Securities ▲▼ | Shares | Value ($K) | |||||
|---|---|---|---|---|---|---|---|
Q4 2023 ▲▼ | Q1 2024 ▲▼ | Change ▲▼ | Q4 2023 ▲▼ | Q1 2024 ▲▼ | Weight (%) ▲▼ | Change ▲▼ | |
| DISC MEDICINE INC(IRON)(Put) | 0 | 396,600 | +396,600 | 0 | 24,692 | — | +24,692 |
| ASTRAZENECA PLC(AZN)(Call) | 0 | 309,200 | +309,200 | 0 | 20,948 | — | +20,948 |
| CORBUS PHARMACEUTICALS HLDGS | 0 | 559,271 | +559,271 | 0 | 21,946 | 2.41% | +21,946 |
| SPDR SER TR(Put) ST STR SP BIOT | 550,000 | 700,000 | +150,000 | 49,110 | 66,423 | — | +17,314 |
| VIKING THERAPEUTICS INC(VKTX)(Put) | 0 | 200,000 | +200,000 | 0 | 16,400 | — | +16,400 |
| CORCEPT THERAPEUTICS INC(CORT)(Put) | 271,300 | 994,500 | +723,200 | 8,812 | 25,051 | — | +16,240 |
| KRYSTAL BIOTECH INC(KRYS)(Put) | 412,000 | 375,000 | -37,000 | 51,113 | 66,724 | — | +15,611 |
| TARSUS PHARMACEUTICALS INC(TARS) | 518,519 | 710,277 | +191,758 | 10,500 | 25,819 | 2.83% | +15,319 |
| CRINETICS PHARMACEUTICALS IN(CRNX)(Put) | 0 | 300,400 | +300,400 | 0 | 14,062 | — | +14,062 |
| MADRIGAL PHARMACEUTICALS INC(MDGL)(Put) | 0 | 51,400 | +51,400 | 0 | 13,726 | — | +13,726 |
| BIOHAVEN LTD(BHVN)(Call) | 0 | 223,700 | +223,700 | 0 | 12,234 | — | +12,234 |
| BRIDGEBIO PHARMA INC(BBIO)(Call) | 0 | 389,400 | +389,400 | 0 | 12,040 | — | +12,040 |
| AEROVATE THERAPEUTICS INC | 0 | 367,965 | +367,965 | 0 | 10,881 | 1.19% | +10,881 |
| INSMED INC(INSM)(Call) | 200 | 347,200 | +347,000 | 6 | 9,420 | — | +9,413 |
| 4D MOLECULAR THERAPEUTICS IN(Put) | 0 | 257,600 | +257,600 | 0 | 8,207 | — | +8,207 |
| 4D MOLECULAR THERAPEUTICS IN(Call) | 0 | 257,600 | +257,600 | 0 | 8,207 | — | +8,207 |
| MACROGENICS INC(Call) | 0 | 523,500 | +523,500 | 0 | 7,706 | — | +7,706 |
| ALNYLAM PHARMACEUTICALS INC(ALNY) | 0 | 51,541 | +51,541 | 0 | 7,703 | 0.84% | +7,703 |
| CYTOKINETICS INC(CYTK) | 30,000 | 145,147 | +115,147 | 2,505 | 10,176 | 1.12% | +7,672 |
| PYXIS ONCOLOGY INC | 0 | 1,662,408 | +1,662,408 | 0 | 7,082 | 0.78% | +7,082 |
| EYEPOINT PHARMACEUTICALS INC(EYPT)(Put) | 283,200 | 658,200 | +375,000 | 6,545 | 13,605 | — | +7,060 |
| AMGEN INC(AMGN)(Call) | 35,000 | 60,000 | +25,000 | 10,081 | 17,059 | — | +6,979 |
| SAREPTA THERAPEUTICS INC(SRPT) | 132,640 | 152,278 | +19,638 | 12,790 | 19,714 | 2.16% | +6,923 |
| CYTOKINETICS INC(CYTK)(Put) | 0 | 100,000 | +100,000 | 0 | 7,011 | — | +7,011 |
| SCHOLAR ROCK HLDG CORP(SRRK)(Call) | 0 | 362,300 | +362,300 | 0 | 6,434 | — | +6,434 |
| CRINETICS PHARMACEUTICALS IN(CRNX) | 680,370 | 643,751 | -36,619 | 24,208 | 30,134 | 3.30% | +5,926 |
| APELLIS PHARMACEUTICALS INC(Put) COM | 0 | 100,000 | +100,000 | 0 | 5,878 | — | +5,878 |
| ARCUTIS BIOTHERAPEUTICS INC(ARQT) | 0 | 589,642 | +589,642 | 0 | 5,843 | 0.64% | +5,843 |
| PRAXIS PRECISION MEDICINES I(PRAX) | 200,000 | 168,388 | -31,612 | 4,456 | 10,275 | 1.13% | +5,819 |
| VERONA PHARMA PLC | 367,468 | 375,310 | +7,842 | 257 | 6,039 | 0.66% | +5,781 |
| CYBIN INC | 0 | 13,953,488 | +13,953,488 | 0 | 5,770 | 0.63% | +5,770 |
| ASTRIA THERAPEUTICS INC(Call) | 0 | 400,000 | +400,000 | 0 | 5,630 | — | +5,630 |
| CERVOMED INC | 0 | 237,345 | +237,345 | 0 | 5,530 | 0.61% | +5,530 |
| KRYSTAL BIOTECH INC(KRYS)(Call) | 100,000 | 100,000 | 0 | 12,406 | 17,793 | — | +5,387 |
| SCHOLAR ROCK HLDG CORP(SRRK) | 0 | 291,701 | +291,701 | 0 | 5,181 | 0.57% | +5,181 |
| STRUCTURE THERAPEUTICS INC(Put) | 0 | 120,400 | +120,400 | 0 | 5,160 | — | +5,160 |
| BIOMEA FUSION INC(Call) | 777,600 | 1,077,600 | +300,000 | 11,291 | 16,110 | — | +4,819 |
| MACROGENICS INC | 0 | 318,167 | +318,167 | 0 | 4,683 | 0.51% | +4,683 |
| XENON PHARMACEUTICALS INC(XENE) | 0 | 107,187 | +107,187 | 0 | 4,614 | 0.51% | +4,614 |
| NURIX THERAPEUTICS INC(NRIX) | 0 | 300,000 | +300,000 | 0 | 4,410 | 0.48% | +4,410 |
| TOURMALINE BIO INC(Call) | 0 | 179,200 | +179,200 | 0 | 4,104 | — | +4,104 |
| ALPINE IMMUNE SCIENCES INC(Call) | 0 | 103,000 | +103,000 | 0 | 4,083 | — | +4,083 |
| WAVE LIFE SCIENCES LTD(WVE) | 0 | 590,088 | +590,088 | 0 | 3,641 | 0.40% | +3,641 |
| ABEONA THERAPEUTICS INC | 600,000 | 888,593 | +288,593 | 3,006 | 6,442 | 0.71% | +3,436 |
| VIRIDIAN THERAPEUTICS INC(VRDN)(Put) | 0 | 178,900 | +178,900 | 0 | 3,133 | — | +3,133 |
| DISC MEDICINE INC(IRON)(Call) | 0 | 49,600 | +49,600 | 0 | 3,088 | — | +3,088 |
| JASPER THERAPEUTICS INC | 0 | 105,175 | +105,175 | 0 | 3,088 | 0.34% | +3,088 |
| ANNOVIS BIO INC(Call) | 0 | 250,000 | +250,000 | 0 | 2,975 | — | +2,975 |
| ANNOVIS BIO INC(Put) | 3,400 | 251,900 | +248,500 | 64 | 2,998 | — | +2,934 |
| VENTYX BIOSCIENCES INC | 5,914 | 507,647 | +501,733 | 15 | 2,792 | 0.31% | +2,777 |
| MARINUS PHARMACEUTICALS INC(Call) | 0 | 303,200 | +303,200 | 0 | 2,741 | — | +2,741 |
| SOLENO THERAPEUTICS INC(Call) | 21,200 | 81,100 | +59,900 | 853 | 3,471 | — | +2,618 |
| TOURMALINE BIO INC | 0 | 108,483 | +108,483 | 0 | 2,484 | 0.27% | +2,484 |
| IBIO INC | 0 | 600,000 | +600,000 | 0 | 2,436 | 0.27% | +2,436 |
| SAGIMET BIOSCIENCES INC | 0 | 412,565 | +412,565 | 0 | 2,236 | 0.25% | +2,236 |
| ASTRIA THERAPEUTICS INC(Put) | 0 | 153,700 | +153,700 | 0 | 2,163 | — | +2,163 |
| IMMUNIC INC | 0 | 1,612,378 | +1,612,378 | 0 | 2,128 | 0.23% | +2,128 |
| INSMED INC(INSM)(Put) | 0 | 70,900 | +70,900 | 0 | 1,924 | — | +1,924 |
| MARINUS PHARMACEUTICALS INC(Put) | 0 | 212,200 | +212,200 | 0 | 1,918 | — | +1,918 |
| LENZ THERAPEUTICS INC | 0 | 85,000 | +85,000 | 0 | 1,898 | 0.21% | +1,898 |
| ACHILLES THERAPEUTICS PLC | 0 | 1,443,181 | +1,443,181 | 0 | 1,804 | 0.20% | +1,804 |
| TARSUS PHARMACEUTICALS INC(TARS)(Call) | 100,000 | 100,000 | 0 | 2,025 | 3,635 | — | +1,610 |
| ALNYLAM PHARMACEUTICALS INC(ALNY)(Put) | 98,600 | 136,700 | +38,100 | 18,873 | 20,430 | — | +1,557 |
| INSMED INC(INSM) | 0 | 51,335 | +51,335 | 0 | 1,393 | 0.15% | +1,393 |
| RAPT THERAPEUTICS INC | 0 | 154,625 | +154,625 | 0 | 1,389 | 0.15% | +1,389 |
| UNIQURE NV(QURE) | 157,365 | 469,133 | +311,768 | 1,065 | 2,439 | 0.27% | +1,374 |
| PRAXIS PRECISION MEDICINES I(PRAX)(Call) | 0 | 21,800 | +21,800 | 0 | 1,330 | — | +1,330 |
| KODIAK SCIENCES INC(KOD) | 412,881 | 476,586 | +63,705 | 1,255 | 2,507 | 0.27% | +1,252 |
| AEON BIOPHARMA INC | 257,977 | 257,977 | 0 | 1,857 | 2,993 | 0.33% | +1,135 |
| ALPINE IMMUNE SCIENCES INC | 487,248 | 261,365 | -225,883 | 9,287 | 10,361 | 1.14% | +1,074 |
| AVALO THERAPEUTICS INC(AVTX) | 0 | 46,648 | +46,648 | 0 | 1,015 | 0.11% | +1,015 |
| ROCKET PHARMACEUTICALS INC | 0 | 297,096 | +297,096 | 0 | 8,004 | 0.88% | +8,004 |
| RAPT THERAPEUTICS INC(Call) | 0 | 87,200 | +87,200 | 0 | 783 | — | +783 |
| RAPT THERAPEUTICS INC(Put) | 58,800 | 246,200 | +187,400 | 1,461 | 2,211 | — | +750 |
| NYXOAH S A SHS | 0 | 50,699 | +50,699 | 0 | 684 | 0.07% | +684 |
| VERU INC | 0 | 946,382 | +946,382 | 0 | 663 | 0.07% | +663 |
| MIND MEDICINE MINDMED INC | 600,000 | 297,481 | -302,519 | 2,196 | 2,796 | 0.31% | +600 |
| LARIMAR THERAPEUTICS INC | 602,868 | 438,528 | -164,340 | 2,743 | 3,328 | 0.36% | +585 |
| AMYLYX PHARMACEUTICALS INC(AMLX)(Put) | 0 | 186,400 | +186,400 | 0 | 529 | — | +529 |
| ALLAKOS INC | 0 | 932,675 | +932,675 | 0 | 1,175 | 0.13% | +1,175 |
| GLYCOMIMETICS INC(Put) | 0 | 172,800 | +172,800 | 0 | 518 | — | +518 |
| GLYCOMIMETICS INC(Call) | 0 | 172,800 | +172,800 | 0 | 518 | — | +518 |
| ABEONA THERAPEUTICS INC(Call) | 0 | 67,500 | +67,500 | 0 | 489 | — | +489 |
| PROTARA THERAPEUTICS INC | 188,664 | 202,701 | +14,037 | 353 | 813 | 0.09% | +460 |
| NUVATION BIO INC(NUVB) | 1,222,852 | 633,282 | -589,570 | 1,847 | 2,305 | 0.25% | +459 |
| SOLENO THERAPEUTICS INC | 590,243 | 565,411 | -24,832 | 23,757 | 24,200 | 2.65% | +442 |
| Q32 BIO INC | 0 | 22,335 | +22,335 | 0 | 381 | 0.04% | +381 |
| KARYOPHARM THERAPEUTICS INC | 0 | 409,355 | +409,355 | 0 | 618 | 0.07% | +618 |
| PROQR THRAPEUTICS N V SHS EURO | 472,625 | 483,583 | +10,958 | 936 | 1,098 | 0.12% | +162 |
| ALEXANDRIA REAL ESTATE EQ IN(Put) | 73,300 | 73,300 | 0 | 9,292 | 9,449 | — | +157 |
| ELEVATION ONCOLOGY INC | 0 | 148,089 | +148,089 | 0 | 760 | 0.08% | +760 |
| STRUCTURE THERAPEUTICS INC(Call) | 0 | 2,000 | +2,000 | 0 | 86 | — | +86 |
| ANEBULO PHARMACEUTICALS INC | 0 | 157,862 | +157,862 | 0 | 453 | 0.05% | +453 |
| MILESTONE PHARMACEUTICALS IN | 0 | 466,019 | +466,019 | 0 | 834 | 0.09% | +834 |
| CHEMOMAB THERAPEUTICS LTD | 0 | 213,392 | +213,392 | 0 | 166 | 0.02% | +166 |
| STOKE THERAPEUTICS INC(STOK) | 12,116 | 6,816 | -5,300 | 64 | 92 | 0.01% | +28 |
| BRAINSTORM CELL THERAPEUTICS | 90,242 | 90,242 | 0 | 25 | 51 | 0.01% | +26 |
| RELMADA THERAPEUTICS INC | 40,369 | 40,369 | 0 | 167 | 188 | 0.02% | +21 |
| APELLIS PHARMACEUTICALS INC COM | 34,361 | 35,092 | +731 | 2,057 | 2,063 | 0.23% | +6 |
| IMMATICS N.V(IMTX) | 0 | 49,415 | +49,415 | 0 | 519 | 0.06% | +519 |