | 115,000 | 31,131 | -83,869 | $52.75M | $18.13M | 1.30% | -$34.62M |
| Savara Inc.(SVRA) | 1,500,000 | 2,797,153 | +1,297,153 | $5.36M | $16.87M | 1.21% | +$11.51M |
| Protagonist Therapeutics Inc | 220,600 | 172,125 | -48,475 | $14.65M | $15.03M | 1.08% | +$378.9K |
| Centessa Pharmaceuticals PlcADS | 1,107,162 | 600,552 | -506,610 | $26.85M | $15.02M | 1.08% | -$11.83M |
| Establishment Labs Holdings Inc.(ESTA) | 310,000 | 200,000 | -110,000 | $12.71M | $14.58M | 1.05% | +$1.87M |
| Erasca, Inc.(ERAS) | 4,285,787 | 3,900,000 | -385,787 | $9.34M | $14.51M | 1.04% | +$5.16M |
| Vera Therapeutics, Inc.CL A(VERA) | 303,330 | 250,000 | -53,330 | $8.81M | $12.66M | 0.91% | +$3.85M |
| Cogent Biosciences, Inc.(COGT) | 0 | 350,000 | +350,000 | $0 | $12.43M | 0.89% | +$12.43M |
| Ovid Therapeutics Inc.(OVID) | 2,650,000 | 7,150,000 | +4,500,000 | $3.44M | $11.65M | 0.84% | +$8.21M |
| Travere Therapeutics, Inc.(TVTX) | 500,000 | 300,000 | -200,000 | $11.95M | $11.46M | 0.82% | -$487.0K |
| Jade Biosciences Inc | 65,317 | 714,956 | +649,639 | $563.7K | $11.03M | 0.79% | +$10.47M |
| Travere Therapeutics, Inc.NOTE 2 250 3 0(TVTX) | 0 | 0 | 0 | $7.93M | $9.99M | 0.72% | +$2.06M |
| Newamsterdam Pharma Company ORDINARY SHARES | 275,000 | 275,000 | 0 | $7.82M | $9.65M | 0.69% | +$1.83M |
| Celldex Therapeutics, Inc.(CLDX) | 300,000 | 350,000 | +50,000 | $7.76M | $9.51M | 0.68% | +$1.75M |
| Zura Bio LimitedCL A(ZURA) | 1,274,351 | 1,813,671 | +539,320 | $5.52M | $9.50M | 0.68% | +$3.99M |
| Tango Therapeutics, Inc.(TNGX) | 0 | 1,000,000 | +1,000,000 | $0 | $8.86M | 0.64% | +$8.86M |
| Sutro Biopharma, Inc.(STRO) | 0 | 748,382 | +748,382 | $0 | $8.66M | 0.62% | +$8.66M |
| Revolution Medicines, Inc.(RVMD) | 100,000 | 100,000 | 0 | $4.67M | $7.96M | 0.57% | +$3.29M |
| MBX Biosciences, Inc.(MBX) | 165,000 | 250,000 | +85,000 | $2.89M | $7.88M | 0.57% | +$5.00M |
| Viridian Therapeutics, Inc.(VRDN) | 250,000 | 250,000 | 0 | $5.39M | $7.78M | 0.56% | +$2.38M |
| Arcus Biosciences, Inc.(RCUS) | 0 | 300,000 | +300,000 | $0 | $7.15M | 0.51% | +$7.15M |
| Sagimet Biosciences Inc.COM SER A(SGMT) | 350,000 | 1,148,245 | +798,245 | $2.40M | $6.80M | 0.49% | +$4.40M |
| Karyopharm Therapeutics Inc.(KPTI) | 0 | 889,575 | +889,575 | $0 | $6.55M | 0.47% | +$6.55M |
| Celcuity Inc.NOTE 2 750 8 0(CELC) | 0 | 0 | 0 | $4.00M | $6.52M | 0.47% | +$2.52M |
| Ascendis Pharma A/SADR(ASND) | 0 | 30,000 | +30,000 | $0 | $6.40M | 0.46% | +$6.40M |
| Verrica Pharmaceuticals Inc.(VRCA) | 0 | 707,338 | +707,338 | $0 | $5.88M | 0.42% | +$5.88M |
| Engene Holdings Inc COM | 77,000 | 643,370 | +566,370 | $525.9K | $5.81M | 0.42% | +$5.28M |
| Newamsterdam Pharma CompanyW EXP 99 99 999 *W EXP 99/99/999 | 245,000 | 245,000 | 0 | $4.19M | $5.63M | 0.40% | +$1.44M |
| Rezolute, Inc.(RZLT) | 2,100,000 | 2,351,144 | +251,144 | $19.74M | $5.55M | 0.40% | -$14.19M |
| Avadel Pharmaceuticals Plc | 0 | 250,000 | +250,000 | $0 | $5.39M | 0.39% | +$5.39M |
| Climb Bio, Inc.(CLYM) | 1,300,000 | 1,300,000 | 0 | $2.61M | $5.20M | 0.37% | +$2.59M |
| Immunovant, Inc.(IMVT) | 300,000 | 200,000 | -100,000 | $4.84M | $5.08M | 0.37% | +$248.0K |
| Proqr Thrapeutics N VSHS EURO SHS EURO | 3,600,000 | 2,454,278 | -1,145,722 | $7.67M | $4.96M | 0.36% | -$2.71M |
| Dianthus Therapeutics, Inc.(DNTH) | 262,100 | 115,000 | -147,100 | $10.31M | $4.74M | 0.34% | -$5.57M |
| Arrowhead Pharmaceuticals, Inc.(ARWR) | 0 | 70,000 | +70,000 | $0 | $4.65M | 0.33% | +$4.65M |
| iBio, Inc.(IBIO) | 0 | 2,057,200 | +2,057,200 | $0 | $3.97M | 0.29% | +$3.97M |
| Nextcure Inc | 191,882 | 247,294 | +55,412 | $1.12M | $3.51M | 0.25% | +$2.38M |
| Crinetics Pharmaceuticals In | 75,000 | 75,000 | 0 | $3.12M | $3.49M | 0.25% | +$367.5K |
| Amgen Inc.(AMGN) | 0 | 10,000 | +10,000 | $0 | $3.27M | 0.24% | +$3.27M |
| Belite Bio, IncADS(BLTE) | 0 | 20,000 | +20,000 | $0 | $3.20M | 0.23% | +$3.20M |
| ArriVent BioPharma, Inc.(AVBP) | 0 | 150,000 | +150,000 | $0 | $3.02M | 0.22% | +$3.02M |
| Mersana Therapeutics Inc | 0 | 100,000 | +100,000 | $0 | $2.89M | 0.21% | +$2.89M |
| Oaktree Acquisition Corp IiiUNIT 10 04 2029 UNIT 10/04/2029 | 250,000 | 250,000 | 0 | $2.66M | $2.65M | 0.19% | -$7.5K |
| Anteris Technologies Global Corp.(AVR) | 450,000 | 486,684 | +36,684 | $2.02M | $2.43M | 0.17% | +$403.6K |
| Orchestra BioMed Holdings, Inc.(OBIO) | 727,272 | 572,804 | -154,468 | $1.80M | $2.38M | 0.17% | +$573.5K |
| Eupraxia Pharmaceuticals Inc.(EPRX) | 300,000 | 300,000 | 0 | $1.77M | $2.27M | 0.16% | +$495.0K |
| Geron Corporation(GERN) | 1,500,000 | 1,500,000 | 0 | $2.06M | $1.98M | 0.14% | -$75.0K |
| Ultragenyx Pharmaceutical Inc.(RARE) | 0 | 75,000 | +75,000 | $0 | $1.73M | 0.12% | +$1.73M |
| Kezar Life Sciences Inc COM NEW | 0 | 229,076 | +229,076 | $0 | $1.44M | 0.10% | +$1.44M |
| COMPASS Pathways plcADS(CMPS) | 200,000 | 200,000 | 0 | $1.15M | $1.38M | 0.10% | +$234.0K |
| uniQure N.V.SHS(QURE) | 300,000 | 50,000 | -250,000 | $17.51M | $1.20M | 0.09% | -$16.31M |
| Cogent Biosciences, Inc.NOTE 1 625 11 1(COGT) | 0 | 0 | 0 | $0 | $1.18M | 0.08% | +$1.18M |
| Perspective Therapeutics, Inc.(CATX) | 300,000 | 300,000 | 0 | $1.03M | $825.0K | 0.06% | -$204.0K |
| MacroGenics, Inc.(MGNX) | 0 | 484,308 | +484,308 | $0 | $779.7K | 0.06% | +$779.7K |
| Perceptive Cap Solutions CorCL A CL A ORD SHS | 350,000 | 50,000 | -300,000 | $3.76M | $651.5K | 0.05% | -$3.10M |
| X4 Pharmaceuticals, Inc.(XFOR) | 0 | 145,000 | +145,000 | $0 | $580.0K | 0.04% | +$580.0K |
| Q32 Bio Inc.(QTTB) | 27,777 | 27,777 | 0 | $55.0K | $92.2K | 0.01% | +$37.2K |
| Adagio Medical Holdings, Inc.(ADGM) | 80,000 | 80,000 | 0 | $155.2K | $83.2K | 0.01% | -$72.0K |
| Rocket Pharmaceuticals, Inc.W EXP 09 02 202(RCKT) | 75,000 | 75,000 | 0 | $3.0K | $1.8K | 0.00% | -$1.2K |
| Akebia Therapeutics, Inc.(AKBA) | 2,450,000 | 0 | -2,450,000 | $6.69M | $0 | — | -$6.69M |
| ARS Pharmaceuticals, Inc.(SPRY) | 2,500 | 0 | -2,500 | $25.1K | $0 | — | -$25.1K |
| Astria Therapeutics Inc | 300,000 | 0 | -300,000 | $2.18M | $0 | — | -$2.18M |
| Autolus Therapeutics plcADS(AUTL) | 1,750,000 | 0 | -1,750,000 | $2.85M | $0 | — | -$2.85M |
| Context Therapeutics Inc.(CNTX) | 402,653 | 0 | -402,653 | $390.1K | $0 | — | -$390.1K |
| Crescent Biopharma, Inc.(CBIO) | 17,998 | 0 | -17,998 | $214.0K | $0 | — | -$214.0K |
| Enliven Therapeutics Inc | 400,000 | 0 | -400,000 | $8.19M | $0 | — | -$8.19M |
| Inspire Medical Systems, Inc.(INSP) | 50,000 | 0 | -50,000 | $3.71M | $0 | — | -$3.71M |
| Jazz Pharmaceuticals plcSHS USD(JAZZ) | 25,000 | 0 | -25,000 | $3.29M | $0 | — | -$3.29M |
| Karyopharm Therapeutics IncNOTE 3 000 10 1 | 0 | 0 | 0 | $12.46M | $0 | — | -$12.46M |
| Merus N V | 285,769 | 0 | -285,769 | $26.91M | $0 | — | -$26.91M |
| Milestone Pharmaceuticals Inc.(MIST) | 666,666 | 0 | -666,666 | $1.33M | $0 | — | -$1.33M |
| Monopar Therapeutics Inc.(MNPR) | 79,483 | 0 | -79,483 | $6.49M | $0 | — | -$6.49M |
| Ocular Therapeutix, Inc.(OCUL) | 239,000 | 0 | -239,000 | $2.79M | $0 | — | -$2.79M |