Fund Holdings

Ikarian Capital, LLC

Filing Period:
Securities
SharesValue ($K)
Q4 2025
Q1 2026
Change
Q4 2025
Q1 2026
Weight (%)
Change
TERNS PHARMACEUTICALS INC(Put)01,200,000+1,200,000063,264,000+63,264,000
INVESCO QQQ TR(Put)0100,000+100,000057,718,000+57,718,000
ISHARES TR(Put)0200,000+200,000049,600,000+49,600,000
CYTOKINETICS INC(CYTK)(Put)0550,500+550,500036,283,455+36,283,455
BRISTOL-MYERS SQUIBB CO(BMY)(Put)0500,000+500,000030,325,000+30,325,000
KODIAK SCIENCES INC(KOD)719,7871,265,795+546,00820,125,24548,252,1066.90%+28,126,861
ALUMIS INC01,213,548+1,213,548026,734,4623.82%+26,734,462
ABIVAX SA(ABVX)(Call)125,100293,300+168,20016,870,36332,658,955+15,788,592
NOVO-NORDISK A S(NVO)(Call)0400,000+400,000014,700,000+14,700,000
CELLDEX THERAPEUTICS INC NEW(CLDX)0461,247+461,247014,630,7552.09%+14,630,755
TERNS PHARMACEUTICALS INC1,596,3781,456,378-140,00064,493,67176,780,24810.98%+12,286,577
BRIDGEBIO PHARMA INC(BBIO)0160,120+160,120011,890,5111.70%+11,890,511
ORUKA THERAPEUTICS INC(ORKA)0242,021+242,021011,871,1301.70%+11,871,130
ANI PHARMACEUTICALS INC(ANIP)0147,085+147,085011,310,8371.62%+11,310,837
CAPRICOR THERAPEUTICS INC(CAPR)(Call)0350,000+350,000010,640,000+10,640,000
HARROW INC(HROW)183,347543,047+359,7008,984,00319,147,8372.74%+10,163,834
ULTRAGENYX PHARMACEUTICAL IN(RARE)12,671482,571+469,900291,43310,109,8631.45%+9,818,430
REVOLUTION MEDICINES INC(RVMD)(Put)095,000+95,00009,238,750+9,238,750
CYTOKINETICS INC(CYTK)(Call)290,900408,400+117,50018,483,78626,917,644+8,433,858
SOLENO THERAPEUTICS INC68,823344,123+275,3003,186,50511,521,2381.65%+8,334,733
PALVELLA THERAPEUTICS INC NE(PVLA)064,626+64,62608,055,6311.15%+8,055,631
VERA THERAPEUTICS INC(VERA)0200,000+200,00008,045,9991.15%+8,045,999
CYTOKINETICS INC(CYTK)172,672283,572+110,90010,971,57918,690,2312.67%+7,718,652
VAXCYTE INC(PCVX)378,682428,682+50,00017,472,38924,910,7113.56%+7,438,322
CONTINEUM THERAPEUTICS INC282,874807,874+525,0003,233,25010,550,8351.51%+7,317,585
OCUGEN INC03,962,972+3,962,97207,172,9791.03%+7,172,979
OVID THERAPEUTICS INC247,5582,894,704+2,647,146403,5206,426,2420.92%+6,022,722
ALUMIS INC(Call)0264,600+264,60005,829,138+5,829,138
INVENTIVA SA(IVA)502,6011,429,101+926,5002,328,8527,842,7811.12%+5,513,929
KARYOPHARM THERAPEUTICS INC(Call)0920,000+920,00005,124,400+5,124,400
KARYOPHARM THERAPEUTICS INC(Put)0920,000+920,00005,124,400+5,124,400
ANI PHARMACEUTICALS INC(ANIP)(Call)82,800150,000+67,2006,536,23211,535,000+4,998,768
AVALO THERAPEUTICS INC(AVTX)(Call)58,100401,500+343,4001,055,0965,994,395+4,939,299
TECTONIC THERAPEUTIC INC0157,537+157,53704,869,4690.70%+4,869,469
REVOLUTION MEDICINES INC(RVMD)138,142163,142+25,00011,003,01115,865,5612.27%+4,862,550
EYEPOINT INC(EYPT)(Call)0370,400+370,40004,774,456+4,774,456
EYEPOINT INC(EYPT)(Put)0370,400+370,40004,774,456+4,774,456
TENAX THERAPEUTICS INC967,6001,017,600+50,00011,795,04416,271,4242.33%+4,476,380
BRIDGEBIO PHARMA INC(BBIO)(Call)058,500+58,50004,344,210+4,344,210
KYMERA THERAPEUTICS INC(KYMR)(Put)050,400+50,40004,197,816+4,197,816
EUPRAXIA PHARMACEUTICALS INC610,0001,214,741+604,7414,605,5008,794,7261.26%+4,189,226
RELMADA THERAPEUTICS INC3,068,3592,688,359-380,00014,820,17518,710,9782.68%+3,890,803
KODIAK SCIENCES INC(KOD)(Call)0100,000+100,00003,812,000+3,812,000
CARDIOL THERAPEUTICS INC02,725,000+2,725,00003,678,7500.53%+3,678,750
CELLDEX THERAPEUTICS INC NEW(CLDX)(Put)0114,000+114,00003,616,080+3,616,080
ARROWHEAD PHARMACEUTICALS IN(ARWR)(Put)057,500+57,50003,605,250+3,605,250
SURROZEN INC65,788173,107+107,3191,486,8095,042,6070.72%+3,555,798
UNIQURE NV(QURE)(Call)105,400355,000+249,6002,522,2225,804,250+3,282,028
ENLIVEN THERAPEUTICS INC(Put)083,700+83,70003,281,040+3,281,040
OLEMA PHARMACEUTICALS INC(OLMA)(Call)200,000549,800+349,8005,000,0008,197,518+3,197,518
ZURA BIO LTD802,3221,193,492+391,1704,204,1677,101,2781.02%+2,897,111
VERA THERAPEUTICS INC(VERA)(Call)071,700+71,70002,884,491+2,884,491
JADE BIOSCIENCES INC300,000512,349+212,3494,629,0017,198,5031.03%+2,569,502
LIPOCINE INC NEW199,542508,556+309,0141,602,3224,063,3620.58%+2,461,040
ALTO NEUROSCIENCE INC(ANRO)515,000515,00009,167,00111,577,2001.66%+2,410,199
AVALO THERAPEUTICS INC(AVTX)(Put)0158,500+158,50002,366,405+2,366,405
REPLIMUNE GROUP INC(REPL)(Put)0300,000+300,00002,295,000+2,295,000
DAMORA THERAPEUTICS INC(DMRA)285,710335,710+50,0006,574,1878,694,8891.24%+2,120,702
ANNEXON INC(ANNX)230,244580,244+350,0001,155,8263,214,5510.46%+2,058,725
ANTERIS TECHNOLOGIES GLOBAL0366,571+366,57102,034,4690.29%+2,034,469
ACUMEN PHARMACEUTICALS INC254,3121,053,797+799,485536,5992,486,9600.36%+1,950,361
TENAX THERAPEUTICS INC(Call)0114,300+114,30001,827,657+1,827,657
ALECTOR INC2,082,6062,082,60603,248,8664,477,6030.64%+1,228,737
DEFINIUM THERAPEUTICS INC(DFTX)058,803+58,80301,111,3770.16%+1,111,377
BIOHAVEN LTD(BHVN)212,481412,481+200,0002,398,9103,489,5890.50%+1,090,679
SOLID BIOSCIENCES INC160,409264,409+104,000904,7071,903,7440.27%+999,037
COMPASS PATHWAYS PLC(CMPS)400,000675,000+275,0002,760,0003,732,7500.53%+972,750
IONIS PHARMACEUTICALS INC(IONS)(Call)94,600112,100+17,5007,483,8068,417,589+933,783
DIREXION SHARES ETF TRUST
DAI BIO BEA ETF
40,822105,822+65,000859,7121,724,8990.25%+865,187
CENTESSA PHARMACEUTICALS PLC018,113+18,1130719,4480.10%+719,448
PROMIS NEUROSCIENCES INC055,000+55,0000698,5000.10%+698,500
ACADIA PHARMACEUTICALS INC028,099+28,0990625,4840.09%+625,484
PASSAGE BIO INC068,124+68,1240534,7730.08%+534,773
TRAWS PHARMA INC678,142678,1420766,2991,241,0000.18%+474,701
CABALETTA BIO INC900,000900,00001,971,0002,421,0000.35%+450,000
MAZE THERAPEUTICS INC(MAZE)(Put)014,400+14,4000429,840+429,840
IMMUNIC INC674,662674,6620360,067748,8760.11%+388,809
PHARVARIS N V
COM
486,856486,856013,510,25513,753,6831.97%+243,428
ADLAI NORTYE LTD033,899+33,8990234,5810.03%+234,581
NEUMORA THERAPEUTICS INC.1,278,4081,278,40802,288,3512,492,8960.36%+204,545
KALVISTA PHARMACEUTICALS INC35,11935,1190567,173706,9460.10%+139,773
EQUILLIUM INC303,555303,5550470,510607,1100.09%+136,600
KEZAR LIFE SCIENCES INC
COM NEW
102,211102,2110642,907758,4050.11%+115,498
DBV TECHNOLOGIES S A525,000525,00002,084,2392,198,7760.31%+114,537
MACROGENICS INC74,89374,8930120,578216,4410.03%+95,863
KARYOPHARM THERAPEUTICS INC544,554733,435+188,8814,007,9184,085,2330.58%+77,315
LEXICON PHARMACEUTICALS INC(LXRX)164,674164,6740189,376256,8920.04%+67,516
NEURONETICS INC701,182701,1820967,6311,016,7140.15%+49,083
HYPERLIQUID STRATEGIES INC(PURR)30,00130,0010106,804152,7050.02%+45,901
BIOMX INC19,47319,473036,41473,1020.01%+36,688
AIRSCULPT TECHNOLOGIES INC16,39816,398032,46846,4050.01%+13,937
REZOLUTE INC16,47916,479038,89150,2610.01%+11,370
VERU INC133,517133,5170285,726295,0730.04%+9,347
NEUPHORIA THERAPEUTICS INC47,44347,4430184,079193,0930.03%+9,014
VYNE THERAPEUTICS INC264,912264,9120153,675158,2840.02%+4,609
SILENCE THERAPEUTICS PLC865,784865,78401,731,5681,731,5680.25%0
PMV PHARMACEUTICALS INC89,13689,1360111,421110,5290.02%-892
THERIVA BIOLOGICS INC112,076112,076023,58021,9440.00%-1,636
AUTONOMIX MED INC18,68818,688010,2787,2900.00%-2,988
VOYAGER THERAPEUTICS INC53,06353,0630208,538204,8230.03%-3,715
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